EXCLUSIVE COmmercialization LICENSE Agreement

[ * ] = Certain confidential information contained in this document, marked by brackets, has been omitted because it is both (i) not material and (ii) would be competitively harmful if publicly disclosed.

Exhibit 10.1

This Exclusive Commercialization License Agreement (the “Agreement”) is entered into as of January 22nd, 2019 (the “Effective Date”), by and between Rigel Pharmaceuticals, Inc., a Delaware company having an address at ▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇., ▇▇▇▇▇ ▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇, ▇▇▇ (“Rigel”) and Grifols Worldwide Operations Limited, an Irish company having an address at Grange Castle Business Park, Clondalkin, ▇▇▇▇▇▇ ▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇▇▇ (“Grifols”). Rigel and Grifols may be referred to herein individually as a “Party” or collectively as the “Parties”.

Recitals

Whereas, Rigel, a biopharmaceutical company, owns or controls certain patents, know-how, and other intellectual property relating to its proprietary compound fostamatinib disodium hexahydrate, also known as TAVALISSE™ in the United States, which has been approved by the FDA (as defined below) for the treatment of chronic immune thrombocytopenia and is under development for the treatment of autoimmune hemolytic anemia, IgA nephropathy, and potentially other indications;

Whereas, Grifols, a healthcare company, possesses substantial resources and expertise in the development, commercialization, distribution and sale of pharmaceutical products;

Whereas, Grifols wishes to obtain, and Rigel wishes to grant Grifols, an exclusive license to develop, market, promote, distribute and sell the Product in the Field in the Grifols Territory (as such terms are defined below), subject to the terms and conditions included herein; and

Whereas, Rigel and Grifols are entering into a commercial supply agreement in relation to and for the purpose of this Agreement, pursuant to which Rigel shall manufacture and supply the Product to Grifols (the “Commercial Supply Agreement”) for use in accordance with the terms of this Agreement.

Agreement

Now, Therefore, in consideration of the foregoing premises and the mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Rigel and Grifols hereby agree as follows:

Definitions

1.1 “Affiliate” means, with respect to any party, any entity that, directly or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with such party, but for only so long as such control exists. As used in this Section 1.1, “control” means (a) to possess, directly or indirectly, the power to direct the management or policies of an entity, whether through ownership of voting securities, by contract relating to voting rights or corporate governance; or (b) direct or indirect beneficial ownership of more than fifty percent (50%) (or such lesser percentage which is the maximum allowed to be owned by a foreign corporation in a particular jurisdiction) of the voting share capital or other equity interest in such entity.

1.2 “AIHA” means autoimmune hemolytic anemia.

1.3 “Applicable Laws” means the applicable provisions of any and all national, supranational, regional, state and local laws, treaties, statutes, rules, regulations, administrative codes, guidance, ordinances, judgments, decrees, directives, injunctions, orders, permits (including ▇▇▇▇ (as defined below)) of or from any court, Regulatory Authority or Governmental Authority (as such terms are defined below) having jurisdiction over or related to the subject item.

1.4 “Auditor” has the meaning set forth in Section ‎9.4.

1.5 “Calendar Quarter” means each respective period of three (3) consecutive months ending on March 31, June 30, September 30, and December 31.

1.6 “Claim” has the meaning set forth in Section ‎12.3.

1.7 “Commercialization” means the conduct of all activities undertaken (a)after Regulatory Approval (as defined below) relating to the promotion, sales, marketing, medical support, and distribution (including importing, exporting, transporting, customs clearance, warehousing, invoicing, handling, and delivering Products to customers) of Products in the Field in the Grifols Territory, including sales force efforts, detailing, advertising, market research, market access (including price and reimbursement activities), medical education and information services, publication, scientific and medical affairs, advisory and collaborative activities with opinion leaders and professional societies including symposia, marketing, sales force training, and sales (including receiving, accepting and filling Product orders) and distribution; and (b) any of the foregoing (but not marketing, promotion, sales, or distribution) that is conducted prior to Regulatory Approval in anticipation of and/or preparation for launch. “Commercialize” and “Commercializing” have correlative meanings.

1.8 “Commercialization Plan” has the meaning set forth in Section ‎6.2.

1.9 “Commercially Reasonable Efforts” means, with respect to a Party and its obligations under this Agreement, those commercially reasonable efforts and resources consistent with the usual practices of a similarly situated company for the development and commercialization of a pharmaceutical product originating from its own research and development department without a royalty obligation to others, which is at a similar stage of research, development, or commercialization, taking into account that product’s profile of efficacy and safety; proprietary position, including patent and regulatory exclusivity; regulatory status, including anticipated or approved labeling and anticipated or approved post-approval requirements; present and future market and commercial potential, including competitive market conditions (but not taking into account any payment owed to the other Party under this Agreement), and all other relevant factors, including technical, legal, scientific and/or medical factors. Commercially Reasonable Efforts requires that a Party: (a) at a minimum establishes a plan to achieve objectives and assigns specific responsibilities for the achievement of that plan and (b) makes and implements decisions and allocate resources designed to advance progress with respect to such objectives.

1.10 “Competing Product” means any product or compound, other than the Compound (as defined below) and Product, that (a) [ * ], or (b) is [ * ], or (c) [ * ], or is any combination of (a), (b) or (c). For the avoidance of doubt, [ * ] Competing Products.

1.11 “Compound” means fostamatinib disodium hexahydrate, having the chemical structure set forth in Exhibit A.

1.12 “Confidentiality Agreement” means that certain Confidential Disclosure Agreement between Rigel and Grifols dated as of [ * ].

1.13 “Confidential Information” means all Know-How (as defined below) and other proprietary scientific, marketing, financial, or commercial information or data that is generated by or on behalf of a Party or its Affiliates or which one Party or any of its Affiliates has supplied or otherwise made available to the other Party or its Affiliates, whether made available orally, in writing, or in electronic form, including information comprising or relating to concepts, discoveries, inventions, data, designs, or formulae in relation to this Agreement; further all Rigel Technology (as defined below) will be deemed Rigel’s Confidential Information.

1.14 “Control” or “Controlled” means, with respect to any Rigel Technology, the legal authority or right (whether by ownership, license, or otherwise, but without taking into account any rights granted by Rigel to Grifols pursuant to this Agreement) of Rigel to grant access, a license, or a sublicense of or under such Rigel

Technology to Grifols, or to otherwise disclose proprietary or trade secret information to Grifols, without breaching the terms of any agreement with a Third Party (as defined below), or misappropriating the proprietary or trade secret information of a Third Party.

1.15 “Data” means any and all scientific, technical, test, marketing, or sales data pertaining to any Product that is generated by or on behalf of Rigel, Grifols, or their respective Affiliates and sublicensees, including research data, clinical pharmacology data, pre-clinical data, clinical data, clinical study reports, or submissions made in association with an IND or MAA with respect to any Product.

1.16 “Development” means all development activities for the Product that are directed to obtaining Regulatory Approval(s) of the Product in the Field and lifecycle management of the Product in any country in the world, including all non-clinical, preclinical, and clinical testing and studies of the Product; toxicology, pharmacokinetic, and pharmacological studies; statistical analyses; assay development; protocol design and development; the preparation, filing, and prosecution of any MAA for the Product; development activities directed to label expansion and/or obtaining Regulatory Approval for one or more additional indications following initial Regulatory Approval; development activities conducted after receipt of Regulatory Approval, including Phase 4 Clinical Trials; and all regulatory affairs related to any of the foregoing. “Develop” and “Developing” have correlative meanings.

1.17 “EMA” means the European Medicines Agency or its successor.

1.18 “Europe” means Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Italy, Ireland, Latvia, Lithuania, Luxembourg, Malta, the Netherlands, Norway, Switzerland, Poland, Portugal, Romania, Spain, Slovakia, Slovenia, Sweden, and the United Kingdom.

1.19 “Executive Officers” means [ * ] of Rigel and [ * ] of Grifols.

1.20 “Export Control Laws” means all applicable U.S. laws and regulations relating to (a) sanctions and embargoes imposed by the Office of Foreign Assets Control of the U.S. Department of Treasury or (b) the export or re-export of commodities, technologies, or services, including the Export Administration Act of 1979, 24 U.S.C. §§ 2401-2420, the International Emergency Economic Powers Act, 50 U.S.C. §§ 1701-1706, the Trading with the Enemy Act, 50 U.S.C. §§ 1 et. seq., the Arms Export Control Act, 22 U.S.C. §§ 2778 and 2779, and the International Boycott Provisions of Section 999 of the U.S. Internal Revenue Code of 1986, in each case, as amended.

1.21 “FCPA” means the U.S. Foreign Corrupt Practices Act (15 U.S.C. Section 78dd-1, et. seq.), as amended.

1.22 “FDA” means the U.S. Food and Drug Administration or its successor.

1.23 “Field” means the treatment, palliation, or prevention of human diseases, including chronic or persistent ITP, AIHA, and IgA nephropathy.

1.24 “First Commercial Sale” means, on a Product-by-Product and country-by-country basis, the first sale of such Product in a country of the Grifols Territory by Grifols or its Affiliates or Sublicensees (as defined below) to a Third Party after Regulatory Approval for such Product has been obtained in such country.

