EXHIBIT 10.22
----------------
REDACTED VERSION
----------------
EXHIBIT 10.22
TO
ICOS CORPORATION'S
FORM 10-K
FOR THE YEAR ENDED
DECEMBER 31, 1996
"[ * ]" = omitted, confidential material, which material has been
separately filed with the Securities and Exchange Commission pursuant to a
request for confidential treatment.
ICOS
LICENSE AGREEMENT
THIS ICOS LICENSE AGREEMENT ("Agreement") is made this 6th day of
February, 1997, by and between SUNCOS CORPORATION, a Delaware corporation
("Company"), and ICOS Corporation, a Delaware corporation ("ICOS").
RECITALS
WHEREAS, ICOS has granted to the Company [ * ] license to
certain proprietary patent rights, technical information, technology and know-
how relating to and useful in the manufacture, production and worldwide
commercial sale of platelet-activating factor acetylhydrolase [ * ];
WHEREAS, ICOS, Suntory Limited, a Japanese corporation ("Suntory"),
and the Company have entered into a Shareholders' Agreement, dated December 18,
1996 ("Shareholders' Agreement"), with respect to the organization and
capitalization of the Company to engage in the development, manufacture,
production and sale of PAF-AH Products (as defined in the Shareholders'
Agreement) [ * ] in the Field of Activity (as defined in the Shareholders'
Agreement);
WHEREAS, ICOS, Suntory and the Company have entered into a Development
and Supply Agreement of even date herewith (the "Development Agreement")
pursuant to which ICOS and Suntory will conduct development work on behalf of
the Company with respect to the Background Technology (as defined in the
Shareholders' Agreement);
WHEREAS, ICOS desires to obtain from the Company the PAF-AH Technology
(as defined in the Shareholders' Agreement) and [ * ] in the Field of
Activity in ICOS Territory (as defined in the Shareholders' Agreement); and in
view of the Shareholders' Agreement and the parties further development
activities pursuant to the Development Agreement, the Company is willing to
grant such a license to ICOS; and
WHEREAS, the Company has granted a similar license to Suntory of even
date herewith, [ * ] on substantially the same terms and conditions
contained herein and for the same purposes described herein ("Suntory License
Agreement").
* Confidential Treatment Requested
NOW, THEREFORE, it is hereby agreed as follows:
ARTICLE I
DEFINITIONS
1.01 INCORPORATION BY REFERENCE
Unless otherwise defined herein, capitalized terms used herein shall
have the meanings specified in the Shareholders' Agreement.
1.02 PARTY
The term Party shall mean ICOS or the Company or, when used in the
plural, ICOS and the Company.
1.03 SUBSIDIARY
The term Subsidiary shall mean a corporate entity other than ICOS or
the Company of which at least fifty percent (50%) of the voting stock is owned
or controlled, directly or indirectly, by ICOS or the Company.
1.04 TERM OF SUPPORT
The term Term of Support shall have the meaning set forth in the
Development Agreement.
1.05 NET SALES
The term Net Sales shall mean [ * ], less the following
deductions related to the sale or other disposition:
[ * ].
* Confidential Treatment Requested
2
ARTICLE II
GRANT OF LICENSE
2.01 GRANT OF LICENSE
Subject to the terms of this Agreement, the Company hereby grants to
ICOS [ * ] license to use the PAF-AH Technology in the Field of Activity
to make, use and sell PAF-AH Products in the ICOS Territory.
2.02 RIGHT TO SUBLICENSE
The Company also hereby grants to ICOS the right to grant sublicenses
within and limited to the scope of the right and license granted by the Company
in Section 2.01 [ * ]; provided, however, that no sublicense shall be
granted under clauses (c) or (d) of this Section 2.02 without the prior written
consent of the Company, which consent shall not be unreasonably withheld. Any
sublicensees of ICOS shall agree in writing to be bound by the provisions of
Section 3.02 to the same extent ICOS is bound. ICOS shall notify the Company of
the identity of each sublicensee a sublicense is granted and provide the Company
a true copy of such sublicense. In the event that the license granted herein to
ICOS is terminated at any time in accordance with Article VII and the Company
shall not be in default under Section 7.03, the Company shall have the option [
* ]. ICOS shall include in all of its sublicenses granted hereunder
provisions for such termination and assignment.
