JOINT FILING AGREEMENT
Exhibit 1 JOINT FILING AGREEMENT We, the signatories of the statement on Schedule 13G to which this Agreement is attached, hereby agree that such statements is, any amendments thereto filed by any of us will be, filed on behalf of each of us. FEBRUARY 14, 2002 ARTAL GROUP S.A. By: /s/ XXXX XXXXXX Name: Xxxx Xxxxxx Title: Managing Director ARTAL LUXEMBOURG S.A. By: /s/ XXXX XXXXXX Name: Xxxx Xxxxxx Title: Managing Director