1.25 “Generic Product” means, with respect to a Product in a particular regulatory jurisdiction, any pharmaceutical product that (a) contains the same active pharmaceutical ingredient(s) as such Product; (b) is approved by the Regulatory Authority in such country as a substitutable generic for such Product on an expedited or abbreviated basis based on bioequivalence or interchangeability with the Product; and (c) is sold in such jurisdiction by a Third Party that is not a Sublicensee and did not purchase such product in a chain of distribution that included any of Rigel, Grifols, or their respective Affiliates, licensees, or sublicensees.

1.26 “Governmental Authority” means any national, international, federal, state, provincial, or local government, or political subdivision thereof, or any multinational organization, or any authority, agency, or commission entitled to exercise any administrative, executive, judicial, legislative, police, regulatory, or taxing authority or power, or any court or tribunal (or any department, bureau or division thereof, or any governmental arbitrator or arbitral body).

1.27 “Grifols Data” has the meaning set forth in Section ‎10.1(a).

1.28 “Grifols Indemnitee” has the meaning set forth in Section ‎12.1.

1.29 “Grifols Territory” means Europe and Turkey.

1.30 “ICH” means the International Conference on Harmonization (of Technical Requirements for Registration of Pharmaceuticals for Human Use).

1.31 “IFRS” means the International Financial Reporting Standards, existing as of the Effective Date and as may be amended from time to time during the Term (as defined below).

1.32 “IND” means an investigational new drug application or equivalent application filed with the applicable Regulatory Authority, which application is required to commence human clinical trials in the applicable country.

1.33 “Indemnitee” has the meaning set forth in Section ‎12.3.

1.34 “Indemnitor” has the meaning set forth in Section ‎12.3.

1.35 “Indication” means a separate and distinct disease, disorder, illness, or health condition and all of its associated signs, symptoms, stages, or progression (including precursor conditions), in each case for which a separate MAA may be filed. For clarity, subpopulations or patients with a primary disease or condition, however stratified (including stratification by stages or progression, particular combinations of symptoms associated with the primary disease or condition, prior treatment courses, response to prior treatment, family history, clinical history, phenotype, or other stratification) shall not be deemed to be separate “Indications” for the purposes of this Agreement.

1.36 “Inventions” means all inventions, whether or not patentable, discovered, made, conceived, or reduced to practice in the course of activities contemplated by this Agreement.

1.37 “ITP” means immune thrombocytopenia.

1.38 “JSC” has the meaning set forth in Section ‎3.1.

1.39 “Know-How” means all technical information, know-how, and data, including inventions, discoveries, trade secrets, specifications, instructions, processes, formulae, compositions of matter, cells, cell lines, assays, animal models, and other physical, biological, or chemical materials, expertise, and other technology applicable to development, registration, use, or marketing or to methods of assaying or testing them, and including all biological, chemical, pharmacological, biochemical, toxicological, pharmaceutical, physical, and analytical safety, nonclinical, and clinical data, regulatory documents, data and filings, instructions, processes, formulae, expertise, and information relevant to the research, development, use, importation, offering for sale, or sale of, or which may be useful in studying, testing, developing, Products. Know-How excludes Patents and manufacturing know-how for the Compound or Product.

1.40 “Losses” has the meaning set forth in Section ‎12.1.

1.41 “MAA” means a marketing authorization application or equivalent application, and all amendments and supplements thereto, filed with the applicable Regulatory Authority in any country or jurisdiction. For clarity, MAA does not include any application for Pricing and Reimbursement Approval (as such terms are defined below).

1.42 “MAA Approval” means approval of an MAA by the applicable Regulatory Authority for marketing and sale of a Product in the applicable country or jurisdiction, but excluding any Pricing and Reimbursement Approval.

1.43 “Major Market Countries” means: [ * ].

1.44 “Medical Affairs” or “Medical Affairs Activities” means activities designed to ensure or improve appropriate medical use of, conduct medical education of, or further research regarding, the Product, including by way of example: (a) activities of medical scientific liaisons who, among their other functions, may: (i) conduct service based medical activities including providing input and assistance with consultancy meetings, proposing investigators for clinical trials sponsored or co-sponsored by a Party or Affiliate, and providing input in the design of such trials and other research related activities; and/or (ii) deliver non-promotional communications and conduct non-promotional activities; (b) grants to support continuing medical education, symposia, or Third Party research related to the Product; (c) development, publication, and dissemination of publications relating to the Product; (d) medical information services provided in response to inquiries communicated via sales representatives or received by letter, phone call, or email; (e) conducting advisory board meetings, international advisory board activities, or other consultant programs, including the engagement of key opinion leaders and health care professional in individual or group advisory and consulting arrangements; and (f) the evaluation of applications submitted to Grifols for support of investigator-initiated trials.

1.45 “Middle East and North Africa” means Algeria, Bahrain, the Comoros Islands, Djibouti, Egypt, Iraq, Jordan, Kuwait, Lebanon, Libya, Morocco, Mauritiana, Oman, Palestine, Qatar, Saudi Arabia, Somalia, Sudan, Syria, Tunisia, the United Arab Emirates, and Yemen.

1.46 “Net Sales” means those invoices issued by Grifols, its Affiliates and/or Sublicensees (but not distributors who purchase the Product from Grifols, its Affiliates or Sublicensees) for the sale of any Product to Third Parties (excluding sales among Grifols, Grifols' Affiliates and Sublicensees) but including any subsequent resale from Grifols, its Affiliates and Sublicensees to an unrelated Third Party), less the following deductions in accordance with IFRS, consistently applied:

(a) normal and customary trade, cash and quantity discounts actually allowed and properly taken directly with respect to sales of such Product;

(b) credits or allowances given or made for rejection or return of previously sold Products or for retroactive price reductions and billing errors;

(c) rebates and chargeback payments granted to managed health care organizations, pharmacy benefit managers (or equivalents thereof), national, state/provincial, local, and other governments, their agencies and purchasers and reimbursers, or to trade customers;

(d) costs of freight, carrier insurance, and other transportation and/or delivery charges directly related to the distribution of such Product;

(e) taxes, duties or other governmental charges (including any tax such as a value added or similar tax, other than any taxes based on income) directly levied on the sale, transportation, delivery or use of a Product which is paid by Grifols or measured by the billing amount for such Product, as adjusted for rebates and refunds; and

(f) any invoiced amounts (not to exceed [ * ]) not able to be reasonably collected by Grifols or its Affiliates or Sublicensees in each case written off by Grifols or its Affiliates or Sublicensees.

In no event will any particular amount identified above be deducted more than once in calculating Net Sales. Sales of a Product between Grifols and its Affiliates or Sublicensees for resale shall be excluded from the computation of Net Sales, but the subsequent resale of such Product to a Third Party shall be included within the computation of Net Sales.

The supply of Product as samples, for use in non-clinical or clinical trials, or for use in any test or studies reasonably necessary to comply with any Applicable Laws, or as is otherwise normal and customary in the industry, shall not be included in the computation of Net Sales, so long as Grifols, its Affiliates, and Sublicensees do not receive payment for such Product in excess of the transfer price paid by Grifols to Rigel for such Product pursuant to the Commercial Supply Agreement.

1.47 “Option” has the meaning set forth in Section ‎2.4.

1.48 “Option Fee” has the meaning set forth in Section ‎2.4(b).

1.49 “Option Territory” means (a) the Middle East and North Africa, and (b) Russia/CIS (as defined below).

1.50 “Patents” means (a) all patents, certificates of invention, applications for certificates of invention, priority patent filings, provisional patent applications and patent applications, and (b) any renewals, divisions, or continuations (in whole or in part) of any of such patents, certificates of invention and patent applications, and any all patents or certificates of invention issuing thereon, and any and all reissues, reexaminations, extensions, supplementary protection certificates, divisions, renewals, substitutions, confirmations, registrations, revalidations, revisions, and additions of or to any of the foregoing.

1.51 “Pharmacovigilance Agreement” has the meaning set forth in Section ‎5.4(a).

1.52 “Pricing and Reimbursement Approval” means, with respect to a Product, the approval, agreement, determination, or decision of any applicable Governmental Authority establishing the price or level of reimbursement for such Product, as required in a given country or jurisdiction prior to sale of such Product in such country or jurisdiction.

1.53 “Product” means any pharmaceutical product in the final form as of the Effective Date, containing the Compound as the sole active ingredient in the form set forth in Exhibit A.

1.54 “Product Infringement” has the meaning set forth in Section ‎10.3(a).

1.55 “Public Official or Entity” means (a) any officer, employee (including physicians, hospital administrators, or other healthcare professionals), agent, representative, department, agency, de facto official, representative, corporate entity, instrumentality, or subdivision of any government, military, or international organization, including any ministry or department of health or any state-owned or affiliated company or hospital, or (b) any candidate for political office, any political party, or any official of a political party.

1.56 “Recall” has the meaning set forth in Section ‎5.7.

1.57 “Regulatory Approval” means, with respect to a country or jurisdiction, any and all approvals (including MAA Approval, and Pricing and Reimbursement Approval, if applicable), licenses, registrations, permits, notifications and authorizations (or waivers) of any Regulatory Authority that are necessary for the use, storage, import, transport, promotion, marketing, distribution, offer for sale, sale, or other commercialization of a Product in such country or jurisdiction.