2.03 LIMITATIONS
No right or license is granted to ICOS hereunder except as expressly
specified in Sections 2.01 and 2.02.
2.04 OTHER LICENSES
It is acknowledged that the Company has granted [ * ] license to
Suntory to utilize the PAF-AH technology in the Suntory Territory in accordance
with the
* Confidential Treatment Requested
3
terms of the Suntory License Agreement and that it may grant licenses to utilize
the PAF-AH Technology in the manner provided in the Shareholders' Agreement.
[ * ].
ARTICLE III
DISCLOSURE
3.01 DISCLOSURE
(a) The Company shall, in accordance with the Shareholders' Agreement
and the Development Agreement during the Term of Support, reasonably disclose
and deliver to ICOS all PAF-AH Technology in sufficient detail to permit ICOS to
employ such information for the purposes provided herein.
(b) ICOS shall, during the Term of Support, have the right to attend
and participate in the Company's technical meetings, conduct plant visits at
reasonable intervals and receive information regarding the PAF-AH Technology.
ICOS shall be provided with reasonable notice of the time and place of such
meetings.
(c) During the term of this Agreement, each Party shall inform the
other Party, promptly and in a manner to be agreed upon, of any [ * ]
related to PAF-AH Products in [ * ].
3.02 CONFIDENTIALITY
(a) Any confidential PAF-AH Technology that is disclosed to ICOS
pursuant to this Agreement or the Shareholders' Agreement shall be designated as
confidential information in the following manner:
(i) If the disclosure is in written form, by prominently marking
or stamping each document containing such information with a notice indicating
the confidential and proprietary nature of the information; and
(ii) If the disclosure is in oral form, by delivering to ICOS
within fifteen (15) days of the oral disclosure written notice confirming the
confidential and proprietary nature of the information.
* Confidential Treatment Requested
4
(b) Except to the extent expressly authorized by this Agreement, the
Shareholders' Agreement, the Development Agreement or by other prior written
consent of the Company during the term of this Agreement and thereafter, ICOS
shall keep completely confidential and shall not publish or otherwise disclose
to others and shall not use any confidential PAF-AH Technology disclosed or
provided to ICOS by the Company. For the purposes of this Agreement, PAF-AH
Technology shall be deemed not confidential to the extent, and only to the
extent, that it:
(i) was known to ICOS at the time of its disclosure and not
otherwise subject to an obligation of ICOS to keep such information
confidential;
(ii) was generally available to the public or was
otherwise part of the public domain at the time of its disclosure;
(iii) became generally available to the public or became
otherwise part of the public domain after its disclosure and other than through
any act or omission of ICOS in breach of this Agreement; or
(iv) became known to ICOS after its disclosure (A) from a source
other than the Company (including from independent development by ICOS), (B)
other than from a third party who had an obligation to the Company not to
disclose such information to others, and (C) other than under an obligation of
confidentiality.
ICOS may disclose any PAF-AH Technology to the extent such disclosure
is necessary for ICOS to comply with applicable laws or regulations or to make,
use or sell under the license granted herein by the Company or to sublicense
others to do so; provided, that ICOS shall give the Company reasonable advance
notice of such proposed disclosure, shall use its best efforts to secure
confidential treatment of PAF-AH Technology to be disclosed and shall advise the
Company in writing of the manner in which that was done.
(c) The obligation of confidentiality imposed by this Section 3.02
shall survive termination of this Agreement for any reason whatsoever.
[ * ]
* Confidential Treatment Requested
5
(b) Except as expressly authorized by this Agreement or by the prior
written consent of the Company, during the term of this Agreement and
thereafter,
[ * ].
ARTICLE IV
ROYALTY
4.01 ROYALTY
ICOS shall pay to the Company a royalty, at the applicable rate
hereinafter specified, on Net Sales of PAF-AH Products that are sold or
otherwise disposed of by ICOS or any of its Subsidiaries or sublicensees in the
ICOS Territory, whether or not such Subsidiaries are sublicensed pursuant to
Section 2.02. The royalty rate to be applied to Net Sales shall be:
[ * ].
Royalties shall be payable with respect to the Net Sales of a PAF-AH
Product occurring prior to the later of [ * ].
4.02 SALES TO SUBSIDIARIES AND SUBLICENSEES
[ * ].
4.03 RECORDS
ICOS shall keep full, complete and accurate records with respect to
the sale or other disposition of PAF-AH Products sufficient to enable the
Company to verify the accuracy of the statements required by Section 4.04(a).
