XCYTE THERAPIES, INC. SERIES F PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT February 5, 2002

Exhibit 10.3

XCYTE THERAPIES, INC.

SERIES F PREFERRED STOCK

AND WARRANT PURCHASE AGREEMENT

February 5, 2002

TABLE OF CONTENTS

			Page
1.	Purchase and Sale of Stock		1
	1.1	Authorization, Sale and Issuance of Shares	1
	1.2	Closing	1
	1.3	Delivery	2
	1.4	Additional Closings	2

2.	Representations and Warranties of the Company		2
	2.1	Organization, Good Standing and Qualification	2
	2.2	Authorization	3
	2.3	Capitalization	3
	2.4	Subsidiaries	4
	2.5	Governmental Consents	4
	2.6	Proprietary Information Agreement	4
	2.7	Patents and Trademarks	4
	2.8	Financial Statements	5
	2.9	Changes	5
	2.10	Liabilities	6
	2.11	Litigation	6
	2.12	Compliance with Other Instruments	7
	2.13	Offering	7
	2.14	Agreements; Action	7
	2.15	Labor Agreements and Actions	8
	2.16	Tax Returns, Payments and Elections	8
	2.17	Title to Property and Assets	8
	2.18	Registration Rights	9
	2.19	Employee Benefit Plans	9
	2.20	Obligations of Management	9
	2.21	Environmental and Safety Laws	9
	2.22	Disclosure	9
	2.23	Section 83(b) Elections	9
	2.24	Real Property Holding Corporation	9
	2.25	Insurance	9
	2.26	Investment Company Act	9

3.	Representations and Warranties of the Investor		9
	3.1	Authorization	10
	3.2	Purchase Entirely for Own Account	10
	3.3	Disclosure of Information	10
	3.4	Investment Experience	10
	3.5	Regulation D	10
	3.6	Restricted Securities	10

TABLE OF CONTENTS

(cont’d.)

			Page
	3.7	Legends	11
	3.8	Regulation S	11

4.	Conditions of Investor’s Obligations at Closing		11
	4.1	Representations and Warranties	11
	4.2	Performance	11
	4.3	Certificate	12
	4.4	Compliance Certificate	12
	4.5	Proceedings and Documents	12
	4.6	Board of Directors	12
	4.7	Rights Agreement	12
	4.8	Co-Sale Agreement	12
	4.9	Opinion of Company Counsel	12

5.	Conditions of the Company’s Obligations at Closing		12
	5.1	Representations and Warranties	12
	5.2	Legal Matters	12

6.	Miscellaneous		13
	6.1	Survival of Warranties	13
	6.2	Successors and Assigns	13
	6.3	Governing Law	13
	6.4	Counterparts	13
	6.5	Titles and Subtitles	13
	6.6	Notices	13
	6.7	Finder’s Fee	13
	6.8	Amendments and Waivers	14
	6.9	Severability	14
	6.10	Exculpation Among Investors	14
	6.11	Expenses	14

EXHIBITS

A	Schedule of Investors

B	Form of Amended and Restated Certificate of Incorporation

C	Schedule of Exceptions

D	Form of Proprietary Information Agreement

E	Form of Amended and Restated Investor Rights Agreement

F	Form of Amended and Restated Right of First Refusal and Co-Sale Agreement

G	Form of Opinion of Counsel to the Company

H	Additional Representations and Warranties of Foreign Investors

XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

THIS SERIES F PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT (the “Agreement”) is made as of the fifth day of February, 2002, by and between Xcyte Therapies, Inc., a Delaware corporation, located at 0000 Xxxxxxxx Xxxxxx, Xxxxx 000, Xxxxxxx, XX 00000 (the “Company”), and the investors listed on Exhibit A hereto, each of which is herein referred to as an “Investor.”

WHEREAS, the Company desires to issue and sell up to 5,395,683 shares of Series F Preferred Stock and to issue warrants to purchase 2,937,650 shares of Common Stock to the Investors; and

WHEREAS, the Investors desire to purchase such shares and warrants from the Company on the terms and subject to the conditions of this Agreement.

NOW THEREFORE, the parties hereby agree as follows:

1. Purchase and Sale of Stock.

1.1 Authorization, Sale and Issuance of Shares

(a) The Company has authorized the sale and issuance of up to 6,500,000 shares of Series F Preferred Stock (the “Series F Shares”) and the issuance of warrants to purchase 2,937,650 shares of Common Stock (the “Warrants” and together with the Series F Shares the “Shares”). The Series F Shares have the rights, preferences, privileges and restrictions as set forth in the Company’s Restated Certificate of Incorporation in the form satisfactory to the Investors, a copy of which is attached hereto as Exhibit B. The Common Stock issuable upon conversion of the Series F Shares is referred to hereinafter as the “Conversion Shares” and the Common Stock issuable upon exercise of the Warrants is referred to hereinafter as the “Warrant Shares.”

(b) Subject to the terms and conditions of this Agreement, the Company shall sell and issue to each Investor, and each Investor agrees, severally and not jointly, to purchase from the Company, that number of (i) Shares of Series F Preferred Stock at a purchase price of $2.78 per share and (ii) Warrants at a cash purchase price of $0.001 per share of Common Stock set forth opposite each Investor’s name on Exhibit A attached hereto. Each Investor understands that the Shares and the Warrants cannot be purchased separately and must be purchased in the proportion allocated on Exhibit A.

