AGREEMENT

EXHIBIT 99.1

AGREEMENT

In accordance with Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended, the undersigned hereby agree that this Statement on Schedule 13G relating to the Ordinary Shares of Bicycle Therapeutics plc is being filed with the Securities and Exchange Commission on behalf of each of them.

February 12, 2024

	XXXXX BROS. ADVISORS LP By: Xxxxx Bros. Advisors (GP) LLC, its general partner
	By:	/s/ Xxxxx X. Xxxxxxx
		Name: Xxxxx X. Xxxxxxx Title: President

	XXXXX BROS. ADVISORS (GP) LLC
	By:	/s/ Xxxxx X. Xxxxxxx
		Name: Xxxxx X. Xxxxxxx Title: President
		/s/ Xxxxxx X. Xxxxx
		Xxxxxx X. Xxxxx
		/s/ Xxxxx X. Xxxxx
		Xxxxx X. Xxxxx