WAIVER

Exhibit 10.1

WAIVER

April 27, 2023

This Waiver (this “Waiver”) is made and entered into as of April 27, 2023, by and among Cerevel Therapeutics Holdings, Inc., a Delaware corporation (the “Company”), and the undersigned investors (the “Investors”).

Reference is hereby made to that certain Xxxxxxx and Restated Registration and Shareholder Rights Agreement, dated as of October 27, 2020, by and among the Company and the investors party thereto, as amended by that certain Waiver, dated as of January 20, 2021 (as so amended, the “Agreement”). Capitalized terms used herein without definition shall have the meanings ascribed to them in the Agreement.

WHEREAS, pursuant to Sections 4.1.1 of the Agreement, the only individuals entitled to be nominated by the Board to be elected or appointed as Directors shall be as set forth therein;

WHEREAS, pursuant to Section 4.1.2 of the Agreement, the Board shall be divided into three (3) classes and shall be as constituted as set forth therein;

WHEREAS, the Board proposes to (a) expand the size of the Board to twelve (12) Directors and (b) appoint Xxxxxx Xxxxxx to serve as a Class I Director on the Board, which shall result in Class I consisting of four (4) Directors, Class II consisting of four (4) Directors and Class III consisting of four (4) Directors (the appointment of Xxxxxx Xxxxxx pursuant to clauses (a) and (b) together, the “Appointment”); and

WHEREAS, pursuant to Section 5.6 of the Agreement, the Agreement may be amended, modified or extended, and the provisions thereof may be waived, only by an agreement in writing signed by the Company and the Majority Sponsor Investors, and each such amendment, modification, extension or waiver shall be binding upon each party thereto.

NOW, THEREFORE, in consideration of the foregoing, the Company and the undersigned Investors hereby acknowledge and agree as follows:

1.The undersigned Investors, together comprising the Majority Sponsor Investors, hereby irrevocably waive, on behalf of themselves and each other party to the Agreement, Sections 4.1.1 and 4.1.2 of the Agreement solely to the extent necessary to expand the size of the Board to twelve (12) Directors and change the number of Directors in each class of the Board, in each case for purposes of permitting the Appointment; provided, however, the waiver provided in this Section 1 is effective only as to the foregoing and in no way affects or impairs any other rights of the parties under the Agreement.

2.Except as expressly amended, modified, supplemented or waived hereby, the provisions of the Agreement are and will remain in full force and effect.

3.This Waiver may be executed in any number of counterparts, each of which shall constitute one agreement binding on all the parties to the Agreement.

4.This Waiver shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware, exclusive of its choice of laws and conflicts of laws rules.

[Signature page follows]

2

ACTIVE/122751479.2

IN WITNESS WHEREOF, the undersigned have executed this Waiver as of the date first set forth above.

CEREVEL THERAPEUTICS HOLDINGS, INC.

By: /s/ X. Xxxxxxx Xxxxx

Name: X. Xxxxxxx Xxxxx

Title: Chief Executive Officer and Chairperson

[Signature Page to Waiver]

IN WITNESS WHEREOF, the undersigned have executed this Waiver as of the date first set forth above.

BC PERCEPTION HOLDINGS, LP

By: BCPE Perception GP, LLC, its general partner

By: /s/ Xxxxx Xxxxxx_________________________

Name: Xxxxx Xxxxxx

Title: Authorized Signatory

[Signature Page to Waiver]

IN WITNESS WHEREOF, the undersigned have executed this Waiver as of the date first set forth above.

PFIZER INC.

By: /s/ Xxxxxx Xxxxxxxx______________________

Name: Xxxxxx Xxxxxxxx

Title: VP & Assistant General Counsel

[Signature Page to Waiver]