Exhibit 8
Joint Filing Agreement Pursuant to Rule 13d-1
This agreement is made pursuant to Rule 13d-l(k)(1)
under the Securities Exchange Act of 1934, as amended
(the "Act") by and among the parties listed below,
each referenced to herein as a "Joint Filer". The Joint
Filers agree that a statement of beneficial ownership
as required by Sections 13(g) or 13(d) of the Act and
the rules thereunder may be filed on each of his, her
or its behalf on Schedule 13G or Schedule 13D, as
appropriate, and that said joint filing may thereafter
be amended by further joint filings. The Joint Filers
state that they each satisfy the requirements for making
a joint filing under Rule 13d-1.
Dated: October 11, 2016
DAFNA CAPITAL MANAGEMENT, LLC
By: /s/ Xxxxxx Xxxxxxx
___________________________________
Xx. Xxxxxx Xxxxxxx
Its: Chief Executive Officer
/s/ Xxxxxx Xxxxxxx
___________________________________
Xxxxxx Xxxxxxx, MD, CFA
/s/ Xxxxxx Xxxxxxxx
___________________________________
Xxxxxx Xxxxxxxx, Ph.D., MBA