The Company shall have the
* Confidential Treatment Requested
6
right, through its accredited auditing representative, to make an examination
and audit, during normal business hours, not more frequently than annually, of
all such records and such other records and accounts as may under recognized
accounting practices contain information bearing upon the amount of royalty
payable to it under this Agreement. Prompt adjustment shall be made by the
proper Party to compensate for any errors or omissions disclosed by such
examination or audit. Neither such right to examine and audit nor the right to
receive such adjustment shall be affected by any statement to the contrary,
appearing on checks or otherwise, unless such statement appears in a letter,
signed by the Party having such right and delivered to the other Party,
expressly waiving such rights.
4.04 TERMS OF ACCOUNTING
(a) Within [ * ] after the end of each [ * ] period ending
on [ * ], commencing with the first [ * ] period in which Net Sales
occur, ICOS shall furnish to the Company a statement, in form acceptable to the
Company, setting forth the number of units of PAF-AH Products sold or otherwise
disposed of during the period, the Net Sales and the amount of royalty payable
thereon.
(b) Within such [ * ] period ICOS shall, irrespective of its own
business and accounting methods, pay to the Company the royalties payable for
such [ * ] period.
(c) ICOS shall furnish whatever additional information the Company may
reasonably request from time to time to enable the Company to ascertain which
PAF-AH Products sold or otherwise disposed of by ICOS or any of its Subsidiaries
or sublicensees are subject to the payment of royalty to the Company and the
amount of royalty payable thereon.
4.05 LATE PAYMENTS
Royalty payments required under this Agreement shall, when overdue, be
subject to a late payment charge [ * ]; provided, however, that if the
amount of such late payment charge exceeds the maximum permitted by law for such
charge, such charge shall be reduced to such maximum amount.
* Confidential Treatment Requested
7
4.06 PAYMENTS
Payment to the Company shall be made in United States dollars. If any
royalty for any [ * ] period referred to in Section 4.04 is computed in
[ * ].
4.07 TAXES
ICOS shall bear all taxes, however designated, imposed as a result of
the existence or operation of this Agreement, including, but not limited to, any
tax on or measured by, any payment or receipt of payment hereunder, any
registration tax, and any tax imposed with respect to the granting or transfer
of licenses or other rights or considerations hereunder, except any such tax
imposed upon the Company by any governmental entity within or without the United
States, including any such tax which ICOS is required to withhold or deduct from
payments to the Company.
ARTICLE V
PATENT APPLICATIONS AND COPYRIGHT REGISTRATIONS
5.01 PATENT APPLICATIONS
ICOS shall pay the Company's reasonable costs and expenses (including
attorneys' fees) incurred to file, prosecute and maintain in force any patent
applications or patents covering the PAF-AH Technology that ICOS desires the
Company to file, prosecute or maintain in the ICOS Territory; provided, that, to
the extent an application or patent includes subject matter not covering the
manufacture, use or sale of products in the Field of Activity, ICOS shall pay an
equitable pro rata share of such costs and expenses.
If the Company's licensor and the Company decline to file, prosecute
or maintain any patent application or patent covering the PAF-AH Technology in
the ICOS Territory, [ * ].
* Confidential Treatment Requested
8
ARTICLE VI
PATENT, COPYRIGHT AND TRADE SECRET ENFORCEMENT
6.01 RIGHTS OF ICOS
Except as provided in the PAF-AH License Agreement and Section 6.02,
ICOS shall have the right, but not the obligation, to bring, defend and maintain
any appropriate suit or action involving infringement of any patent or
copyright, misappropriation of any trade secret or interference with any other
intellectual property right included in the PAF-AH Technology in the ICOS
Territory that ICOS has licensed hereunder. If ICOS finds it necessary to join
the Company in such suit or action, the Company shall execute all papers and
perform such other acts as may be reasonably required and may, at its option, be
represented by counsel of its choice. ICOS shall pay to the Company its
reasonable expenses (excluding its attorneys' fees) in connection with such suit
or action. If ICOS lacks standing to bring any suit or action, then ICOS may
cause the Company to do so upon first undertaking to indemnify and hold the
Company harmless (to the extent permissible by law) from all consequent
liability and to promptly reimburse all reasonable expenses (including
attorneys' fees) stemming therefrom. Any amount recovered in any such suit or
action, whether by judgment or settlement, shall be paid to or retained entirely
by ICOS.