1.2 Closing. The purchase and sale of the Shares shall take place at the offices of Venture Law Group, 0000 Xxxxxxxx Xxxxx, Xxxxxxxx, Xxxxxxxxxx, at 10:00 a.m., on February 5, 2002, or at such other time and place as the Company and Investors may agree (which time and

place are designated as the “Closing”). The date of such Closing is hereinafter referred to as the “Closing Date.”

1.3 Delivery. At the Closing, the Company shall deliver to each Investor a certificate representing the Shares which such Investor is purchasing against delivery to the Company by such Investor of a check, wire transfer of immediately available funds payable to the Company’s order or cancellation of indebtedness (or any combination thereof) in the aggregate amount of the purchase price therefor.

1.4 Additional Closings. If the full number of Series F Shares of the Company is not sold at the Closing, the Company shall have the right, at any time within thirty (30) days of the Closing Date (the “Subsequent Closing Date”), to sell the remaining authorized but unissued shares of Series F Shares and Warrants to purchase Common Stock to one or more additional purchasers as determined by the Company, or to any Investor hereunder who wishes to acquire additional shares of Series F Shares and Warrants to purchase Common Stock at the price and on the terms set forth herein, provided that any such additional purchaser shall be required to execute counterpart signature pages to this Agreement, the Investors’ Rights Agreement and the Co-Sale Agreement (each as defined in Section 2.2), and such additional purchasers will, upon delivery to the Company of such signature pages and the purchase price, become parties to, and be bound by, such agreements, each to the same extent as if they had been Investors at the initial Closing. Immediately after each additional closing, Exhibit A to this Agreement will be amended to list the additional purchasers purchasing shares of Series F Shares and Warrants to purchase Common Stock hereunder at each such additional closing. Any additional purchaser so acquiring shares of Series F Shares and Warrants to purchase Common Stock shall be considered an “Investor” for the purposes of the Financing Documents (as defined below), and any Series F Shares so acquired by such additional purchaser shall be considered “Series F Shares” and any Warrants to purchase Common Stock so acquired by such additional purchaser shall be considered “Warrants,” and together with the Series F Shares the “Shares”) for purposes of this Agreement and all other agreements contemplated hereby.

2. Representations and Warranties of the Company. The Company hereby represents and warrants to each Investor that, except as set forth on the Schedule of Exceptions attached hereto as Exhibit C, which exceptions shall be deemed to be representations and warranties as if made hereunder:

2.1 Organization, Good Standing and Qualification. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to carry on its business as now conducted and as proposed to be conducted. The Company is duly qualified to transact business and is in good standing in each jurisdiction in which the failure so to qualify would have a material adverse effect on its business or properties. As of the Closing, the Certificate shall be in the form attached hereto as Exhibit B and the Bylaws of the Company shall be in the form provided to counsel for the Investors prior to the Closing.

2.2 Authorization.

(a) The Company has all requisite corporate power and authority to execute and deliver, and to consummate the transactions contemplated by this Agreement, the Amended and Restated Investor Rights Agreement attached as Exhibit E (“Rights Agreement”) and the Amended and Restated Right of First Refusal and Co-Sale Agreement attached as Exhibit F (the “Co-Sale Agreement” with the Agreement and Rights Agreement, the “Financing Documents”). All corporate action on the part of the Company, its officers, directors and stockholders necessary for the execution and delivery of, and the consummation of the transactions contemplated by the Financing Documents, the performance of all obligations of the Company under the Financing Documents and the authorization, sale, issuance (or reservation for issuance) and delivery of the Shares being sold hereunder and the Conversion Shares and Warrant Shares has been taken or will be taken prior to the Closing. The Financing Documents, upon execution and delivery by the Company and assuming the due and proper execution and delivery by the other parties, constitute valid and binding obligations of the Company enforceable in accordance with their respective terms, except as such enforcement may be limited by bankruptcy, insolvency, moratorium and other laws of general application affecting the enforcement of creditors’ rights.

(b) The Shares, when issued in compliance with the provisions of this Agreement, will be validly issued, fully paid and nonassessable and will be free of any liens or encumbrances known to, or caused or created by, the Company; provided, however, that the Shares may be subject to restrictions on transfer under state and/or federal securities laws as set forth herein, as may be required by changes in such laws and as contemplated by the Financing Documents. Upon conversion of the Series F Shares into the Conversion Shares and Warrants into Warrant Shares in conformity with the Certificate, such Conversion Shares and Warrant Shares will be duly authorized, validly issued, fully paid and nonassessable, and will be free of any liens or encumbrances caused or created by the Company; provided, however, that the Conversion Shares and Warrant Shares may be subject to restrictions on transfer under state and/or federal securities laws as set forth herein, as may be required by changes in such law and as contemplated by the Financing Documents.

(c) Except as set forth herein or in the Financing Documents, no entity has any right of first refusal or any preemptive rights in connection with the issuance of the Shares, the Warrant Shares, the Conversion Shares or any future issuances of securities by the Company.

2.3 Capitalization.

(a) As of Closing, the authorized capital of the Company shall consist of: (i) 70,000,000 shares of Common Stock, and (ii), 42,000,000 shares of Preferred Stock (the “Preferred Stock”), of which 7,300,080 have been designated Series A Preferred Stock, 4,097,580 have been designated Series B Preferred Stock, 7,212,316 have been designated Series C Preferred Stock, 10,300,000 have been designated Series D Preferred Stock, 6,500,000 have been designated Series E Preferred Stock and 6,500,000 have been designated Series F Preferred

Stock. As of the Closing, 7,437,380 shares of Common Stock, warrants to purchase 3,083,110 shares of Common Stock, 6,860,512 shares of Series A Preferred Stock, warrants to purchase 439,568 shares of Series A Preferred Stock, 3,903,080 shares of Series B Preferred Stock, warrants to purchase 194,500 shares of Series B Preferred Stock, 7,185,630 shares of Series C Preferred Stock, and warrants to purchase 26,686 shares of Series C Preferred Stock, 10,109,825 shares of Series D Preferred Stock, warrants to purchase 103,741 shares of Series D Preferred Stock, 4,750,095 shares of Series E Preferred Stock, warrants to purchase 10,000 shares of Series E Preferred Stock and no shares of Series F Preferred Stock will be outstanding.

