EXHIBIT 4.30 AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD DATED 1ST APRIL 2000. 22nd February 2001 Following a change, the registered address of the "Company" shall now read 8 Centre One, Old Sarum Park, Lysander Way, Salisbury,...

                                                                    EXHIBIT 4.30


        AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD
                              DATED 1ST APRIL 2000.




22nd February 2001


Following a change, the registered address of the "Company" shall now read 8
Centre One, Xxx Xxxxx Xxxx, Xxxxxxxx Xxx, Xxxxxxxxx, XX0 0XX.



Signed for both Parties by:




/s/ illegible                                   /s/ M.A. Xxxxxxxx
-----------------------------                   ------------------------------
for and on behalf of                            for and on behalf of
ENACT PHARMA PLC                                CHIMAERON LTD