AVEO Pharmaceuticals, Inc. 75 Sidney Street Cambridge, MA 02139 www.aveopharma.com

Exhibit 10.23

AVEO Pharmaceuticals, Inc. 00 Xxxxxx Xxxxxx Xxxxxxxxx, XX 00000   xxx.xxxxxxxxxx.xxx

October 31, 2011

Xxxx Xxxxxxxxxxxx, PhD

0 Xxxxxxxxxx Xxxx

Xxxxxx, XX 00000

Re: Consulting and Scientific Advisory Board Agreement by and between Xxxx Xxxxxxxxxxxx, PhD and AVEO Pharmaceuticals, Inc. effective as of January 1, 2010 (the “Agreement”)

Dear Xx. Xxxxxxxxxxxx,

It is hereby agreed that Section 2 of the Agreement shall be amended to extend the Consultation Period through and including December 31, 2013 unless sooner terminated in accordance with Section 11 of the Agreement. All other terms and obligations under the Agreement shall remain the same.

Sincerely,

/s/ Xxxxxx X. Xxxxxxxx

Xxxxxx X. Xxxxxxxx, PhD

Senior Vice President, Translational Research

Chair of the Scientific Advisory Board

Agreed and Acknowledged:
/s/ Xxxx Xxxxxxxxxxxx				Xxxxxxxx 0, 0000
Xxxx Xxxxxxxxxxxx, XxX				Date