(b) Except as set forth in this Agreement and the exhibits thereto, there are no outstanding options, warrants, rights (including conversion or preemptive rights) or agreements for the purchase or acquisition from the Company of any shares of its capital stock except that the Company has reserved (i) the Shares for issuance at each Closing, (ii) the Common Stock issuable upon conversion of the Preferred Stock, (iii) 4,400,000 shares of Common Stock reserved for issuance pursuant to stock option plans adopted by the Company of which 2,944,354 options have been granted and remain outstanding, with 680,414 shares remaining for grant as of the Closing.

2.4 Subsidiaries. The Company does not presently own or control, directly or indirectly, any interest in any other corporation, association, or other business entity.

2.5 Governmental Consents.

(a) No consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority on the part of the Company is required in connection with the consummation of the transactions contemplated by the Financing Documents.

(b) No consent, approval, waiver or other action by any person under any contract, agreement, indenture, lease, instrument or other document to which the Company is a party or bound is required or necessary for the execution, delivery and performance of, or the consummation of the transactions contemplated by, any of the Financing Documents by the Company.

2.6 Proprietary Information. Each former and present employee, consultant and officer of the Company has executed and each future employee, consultant and officer will execute, a Proprietary Information Agreement in the form attached hereto as Exhibit D and no exceptions have been taken by any such employee, consultant or officer to the terms of such agreement. The Company, after reasonable investigation, is not aware that any of its employees, officers or consultants are in violation thereof, and the Company will use its best efforts to prevent any such violation.

2.7 Patents and Trademarks. The Company has sufficient title and ownership of all patents, trademarks, service marks, trade names, copyrights, trade secrets, information, proprietary rights and processes necessary for its business as now conducted and as proposed to

be conducted without any conflict with or infringement of the rights of others. There are no outstanding options, licenses, or agreements of any kind relating to the foregoing, nor is the Company bound by or a party to any options, licenses or agreements of any kind with respect to the patents, trademarks, service marks, trade names, copyrights, trade secrets, licenses, information, proprietary rights and processes of any other person or entity. The Company has not received any communications alleging that the Company has violated or, by conducting its business as proposed, would violate any of the patents, trademarks, service marks, trade names, copyrights or trade secrets or other proprietary rights of any other person or entity. The Company is not aware that any of its employees is obligated under any contract (including licenses, covenants or commitments of any nature) or other agreement, or subject to any judgment, decree or order of any court or administrative agency, that would interfere with the use of his or her best efforts to promote the interests of the Company or that would conflict with the Company’s business as proposed to be conducted. Neither the execution nor delivery of this Agreement, nor the carrying on of the Company’s business by the employees of the Company, nor the conduct of the Company’s business as proposed, will, to the best of the Company’s knowledge, conflict with or result in a breach of the terms, conditions or provisions of, or constitute a default under, any contract, covenant or instrument under which any of such employees is now obligated. The Company does not believe it is or will be necessary to utilize any inventions of any of its employees (or people it currently intends to hire) made prior to their employment by the Company.

2.8 Financial Statements. The Company has delivered to each Investor (i) its unaudited balance sheet as of December 31, 2001 and unaudited statement of income for the period from January 1, 2001 to December 31, 2001 and audited financial statements as of December 31, 2000 (collectively the “Financial Statements”). The Financial Statements, together with the notes thereto, are complete and correct in all material respects and have been prepared in accordance with generally accepted accounting principles applied on a consistent basis throughout the periods indicated, except as disclosed therein, and present fairly the financial condition and position of the Company as of December 31, 2001; provided, however, that the unaudited financial statements are subject to normal recurring year-end audit adjustments (which are not expected to be material), and do not contain all footnotes required under generally accepted accounting principles.

2.9 Changes. Since December 31, 2001, there has not been:

(a) Any change in the assets, liabilities, financial condition or operations of the Company from that reflected in the Financial Statements, other than changes in the ordinary course of business, or any other event or condition of any character, any of which individually or in the aggregate has had or is expected to have a material adverse effect on such assets, liabilities, financial condition or operations of the Company;

(b) Any resignation or termination of any key officers of the Company; and the Company, to the best of its knowledge, does not know of the impending resignation or termination of employment of any such officer;

(c) Any material change, except in the ordinary course of business, in the contingent obligations of the Company by way of guaranty, endorsement, indemnity, warranty or otherwise;

(d) Any damage, destruction or loss, whether or not covered by insurance, materially and adversely affecting the properties, business or prospects or financial condition of the Company;

(e) Any direct or indirect loans made by the Company to, or any material change in, any compensation arrangement or agreement with, any stockholder, employee, officer or director of the Company, other than advances made in the ordinary course of business;

(f) Any declaration or payment of any dividend or other distribution of the assets of the Company;

(g) Any debt, obligation or liability incurred, assumed or guaranteed by the Company, except those for immaterial amounts and for current liabilities incurred in the ordinary course of business; or any waiver by the Company of a valuable right or of a material debt owed to it;

(h) Any sale, assignment or transfer of any patents, trademarks, copyrights, trade secrets or other intangible assets; and

(i) To the Company’s knowledge, any change in any material agreement to which the Company is a party or by which it is bound which materially and adversely affects the business, assets, liabilities, financial condition, operations or prospects of the Company, including compensation agreements with the Company’s employees.

