April 5, 2012 Dr. David Jacofsky

April 5, 2012

Xx. Xxxxx Xxxxxxxx

0000 X. Xxxx Xxxx Xxxxxxx, Xxxxx 000

Phoenix, AZ 85027

Dear Xx. Xxxxxxxx:

This letter serves to confirm our mutual agreement to terminate your Consulting Agreement dated August 11, 2011, effective as of April 5, 2012. For avoidance of doubt, your prior Consulting Agreement dated August 10, 2010 shall remain in effect.

Please indicate your agreement regarding the termination of your August 11, 2011 Consulting Agreement by signing below.

Very truly yours,

Bacterin International Holdings, Inc.

/s/ Xxx Xxxx

By:  Xxx Xxxx, CEO

AGREED AND ACCEPTED

/s/ Xxxxx Xxxxxxxx

Xxxxx Xxxxxxxx