JOINT FILING AGREEMENT

Exhibit 99.2

JOINT FILING AGREEMENT

The undersigned hereby agree that the Statement on Schedule 13G filed herewith (and any amendments thereto), relating to the Common Stock of Cortexyme, Inc., a Delaware corporation, is being filed jointly with the Securities and Exchange Commission pursuant to Rule 13d-1(d) under the Securities Exchange Act of 1934, as amended, on behalf of each of the undersigned. In addition, each party to this Agreement expressly authorizes each other party to this Agreement to file on its behalf any and all amendments to such Statement on Schedule 13G.

This Agreement may be executed in counterparts and each of such counterparts taken together shall constitute one and the same instrument.

Date: May 17, 2019

TAKEDA PHARMACEUTICAL COMPANY LIMITED
By			/s/ Xxxxxxxxx Xxxxxxxx
			Name:			Xxxxxxxxx Xxxxxxxx
			Title:			Corporate Officer, Global General Counsel

TAKEDA PHARMACEUTICALS INTERNATIONAL AG
By			/s/ Xxxxxx Xxxxxxx
			Name:			Xxxxxx Xxxxxxx
			Title:			Director and Secretary VP, Regional General Counsel Europe and Canada

TAKEDA PHARMACEUTICALS U.S.A., INC.
By			/s/ Xxxx Xxxxxxxx
			Name:			Xxxx Xxxxxxxx
			Title:			Assistant Secretary

TAKEDA VENTURES, INC.
By			/s/ Xxxxxxx Xxxxxx
			Name:			Xxxxxxx Xxxxxx
			Title:			President