Contract

Exhibit 10.35

Confidential treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated as [*****]. A complete version of this exhibit has been filed separately with the Securities and Exchange Commission.

AMENDMENT NO. 5

TO THE

SERVICES AGREEMENT

between

LONZA BIOLOGICS PLC

and

XCYTE THERAPIES INC

RELATING TO [**]

THIS AMENDMENT is made the 5^th day of August 2003.

BETWEEN

1. Lonza Biologics plc of 000 Xxxx Xxxx, Xxxxxx, XX0 0XX, Xxxxxxxxx, Xxxxxxx (“LB”) and

2. Xcyte Therapies Inc of 0000 Xxxxxxxx Xxxxxx, Xxxxx 000, Xxxxxxx, Xxxxxxxxxx 00000, XXX (“Customer”).

WHEREAS

A. The parties have entered into an Agreement dated 6^th June 2000 relating to the supply of Services (as therein defined), and

B. The parties now wish to amend the terms of the Agreement

THEREFORE it is hereby agreed by and between the parties that the Agreement shall be amended as follows: -

1. Stage 20 shall be added to Schedule 2 as follows:

20.0 “Stage 20— Additional Regulatory Services for [**]

20.1 Objectives

20.1.1 To respond to the FDA questions received by LB regarding [**] on 02^nd April 2003.

20.1.2 To prepare the 2003 update of the [**] for [**].

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[*] Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

20.2 Activities

20.2.1 Prepare and submit a draft of the responses to the FDA questions received on 02^nd April 2003 to the Customer.

20.2.2 Agree any Customer comments and incorporate them into the responses.

20.2.3 Submit the responses to the FDA and provide a copy of the responses to the Customer.

20.2.4 Prepare and submit a draft of the [**] update for [**] to the Customer.

20.2.5 Agree any Customer comments and incorporate them into the update.

20.2.6 Submit the [**] update to the relevant authorities.

20.2 Timescale

Stage 20 shall be completed on submission of the responses to the FDA and submission of the [**] update to the relevant authorities”

2. Schedule 3, Part 1 shall be amended by the inclusion of the following:

Stage		Description		Cost Price (UK £ Sterling)
Stage 20		Additional Regulatory Services for [**]		£ [**]

3. Schedule 3, Part 2 Price shall be amended by the inclusion of the following:

Stage		Payment
Stage 20		[**] upon completion of Stage 20

3

[*] Certain information on this page has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

As witness the hands of the duly authorized representatives of the parties hereto, the day and year first before written.

Signed by
for and on behalf of Xcyte Therapies Inc.		/s/ Xxxxxx X. Xxxxxxxx
Signed by
for and on behalf of Lonza Biologics plc.		/s/ Xxxxxx Xxxxx

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