2.10 Liabilities. The Company has no material liabilities and knows of no material contingent liabilities not disclosed in the Financial Statements, except current liabilities incurred in the ordinary course of business subsequent to December 31, 2001, which have not been, either in any individual case or in the aggregate, materially adverse.

2.11 Litigation. There is no action, suit, proceeding or investigation pending or currently threatened against the Company that questions the validity of this Agreement or the right of the Company to enter into it, or to consummate the transactions contemplated hereby, or which might result, either individually or in the aggregate, in any material adverse changes in the assets, condition, affairs or prospects of the Company, financially or otherwise, or any change in the current equity ownership of the Company, nor is the Company aware that there is any basis for the foregoing. The foregoing includes, without limitation, actions pending or threatened (or any basis therefor known to the Company) involving the prior employment of any of the Company’s employees, their use in connection with the Company’s business of any information or techniques allegedly proprietary to any of their former employers, or their obligations under any agreements with prior employers. The Company is not a party or subject to the provisions of

any order, writ, injunction, judgment or decree of any court or government agency or instrumentality. There is no action, suit, proceeding or investigation by the Company currently pending or which the Company intends to initiate.

2.12 Compliance with Other Instruments. The Company is not in violation or default of any provision of its Certificate or Bylaws or any provision of any mortgage, indenture, contract, agreement, instrument, judgment, order, writ, or decree to which it is a party or by which it is bound or, to its knowledge, of any provision of federal or state statute, rule or regulation applicable to the Company which would materially and adversely affect the business, assets, liabilities, financial condition, operations or prospects of the Company. The execution, delivery and performance of this Agreement, the Rights Agreement and the Co-Sale Agreement and the consummation of the transactions contemplated hereby and thereby will not result in any such material violation or be in conflict with or constitute, with or without the passage of time and giving of notice, either a default under any such provision, instrument, judgment, order, writ, decree or contract or an event which results in the creation of any lien, charge or encumbrance upon any assets of the Company.

2.13 Offering. Subject in part to the accuracy of the Investors’ representations set forth in Section 3 hereof, the offer, sale and issuance of the Shares as contemplated by this Agreement and the issuance of the Conversion Shares or Warrant Shares upon the conversion of such Shares are exempt from the registration requirements of the Securities Act of 1933, as amended (the “Securities Act”), and the registration, qualification or compliance requirements of any applicable blue sky or other state securities laws, and neither the Company nor any authorized agent acting on its behalf will take any action that would cause the loss of any such exemption.

2.14 Agreements; Action.

(a) There are no agreements, understandings or proposed transactions between the Company and any of its officers, directors, affiliates, or any affiliate thereof.

(b) There are no agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which it is bound which involve (i) obligations of, or payments to the Company in excess of $25,000, or (ii) the license of any patent, copyright, trade secret or other proprietary right to or from the Company (other than licenses arising from the purchase of “off-the-shelf” products) or (iii) obligations of, or payments by, the Company to any officer, director, employee or family member of any such individual.

(c) The Company has not (i) declared or paid any dividends, or authorized or made any distribution upon or with respect to any class or series of its capital stock, (ii) incurred any indebtedness for money borrowed or incurred any other liabilities individually in excess of $25,000 or in excess of $75,000 in the aggregate, (iii) made any loans or advances to any person, other than ordinary advances for travel expenses, or (iv) sold, exchanged or otherwise disposed of any of its assets or rights, other than in the ordinary course of business.

(d) The Company is not a party to and is not bound by any contract, agreement or instrument, or subject to any restriction under its Certificate or Bylaws, which materially adversely affects its business as now conducted and as proposed to be conducted.

(e) The Company has not engaged in the past twelve (12) months in any discussion (i) with any representative of any corporation or corporations regarding the consolidation or merger of the Company with or into any such corporation or corporations, (ii) with any corporation, partnership, association or other business entity or any individual regarding the sale, conveyance or disposition of all or substantially all of the assets of the Company, or (iii) regarding any other form of liquidation, dissolution or winding up of the Company.

2.15 Labor Agreements and Actions. The Company is not bound by or subject to (and none of its assets or properties is bound by or subject to) any written or oral, express or implied, contract, commitment or arrangement with any labor union, and no labor union has requested or, to the knowledge of the Company, has sought to represent any of the employees, representatives or agents of the Company. There is no strike or other labor dispute involving the Company pending, or to the knowledge of the Company threatened, which could have a material adverse effect on the assets, properties, financial condition, operating results, or business of the Company (as such business is presently conducted and as it is proposed to be conducted), nor is the Company aware of any labor organization activity involving its employees. To the best of its knowledge, the Company is not aware that any officer or key employee, or that any group of key employees, intends to terminate their employment with the Company, nor does the Company have a present intention to terminate the employment of any of the foregoing. The employment of each officer and employee of the Company is terminable at the will of the Company.

