Exhibit 8.1 [LETTERHEAD OF LATHAM & WATKINS] December 13, 2002 Hyseq, Inc. 670 Alamanor Avenue Sunnyvale, California 94085 RE: AGREEMENT AND PLAN OF MERGER BY AND AMONG HYSEQ, INC., VERTICAL MERGER CORP., AND VARIAGENICS, INC. DATED AS OF NOVEMBER 9,...

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