1.58 “Regulatory Authority” means any Governmental Authority that has responsibility in its applicable jurisdiction over the testing, development, manufacture, use, storage, import, transport, promotion, marketing, distribution, offer for sale, sale, or other commercialization of pharmaceutical products in a given jurisdiction, including the FDA and EMA. For countries where Pricing and Reimbursement Approval is required, Regulatory Authority shall also include any Governmental Authority whose grant of Pricing and Reimbursement Approval of the Product is required.

1.59 “Regulatory Filing” means all applications, filings, submissions, approvals, licenses, registrations, permits, notifications, and authorizations (or waivers) with respect to the testing, development, manufacture, or Commercialization of any Product made to or received from any Regulatory Authority in a given country, including any INDs and ▇▇▇▇.

1.60 “Rigel Data” has the meaning set forth in Section ‎10.1(a).

1.61 “Rigel Indemnitee” has the meaning set forth in Section ‎12.2.

1.62 “Rigel Know-How” means all Know-How that Rigel Controls as of the Effective Date or during the Term, that is necessary or reasonably useful for the use, importation, offer for sale, or sale of the Compound or Product in the Field in the Grifols Territory. For clarity, the Rigel Know-How includes the Rigel Data.

1.63 “Rigel Patents” means all Patents in the Grifols Territory that Rigel Controls as of the Effective Date or during the Term that would be infringed, absent a license or other right to practice granted under such Patents, by the Development, use, importation, offer for sale or sale of any Compound or Product in the Field in the Grifols Territory (considering patent applications to be issued with the then-pending claims). The Rigel Patents existing as of the Effective Date are set forth in Exhibit B.

1.64 “Rigel Technology” means the Rigel Know‑How and the Rigel Patents.

1.65 “Rigel Territory” means the world outside the Grifols Territory.

1.66 “Royalty Term” has the meaning set forth in Section ‎8.4(b).

1.67 “Russia/CIS” means Russia, Armenia, Azerbaijan, Belarus, Kazakhstan, Kyrgyzstan, Moldova, Tajikistan, and Uzbekistan.

1.68 “Safety Data” means Data related solely to any adverse drug experiences and serious adverse drug experience as such information is reportable to Regulatory Authorities. Safety Data also includes “adverse events”, “adverse drug reactions”, and “unexpected adverse drug reactions” as defined in the ICH Harmonised Tripartite Guideline for Clinical Safety Data Management: Definitions and Standards for Expedited Reporting.

1.69 “SEC” means the U.S. Securities and Exchange Commission, or any successor entity or its foreign equivalent, as applicable.

1.70 “Sublicensee” means a Third Party to whom Grifols grants a sublicense to use, import, promote, offer for sale, or sell any Product in the Field in the Grifols Territory, beyond the mere right to purchase Products from Grifols and its Affiliates, and excluding wholesalers and full-service distributors that do not promote the sale of the Product, and other similar physical distributors. In no event shall Rigel or any of its Affiliates be deemed a Sublicensee.

1.71 “Sunshine Reporting Laws” has the meaning set forth in Section 6.10.

1.72 “Term” has the meaning set forth in Section ‎14.1.

1.73 “Third Party” means any entity that is not Rigel or Grifols or an Affiliate of Rigel or Grifols.

1.74 “Valid Claim” means (a) a claim of an issued and unexpired patent that has not been revoked or held unenforceable, unpatentable, or invalid by a decision of a court or other governmental agency of competent jurisdiction that is not appealable or has not been appealed within the time allowed for appeal, and that has not been abandoned, disclaimed, denied, or admitted to be invalid or unenforceable through reissue, re-examination, or disclaimer or otherwise, or (b) a claim of a pending patent application that has not been cancelled, withdrawn or abandoned or finally rejected by an administrative agency action from which no appeal can be taken.

1.75 “Year” means, initially, the period of time commencing on the date of the first shipment of Product from Rigel to Grifols under the Commercial Supply Agreement intended for the First Commercial Sale in any country of the Grifols Territory and ending December 31st of the same calendar year, and, thereafter, each consecutive 365-day period (or 366-day period in the event of a leap year) beginning on January 1st and ending on December 31st of each calendar year during the Term.

Grant of License and Option

2.1 License Grant to Grifols. Subject to the terms and conditions of this Agreement, Rigel hereby grants to Grifols, during the Term, (a) an exclusive (even as to Rigel and its Affiliates, except as expressly set forth herein), royalty-bearing license, with the right to grant sublicenses (through multiple tiers) solely as provided in Section 2.2, under the Rigel Technology to use, promote, sell, offer for sale, import, export, and otherwise Commercialize (but not to make or have made) the Product in the Field in the Grifols Territory and (b) a non-exclusive license, with the right to grant sublicenses (through multiple tiers) solely as provided in Section 2.2, under the Rigel Technology to Develop (but not to make or have made) the Product in the Grifols Territory and to use the Product for that purpose.

2.2 Sublicenses. Grifols shall have the right to grant sublicenses under the licenses granted in Section 2.1:

(a) to an Affiliate of Grifols without providing any written notice to Rigel;

(b) to a Third Party in up to [ * ] Major Market Countries upon written notice to Rigel and to a Third Party in any of the remaining [ * ] Major Market Countries with Rigel’s express prior written consent; and

(c) to a Third Party in any country in the Grifols Territory other than a Major Market Country upon written notice to Rigel.

All sublicenses granted under the licenses granted to Grifols in Section 2.1 other than to an Affiliate of Grifols shall be in writing and shall be subject to, and consistent with, the terms and conditions of this Agreement and shall provide that any such Sublicensee shall not further sublicense except with the consent of Rigel. Grifols shall ensure that each agreement with a Sublicensee grants Rigel the same rights with respect to Regulatory Filings and Compound Inventions made or generated by such Sublicensee as if such Regulatory Filings and Compound Inventions were made or generated by Grifols pursuant to the terms and conditions set forth herein. Grifols shall be responsible for the compliance of its Affiliates, Sublicensees, and subcontractors with the terms and conditions of this Agreement.

2.3 Reserved Rights. Rigel hereby expressly reserves:

(a) the right under the Rigel Technology to exercise its rights and perform its obligations under this Agreement, whether directly or through one or more licensees or subcontractors; and

(b) all rights to practice, and to grant licenses under, the Rigel Technology outside of the scope of the licenses granted in Section 2.1, including the exclusive right to make and have made the Compound and Product anywhere in the world, the exclusive rights to practice the Rigel Patents and Rigel Know-How with respect to

compounds and products other than Compound and Product anywhere in the world, and the non-exclusive right to develop the Compound and Product anywhere in the world.

2.4 Option Grant to Grifols. Subject to the terms and conditions of this Agreement, Grifols shall be entitled to expand the Grifols Territory to include the Option Territory (the “Option”) as set forth below. Grifols may exercise the Option:

(a) subject to remainder of this Section 2.4, at any time during the Term by providing written notice thereof to Rigel; or

(b) in the case Rigel notifies Grifols in writing of its intention to commercialize, directly or indirectly, the Product within the Option Territory, Grifols shall have a maximum term of [ * ] from receipt of Rigel’s notice to exercise the Option by providing Rigel with written notice of such exercise.

Once Grifols exercises the Option, it shall pay to Rigel a one-time payment of [ * ] (the “Option Fee”) within [ * ] from the date of the corresponding invoice issued by Rigel and the Parties shall amend this Agreement to include the Option Territory as part of the Grifols Territory. For the avoidance of doubt, the Commercialization of the Products in the Field in the Option Territory will be subject to the same terms and conditions set forth in this Agreement and in the Commercial Supply Agreement and any and all references herein to the Grifols Territory will be understood as including the Option Territory. For the further avoidance of doubt, the Option Fee payment includes all countries of the Option Territory.

If Grifols fails to exercise the Option as set forth in this Section 2.4(b), the Option shall expire and Rigel shall have no further obligation to Grifols with respect to the Option Territory.

2.5 No Implied Licenses; Negative Covenant. Except as set forth in this Agreement, neither Party shall acquire any license or other intellectual property interest, by implication or otherwise, under or to any Patents, Know-How, or other intellectual property owned or controlled by the other Party. Neither Party shall, nor shall it permit any of its Affiliates or sublicensees to, practice any Patents or Know-How licensed to it by the other Party outside the scope of the licenses granted to it under this Agreement.

2.6 Third Party Licenses.

(a) Grifols shall promptly notify Rigel if it becomes aware of any Third Party Know-How or Patent that is necessary to assure the Commercialization in the Grifols Territory of the Product [ * ]. Rigel shall negotiate in good faith to obtain a license from such Third Party under such Know-How or Patent and [ * ] or [ * ] in the Grifols Territory. It is understood that any such Third Party license will [ * ] herein.

(b) If the Parties become aware of any Third Party Know-How or Patent that is useful, but not necessary, to exploit the license granted to Grifols in Section 2.1, the Parties will notify one another of such Know-How or Patent and evaluate, through the JSC, the benefit of obtaining a license under such Know-How or Patent. If the JSC and the Parties determine that obtaining a license to such Know-How or Patent is desirable, the Parties, through the JSC, will work together to determine the best strategy to obtaining such license.