6.02 RIGHTS OF THE COMPANY AND SUNTORY
ICOS shall notify the Company of any infringement in the Field of
Activity in the ICOS Territory of any patent within the PAF-AH Technology
covering the making, use or sale of products or the use of processes both within
and outside the Field of Activity and shall provide the Company with any
available evidence of such infringement. The Company, ICOS and Suntory shall
consult with each other as to the best manner in which to proceed. The Party
whose patent is involved shall have the first right, but not the obligation, to
bring, defend and maintain any appropriate suit or action for such infringement.
If the Party finds it necessary or desirable to join either or both other
Parties in such suit or action, such other Parties shall execute all papers and
perform such other acts as may be reasonably required to do so and may, at its
option be represented by counsel of its choice. The pursuing Party shall pay
such other Parties' reasonable expenses (excluding attorneys' fees) in
connection with such suit or action. Any amount recovered in any such action,
whether by judgment or settlement, shall first be used to reimburse the pursuing
Party for its costs and expenses (including attorneys' fees) and then paid to
the Company and ICOS in accordance with their interests. In the event the Party
whose patent is involved fails or declines to take action to enforce the patent
within three (3) months following
9
receipt of notice and evidence of such infringement, ICOS shall have the right
to bring, defend and maintain any appropriate suit or action for such
infringement in accordance with Section 6.01.
ARTICLE VII
TERM AND TERMINATION
7.01 TERM
Unless sooner terminated as provided below, this Agreement shall
remain in full force and effect [ * ]. Upon the expiration of this
Agreement as provided in the preceding sentence, the license granted to ICOS
hereunder shall [ * ].
7.02 EFFECTIVE DATE
This Agreement (including the license and rights granted under
Sections 2.01 and 2.02) shall come into effect as of the date hereof and shall
remain in full force and effect until the earlier of [ * ].
7.03 DEFAULT
In the event that a Party (the "Defaulting Party") shall (a) fail to
make any payment hereunder when and as due, or otherwise default in its
obligations hereunder and fail to remedy such default within sixty (60) days
after such default shall have been called to its attention by notice from
another Party, (b) become bankrupt or insolvent, or file a petition in
bankruptcy or make a general assignment for the benefit of creditors or
otherwise acknowledge insolvency, or be adjudged bankruptcy, (c) go or be placed
in a process of complete liquidation other than in connection with a
continuation of the business of the Company in some other legal form, or (d)
suffer the appointment of a receiver for any substantial portion of its business
who shall not be discharged within sixty (60) days after his appointment, then,
and in any such event, any other Party, at its] option, may terminate its
obligations to and the rights of the Defaulting Party under this Agreement upon
ten (10) days' written notice to the Defaulting Party, which termination shall
be effective as of the occurrence of the event giving rise to the option to
terminate.
* Confidential Treatment Requested
10
7.04 SURVIVAL
Notwithstanding the termination or expiration of a Party's obligations
to or the rights of the Defaulting Party under this Agreement in accordance with
the provisions of Sections 7.01, 7.02 or 7.03, the provisions of Section 3.02,
Section 7.01, this Section 7.04 and Article X shall survive such termination and
continue in full force and effect for an indefinite term. Upon termination of
this Agreement for any reason under Section 7.02 or 7.03, and without limitation
of other remedies, ICOS shall
[ * ].
ARTICLE VIII
INFRINGEMENTS
8.01 INFRINGEMENTS
In the event that ICOS is charged with infringement or unauthorized
use of the alleged patent rights or proprietary rights of others [ * ]
then any damage recovery with respect to such claim and legal costs incurred in
ICOS's defense shall be reasonably shared by ICOS and the Company in accordance
with their interests, but the Company's share shall not exceed the percentage of
the Company's outstanding capital stock held by ICOS and the Company's total
liability shall not exceed the aggregate royalties previously paid hereunder by
ICOS and the royalties that ICOS will pay hereunder thereafter (i.e., ICOS will
receive a credit against its future royalty obligations for the Company's unpaid
share of such damage recovery and legal costs).
ARTICLE IX
CONSENTS AND APPROVALS
9.01 BEST EFFORTS
The Parties hereto shall use their best efforts to obtain as soon as
practicable any and all consents, approvals, orders or authorizations required
to be obtained from any governmental authority with respect to the provisions
hereof.
