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EXHIBIT NO. 10.10
CONFIDENTIAL MATERIALS OMITTED AND FILED SEPARATELY WITH THE
SECURITIES AND EXCHANGE COMMISSION. ASTERISKS DENOTE OMISSIONS.
AGREEMENT
THIS AGREEMENT, effective March 13, 1995, is made by and between NitroMed,
Inc., Xxx Xxxxxxx Xxxxxx, Xxxxxxxx 000, Xxxxxxxxx, XX 00000 ("NitroMed") and
Xxxx X. Xxxxx, Ph.D., 0000 Xxxxxxxxxxx Xxxxxx, Xxxxxxx, XX 00000 ("Xxxxx").
1. In consideration of the mutual promises contained herein and for other
good and valuable consideration, Xxxxx has assigned his entire right, title and
interest in and to the U.S. patent application entitled "Use of Nitric Oxide
Adducts to Prevent Thrombosis on Artificial and Vascular Surfaces" having Serial
No. 08/123,331 which was filed on September 17, 1993 and in and to the subject
matter disclosed therein and to all divisional, continuing, substitute, renewal,
reissue, extension and all other applications for Letters Patent which have been
or shall be filed in the United States and all other countries on any of said
improvements, and in and to all original and reissued patents which have been or
shall be issued in the United States and all other countries on said
applications (the "Patent Rights").
2. Xxxxx represents and warrants to NitroMed that he had an unencumbered
ownership interest in and to the Patent Rights as well as the unencumbered right
to assign his right, title and interest in and to the Patent Rights.
3. The term "Product" as used herein means any article, composition,
apparatus, substance, chemical, material, method or service which is covered by
the Patent Rights.
4. The term "Net Sales Price" means the total amount received by NitroMed
from sale of Product, less transportation charges and insurance, sales taxes,
use taxes, excise taxes, value
added taxes, customs duties or other imports, normal and customary quantity and
cash discounts, and allowances and credit on account of rejection or return of
Product.
5. The term "Sublicensee" shall mean any non-Affiliate third party licensed
by NitroMed to make, have made, import, use or sell any Product under the Patent
Rights. The term "Affiliate" means any company or other legal entity other than
NitroMed in whatever country organized, controlling, controlled by or under
commoncontrol with NitroMed. The term "control" means possession of the power to
direct or cause the direction of the management and policies whether through the
ownership of voting securities, by contract or otherwise.
6. From and after the effective date of this Agreement, NitroMed shall pay
(i) [**]percent ([**]%) of Net Sales Price by NitroMed and its Affiliates and
(ii) [**] percent ([**]%) of Net Sales Price by its Sublicensees of Product for
so long as pending or issued Patent Rights are in force. Such payments shall be
made at the beginning of each calendar quarter for sales which occurred in the
preceding quarter.
7. This Agreement constitutes the entire understanding between the parties
with respect to the subject matter contained herein and any amendment or change
shall not be binding unless in writing and signed by the parties hereto. In
addition, this Agreement shall be construed in accordance with the laws of the
Commonwealth of Massachusetts, other than those provisions governing conflicts
of law.
Accordingly, the parties have executed this Agreement by their authorized
representatives.
NITROMED, INC. XXXX X. XXXXX, Ph.D.
By: /s/Xxxxxx Xxxxxx /s/Xxxx X. Xxxxx
----------------- -----------------
Title: President and Chief Executive Officer Xxxx X. Xxxxx, Ph.D.
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AMENDMENT TO AGREEMENT BETWEEN
XXXX X. XXXXX AND NITROMED, INC.
This Amendment is effective as of November 22, 1996 by and between
NitroMed, Inc., a Delaware corporation, having offices at 000 Xxxxxx Xxxxxx,
Xxxxxx, Xxxxxxxxxxxxx 00000 ("NitroMed") and Xxxx X. Xxxxx, Ph.D., 0000
Xxxxxxxxxxx Xxxxxx, Xxxxxxx, Xxxxxxxxx 00000 ("Xxxxx").
WHEREAS, NitroMed and Xxxxx entered into an Agreement effective as of March
13, 1995 (the "Agreement"); and
WHEREAS, NitroMed and Xxxxx desire to amend such Agreement.