2.7 Non-Compete.

(a) For the period starting from the Effective Date and for [ * ] of the Product in the first Indication in the Grifols Territory, Grifols shall not, directly or indirectly (including through an Affiliate or a Third Party), [ * ] any Competing Product to be sold or distributed in the Field in the Grifols Territory (a “Competing Program”). For the avoidance of doubt, Grifols is free to [ * ] any Competing Product outside the Grifols Territory (and/or inside of the Grifols Territory but outside the Field), either directly or indirectly.

(b) In the event that a Third Party becomes an assignee of this Agreement or an Affiliate of Grifols after the Effective Date through merger, acquisition, consolidation, or other similar transaction, and such Third Party, as of the closing date of such transaction, is engaged in the conduct of a Competing Program, then Rigel shall have the right to terminate this Agreement upon immediate written notice to Grifols if, within [ * ] after the closing of such transaction, the successor-in-interest of such Competing Program does not completely Divest such Competing Program. An additional [ * ] shall be provided as long as such assignee is using commercially reasonable efforts to Divest such Competing Program. “Divest” means (i) the sale or transfer of rights to the Competing Program to a Third Party (i.e., not an Affiliate of either Grifols or such successor-in-interest) without receiving a continuing share of profit, royalty payment, or other economic interest in the success of such Competing Program, or (ii) the termination of any direct or indirect commercialization activity for or in relation to such Competing Product.

Governance

3.1 Joint Steering Committee. On or about the Effective Date, the Parties will establish a joint steering committee (the “JSC”), composed of an equal number of up to [ * ] senior employees of each Party, to oversee and guide the strategic direction of the collaboration of the Parties under this Agreement. The JSC shall act as a joint consultative body and, to the extent expressly provided herein, a joint decision-making body. The JSC shall in particular:

(a) review and discuss the strategy and progress of the Development and Commercialization of the Product in the Grifols Territory;

(b) monitor and coordinate regulatory actions and pharmacovigilance and safety matters for the Product in the Grifols Territory;

(d) review the manufacturing and supply strategy and supply needs for the Grifols Territory;

(e) establish joint subcommittees as it deems necessary or advisable to further the purpose of this Agreement; and

(f) perform such other functions as appropriate to further the purposes of this Agreement, as expressly set forth in this Agreement or allocated to it by the Parties’ written agreement.

3.2 JSC Membership and Meetings.

(a) Committee Members. Each JSC representative shall have appropriate knowledge and expertise and sufficient seniority within the applicable Party to make decisions arising within the scope of the JSC’s responsibilities. Each Party may replace its representatives on the JSC on written notice to the other Party, but each Party shall strive to maintain continuity in the representation of its JSC members. The JSC chairperson shall [ * ]. The chairperson shall prepare and circulate agendas to JSC members at least [ * ] before each JSC meeting and shall direct the preparation of reasonably detailed minutes for each JSC meeting, which shall be approved by the chairperson and circulated to JSC members within [ * ] after such meeting. The Parties shall determine their respective initial members of the JSC promptly following the Effective Date.

(b) Meetings. The JSC shall hold meetings at such times as it elects to do so, but in no event shall meetings of the JSC be held less frequently than once every [ * ] prior to [ * ] unless otherwise agreed to by the parties. The first JSC meeting shall be held within [ * ] after the Effective Date, at which meeting the dates for the first calendar year shall be set. JSC meetings may be held in person or by audio or video teleconference; provided that, unless otherwise agreed by both Parties, at least one (1) meeting per calendar year shall be held in person. In-person JSC meetings shall be held at locations alternately selected by the Parties. Each Party shall be responsible for

all of its own expenses of participating in any JSC meeting. No action taken at any JSC meeting shall be effective unless at least [ * ] of each Party is participating. In addition, upon written notice to the other Party, either Party may request that a special ad hoc meeting of the JSC be convened for the purpose of resolving any disputes in connection with, or for the purpose of reviewing or making a decision pertaining to any material subject-matter within the scope of the JSC, the review or resolution of which cannot be reasonably postponed until the following scheduled JSC meeting. Such ad hoc meeting shall be convened at such time as may be mutually agreed by the Parties, but no later than [ * ] following the notification date of request that such meeting be held.

(c) Non-Member Attendance. Each Party may from time to time invite a reasonable number of participants, in addition to its representatives, to attend JSC meetings in a non‑voting capacity; provided that if either Party intends to have any Third Party (including any consultant) attend such a meeting, such Party shall provide reasonable prior written notice to the other Party and obtain the other Party’s approval for such Third Party to attend such meeting, which approval shall not be unreasonably withheld or delayed. Such Party shall ensure that such Third Party is bound by written confidentiality and non-use obligations consistent with the terms of this Agreement.

3.3 Decision-Making.

(a) All decisions of the JSC shall be made by unanimous vote, with each Party’s representatives collectively having one (1) vote. If after reasonable discussion and good faith consideration of each Party’s view on a particular matter, the representatives of the Parties cannot reach an agreement as to such matter within [ * ] after such matter was brought to the JSC for resolution, then either Party at any time may refer such issue to the following Senior Managers of each Party:

For Rigel: [ * ]

· For Grifols: [ * ]

(b) If the Seniors Managers of the Parties cannot resolve such matter within [ * ] after such matter has been referred to them, then Article ‎15 of this Agreement applies.

3.4 Limitations on Authority. The JSC shall have only such powers as are expressly assigned to it in this Agreement, and such powers shall be subject to the terms and conditions of this Agreement. Without limiting the generality of the foregoing, the JSC will not have the power to amend this Agreement, and no JSC decision may be in contravention of any terms and conditions of this Agreement.

3.5 Discontinuation of the JSC. The activities to be performed by the JSC shall solely relate to governance under this Agreement, and are not intended to be or involve the delivery of services. The JSC shall continue to exist until the first to occur of the following: (a) the Parties mutually agree to disband the JSC; or (b) Rigel provides written notice to Grifols of its intention to disband and no longer participate in the JSC, provided that Rigel shall not give such notice within the first [ * ] following the Effective Date. Once the Parties mutually agree or Rigel has provided written notice to disband the JSC, the JSC shall have no further obligations under this Agreement and, thereafter, each Party shall designate a contact person for the exchange of information under this Agreement that would have otherwise been exchanged through the JSC or such exchange of information shall be made through Alliance Managers, and decisions formerly made by the JSC shall be decisions as between the Parties, subject to the other terms and conditions of this Agreement.

3.6 Alliance Managers. Promptly after the Effective Date, each Party shall appoint an employee of such Party having appropriate qualification and experience to act as the alliance manager for such Party (the “Alliance Manager”). Each Alliance Manager shall be responsible for coordinating and managing processes and interfacing between the Parties on a day-to-day basis throughout the Term and shall be permitted to attend meetings of the JSC as non-voting participants. The Alliance Managers shall be the primary contact for the Parties regarding the activities contemplated by this Agreement and shall facilitate all such activities hereunder. Each Party shall bear its own costs of its Alliance Manager.

Development

4.1 Development Activities.

(a) Rigel Responsibilities. Rigel shall be responsible, and bear all associated costs and expenses, for and shall use Commercially Reasonable Efforts to continue the extension portion of the phase 3 clinical trial for ITP currently on-going until MAA Approval or until such clinical trial is concluded, and to the extent agreed by both Parties, conduct any other follow up clinical trials of the Product for ITP required by the EMA to obtain MAA approval as of the Effective Date until MAA Approval is obtained from the EMA. Rigel shall also be responsible, and bear all associated costs and expenses, for and shall use Commercially Reasonable Efforts to conduct the phase 3 clinical trial for AIHA planned as of the Effective Date, and, to the extent agreed by both Parties, conduct any other follow up clinical trials of the Product for AIHA required by the EMA to obtain MAA approval as of the Effective Date. For clarity, Rigel shall also have the right, but not the obligation, to conduct any other Development activities with respect to the Product in the Grifols Territory.

(b) Grifols Responsibilities. Except for the activities specified in Section ‎4.1(a), Grifols shall be responsible for all territory-specific Development activities that are for the benefit of the countries within the Grifols Territory.

(c) Indications Other Than ITP and AIHA. For any Indication that either Party seeks a MAA for in the Grifols Territory, other than ITP and AIHA, for which Rigel conducted Phase 3 clinical trials, or the equivalent thereof, the Parties shall negotiate in good faith to reimburse Rigel for its expenses related to such trials [ * ]. If an agreement is reached, Grifols shall proceed to reimburse [ * ] within the following [ * ]. In the event an agreement is not reached, such Indication shall be excluded from the Field.

4.2 Rigel’s Right to Develop. If Grifols elects to not conduct a clinical trial of the Product for an Indication other than ITP and AIHA required by a Regulatory Authority in the Grifols Territory to obtain MAA Approval of the Product for such Indication, or any Development activities required in the Grifols Territory for Pricing and Reimbursement Approval of the Product for an Indication other than ITP and AIHA, Grifols shall promptly provide Rigel written notice of such election. Following Rigel’s receipt of such notice, [ * ] Rigel shall have the right, but not the obligation, to conduct such clinical trial or other Development activity of the Product for such Indication in the Grifols Territory, in Rigel’s sole discretion. In such event, the Parties will negotiate in good faith the terms of an amendment to this Agreement or side letter between the Parties to govern such Development activities by Rigel.