* Confidential Treatment Requested
11
ARTICLE X
NOTICE
10.01 NOTICES
All notices, requests, demands and other communications required or
permitted to be given under this Agreement shall be in writing and shall be
mailed to the Party to whom notice is to be given, by telex or facsimile, and
confirmed by first class mail, registered or certified, return receipt
requested, postage prepaid, and properly addressed as follows (in which case
such notice shall be deemed to have been duly given on the third (3rd) day
following the date of such sending):
"ICOS" ICOS Corporation
00000 - 00xx Xxxxxx X.X.
Xxxxxxx, XX 00000
U.S.A.
Attn: President
With a copy to: Xxxxxxx Coie
0000 Xxxxx Xxxxxx, 00xx Xxxxx
Xxxxxxx, XX 00000-0000
U.S.A.
Attn: Xxxxx X. Xxxxxxxxx, Esq.
"Company" Suncos Corporation
c/o Suntory Limited
The Garden Court 8-F
0-0 Xxxx-xxx, Xxxxxxx-xx
Xxxxx 000, Xxxxx
Attn: President
Pharmaceutical Division
Any Party by giving notice to the others in the manner provided above may change
such Party's address for purposes of this Section 10.01.
12
ARTICLE XI
MISCELLANEOUS
11.01 ENTIRE AGREEMENT
This Agreement, together with the other written agreements between the
Parties hereto which are referenced in the Shareholders' Agreement, sets forth
the entire agreement of the Parties with respect to the subject matter hereof
and may not be modified except by a writing signed by authorized representatives
of the Parties hereto. To the extent that there may be conflicts or
inconsistencies between the provisions of this Agreement and those contained in
the Shareholders' Agreement, the provisions of the Shareholders' Agreement shall
prevail and govern interpretation.
11.02 HEADINGS
Article and section headings in this Agreement are included for
convenience of reference only and shall not constitute a part of this Agreement
for any other purpose.
11.03 EXECUTION IN COUNTERPARTS
This Agreement may be executed in any number of counterparts and by
different Parties hereto in separate counterparts each of which when so executed
and delivered shall be deemed to be an original and all of which counterparts of
this Agreement taken together shall constitute but one and the same instrument.
11.04 FORCE MAJEURE
It is agreed that each of the Parties hereto is excused from
performing such acts as are required hereunder as may be prevented by or whose
purpose is frustrated by Force Majeure. The Party so affected shall give notice
to the other Party in writing promptly and thereupon shall be excused from such
of its obligations hereunder as it is unable to perform on account of the Force
Majeure throughout the duration thereof plus a period of thirty (30) days.
11.05 APPLICABLE LAW
This Agreement shall be governed by and construed in accordance with
the internal laws, and not the law of conflicts, of the State of Delaware
applicable to agreements made and to be performed in such state.
13
11.06 ASSIGNMENT ON WRITTEN CONSENT
This Agreement shall be binding upon and inure to the benefit of the
Company and ICOS and their respective successors and assigns to the extent it is
assignable. This Agreement may not be assigned in whole or in part by ICOS,
except with the prior written consent of the Company or except as part of
[ * ].
11.07 SEVERABILITY
In the event any one or more of the provisions contained in this
Agreement shall be invalid, illegal or unenforceable in any respect, the
validity, legality or enforceability of the remaining provisions contained
herein shall not in any way be affected or impaired thereby. In such event,
such invalid provision or provisions shall be validly reformed to as nearly
approximate the intent of the Parties as possible and if unreformable, shall be
severed and deleted from this Agreement.
11.08 NO WAIVER
No failure or delay on the part of either Party in exercising any
right, power or remedy hereunder shall operate as a waiver thereof, nor shall
any single or partial exercise of any such right, power or remedy preclude any
other or further exercise thereof or the exercise of any other right, power or
remedy hereunder or the remedies provided by law.
11.09 TRADEMARKS AND TRADENAMES
The Company grants no rights to ICOS in any trademarks or tradenames
of the Company or of any of its respective Subsidiaries or affiliated companies.