2.16 Tax Returns, Payments and Elections. The Company has filed all tax returns and reports as required by law. These returns and reports are true and correct in all material respects. The Company has paid all taxes and other assessments due, except those contested by it in good faith which are listed in the Schedule of Exceptions, attached hereto as Exhibit C. The provision for taxes of the Company as shown in the Balance Sheet is adequate for taxes due or accrued as of the date thereof. The Company has not elected pursuant to the Internal Revenue Code of 1986, as amended (the “Code”), to be treated as a Subchapter S corporation or a collapsible corporation pursuant to Section 1362(a) or Section 341(f) of the Code, respectively, nor has it made any other elections pursuant to the Code (other than elections which relate solely to methods of accounting, depreciation or amortization) which would have a material effect on the Company, its financial condition, its business as presently conducted or proposed to be conducted or any of its properties or material assets.

2.17 Title to Property and Assets. The Company owns its property and assets free and clear of all mortgages, liens, loans and encumbrances, except such encumbrances and liens which arise in the ordinary course of business and do not materially impair the Company’s ownership or use of such property or assets. With respect to the property and assets it leases, the Company is in compliance with such leases and, to the best of its knowledge, holds a valid leasehold interest free of any liens, claims or encumbrances.

2.18 Registration Rights. Except as provided in the Rights Agreement, a form of which is attached hereto as Exhibit E, the Company has not granted or agreed to grant any registration rights, including piggyback rights, to any person or entity.

2.19 Employee Benefit Plans. The Company does not have any Employee Benefit Plan as defined in the Employee Retirement Income Security Act of 1974, as amended.

2.20 Obligations of Management. Each officer of the Company is currently devoting his or her full-time to the conduct of the business of the Company. The Company is not aware of any officer or key employee or the Company planning to work less than full-time at the Company in the future.

2.21 Environmental and Safety Laws. To the best of its knowledge, the Company is not in violation of any applicable statute, law or regulation relating to the environment or occupational health and safety, and to its knowledge, no material expenditures are or will be required in order to comply with any such existing statute, law or regulation.

2.22 Disclosure. The Company has fully provided each Investor with all the information which such Investor has requested for deciding whether to purchase the Shares and all information which the Company believes is reasonably necessary to enable such Investor to make such decision. To the best of the Company’s knowledge, neither this Agreement, the Rights Agreement, the Co-Sale Agreement nor any other statements or certificates made or delivered in connection herewith, when taken as a whole, contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements herein or therein not misleading.

2.23 Section 83(b) Elections.2.23. To the Company’s knowledge, all elections and notices permitted by Section 83(b) of the Internal Revenue Code and analogous provisions of applicable state tax laws have been timely filed by all employees who have purchased shares of the Company’s common stock under agreements that provide for the vesting of such shares.

2.24 Real Property Holding Corporation. The Company is not a real property holding corporation within the meaning of Internal Revenue Code Section 897(c)(2) and any regulations promulgated thereunder.

2.25 Insurance. The Company has fire and casualty insurance policies with coverage customary for companies similarly situated to the Company.

2.26 Investment Company Act. The Company is not an “investment company”, or a company “controlled” by an “investment”, within the meaning of the Investment Company Act of 1940, as amended.

3. Representations and Warranties of the Investor. Each Investor hereby severally and not jointly represents and warrants that:

3.1 Authorization. This Agreement when executed and delivered by such Investor shall constitute a valid and legally binding obligation, enforceable in accordance with its terms, subject to the effect of applicable bankruptcy, insolvency, reorganization, moratorium or other similar federal or state laws affecting the rights of creditors and the effect of rules of law governing specific performance, injunctive relief or other equitable remedies.

3.2 Purchase Entirely for Own Account. This Agreement is made with each Investor in reliance upon such Investor’s representations and warranties to the Company, which by such Investor’s execution of this Agreement such Investor hereby confirms, that the Shares to be received by such Investor, the Warrant Shares and the Conversion Shares (collectively, the “Securities”) will be acquired for investment for such Investor’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that such Investor has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing this Agreement, each Investor further represents that such Investor does not have any contract, undertaking, agreement or arrangement with any person or entity to sell, transfer or grant participation to such person or to any third person, with respect to any of the Securities. Each Investor represents that it has full power and authority to enter into this Agreement.

3.3 Disclosure of Information. Each Investor believes it has received all the information it considers necessary or appropriate for deciding whether to purchase the Shares. Each Investor further represents that it has had an opportunity to ask questions, if any, and receive answers from the Company regarding the terms and conditions of the offering of the Shares. The foregoing, however, does not limit or modify the representations and warranties of the Company in Section 2 of this Agreement or the right of the Investors to rely thereon.

3.4 Investment Experience. Each Investor is an investor in securities of companies in the development stage and acknowledges that it is able to fend for itself, and bear the economic risk of its investment and has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and risks of the investment in the Shares. If other than an individual, Investor also represents it has not been organized for the purpose of acquiring the Shares.

3.5 Regulation D. Each Investor is an “Accredited Investor” as that term is defined in Regulation D promulgated under the Securities Act.

3.6 Restricted Securities. Each Investor understands that the Shares it is purchasing (and the Conversion Shares) are characterized as “restricted securities” under the federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such laws and applicable regulations such securities may be resold without registration under the Securities Act only in certain limited circumstances. In this connection, each Investor represents that it is familiar with Rule 144, as presently in effect, and understands the resale limitations imposed thereby and by the Securities Act. Each Investor acknowledges that the Company filed a registration statement for a public offering of its common stock, which was withdrawn effective December 3, 2001. Each Investor

understands that this offering is not intended to be part of the public offering, and that the Investor will not be able to rely on the protection of Section 11 of the Securities Act.

