EXHIBIT 4.31
AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD
DATED 1ST APRIL 2000.
1st December 2001
The paragraph referring to Consultant's Fees shall be amended to read "The fee
is at present L90,000 per annum exclusive of VAT, or such other rate as
may be agreed from time to time payable monthly in arrears by bank credit
transfer. This agreement shall be terminable by either party giving to the
other not less than six months' prior written notice."
Signed for both Parties by:
/s/ signature to come /s/ M.A. Xxxxxxxx
----------------------------- ------------------------------
for and on behalf of for and on behalf of
ENACT PHARMA PLC CHIMAERON LTD