NOW, THEREFORE, in consideration of the mutual promises and other good and
valuable consideration, the parties agree as follows:
1. All initially capitalized terms in this Amendment shall have the same
meaning as in the AGREEMENT of March 13, 1995.
2. Section 6 of the AGREEMENT is amended and rewritten in its entirety to
read as follows:
From and after the effective date of this Amendment, NitroMed shall pay
(i) [**] percent ([**]%) of the Net Sales Price of Product sold or distributed
by NitroMed and its Affiliates and (ii) [**] percent ([**]%) of royalties
received by NitroMed from a Sublicensee for sale or distribution of a Product by
such Sublicensee, in each case for so long as pending or issued Patent Rights
are in force which cover such Product. Such payments shall be made at the
beginning of each calendar quarter for sales which occurred in the preceding
quarter.
3. The AGREEMENT is hereby amended effective as of the date first above
written in accordance with Paragraph 7 thereof. Except as amended herein or
previously amended, the terms and conditions of the AGREEMENT remain in full
force and effect as originally written.
IN WITNESS WHEREOF, the parties have executed this Agreement as of the Date
set forth above.
NITROMED, INC. XXXX X. XXXXX, Ph.D.
By: /s/Xxxxxx Xxxxxx /s/Xxxx X. Xxxxx
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Xxxxxx Xxxxxx, M.D.
Title: President and Chief Executive Officer Title: Professor of Medicine
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AMENDMENT TO AGREEMENT BETWEEN
XXXX X. XXXXX AND NITROMED, INC.
This Amendment is effective as of December 2, 1998 by and between
NitroMed, Inc., a Delaware corporation, having offices at 00 Xxx Xxxx Xxxxx,
Xxxxxxx, Xxxxxxxxxxxxx 00000 ("NitroMed") and Xxxx X. Xxxxx, Ph.D., 0000
Xxxxxxxxxxx Xxxxxx, Xxxxxxx, Xxxxxxxxx 00000 ("Xxxxx").
WHEREAS, NitroMed and Xxxxx entered into an Agreement effective as of
March 13, 1995 and amended as of November 22, 1996 (the "AGREEMENT"); and
WHEREAS, NitroMed and Xxxxx desire to amend such Agreement,
NOW, THEREFORE, in consideration of the mutual promises and other good
and valuable consideration, the parties agree as follows:
1. All initially capitalized terms in this Amendment shall have the
same meaning as in the AGREEMENT of March 13, 1995.
2. Section 1 of the AGREEMENT is amended and rewritten in its entirety
to read as follows:
In consideration of the mutual promises contained herein and for good
and valuable consideration, Xxxxx has assigned his entire right, title and
interest in and to the U.S. patent applications entitled
"Use of Nitric Oxide Adducts to Prevent Thrombosis on Artificial and
Vascular Surfaces" having Serial No. 08/123,331, which was filed on September
15, 1993,
"Localized Use of Nitric Oxide Adducts to Prevent Internal Tissue
Damage" having serial number 08/438,418, which was filed on May 10, 1995, and
"Localized Use of Nitric Oxide Adducts to Prevent Internal Tissue
Damage" having Serial No. 08/460,465, which was filed on June 2, 1995,
and in and to the subject matter disclosed therein and to all divisional,
continuing substitute, renewal, reissue, extension and all other applications
for Letters Patent which have been or shall be filed in the United States and
all other countries on any of said applications, and in and to all original
and reissued patents which have been or shall be issued in the United States
and all other countries on said applications (the "Patent Rights").
3. The AGREEMENT is hereby amended effective as of the date first above
written in accordance with Paragraph 7 thereof. Except as amended herein or
previously amended, the terms and conditions of the AGREEMENT remain in full
force and effect as originally written.
IN WITNESS WHEREOF, the parties have executed this Agreement by their
authorized representatives.
NITROMED, INC. XXXX X. XXXXX, Ph.D.
By: /s/ XXXXXX XXXXXX, M.D. By: /s/ XXXX X. XXXXX, Ph.D.
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Xxxxxx Xxxxxx, M.D. Xxxx X. Xxxxx, Ph.D.
President
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