3.7 Legends. It is understood that the certificates evidencing the Series F Preferred Stock (or the Conversion Shares) and the Warrants (or the Warrant Shares) may bear one or all of the following legends:

(a) “THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”). THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES UNDER SUCH ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED OR UNLESS SOLD PURSUANT TO RULE 144 OF SUCH ACT. THESE SECURITIES ARE SUBJECT TO A CERTAIN VOTING PROVISION ENTERED INTO BY AND AMONG THE INVESTORS.”

(b) “THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”) OR APPLICABLE SECURITIES LAWS. THESE SECURITIES MAY NOT BE SOLD, MORTGAGED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED OTHER THAN IN COMPLIANCE WITH REGULATION S OF THE ACT OR WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS, OR THE AVAILABILITY OF AN EXEMPTION FROM THE REGISTRATION PROVISIONS OF THE ACT AND APPLICABLE STATE SECURITIES LAWS.”

(c) Any other legends required by the laws of the State of Delaware or any other applicable blue sky or state securities laws.

3.8 Regulation S. V-Sciences Investments Pte Ltd hereby makes the additional representations and warranties set forth in Exhibit H.

4. Conditions of Investor’s Obligations at Closing. The obligations of each Investor under this Agreement are subject to the fulfillment on or before the Closing of each of the following conditions, any of which may be waived in whole or in part by such Investor with respect to himself, herself or itself unless required by state or federal law:

4.1 Representations and Warranties. The representations and warranties of the Company contained in Section 2 shall be true on and as of the Closing Date with the same effect as though such representations and warranties had been made on and as of the date of the Closing.

4.2 Performance. The Company shall have performed and complied with all agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by it on or before the Closing.

4.3 Certificate. The Certificate shall have been filed with the Secretary of State of the State of Delaware.

4.4 Compliance Certificate. The President of the Company shall deliver to counsel for the Investors at the Closing a certificate certifying that the conditions specified in Sections 4.1, 4.2 and 4.3 have been fulfilled and stating that there shall have been no adverse change in the business, affairs, prospects, operations, properties, assets, liabilities or condition of the Company since the date of this Agreement.

4.5 Proceedings and Documents. All corporate and other proceedings in connection with the transactions contemplated at the Closing and all documents incident thereto shall be reasonably satisfactory in form and substance to each Investor and counsel to any of the Investors, and they shall have received all such counterpart original and certified or other copies of such documents as they may reasonably request.

4.6 Board of Directors. As of the Closing, the Board of Directors will be comprised of seven members: Xxxxxx X. Xxxxxxxx, Xxxxx Xxxxxx, Xxxx Xxxxxxx, Xxxxx Xxxxxxxxx, Xxxxxx Xxxxxx, Xxxxxxx Xxxxxxxxx and Xxxxxx Xxxxxxxx.

4.7 Rights Agreement. The Company and the Investors shall have entered into the Rights Agreement in the form attached hereto as Exhibit E.

4.8 Co-Sale Agreement. The Company, certain stockholders and certain of the Investors shall have entered into the Co-Sale Agreement in the form attached hereto as Exhibit F.

4.9 Opinion of Company Counsel. The Investors shall have received from Venture Law Group, counsel to the Company, an opinion addressed to them, dated the Closing Date, in the form attached hereto as Exhibit G.

5. Conditions of the Company’s Obligations at Closing. The obligations of the Company to each Investor under this Agreement are subject to the fulfillment on or before the Closing of each of the following conditions any of which may be waived in whole or in part by the Company unless required by state or federal law:

5.1 Representations and Warranties. The representations and warranties of each Investor contained in Section 3 hereof shall be true and correct on and as of the Closing Date with the same effect as though such representations and warranties had been made on and as of that date; and each Investor shall have performed all obligations and conditions required to be performed or observed by he, she or it on or prior to the Closing Date.

5.2 Legal Matters. All material matters of a legal nature which pertain to this agreement and the transactions contemplated hereby, shall have been reasonably approved by counsel to the Company.

6. Miscellaneous.

6.1 Survival of Warranties. The warranties, representations and covenants of the Company and Investors contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and the Closing and shall in no way be affected by any investigation of the subject matter thereof made by or on behalf of the Investors or the Company.

6.2 Successors and Assigns. The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement.

6.3 Governing Law. This Agreement shall be governed by and construed under the laws of the State of Washington.

6.4 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

6.5 Titles and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this Agreement.

6.6 Notices. Unless otherwise provided, any notice required or permitted under this Agreement shall be given in writing and shall be deemed effectively given upon personal deliver to the party to be notified, the refusal of delivery by such person, or five (5) days after deposit with the United States Post Office, by registered or certified mail, postage prepaid and addressed to the party to be notified at the address indicated for such party in Exhibit A attached hereto or in the case of the Company on the first page of this Agreement, or at such other address as such party may designate by ten (10) days’ advance written notice to the other parties.

6.7 Finder’s Fee. Each party represents that it neither is nor will be obligated for any finders’ fee or commission in connection with this transaction. Each Investor agrees to indemnify and to hold harmless the Company from any liability for any commission or compensation in the nature of a finders’ fee (and the costs and expenses of defending against such liability or asserted liability) for which the Investor or any of its officers, partners, employees, or representatives is responsible. The Company agrees to indemnify and hold harmless each Investor from any liability for any commission or compensation in the nature of a finders’ fee (and the costs and expenses of defending against such liability or asserted liability) for which the Company or any of its officers, employees or representatives is responsible.

6.8 Amendments and Waivers. Any term of this Agreement may be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the holders of a majority of the Series F Shares. Any amendment or waiver effected in accordance with this Section 6.8 shall be binding upon each holder of any securities purchased under this Agreement at the time outstanding (including securities into which such securities are convertible), each future holder of all such securities, and the Company; provided, however, that no condition set forth in Section 4 hereof may be waived with respect to any Investor who does not consent thereto.