4.3 Data Use. Grifols shall have the right to use and reference, without additional consideration, any and all Rigel Data generated pursuant to Section ‎4.1(a) for obtaining and maintaining Regulatory Approval of the Product and Commercializing the Product in the Grifols Territory in accordance with the terms of this Agreement. Rigel shall have the right to use and reference, without additional consideration, any and all Grifols Data for obtaining and maintaining Regulatory Approval of the Product and Commercializing the Product in the Rigel Territory and, subject to the terms of this Agreement, in the Grifols Territory.

4.4 Diligence. Each Party shall use Commercially Reasonable Efforts to perform its obligations under this Article 4.

4.5 Development Records. Each Party shall maintain complete, current, and accurate records of all Development activities conducted by it under this Agreement, and all data and other information resulting from such activities. Such records shall fully and properly reflect all work done and results achieved in the performance of the Development activities in good scientific manner appropriate for regulatory and patent purposes. Each Party shall document all non-clinical studies and clinical trials in formal written study reports according to Applicable Laws and national and international guidelines (e.g., ICH).

4.6 Development Reports and Data Exchange. At each regularly scheduled JSC meeting, both Parties shall provide the JSC with a report detailing their Development activities for the Product under this Agreement, if any,

and the results of such activities. In addition, after the completion of any clinical trial or other study of the Product, Each Party shall in a timely manner provide the other party with a data package consisting of, at a minimum, tables, lists, and figures, as well as any other Data for such clinical trial or study. After the disbanding of the JSC, the Parties shall continue to exchange information regarding any remaining Development, regulatory and other related activities with respect to the Product by providing updates to each other on a periodic basis not less than [ * ], through a development review board. Decisions in such review board shall be made by unanimous vote with each Party's representative collectively having one (1) vote.

4.7 Use of Subcontractors. Each Party may perform its Development activities under this Agreement through one or more subcontractors, provided that (a) such Party will remain responsible for the work allocated to, and payment to, such subcontractors to the same extent it would if it had done such work itself, (b) each subcontractor undertakes in writing obligations of confidentiality and non-use regarding Confidential Information that are substantially the same as those undertaken by the Parties pursuant to Article 13, and (c) each subcontractor agrees in writing to assign all intellectual property developed in the course of performing any such work to such Party (or, in the event such assignment is not feasible, a license to such intellectual property with the right to sublicense to such other Party).

Regulatory Activities

5.1 Regulatory Responsibilities. Except as otherwise imposed by Applicable Law in any country of the Grifols Territory, Rigel shall be responsible for the preparation and submission of any and all Regulatory Fillings to, and for obtaining all Product registrations and ▇▇▇▇ (including Regulatory Approval) from, the EMA for the Commercialization of the Product in those countries of the Grifols Territory for which the EMA has jurisdiction. Rigel shall do so at its own expense for [ * ]. For other Indications, Grifols shall reimburse Rigel [ * ] once MAA Approval from the EMA is obtained. Grifols shall be responsible, at its own expense, for the preparation and submission of any and all Regulatory Filings to, and for obtaining all Product registrations and ▇▇▇▇ (including Regulatory Approval) from, the applicable Regulatory Authorities for the Commercialization of the Product for all countries in the Grifols Territory outside of the jurisdiction of the EMA. If by the [ * ] anniversary of the date of MAA Approval of the Product for [ * ] from the EMA, Grifols has not initiated efforts to obtain MAA Approval of the Product for the applicable Indication in any of the remaining countries in the Grifols Territory outside the jurisdiction of the EMA, then such countries shall cease to be included as part of the Territory under this Agreement. Each Party agrees to cooperate fully with the other in any Product registration and MAA activity or action that such Party may reasonably request of the other Party.

5.2 Rigel Transfer of Regulatory Filings and Right of Reference.

(a) Rigel shall transfer to Grifols the ▇▇▇▇ submitted to any Regulatory Authority in the Grifols Territory for the Compound and Product that are in Rigel’s name and Controlled by Rigel promptly after the receipt of Regulatory Approval for the applicable MAA from such Regulatory Authority.

(b) To the extent that any such transfer is not permitted under Applicable Laws, Rigel shall provide to Grifols a right of reference or use to such Regulatory Approvals and Regulatory Filings. Rigel shall provide appropriate notification of Grifols’ access and reference rights to the applicable Regulatory Authorities, at Rigel's expense. For the purposes of this Agreement, “right of reference” means the “right of reference or use” as defined in 21 C.F.R. §314.3(b) and any equivalent regulation outside the U.S., including Article 10c of Directive 2001/83/EC, as each may be amended.

5.3 Grifols Regulatory Information Sharing and Right of Reference.

(a) In the case where Grifols submits any Regulatory Filings with respect to the Product, Grifols shall promptly provide Rigel with copies of such Regulatory Filings and documents of communication prepared (including any drafts), submitted, or received by Grifols in the Grifols Territory pertaining to the Product, including English translations, and Rigel shall have the right to review and comment on drafts of such Regulatory

Filings and communications. Grifols shall use Commercially Reasonable Efforts to grant to Rigel access and rights to use any such communications with any Regulatory Authority generated by or on behalf of any Sublicensee. Should Grifols fails to obtain such access and rights from any Sublicensee because under applicable laws prohibit such access or the market access is denied by Regulatory Authorities, Grifols shall not have the right to grant access or rights to such Sublicensee to any Regulatory Filing or right of reference granted to Grifols by Rigel pursuant to Section ‎5.2(b).

(b) Grifols hereby grants to Rigel a right of reference to all Regulatory Filings pertaining to the Compound and Product submitted by or on behalf of Grifols. Rigel may use such right of reference to seek, obtain, and maintain Regulatory Approval of the Product in the Rigel Territory.

5.4 Adverse Event Reporting; Pharmacovigilance Agreement.

(a) As soon as reasonably practicable after the Effective Date, the Parties shall enter into a pharmacovigilance agreement setting forth the pharmacovigilance procedures for the Parties with respect to the Product, such as Safety Data sharing, adverse events reporting, and safety signal and risk management (the “Pharmacovigilance Agreement”), which agreement shall be amended by the Parties [ * ] to comply with any changes in Applicable Laws or any guidance received from Regulatory Authorities. Such procedures shall be in accordance with, and enable the Parties to fulfill, local and national regulatory reporting obligations under Applicable Laws (including, to the extent applicable, those obligations contained in ICH guidelines) to monitor patients’ safety.

(b) Rigel has established, and shall continue to hold (either by itself or through a vendor engaged by Rigel) the global safety database for the Product, and shall maintain such global safety database for so long as such Product is under Development or Commercialization by the Parties. Rigel shall [ * ] such database and preparing such reports. Rigel will ensure that each Party is able to access the data from the global safety database in order to meet legal and regulatory obligations. Grifols shall maintain its own safety database for the Product in the Grifols Territory and shall provide all Safety Data, including adverse event reports, in such database to Rigel in accordance with this Section ‎5.4 and the Pharmacovigilance Agreement. Grifols shall [ * ] such database for the Grifols Territory and preparing reports for the Grifols Territory.

(c) Each Party shall be primarily responsible for reporting quality complaints, adverse events, and Safety Data related to the Product to any necessary Regulatory Authorities, and responding to safety issues and to all requests of Regulatory Authorities related to the Product under any MAA or Regulatory Approval for the Product held by such Party and filed with such Regulatory Authorities, [ * ]. Each Party agrees to comply with its respective obligations under the Pharmacovigilance Agreement and to cause its Affiliates, licensees, and sublicensees to comply with such obligations.

5.5 No Harmful Actions. If a Party reasonably believes that the other Party is taking or intends to take any action with respect to a Product that could reasonably be expected to have a material adverse impact upon the regulatory status of such Product in the first Party’s territory, then such Party may bring the matter to the attention of the JSC and the Parties shall discuss in good faith to promptly resolve such concern.

5.6 Notification of Threatened Action. Each Party shall notify the other Party within [ * ] of any information it receives regarding any threatened or pending action, inspection, or communication by any Regulatory Authority which may adversely affect the safety or efficacy claims of any Product or the continued Development or Commercialization of any Product. Upon receipt of such information, the Parties shall promptly consult with each other in an effort to arrive at a mutually acceptable procedure for taking appropriate action.

5.7 Recalls. In the event that a recall, withdrawal, or correction (including the dissemination of relevant information) of any Product in a Party’s territory is required by a Regulatory Authority of competent jurisdiction, or if any Regulatory Authority requires or advises either Party or such Party’s Affiliates or sublicensees to distribute a “Dear Doctor” letter or its equivalent regarding use of such Product in a Party’s territory, or if a recall, withdraw, or correction of a Product in its territory is deemed advisable by such Party in its sole discretion, such Party shall so notify the other Party no later than [ * ] in advance of the earlier of (a) initiation of a recall, withdrawal, or correction,

or (b) the submission of plans for such an action to a Regulatory Authority. Any such recall, withdrawal, correction, or dissemination of information (e.g., “Dear Doctor” letter) shall be referred to herein as a “Recall”. Promptly after being notified of a Recall, each Party shall provide the other Party with such assistance in connection with such Recall as may be reasonably requested by such other Party. All costs and expenses to conduct the Recall [ * ] shall be the responsibility of [ * ], including the costs and expenses related to the dissemination of relevant information. Each Party shall handle exclusively the organization and implementation of all Recalls of Products in its territory. Notwithstanding the foregoing, any Recall related to the manufacture and supply of the Product by Rigel to Grifols shall be governed by the terms and conditions of the Commercial Supply Agreement.

