JOINT FILING AGREEMENT

Exhibit 99.1

JOINT FILING AGREEMENT

This Joint Filing Agreement, dated as of November 21, 2017, is by and among HealthCare Ventures IX, L.P., HealthCare Partners IX, L.P., HealthCare Partners IX, LLC, Xxxxxxxxxxx X. Xxxxxxxxx, Ph.D., Xxxxxxxxx Xxxxxx and Xxxxxxx X. Xxxx (collectively, the “Filers”).

Each of the Filers may be required to file with the United States Securities and Exchange Commission a statement on Schedule 13G and/or 13D with respect to shares of Common Stock, $0.001 par value per share, of Leap Therapeutics, Inc. that may be beneficially owned by them from time to time.

Pursuant to and in accordance with Rule 13(d)(1)(k) promulgated under the Securities Exchange Act of 1934, as amended, the Filers hereby agree to file a single statement on Schedule 13G and/or 13D (and any amendments thereto) on behalf of each of such parties, and hereby further agree to file this Joint Filing Agreement as an exhibit to such statement, as required by such rule.

This Joint Filing Agreement may be terminated by any of the Filers upon one week’s prior written notice (or such lesser period of notice as the Filers may mutually agree) to the other party.

Executed and delivered as of the date first above written.

	HEALTHCARE VENTURES IX, L.P.
	By: HealthCare Partners IX, L.P., its general partner
	By: HealthCare Partners IX, LLC, its general partner
		By:	/s/ Xxxxxxxxx Xxxxxx
		Name: Xxxxxxxxx Xxxxxx
		Title: Managing Director
	HEALTHCARE PARTNERS IX, L.P.
	By: HealthCare Partners IX, LLC, its general partner
		By:	/s/ Xxxxxxxxx Xxxxxx
		Name: Xxxxxxxxx Xxxxxx
		Title: Managing Director

	HEALTHCARE PARTNERS IX, LLC
		By:	/s/ Xxxxxxxxx Xxxxxx
		Name: Xxxxxxxxx Xxxxxx
		Title: Managing Director
	XXXXXXXXXXX X. XXXXXXXXX, Ph.D.
		By:	/s/ Xxxxxxxxxxx X. Xxxxxxxxx
		Name: Xxxxxxxxxxx X. Xxxxxxxxx, Ph.D.
	XXXXXXXXX XXXXXX
		By:	/s/ Xxxxxxxxx Xxxxxx
		Name: Xxxxxxxxx Xxxxxx
	XXXXXXX X. XXXX
		By:	/s/ Xxxxxxx X. Xxxx
		Name: Xxxxxxx X. Xxxx