AGREEMENT The undersigned hereby agree that this Amendment No. 2 to Schedule 13D filed by us with respect to the Common Stock, no par value, of North American Vaccine, Inc. is filed on behalf of each of us.

                                    EXHIBIT 1

                                    AGREEMENT


        The undersigned hereby agree that this Amendment No. 2 to Schedule 13D
filed by us with respect to the Common Stock, no par value, of North American
Vaccine, Inc. is filed on behalf of each of us.

Date: November 25, 1998            /S/ XXXXXXX XXXXX, M.D.
                                   ---------------------------------------------
                                   Xxxxxxx Xxxxx, M.D.

                                   FROST-NEVADA, LIMITED PARTNERSHIP



Date: November 25, 1998            By:  *                                       
                                        ----------------------------------------
                                        Xxxxx X. Xxxxxxxxx, President of Frost-
                                        Nevada Corporation, General Partner


                                   FROST-NEVADA CORPORATION



Date: November 25, 1998            By:  *                                       
                                        ----------------------------------------
                                        Xxxxx X. Xxxxxxxxx, President




*By: /S/ XXXXXXX XXXXX, M.D.        
     -----------------------------
         Xxxxxxx Xxxxx, M.D.
        (Attorney-in-fact pursuant
        to Power of Attorney)