Commercialization

6.1 General. Subject to the terms and conditions of this Article 6, Grifols shall have the sole and exclusive responsibility, at its own expense, for all aspects of the Commercialization of the Product in the Field in the Grifols Territory, including (a) developing and executing a commercial launch and pre-launch plan, (b) negotiating with applicable Governmental Authorities and other payors regarding the price and reimbursement status of the Product, (c) marketing and promotion, (d) booking sales and distribution and performance of related services, (e) handling all aspects of order processing, invoicing and collection, inventory and receivables, (f) providing customer support, including handling medical queries, and performing other related functions, and (g) conforming its practices and procedures to Applicable Laws relating to the promotion, sales and marketing, access, and distribution of the Product in the Field in the Grifols Territory.

6.2 Knowledge Transfer. Grifols' and Rigel’s employees dedicated to the Product shall participate in knowledge transfer meetings, at a mutually agreeable location, [ * ] to support Grifols’ Product launch and as the JSC may consider necessary and convenient, provided however that at least [ * ] such meetings will be provided within the first [ * ] as of the Effective Date and, thereafter, [ * ], or as mutually agreed between the Parties. Each Party shall bear their own travel and accommodation expenses if any, [ * ].

6.3 Commercialization Plan. As soon as reasonably practicable, but no later than [ * ] after the Effective Date, Grifols shall prepare and present to the JSC a [ * ] plan for the Commercialization of the Product in the Field in the Grifols Territory, [ * ] (the “Commercialization Plan”). The Commercialization Plan shall include such information [ * ] for the Grifols Territory. Grifols shall update and amend the Commercialization Plan [ * ] following the initial First Commercial Sale of the Product in the Grifols Territory and present such updates and any amendments to the JSC for review and discussion. Subject to the provisions of this Agreement and the terms of Commercialization Plan, Grifols shall have full control and authority with respect to the day-to-day Commercialization of the Product and implementation of the Commercialization Plan, except that Grifols will consider incorporating Rigel’s reasonable suggestions [ * ] into the Commercialization Plan.

6.4 Diligence.

(a) General. During the Term, Grifols shall use Commercially Reasonable Efforts to Commercialize the Product for each and every Indication that has received or will receive Regulatory Approval in the Grifols Territory.

(b) Product Launch. Grifols shall launch the Product for each Indication that has received Regulatory Approval in the Grifols Territory as soon as reasonably possible following receipt of such Regulatory Approval. As applicable, Grifols shall obtain all necessary Pricing and Reimbursement Approvals necessary to launch such Product as soon as reasonably possible following receipt of MAA Approval of such Product in any such country. Without limiting the generality of the foregoing, with respect to the Product for ITP, Grifols shall launch the Product in (i) [ * ] within [ * ] after receiving Regulatory Approval of the Product for ITP from the EMA, and (ii) [ * ] within [ * ] after receiving such Regulatory Approval. Thereafter, Grifols shall utilize Commercially Reasonable Efforts in the ongoing support for the Commercialization of the Product for ITP in the Grifols Territory. If Grifols fails to timely achieve the obligation in the foregoing subsections (i) (ii), the rights granted herein to Grifols for [ * ] in the case (i)

is not achieved, and [ * ] in the case (ii) is not achieved, shall revert to Rigel, unless the Parties otherwise mutually agree on the terms and conditions for any extension to the launch timeline set forth above.

(c) Sales Force. Specifically and without limiting the infrastructure requirement as set forth in the Commercialization Plan, within [ * ] after obtaining Regulatory Approval of the Product for a new Indication in the Grifols Territory, Grifols shall use Commercially Reasonable Efforts to promote and detail the Product in the Grifols Territory for such new Indication. If Grifols does not apply Commercially Reasonable Efforts to achieve the obligations in this subsection (c) and/or does not, [ * ], significantly adhere to the Commercialization Plan, such failure shall be deemed a material breach and Rigel shall have the right to terminate this Agreement pursuant to Section 14.2(c).

6.5 Commercial Updates. Grifols shall update the JSC on [ * ] basis regarding its Commercialization activities with respect to the Product in the Grifols Territory. Each such update shall be in a form to be agreed by the JSC and shall summarize Grifols’ and its Affiliates’ and Sublicensees’ significant Commercialization activities with respect to the Product in the Grifols Territory, and shall contain at least such information at such level of detail reasonably required by the JSC to determine Grifols’ compliance with its diligence obligations set forth in this Section ‎6.4. Such updates shall include, [ * ], Grifols’ promotion and marketing activities, sales and purchase forecasts for at least the next [ * ], and Medical Affairs Activities. All such updates shall be deemed Grifols’ Confidential Information. After the disbanding of the JSC, the Parties shall continue to exchange information regarding their Commercialization activities with respect to the Product by providing updates to each other on a periodic basis [ * ], through a Commercialization review board. Decisions in such review board shall be made by unanimous vote with each Party's representative collectively having one (1) vote.

6.6 Rigel’s Right to Promote. Notwithstanding the foregoing, if Grifols elects not to launch or Commercialize the Product for an Indication other than ITP [ * ] following receipt of MAA Approval of the Product for such Indication, Grifols shall promptly provide Rigel written notice of such election. Following Rigel’s receipt of such notice, [ * ] Rigel shall have the right, but not the obligation, to Commercialize the Product for such Indication [ * ]. In such event, the Parties will negotiate in good faith the terms of an amendment to this Agreement or side letter between the Parties to govern such Commercialization activities by Rigel, including, without limitation, [ * ] for the corresponding Indication [ * ].

6.7 Coordination of Commercialization Activities.

(a) Generally. Grifols, through the JSC, shall update Rigel on Commercialization strategies for the Product (e.g., for branding and messaging, international congresses, advisory boards) in the Grifols Territory, and the Parties shall work together to identify and take advantage of any potential global strategies and messaging. The foregoing shall not be construed as requiring Grifols to seek Rigel’s consent in connection with Grifols establishing or implementing any sales, marketing, or medical affairs practices in the Grifols Territory.

(b) Pricing. Grifols shall keep Rigel timely informed on the status of any application for Pricing and Reimbursement Approval or material updates to an existing Pricing and Reimbursement Approval in the Grifols Territory, including any discussion with a Regulatory Authority with respect thereto. Grifols and its Affiliates and Sublicensees shall not sell any Product [ * ]. For the avoidance of doubt, Grifols and its Affiliates and Sublicensees are free to determine the resale price of the Products to its customers.

(c) Promotional Materials. Rigel shall provide Grifols with sufficient samples of Promotional Material (as defined below) produced and released for the US market so as to provide Grifols with ideas and information. Subsequently, Grifols shall, at its own expense, prepare, develop, produce, or otherwise obtain and utilize sales, promotional, advertising, marketing, website, educational, and training materials for the Products (the “Promotional Materials”) to support its Commercialization activities in the Grifols Territory, and shall ensure that such Promotional Materials, as well as all information contained therein, are accurate and comply with all Applicable Laws and are consistent with any Regulatory Approvals obtained for the Product in the applicable jurisdiction in the

Grifols Territory. At Rigel’s request, Grifols shall share samples of and updates to Promotional Materials with respect to the Commercialization of the Product with Rigel.

6.8 Medical Affairs Activities. Grifols shall be responsible for Medical Affairs Activities in the Grifols Territory. Rigel shall collaborate, at its own cost, in knowledge transfer to Grifols and in support of Grifols’ execution of Medical Affairs Activities in the Grifols Territory in global support of the Product, based on the Commercialization Plan as discussed within the JSC from time to time.

6.9 Diversion. Each Party hereby covenants and agrees that it and its Affiliates shall not, and it shall contractually obligate (and use Commercially Reasonable Efforts to enforce such contractual obligation) its sublicensees not to, directly or indirectly, actively promote, market, distribute, import, sell, or have sold any Product, including via the Internet or mail order, to any Third Party or to any address or Internet Protocol address or the like in the other Party’s territory. Neither Party shall engage, nor permit its Affiliates and sublicensees to engage, in any advertising or promotional activities relating to any Product for use directed primarily to customers or other buyers or users of such Product located in any country or jurisdiction in the other Party’s territory, or solicit orders from any prospective purchaser located in any country or jurisdiction in the other Party’s territory. If a Party or its Affiliates or sublicensees receives any order for a Product for use from a prospective purchaser located in a country or jurisdiction in the other Party’s territory, such Party shall immediately refer that order to such other Party and shall not accept any such orders. Neither Party shall, nor permit its Affiliates and sublicensees to, deliver or tender (or cause to be delivered or tendered) any Product for use in the other Party’s territory.

6.10 Sunshine Reporting Laws. Each Party acknowledges that the other Party may be subject to (or voluntarily applies) federal, state, local, and international laws, regulations, and rules related to the tracking and reporting of payments and transfers of value provided to health care professionals, health care organizations, and other relevant individuals and entities (collectively, “Sunshine Reporting Laws”), and agrees to provide the other Party with all information regarding such payments or transfers of value by such Party as necessary for such other Party to comply in a timely manner with its reporting obligations under the Sunshine Reporting Laws.

