EXHIBIT 1
JOINT FILING AGREEMENT
By this Agreement, the undersigned agree that this Statement on Schedule
13G being filed on or about this date, and any subsequent amendments thereto
filed by any of us, with respect to the securities of Orexigen Therapeutics,
Inc. is being filed on behalf of each of us.
February 9, 2010
XXXXX XXXXX
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx*
Title: Attorney-in-fact
X. XXXXX (1999) LTD.
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx**
Title: Attorney-in-fact for Xxxxx Xxxxx,
Chairman of X. Xxxxx (1999) Ltd.
SPHERA GLOBAL HEALTHCARE GP LTD.
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx***
Title: Director
/s/ Xxxxx Xxxxx
----------------------------
By: Xxxxx Xxxxx***
Title: Director
SPHERA GLOBAL HEALTHCARE MANAGEMENT L.P.
BY SPHERA GLOBAL HEALTHCARE GP LTD.,
GENERAL PARTNER
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx***
Title: Director
/s/ Xxxxx Xxxxx
----------------------------
By: Xxxxx Xxxxx***
Title: Director
SPHERA GLOBAL HEALTHCARE FUND
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx****
Title: Director
/s/ Xxxxx Xxxxx
----------------------------
By: Xxxxx Xxxxx****
Title: Director
SPHERA GLOBAL HEALTHCARE MASTER FUND
/s/ Xxxxxxxx Xxxxx
----------------------------
By: Xxxxxxxx Xxxxx*****
Title: Director
/s/ Xxxxx Xxxxx
----------------------------
By: Xxxxx Xxxxx*****
Title: Director
* Duly authorized under Special Power of Attorney appointing Xxxxxxxx Xxxxx
attorney-in-fact, dated February 9, 2010 by and on behalf of Xxxxx Xxxxx,
attached hereto as Exhibit 2.
** Duly authorized under Special Power of Attorney appointing Xxxxxxxx Xxxxx
attorney-in-fact, dated February 9, 2010 by and on behalf of Xxxxx Xxxxx as
Chairman of X. Xxxxx (1999) Ltd., attached hereto as Exhibit 3.
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*** Duly authorized by Unanimous Written Consent of the Board of Directors of
Sphera Global Healthcare GP Ltd. allowing Xxxxxxxx Xxxxx and Xxxxx Xxxxx, acting
together, to bind Sphera Global Healthcare Management L.P. for any and all
matters, including the filing of any report with any governmental authority,
dated November 29, 2009, attached hereto as Exhibit 4.
**** Duly authorized by Unanimous Written Resolution of the Board of Directors
of Sphera Global Healthcare Fund allowing Xxxxxxxx Xxxxx and Xxxxx Xxxxx, acting
together, to bind Sphera Global Healthcare Fund for any and all matters, dated
November 29, 2009, attached hereto as Exhibit 5.
***** Duly authorized by Unanimous Written Resolution of the Board of Directors
of Sphera Global Healthcare Master Fund allowing Xxxxxxxx Xxxxx and Xxxxx Xxxxx,
acting together, to bind Sphera Global Healthcare Master Fund for any and all
matters, dated November 29, 2009, attached hereto as Exhibit 6.
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