Agreement of Joint Filing

Exhibit 1

Agreement of Joint Filing

Pursuant to 13d-1(k)(1) promulgated under the Securities Exchange Act of 1934, the undersigned persons hereby agree to file with the Securities and Exchange Commission the Statement on Schedule 13D (the “Statement”) to which this Agreement is attached as an exhibit, and agree that such Statement, as so filed, is filed on behalf of each of them.

IN WITNESS WHEREOF, the undersigned have executed this Agreement.

Dated: October 19, 2011

QVT FINANCIAL LP				QVT FUND LP
By: QVT Financial GP LLC, its General Partner				By: QVT Associates GP LLC, its General Partner
By:		/s/ Xxxxxx Xxxx		By:		/s/ Xxxxxx Xxxx
		Name: Xxxxxx Xxxx				Name: Xxxxxx Xxxx
		Title: Managing Member				Title: Managing Member
By:		/s/ Xxx Xxxxxx		By:		/s/ Xxx Xxxxxx
		Name: Xxx Xxxxxx				Name: Xxx Xxxxxx
		Title: Authorized Signatory				Title: Authorized Signatory
QVT FINANCIAL GP LLC				QVT ASSOCIATES GP LLC
By:		/s/ Xxxxxx Xxxx		By:		/s/ Xxxxxx Xxxx
		Name: Xxxxxx Xxxx				Name: Xxxxxx Xxxx
		Title: Managing Member				Title: Managing Member
By:		/s/ Xxx Xxxxxx		By:		/s/ Xxx Xxxxxx
		Name: Xxx Xxxxxx				Name: Xxx Xxxxxx
		Title: Authorized Signatory				Title: Authorized Signatory

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