Manufacture and Supply

7.1 Manufacture and Supply. The Parties shall endeavor to negotiate and enter into the Commercial Supply Agreement within a reasonable period as of the Effective Date, pursuant to which Rigel will manufacture and supply, on an exclusive basis, by itself or through a Third Party contract manufacturer, the Product in fill and finished form as specified in the Commercial Supply Agreement, but without final packaging or labeling, for use by Grifols in the Commercialization of the Product under this Agreement. Grifols shall be responsible, at its expense, for the final packaging and labeling of the Product for all countries in the Grifols Territory, and shall ensure that such packaging and labeling, as well as all information contained therein, are accurate and comply with all Applicable Laws and are consistent with any Regulatory Approvals obtained for the Product in the applicable jurisdiction in the Grifols Territory.

7.2 After the disbanding of the JSC, the Parties shall continue to exchange information regarding the manufacturing and supply activities with respect to the Compound and the Product by providing updates to each other on a periodic basis [ * ], through a manufacturing and supply review board. Decisions in such review board shall be made by unanimous vote with each Party's representative collectively having one (1) vote.

Financial Provisions

8.1 Upfront Payment. Within ten (10) days after the Effective Date, Grifols shall make a (a) one-time, non-refundable, non‑creditable upfront payment to Rigel of five million dollars ($5,000,000), and (b) one-time payment to Rigel of twenty-five million dollars ($25,000,000), which twenty-five million dollar ($25,000,000) payment shall be refundable to Grifols solely as set forth in Section 14.2(a).

8.2 Development and Advance Royalty Milestones.

(a) Development Milestone Payments. Subject to the remainder of this Section ‎8.2, Grifols shall pay to Rigel the one-time, non-refundable payments set forth in the table below upon the achievement of the applicable milestone event (whether by or on behalf of Grifols or its Affiliates or Sublicensees or Rigel or its Affiliates or licensee(s) (other than Grifols)).

Milestone Event	Milestone Payment
1. MAA Approval by the EMA for the Product for the first Indication	$17.5 million
2. [ * ]	$[ * ]
3. [ * ]	$[ * ]
TOTAL	$40 million

(b) Advance Royalty Milestone. Upon obtaining MAA Approval by the EMA for the Product for the first Indication, Grifols shall pay to Rigel the one-time payment of two million five hundred thousand dollars ($2,500,000), which payment shall be creditable as an advanced royalty payment solely as set forth in Section ‎8.4(d).

(c) Notice and Payment. Each Party shall notify the other Party in writing within [ * ] after the achievement of any milestone set forth in this Section ‎8.2 by such Party or its Affiliates or Sublicensees. After the delivery or receipt of such notice, Grifols shall pay to Rigel the applicable milestone payment within [ * ] from the date of the corresponding invoice issued by Rigel.

8.3 Net Sales Milestones Payments.

(a) Grifols shall pay to Rigel the one-time, non-refundable payments set forth in the table below when the aggregated Net Sales of all Products in the Grifols Territory in any Year first reach the values indicated in the table below. For clarity, each payment in this Section ‎8.3 shall be payable only once upon first achievement of the applicable milestone event, regardless of the number of times such milestone is subsequently achieved.

Aggregate Net Sales of all Products in the Grifols Territory in a Year	Milestone Payment
Equal or exceed$[ * ]	$[ * ]
Equal or exceed$[ * ]	$[ * ]
Equal or exceed $[ * ]	$[ * ]
Equal or exceed $[ * ]	$[ * ]
Equal or exceed $[ * ]	$[ * ]
TOTAL	$255 million

(b) Notice and Payment. As part of the report set forth in Section ‎9.1, Grifols shall provide written notice to Rigel if the aggregated Net Sales of all Products in the Grifols Territory in any Year first reach the

values set forth in Section ‎8.3(a) above, and Grifols shall pay to Rigel the corresponding Net Sales milestone payment within [ * ] upon receipt of the corresponding invoice.

8.4 Royalty Payments.

(a) Royalty Rate. During the Royalty Term, Grifols shall make non-refundable royalty payments to Rigel on the annual Net Sales of all Products sold in the Grifols Territory at the applicable rate set forth below:

Annual Net Sales of all Products in the Grifols Territory	Royalty Rate
Portion less than or equal to $[ * ]	[ * ]%
Portion greater than $[ * ] and less than or equal to $[ * ]	[ * ]%
Portion greater than $[ * ]	30%

(b) Royalty Term. Royalties shall be paid on a Product-by-Product and country-by-country basis in the Grifols Territory from the First Commercial Sale of such Product in such country by or on behalf of Grifols, its Affiliates, or Sublicensees, until the later of: (i) the expiration of the last‑to‑expire Valid Claim of the Rigel Patents covering such Product in such country, including its composition, method of manufacture, and/or method of use, in each case covering the Product as Commercialized, and (ii) twelve (12) years after the First Commercial Sale of such Product in such country (the “Royalty Term”).

(i) If one or more Generic Products to a Product is sold in any country in the Grifols Territory during the Royalty Term for such Product in such country, and such Generic Products in the aggregate have a unit market share in such country of [ * ], [ * ].

(ii) If the Applicable Laws (including legal doctrine) in a particular country or jurisdiction require a royalty reduction after the expiration of the relevant patents, and the Royalty Term for a particular Product in such country or jurisdiction extends beyond the time period set forth in Section ‎8.4(b)(i), [ * ].

(d) Royalty Credit for ITP. Following the initial First Commercial Sale of the Product for ITP in the Grifols Territory, Grifols shall be entitled to credit two and one-half million dollars ($2,500,000) of the milestone payment paid by Grifols to Rigel under Section ‎8.2(b) against the royalties owed by Grifols to Rigel pursuant to Section ‎8.4(a) with respect to the Net Sales of such Product.

Payment; Records; Audits

9.1 Payment; Reports. Royalty payments due by Grifols to Rigel under Section ‎8.4 shall be calculated and reported for and at the end of each Calendar Quarter. All royalty payments due under Section ‎8.4 shall be paid within [ * ] after the end of the relevant Calendar Quarter for which royalties are due and shall be accompanied by a report setting forth, on a country-by-country basis, Net Sales of the Products by Grifols and its Affiliates and Sublicensees in the Grifols Territory in sufficient detail to permit confirmation of the accuracy of the royalty payment made, including, for each country, the number of Products sold, the Net Sales of Products, including the deductions to arrive at Net Sales as provided for under Section 1.46, the royalties payable, the method used to calculate the royalties, the exchange rates used, any adjustments to royalties in accordance with Section ‎8.4(d), and whether any

Net Sales milestone under Section ‎8.3 has been achieved. Prior to the First Commercial Sale of the Product in the Grifols Territory, the Parties will agree on the form of royalty report through the JSC. Grifols shall submit a single report for all Net Sales during a Calendar Quarter, including all of Grifols’ and its Affiliates’ and Sublicensees’ Net Sales.

9.2 Exchange Rate; Manner and Place of Payment. All references to dollars and “$” herein shall refer to U.S. dollars. All payments hereunder shall be payable in U.S. dollars. When conversion of Net Sales from any currency other than U.S. dollars is required, such conversion shall be at the exchange rate equal to the conversion rate for the U.S. dollar for the currency of the country in which the applicable Net Sales were made as published by [ * ]. All payments owed under this Agreement shall be made by wire transfer in immediately available funds to a bank and account designated in writing by Rigel, unless otherwise specified in writing by Rigel.

9.3 Taxes.

(a) Taxes on Income. Each Party shall be solely responsible for the payment of all taxes imposed on its share of income arising directly or indirectly from the activities of the Parties under this Agreement.

(b) Tax Cooperation. The Parties agree to cooperate with one another and use reasonable efforts to avoid or reduce tax withholding or similar obligations in respect of the milestone payments, royalty payments, and other payments made by Grifols to Rigel under this Agreement. To the extent that Grifols is required by Applicable Laws to deduct and withhold taxes on any payment to Rigel, Grifols shall pay the amounts of such taxes to the proper Governmental Authority in a timely manner and promptly transmit to Rigel an official tax certificate or other evidence of such payment sufficient to enable Rigel to claim such payment of taxes. Rigel shall provide Grifols any tax forms that may be reasonably necessary in order for Grifols to not withhold tax or to withhold tax at a reduced rate under an applicable bilateral income tax treaty, to the extent legally able to do so. Rigel shall use reasonable efforts to provide any such tax forms to Grifols in advance of the due date. Grifols shall provide Rigel with reasonable assistance to enable the recovery, as permitted by Applicable Laws, of withholding taxes or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of Rigel. Grifols shall have the right to deduct any such tax, levy, or charge actually paid from payment due to Rigel. Each Party agrees to assist the other Party in claiming exemption from such deductions or withholdings under double taxation or similar agreement or treaty from time to time in force and in minimizing the amount required to be so withheld or deducted.

