September 21, 2004 Richard Hooper OraSure Technologies, Inc.

Exhibit 10

September 21, 2004

Xxxxxxx Xxxxxx

OraSure Technologies, Inc.

000 Xxxx Xxxxx Xxxxxx

Bethlehem, Pennsylvania 18015

Re: LOAN EXTENSION

Borrower Name: OraSure Technologies, Inc.

Customer Number/Obligor Number: 5793834584

Loan Number/Note Number: 18/26

Dear Rich:

Comerica Bank, successor by merger to Comerica Bank- California, has approved an extension of the Revolving Maturity Date to April 30, 2005, under that certain Loan and Security Agreement dated September 10, 2002, as may be or have been modified from time to time (the “Loan Agreement”).

Except as modified and extended hereby, the Loan Agreement remains in full force and effect.

Very truly yours,

/s/ Xxxxx Xxxxxx

Xxxxx Xxxxxx

Acknowledged and accepted on September 27, 2004
OraSure Technologies, Inc.
By:		/s/ Xxxxxxx X. Xxxxxx