ING INVESTORS TRUST AMENDMENT #45 TO THE AMENDED AND RESTATED AGREEMENT AND DECLARATION OF TRUST Effective: February 22, 2008

Exhibit 99.B(a)(49)

ING INVESTORS TRUST

AMENDMENT #45 TO THE AMENDED AND RESTATED AGREEMENT AND

DECLARATION OF TRUST

Effective: February 22, 2008

The undersigned being a majority of the trustees of ING Investors Trust, a Massachusetts business trust (the “Trust”), acting pursuant to Article VI, Sections 6.2 and 6.3 and Article XI, Section 11.4 of the Trust’s Amended and Restated Agreement and Declaration of Trust dated February 26, 2002, as amended (the “Declaration of Trust”), hereby amend the Declaration of Trust to establish additional separate Series designated as ING Xxxxxxx Xxxxx Commodities Portfolio and ING Multi-Manager International Small Cap Portfolio of the Trust as follows:

“The Series that have been established and designated as of the date first above written are as follows:

ING AllianceBernstein Mid Cap Growth Portfolio

ING American Funds Asset Allocation Portfolio

ING American Funds Bond Portfolio

ING American Funds Growth Portfolio

ING American Funds Growth-Income Portfolio

ING American Funds International Portfolio

ING BlackRock Inflation Protected Bond Portfolio

ING BlackRock Large Cap Growth Portfolio

ING BlackRock Large Cap Value Portfolio

ING Capital Guardian U.S. Equities Portfolio

ING Disciplined Small Cap Value Portfolio

ING EquitiesPlus Portfolio

ING Evergreen Health Sciences Portfolio

ING Evergreen Omega Portfolio

ING FMR^SM Diversified Mid Cap Portfolio

ING FMR^SM Equity Income Portfolio

ING FMR^SM Small Cap Equity Portfolio

ING Focus 5 Portfolio

ING Franklin Income Portfolio

ING Franklin Mutual Shares Portfolio

ING Franklin Xxxxxxxxx Founding Strategy Portfolio

ING Global Real Estate Portfolio

ING Global Resources Portfolio

ING Global Technology Portfolio

ING Xxxxxxx Sachs Commodities Portfolio

ING International Growth Opportunities Portfolio

ING Janus Contrarian Portfolio

ING JPMorgan Emerging Markets Equity Portfolio

ING JPMorgan Small Cap Core Equity Portfolio

ING JPMorgan Value Opportunities Portfolio

ING Xxxxxx Xxxx Foreign Portfolio

ING Xxxx Xxxxx Value Portfolio

ING LifeStyle Aggressive Growth Portfolio

ING LifeStyle Conservative Portfolio

ING LifeStyle Growth Portfolio

ING LifeStyle Moderate Growth Portfolio

ING LifeStyle Moderate Portfolio

ING Limited Maturity Bond Portfolio

ING Liquid Assets Portfolio

ING Lord Xxxxxx Affiliated Portfolio

ING Xxxxxxx Growth Portfolio

ING Xxxxxxx International Opportunities Portfolio

ING MFS Total Return Portfolio

ING MFS Utilities Portfolio

ING Mid Cap Growth Portfolio

ING Multi-Manager International Small Cap Portfolio

ING Xxxxxxxxxxx Main Street Portfolio®

ING PIMCO Core Bond Portfolio

ING PIMCO High Yield Portfolio

ING Pioneer Equity Income Portfolio

ING Pioneer Fund Portfolio

ING Pioneer Mid Cap Value Portfolio

ING Stock Index Portfolio

ING X. Xxxx Price Capital Appreciation Portfolio

ING X. Xxxx Price Equity Income Portfolio

ING Xxxxxxxxx Global Growth Portfolio

ING UBS U.S. Allocation Portfolio

ING Xxx Xxxxxx Capital Growth Portfolio

ING Xxx Xxxxxx Global Franchise Portfolio

ING Xxx Xxxxxx Growth and Income Portfolio

ING Xxx Xxxxxx Large Cap Growth Portfolio

ING Xxx Xxxxxx Real Estate Portfolio

ING VP Index Plus International Equity Portfolio

ING Xxxxx Fargo Disciplined Value Portfolio

ING Xxxxx Fargo Small Cap Disciplined Portfolio”

The foregoing shall be effective upon the date first written above.

/s/ Xxxxxxx X. Xxxxxxx		/s/ Xxxxxxx X. Xxxxx
Xxxxxxx X. Xxxxxxx, as Trustee		Xxxxxxx X. Xxxxx, as Trustee
/s/ Xxxx X. Xxxxx		/s/ Xxxxx X. Xxxxxxx
Xxxx X. Xxxxx, as Trustee		Xxxxx X. Xxxxxxx, as Trustee
/s/ Xxxxxxxx X. Xxxxxxxx		/s/ Xxxxxx X. Xxxxxxxx
Xxxxxxxx X. Xxxxxxxx, as Trustee		Xxxxxx X. Xxxxxxxx, as Trustee
/s/ Xxxxxx X. Xxxxxxx		/s/ Xxxxx X.X. Xxxxxx
Xxxxxx X. Xxxxxxx, as Trustee		Xxxxx X.X. Xxxxxx, as Trustee
/s/ Xxxxx X. Xxxxxx		/s/ Xxxxx X. Xxxxxxx
Xxxxx X. Xxxxxx, as Trustee		Xxxxx X. Xxxxxxx, as Trustee
/s/ J. Xxxxxxx Xxxxxx
J. Xxxxxxx Xxxxxx, as Trustee