6.9 Severability. If one or more provisions of this Agreement are held to be unenforceable under applicable law, such provision shall be excluded from this Agreement and the balance of the Agreement shall be interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms.

6.10 Exculpation Among Investors. Each Investor acknowledges that it is not relying upon any person, firm or corporation, other than the Company and its officers and directors, in making its investment decision to invest in the Company. Each Investor agrees that no other Investor nor the respective controlling persons, officers, directors, partners, agents or employees of any such other Investor shall be liable for any action heretofore or hereafter taken or omitted to be taken by any of them in connection with each Investor’s purchase of the Shares, Conversion Shares and Warrant Shares.

6.11 Expenses. Upon the Closing of the purchase and sale of securities as contemplated by this Agreement and the exhibits thereto, the Company shall pay the fees and reasonable expenses of counsel for the Investors, which fees shall not exceed $10,000.00.

(signature page follows)

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written.

XCYTE THERAPIES, INC.

By:		/s/ Xxxxxx X. Xxxxxxxx

Name:		Xxx Xxxxxxxx
(print)

Title:		President & CEO

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

CALPERS HEALTHCARE SIDE FUND, L.P.
By: ARCH Venture Partners V, L.P.,
its general partner
By: ARCH Venture Partners V, LLC,
its general partner

By:		/s/ XXXXXX X. XXXXXX

Name:		Xxxxxx X. Xxxxxx

Title:		Its Managing Director

Address: c/o ARCH Venture Partners V, L.P.
0000 X. Xxxxxxx Xxxx, Xxxxx 000
Xxxxxxx, XX 00000
Attn: Xxxx XxXxxxxxx

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

VECTOR LATER-STAGE EQUITY FUND II (QP), L.P.
By:		VECTOR FUND MANAGEMENT II, L.L.C.
		Its:General Partner

By:		/s/ XXXXXXX XXXX
		Xxxxxxx Xxxx, M.D.

Its:		Managing Director

Address: 0000 Xxxx Xxxx Xxxx, Xxxxx 000 Xxxxxxxxx, XX 00000

Phone Number: (000) 000-0000

VECTOR LATER-STAGE EQUITY FUND II, L.P.
By:		VECTOR FUND MANAGEMENT II, L.L.C.
		Its:General Partner

By:		/s/ XXXXXXX XXXX
		Xxxxxxx Xxxx, M.D.

Its:		Managing Director

Address: 0000 Xxxx Xxxx Xxxx, Xxxxx 000 Xxxxxxxxx, XX 00000

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

PALIVACINNI PARTNERS, LLC

By:		/S/ XXXXXXX XXXX
		Xxxxxxx Xxxx, M.D.
		Managing Member

Address: c/o Vector Fund Management, L.P.
		0000 Xxxx Xxxx Xxxx, Xxxxx 000
		Xxxxxxxxx, XX 00000

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

RIVERVEST VENTURE FUND I, L.P.
By: Its general partner, RiverVest Venture Partners I, LLC

By:		/S/ XXXX XXXXXX

Name: Xxxx Xxxxxx

Title: Managing Member

Address: 0000 Xxxxxxx Xxxxxxxxx, Xxxxx 0000 Xx. Xxxxx, XX 00000

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

XXXXXX X. XXXXXXX

/s/ XXXXXX X. XXXXXXX
Address: 0000 Xxxxxxxx Xxxx. Xxx Xxxxxxxxx, XX 00000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

1998 CO-INVESTING LLC

By:		/s/ XXXXXXX XXXXXXXXX

Name:		Xxxxxxx XxXxxxxxx

Title:		Manager

Address: c/o J&J Management Services 0000 X. Xxxxxxxxx Xxxxxxxxx, Xxxxx 0000 Xx. Xxxxx, XX 00000-0000 Attn: Xxxxxxx X. XxXxxxxxx

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

SPROUT CEO FUND, L.P.

By:		/s/ XXXXX X. XXXXXX

Name:		Xxxxx X. Xxxxxx

Title:		Partner

Address: c/o Sprout Group 000 Xxxx Xxxxxx, 00^xx Xxxxx Xxx Xxxx, XX 00000 Attn: Xxxxx X. Xxxxxx

Phone Number: 000-000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

ALTA EMBARCADERO PARTNERS, LLC
By: Alta California Management Partners, L.P.

By:		/s/ XXXX XXXXXXX
Member
Name:
Address: Xxx Xxxxxxxxxxx Xxxxxx, Xxxxx 0000 Xxx Xxxxxxxxx, XX 00000 Attn: Xxxxxx Xxxxxx

Phone Number: (000) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

XXX XXXXXX

/s/ XXX XXXXXX
Address:		c/o Madrona Investment Group 0000 - 0^xx Xxxxxx Xxxxxxx, XX 00000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

V–Sciences Investments Pte Ltd

By:		/s/ S Iswaran

Name:		Mr S Iswaran

Title:		Director

Address: 0 Xxxxxxx Xxx # 00-00 Xxxxxxx Xxxxx Xxxxxxxxx 00000

Fax Number: (00) 000-0000

SIGNATURE PAGE TO XCYTE THERAPIES, INC.

