March 8, 2012

Exhibit 10.58

March 8, 0000

Xxxx Xxxxxxxxxxx, plc
Elan Science Three Limited
Xxxxxxxx Xxxxxxxx
Xxxxx Xxxxx Xxxxx Xxxxxx
Xxxxxx 0
Xxxxxxx

Ladies and Gentlemen:

Reference is made to the Shareholder’s Agreement dated as of September 16, 2011 (the “Shareholder’s Agreement”), by and among Alkermes plc, a public limited company incorporated in Ireland (registered number 498284), whose registered address is Xxxxxxxxx Xxxxx, 0 Xxxxxxxxxx Xxxx, Xxxxxx 0, Xxxxxxx (“Alkermes”), Elan Corporation, plc, a public limited company incorporated in Ireland (registered number 30356), whose registered address is Xxxxxxxx Xxxxxxxx, Xxxxx Xxxxx Xxxxx Xxxxxx, Xxxxxx 0, Xxxxxxx (the “Shareholder Parent”), and Elan Science Three Limited, a private limited company incorporated in Ireland (registered number 477401) and a wholly-owned subsidiary of the Shareholder Parent, whose registered address is Xxxxxxxx Xxxxxxxx, Xxxxx Xxxxx Xxxxx Xxxxxx, Xxxxxx 0, Xxxxxxx (the “Shareholder,” together with the Shareholder Parent and Alkermes, the “Parties”).  Unless specified otherwise, defined terms in this waiver and consent letter shall have the meaning assigned to them in the Shareholder’s Agreement.

The Shareholder Parent has advised Alkermes of the Shareholder’s desire to Transfer 24,150,000 Shareholder Shares, which represents 75.7% of the Shareholder Shares, in a marketed, underwritten registered offering pursuant to a registration statement that has been filed with the SEC on Form S-1 under File No. 333-179550 (the “Registered Offering”).  Alkermes previously executed and delivered to the Shareholder a Waiver and Consent Letter (the “Waiver and Consent Letter”) with respect to the Shareholder’s Agreement, (i) agreeing to waive certain limitations set forth in Section 5.1(b)(i) of the Shareholder’s Agreement in connection with the Registered Offering and (ii) agreeing and consenting to the Transfer of up to 15,985,000 Shareholder Shares by the Shareholder in the Registered Offering.

By execution of this waiver and consent letter in accordance with Section 7.4 of the Shareholder’s Agreement, Alkermes hereby waives the limitations set forth in Section 5.1(b)(i) of the Shareholder’s Agreement and consents to the Transfer of up to 8,165,000 Shareholder Shares (in addition to the 15,985,000 Shareholder Shares for which the waiver and consent were previously provided in the Waiver and Consent Letter), representing a waiver and consent with respect to the Transfer of an aggregate number of up to 24,150,000 Shareholder Shares, by the Shareholder in the Registered Offering.

This waiver and consent letter shall not be deemed to modify any other provision of the Shareholder’s Agreement or to constitute a waiver of any existing right or remedy thereunder not expressly stated above.  Except as expressly stated herein, Alkermes hereby reserves all rights and remedies available to it for the full protection and enforcement of its rights under the Shareholder’s Agreement.

Alkermes plc. Registered in Ireland (company number 498284). Registered Office: Xxxxxxxxx Xxxxx, 0 Xxxxxxxxxx Xxxx, Xxxxxx 0, Xxxxxxx. Directors: Xxxxxxx Xxxx - Chairman (USA), Xxxxx Xxxxxxx (USA), Xxxxx Xxxxx (USA), Xxxxxx Xxxxxx (USA), Xxxxx Xxxxx (USA), Xxxxxxxxx Xxxxxxx (USA), Xxxx Xxxxxxxx (USA), Xxxx Xxxxxxxxx (USA)

The waiver and consent set forth herein shall become effective on and as of the date hereof.  In the event the Transfer of Shareholder Shares contemplated in this waiver and consent letter is not consummated on or prior to Xxxxx 00, 0000 (xxxxx than any Transfer pursuant to any underwriters’ option to purchase additional shares in connection with such Registered Offering), this waiver and consent letter shall be revoked and cease to have any effect.

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	Sincerely,
	/s/ Xxxxx Xxxxx
	By:	Alkermes plc
	Name:	Xxxxx Xxxxx
	Title:	President

Agreed and acknowledged:

/s/ Xxxxxxx X. Xxxxxx
By:	Elan Corporation, plc
Name:	Xxxxxxx X. Xxxxxx
Title:	Executive Vice President and Company Secretary
/s/ Xxxxxxx X. Xxxxxx
By:	Elan Science Three Limited
Name:	Xxxxxxx X. Xxxxxx
Title:	Director

[Waiver and Consent]