11.10 INDEMNITY
ICOS hereby (a) releases the Company from any obligation to defend,
indemnify or save ICOS and its agents and employees harmless from and (b) agrees
to defend, indemnify and save the Company harmless from any and all cost,
expenses (including attorneys' fees), liabilities, damages and claims for any
injury or death to persons or damage to or destruction of property, or other
loss, arising out of or in connection with any product made, used or sold by
ICOS or the use by ICOS of the PAF-AH Technology licensed hereunder, or
otherwise arising out of or related to the performance of this Agreement.
* Confidential Treatment Requested
14
11.11 OTHER AGREEMENTS
Any other provision of this Agreement notwithstanding, nothing in this
Agreement shall obligate the Company to disclose to ICOS any information or to
make available to ICOS any materials in violation of an obligation of secrecy or
a limitation of use imposed by a third party from whom such information or
materials shall have been received.
11.12 REMEDIES
No right, power or remedy herein conferred upon or reserved to any
Party is intended to be exclusive of any other right, power or remedy or
remedies, and each and every right, power and remedy of any Party pursuant to
this Agreement or now or hereafter existing at law or in equity or by statute or
otherwise shall to the extent permitted by law be cumulative and concurrent, and
shall be in addition to every other right, power or remedy pursuant to this
Agreement, or now or hereafter existing at law or in equity or by statute or
otherwise and the exercise or beginning of the exercise by any Party of any one
or more of such rights, powers or remedies shall not preclude the simultaneous
or later exercise by any Party of any or all such other rights, powers or
remedies.
11.13 ATTORNEYS' FEES AND COSTS
In the event of any action at law or in equity between the Parties
hereto to enforce any of the provisions hereof, the unsuccessful party or
parties to such litigation shall pay to the successful party or parties all
costs and expenses, including actual attorneys' fees, incurred therein by such
successful party or parties; and if such successful party or parties shall
recover judgment in any such action or proceeding, such costs, expenses and
attorneys' fees may be included in and as part of such judgment. The successful
party shall be the party who is entitled to recover its costs of suit, whether
or not the suit proceeds to final judgment. A party not entitled to recover its
costs shall not recover attorneys' fees.
11.14 NUMBER AND GENDER
Words in the singular shall include the plural, and words in a
particular gender shall include either or both additional genders, when the
context in which such words are used indicates that such is the intent.
15
11.15 AGREEMENT TO PERFORM NECESSARY ACTS
Each Party agrees to perform any further acts and execute and deliver
any and all further documents and/or instruments which may be reasonably
necessary to carry out the provisions of this Agreement.
11.16 REPRESENTATIONS
Each of the Parties hereto acknowledges and agrees (i) that no
representation or promise not expressly contained in this Agreement has been
made by any other Party hereto or by any of its agents, employees,
representatives or attorneys; (ii) that this Agreement is not being entered into
on the basis of, or in reliance on, any promise or representation, expressed or
implied, covering the subject matter hereof, other than those which are set
forth expressly in this Agreement; and (iii) that each has had the opportunity
to be represented by counsel of its own choice in this matter, including the
negotiations which preceded the execution of this Agreement.
11.17 RIGHTS IN THE EVENT OF BANKRUPTCY
All rights in the PAF-AH Technology granted under this Agreement to
ICOS by the Company are, and shall otherwise be deemed to be, for purposes of
Section 365(n) of the U.S. Bankruptcy Code, a license of rights to "intellectual
property" as defined in Section 101 of the U.S. Bankruptcy Code. ICOS, as
licensee of such rights under this Agreement, shall retain and may fully
exercise all of its rights and elections under the U.S. Bankruptcy Code. In the
event of the commencement of a bankruptcy proceeding by or against the Company
under the U.S. Bankruptcy Code, ICOS shall be entitled to complete access to (or
a complete duplicate of, as appropriate) such PAF-AH Technology.
16
IN WITNESS WHEREOF, the Parties have caused this Agreement to be
executed by their duly authorized representatives in the manner legally binding
on them as of the date first above written.
SUNCOS CORPORATION
By /s/ Xxxxxx Xxxxxxxx
-------------------
Xxxxxx Xxxxxxxx
Chairman of the Board
By /s/ Xxxxxx X. Xxxxxxxx
----------------------
Xxxxxx X. Xxxxxxxx,
President and Chief Executive Officer
ICOS CORPORATION
By /s/ Xxxxxx X. Xxxxxxxx
----------------------
Xxxxxx X. Xxxxxxxx,
Chairman of the Board,
President and Chief Executive Officer
17
