AMENDMENT NO. 2 TO CLINICAL TRIAL COLLABORATION AND SUPPLY AGREEMENT
Exhibit 4.20
Certain identified information has been excluded from this exhibit because it is
both (i) not material and (ii) would likely cause competitive harm to the registrant if publicly disclosed. [*] indicates that information has been redacted.
CONFIDENTIAL
AMENDMENT NO. 2 TO
(FOR PANCREATIC CANCER STUDY)
This Amendment No. 2 to the CLINICAL TRIAL COLLABORATION AND SUPPLY AGREEMENT (this “Amendment No. 2”), made as of the date of last
signature hereunder (the “Amendment No. 2 Effective Date”), is by and between Merck Sharp & Dohme B.V. (“Merck”) and BioLineRx Ltd. (“BioLineRx”).
Capitalized terms used but not defined herein shall have the meanings ascribed to such terms in the Agreement.
WHEREAS, the Parties entered into a Clinical Trial Collaboration and Supply Agreement effective January 11, 2016 and amended it as of the
same date (such agreement, as amended, will be referred to hereunder as the “Agreement”); and
WHEREAS, the Parties wish to amend certain provisions of the Agreement, including with respect to the supply of the Compounds.
NOW, THEREFORE, the Parties hereby agree as follows:
| 1 |
Section 1.65 of the Agreement is hereby deleted in its entirety and replaced with the following
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“1.65. “Protocol” means the written documentation that describes the Study and sets forth specific
activities to be performed as part of the Study conduct, a copy of which in its approved final form is attached hereto as Appendix A.”
| 2 |
Section 4.1 of the Agreement is hereby deleted in its entirety and replaced with the following.
|
| “4.1. |
Protocol. The approved final Protocol is attached hereto as Appendix A. BioLineRx shall provide any subsequent proposed revisions to the approved final Protocol to Merck for
Merck’s review and comment, consistent with the remaining provisions of this Section 4.1.
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| 4.1.1. |
Notwithstanding the provisions of Section 4.1, each Party shall have the following decision rights:
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| a) |
Any further, material changes to the approved final Protocol (other than relating solely to the BioLineRx Compound) and [*] shall require Merck’s prior written consent. Any such proposed changes will be sent in writing to Merck’s Project
Manager and Merck’s Alliance Manager. Merck will provide such consent, or a written explanation for why such consent is
|
being withheld, within [*] Business Days of receiving a copy of BioLineRx’s requested changes.
CONFIDENTIAL
| b) |
[*]
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| c) |
[*]
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| 3 |
Section 8.1 of the Agreement is hereby deleted in its entirety and replaced with the following.
|
| “8.1. |
Supply of the Compounds. Subject to the terms and conditions of this Agreement, BioLineRx and Merck will each use commercially reasonable efforts to supply, or cause to be supplied, such
quantities of its Compound in accordance with the delivery schedule set forth on Appendix B. In the event that BioLineRx determines that the quantities of Compounds as set forth on Appendix B are not sufficient to complete
the Study, BioLineRx shall so notify Merck in writing, and the Parties shall discuss in good faith regarding whether additional quantities of Compounds may be provided and the schedule on which such additional quantities may be provided.
Each Party shall also provide to the Party a contact person for the supply of its Compound under this Agreement. [*].”
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| 4 |
Appendix A of the Agreement is hereby deleted in its entirety and replaced with the new Appendix A, which is attached to this Amendment No. 2 as Exhibit 1.
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| 5 |
Appendix B of the Agreement is hereby deleted in its entirety and replaced with the new Appendix B, which is attached to this Amendment No. 2 as Exhibit 2.
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| 6 |
Schedule I of the Agreement is hereby deleted in its entirety and replaced with the new Schedule I, which is attached to this Amendment No. 2 as Exhibit 3.
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| 7 |
The remaining provisions of the Agreement shall remain in full force and effect Upon execution of this Amendment No. 2 by both Parties, all references in the Agreement to the “Agreement” shall mean the Agreement as modified by this
Amendment No. 2.
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| 8 |
This Amendment No. 2 may be executed in two (2) or more counterparts as set forth in the Agreement.
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[Remainder of page intentionally left blank.]
2
CONFIDENTIAL
IN WITNESS WHEREOF, the respective authorized representatives of the Parties have executed this Amendment No. 2 on the date set forth under
the signatures below.
By: /s/ Xxxxxx Xxxxxx
Xxxxxx Xxxxxx
Name
Chief Executive officer
Title
24-July-2018
Date
Merck Sharp & Dohme B.V.
By: /s/ X. X. Xxxxxxx
X. X. Xxxxxxx
Name
Proxy Holder
Title
July 17, 2018
Date
3
CONFIDENTIAL
Exhibit 1
Appendix A PROTOCOL
[*]
CONFIDENTIAL
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Exhibit 2
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Appendix B DELIVERY SCHEDULE
[*]
CONFIDENTIAL
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Exhibit 3
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Schedule I
DATA SHARING AND SAMPLE TESTING SCHEDULE
[*]