SERIES F STOCK AND WARRANT PURCHASE AGREEMENT

EXHIBIT A

SCHEDULE OF INVESTORS

First Closing: February 5, 2002

Investor Name and Address	Number of Series F Preferred Shares	Number of Warrant Shares	Amount of Investment for Series F Shares		Purchase Price for Warrants
RiverVest Venture Fund I, L.P. 0000 Xxxxxxx Xxxxxxxxx, Xxxxx 0000 Xx. Xxxxx, XX 00000	1,078,925	587,415	$	2,999,411.50	$	587.42

CalPERS Healthcare Side Fund, L.P. c/o ARCH Venture Partners V, L.P. 0000 X. Xxxxxxx Xxxx, Xxxxx 000 Xxxxxxx, XX 00000 Attn: Xxxx XxXxxxxxx	899,104	489,512	$	2,499,509.12	$	489.51

Vector Later-Stage Equity Fund II (QP), L.P. 0000 Xxxx Xxxx Xxxx, Xxxxx 000 Xxxxxxxxx, XX 00000	809,194	440,561	$	2,249,559.32	$	440.56

Vector Later-Stage Equity Fund II, L.P. 0000 Xxxx Xxxx Xxxx, Xxxxx 000 Xxxxxxxxx, XX 00000	269,731	146,854	$	749,852.18	$	146.85

1998 Co-Investing LLC c/o J&J Management Services 0000 X. Xxxxxxxxx Xxxx., Xxxxx 0000 Xx. Xxxxx, XX 00000-0000 Attn: Xxxxxxx X. XxXxxxxxx	179,820	97,902	$	499,899.60	$	97.90

Xxx Xxxxxx c/o Madrona Investment Group 0000 - 0^xx Xxxxxx Xxxxxxx, XX 00000	71,928	39,161	$	199,959.84	$	39.16

Palivacinni Partners, LLC 0000 Xxxx Xxxx Xxxx, Xxxxx 000 Xxxxxxxxx, XX 00000 Attn: Xxxxxxx Xxxx, Managing Member	35,964	19,580	$	99,979.92	$	19.58

Investor Name and Address	Number of Series F Preferred Shares	Number of Warrant Shares	Amount of Investment for Series F Shares		Purchase Price for Warrants
Xxxxxx X. Xxxxxxx 0000 Xxxxxxxx Xxxx. Xxx Xxxxxxxxx, XX 00000-0000	8,991	4,895	$	24,994.98	$	4.90

Alta Embarcadero Partners, LLC Xxx Xxxxxxxxxxx Xxxxxx, Xxxxx 0000 Xxx Xxxxxxxxx, XX 00000 Attn: Xxxxxx Xxxxxx	8,035	4,375	$	22,337.30	$	4.38

Sprout CEO Fund, L.P. c/o Sprout Group 000 Xxxx Xxxxxx, 00^xx Xxxxx Xxx Xxxx, XX 00000 Attn: Xxxxx X. Xxxxxx	3,634	1,979	$	10,102.52	$	1.98

FIRST CLOSING TOTAL:	3,365,326	1,832,234	$	9,355,606.28	$	1,832.24

Second Closing: Xxxxx 0, 0000

Xxxxxxxx Name and Address	Number of Series F Preferred Shares	Number of Warrant Shares	Amount of Investment for Series F Shares		Purchase Price for Warrants
V-Sciences Investments Pte Ltd 0 Xxxxxxx Xxx #00-00 Xxxxxxx Xxxxx Xxxxxxxxx 000000 Attn: Xx. X. Xxxxxxx	1,078,925	587,415	$	2,999,411.50	$	587.42

SECOND CLOSING TOTAL:	1,078,925	587,415	$	2,999,411.50	$	587.42
AGGREGATE TOTAL:	4,444,251	2,419,649	$	12,355,017.78	$	2,419.66

EXHIBIT B

FORM OF AMENDED AND RESTATED

CERTIFICATE OF INCORPORATION

EXHIBIT C

SCHEDULE OF EXCEPTIONS

EXHIBIT D

FORM OF PROPRIETARY INFORMATION AGREEMENT

EXHIBIT E

FORM OF AMENDED AND RESTATED

INVESTOR RIGHTS AGREEMENT

EXHIBIT F

FORM OF AMENDED AND RESTATED

RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT

EXHIBIT G

FORM OF OPINION OF COUNSEL TO THE COMPANY

EXHIBIT H

ADDITIONAL REPRESENTATIONS AND WARRANTIES

OF FOREIGN INVESTORS

V-Sciences Investments Pte Ltd (each a “Foreign Investor”), in addition to the other representations and warranties it has made in this Agreement, each further represents and warrants to the Company that:

It is familiar with Regulation S under the Securities Act and is not a “U.S. Person” as that term is defined in Regulation S and is not acquiring the Shares for the account or benefit of a U.S. Person, and it agrees not to make any disposition of all or any portion of the Shares unless and until (A) such disposition is in accordance with Regulation S, and (B) (1) there is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement, or (2) the Foreign Investor shall have notified the Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and if requested by the Company, the Foreign Investor shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration under the Securities Act.

The acquisition by the Foreign Investor of the Shares shall constitute a confirmation of the representations and warranties made by the Foreign Investor as of the Closing. The Foreign Investor further represents that it understands and agrees that, until registered under the Securities Act or properly transferred pursuant to the provisions of Rule 144 as promulgated by the SEC, all certificates evidencing any of the Shares, whether upon initial issuance or upon any transfer thereof, shall bear a legend (in addition to any legend required pursuant to the Investors’ Rights Agreement), prominently stamped or printed thereon, reading substantially as stated in Section 3.7(b).

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XCYTE THERAPIES, INC. SERIES F PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT February 5, 2002

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