(c) Taxes Resulting From Grifols’ Action. Grifols represents and warrants that, as of the Effective Date, Grifols is not required by Applicable Law to deduct or withhold taxes on the upfront payment, milestone payments, royalty payments, or other payments payable to Rigel under this Agreement. If a Party takes any action of its own discretion (not required by a Regulatory Authority) which results in a withholding or deduction obligation (“Withholding Tax Action”), then such Party shall pay the sum associated with such Withholding Tax Action. For clarity, if Grifols undertakes a Withholding Tax Action, then the sum payable by Grifols (in respect of which such deduction or withholding is required to be made) shall be increased to the extent necessary to ensure that Rigel receives a sum equal to the sum which it would have received had no such Withholding Tax Action occurred. If a change in Applicable Laws results in a withholding or deduction obligation absent either Party taking a Withholding Tax Action, then the amount of such withholding or deduction obligation shall be paid by Grifols to the applicable Governmental Authority on behalf of Rigel, provided that Grifols shall assist Rigel in minimizing or recovering such withholding or deduction obligation. The Parties shall use commercially reasonable efforts to invoke the application of any applicable bilateral income tax treaty that would reduce or eliminate otherwise applicable taxes with respect to payments payable pursuant to this Agreement.

9.4 Records; Audit. Grifols shall maintain complete and accurate records in sufficient detail in relation to this Agreement to permit Rigel to confirm the achievement of Net Sales milestones and the amount of royalty and other payments payable under this Agreement. Each Party will keep such books and records for at least [ * ] following the Year to which they pertain. Upon reasonable prior notice, such records shall be inspected during regular business hours at such place or places where such records are customarily kept by an independent certified public accountant (the “Auditor”) selected by Rigel and reasonably acceptable to Grifols for the sole purpose of verifying for the

auditing Party the accuracy of the financial reports furnished by Grifols pursuant to this Agreement or of any payments made, or required to be made, by or to the audited Party pursuant to this Agreement. Before beginning its audit, the Auditor shall execute an undertaking acceptable to Grifols by which the Auditor agrees to keep confidential all information reviewed during the audit. Such audits may occur no more often than [ * ] each Year and not more frequently than [ * ] with respect to records covering any specific period of time. Rigel shall only be entitled to audit the books and records from the [ * ] prior to the Year in which the audit request is made. Other than the audit report, such Auditor shall not disclose the audited Party’s Confidential Information to the auditing Party, its Affiliates or Third Parties. In the event that the final result of the inspection reveals an undisputed underpayment or overpayment, the underpaid or overpaid amount shall be settled within [ * ] after the Auditor’s report. Rigel shall bear the full cost of such audit unless such audit reveals an underpayment by Grifols that resulted from a discrepancy in the financial report provided by Grifols for the audited period, which underpayment was more than [ * ] of the amount set forth in such report, in which case Grifols shall reimburse Rigel for the costs for such audit. In case of overpayment, Rigel shall, at Grifols’ discretion, reimburse Grifols the amounts overpaid by Grifols or settle them against any amount due or to be due by Grifols to Rigel pursuant to this Agreement.

9.5 Late Payments. In the event that any payment due under this Agreement is not paid when due in accordance with the applicable provisions of this Agreement, the payment shall accrue interest from the date due [ * ]; provided, however, that in no event shall such rate exceed the maximum legal annual interest rate. The payment of such interest shall not limit the Party entitled to receive payment from exercising any other rights it may have as a consequence of the lateness of any payment.

10.

Intellectual Property

10.1 Ownership.

(a) Data. All Data generated in connection with the Development or Commercial activities with respect to the Product conducted solely by or on behalf of Rigel and its Affiliates and licensees (other than Grifols, its Affiliates and Sublicensees) (the “Rigel Data”) shall be the sole and exclusive property of Rigel or its Affiliates or licensees, as applicable. All Data generated in connection with any Development or Commercial activities with respect to the Product conducted solely by or on behalf of Grifols, its Affiliates or Sublicensees (the “Grifols Data”) shall be the sole and exclusive property of Grifols or of its Affiliates or Sublicensees, as applicable. Grifols Data will be deemed Grifols’ Confidential Information and Rigel Data will be deemed Rigel’s Confidential Information. Notwithstanding the foregoing, Grifols shall receive reasonable and customary data fees for any Phase IV market support studies, excluding studies in ITP or AIHA, which would be utilized by Rigel outside the Grifols Territory for purposes beyond safety data sharing and regulatory compliance. Customary data fees shall be determined in good faith by the Parties.

(b) Inventions. Inventorship of any Inventions will be determined in accordance with the standards of inventorship and conception under U.S. patent laws. The Parties will work together to resolve any issues regarding inventorship or ownership of Inventions. Ownership of Inventions will be allocated as follows: Rigel shall solely own all data, Inventions, and Patents claiming such Inventions that relate to the composition, manufacture, or use of the Compound, or any improvement of any such composition, manufacture, or use, including in combination with other agents or components (each, a “Compound Invention”). All Compound Inventions will be included in the Rigel Know-How, and Patents in the Grifols Territory claiming such Inventions will be included in the Rigel Patents, including any Compound Invention made by Grifols, its Affiliates, employees, agents, and Sublicensees. Grifols hereby assigns, or shall assign if under any Applicable Law assignment of future rights is not deemed effective, all of Grifols’ right, title, and interest in and to any and all Compound Inventions to Rigel and warrants that its Affiliates, employees, agents, and Sublicensees are or shall be contractually obliged to assign their right, title, and interest in and to any such Compound Inventions to Grifols to effectuate the foregoing assignment to Rigel.

10.2 Patent Prosecution and Maintenance.

(a) Rigel Patents. Rigel shall be responsible, [ * ], for the preparation, filing, prosecution, and continued maintenance and registration (including any interferences, reissue proceedings, reexaminations, inter partes review, patent term extensions, applications for supplementary protection certificates, oppositions, invalidation proceedings and defense of validity or enforceability challenges) of the Rigel Patents worldwide, using counsel of its own choice. Rigel shall keep Grifols informed of material progress with regard to the preparation, filing, prosecution, and maintenance of the Rigel Patents in the Grifols Territory, sufficiently in advance for Grifols to be able to review any material documents, including content, timing, and jurisdiction of the filing of such Rigel Patents in the Grifols Territory, and Rigel shall consult with, and consider in good faith the requests and suggestions of, Grifols with respect to strategies for filing, prosecuting, and defending, if any, the Rigel Patents in the Grifols Territory.

(b) Patent Term Extension. Rigel shall use Commercially Reasonable Efforts to maximize the term of the Rigel Patents, including obtaining any patent term extensions or supplementary protection certificates or their equivalents, where available.

(c) Cooperation. Notwithstanding Rigel's obligations under Section 10.2 (a), Grifols agrees to cooperate fully with Rigel, upon Rigel's request, in the preparation, filing, prosecution, maintenance, and defense, if any, of Patents under this Section ‎10.2 and in the obtaining and maintenance of any Patent term extensions and supplementary protection certificates and their equivalents. Such cooperation includes (i) executing all papers and instruments, or requiring its employees or contractors, to execute such papers and instruments, so as to enable Rigel to apply for and to maintain and prosecute patent applications in any country as permitted by this Section ‎10.2; and (ii) promptly informing Rigel of any matters coming to Grifols’ attention that may affect the preparation, filing, prosecution, or maintenance of any such patent application and the obtaining of any patent term extensions or supplementary protection certificates or their equivalents.

10.3 Patent Enforcement.

(a) Notice. Each Party shall notify the other within [ * ] of becoming aware of any alleged or threatened infringement by a Third Party of any of the Rigel Patents in the Field in the Grifols Territory, which infringement adversely affects or is reasonably expected to adversely affect any Product, including any declaratory judgment, opposition, or similar action alleging the invalidity, unenforceability, or non-infringement of any of the Rigel Patents (collectively, “Product Infringement”).

(b) Enforcement Right. Rigel shall have the first right to bring and control any legal action in connection with such Product Infringement [ * ] as it reasonably determines appropriate. If Rigel (i) decides not to bring such legal action against a Product Infringement (the decision of which Rigel shall inform Grifols promptly) or (ii) Rigel otherwise fails to bring such legal action against a Product Infringement within [ * ] of first becoming aware of such Product Infringement, Grifols shall have the right to bring and control any legal action in connection with such Product Infringement at its own expense as it reasonably determines appropriate after consultation with Rigel. Any recovery received by Grifols from legal action initiated pursuant to this Section ‎10.3(b), whether by judgment, award, decree or settlement, shall be [ * ]. The remainder of any recovery received by Grifols under this Section ‎10.3(b) shall be [ * ]. Any recovery received by Rigel from legal action initiated pursuant to this Section ‎10.3(b), whether by judgment, award, decree or settlement, shall be [ * ].

(c) Collaboration. Each Party shall provide to the enforcing Party reasonable assistance in such enforcement, at such enforcing Party’s request and expense, including to be named in such action if required by Applicable Laws to pursue such action. The enforcing Party shall keep the other Party regularly informed of the status and progress of such enforcement efforts, shall reasonably consider the other Party’s comments on any such efforts, including determination of litigation strategy and filing of material papers to the competent court. The non-enforcing Party shall be entitled to separate representation in such matter by counsel of its own choice and at its own expense, but such Party shall at all times cooperate fully with the enforcing Party.

10.4 Infringement of Third Party Rights. If any Product used or sold by Grifols, its Affiliates, or Sublicensees becomes the subject of a Third Party’s claim or assertion of infringement of any intellectual property

rights in a jurisdiction within the Grifols Territory, Grifols shall promptly notify Rigel and the Parties shall promptly meet to consider the claim or assertion and the appropriate course of action and may, if appropriate, agree on and enter into a “common interest agreement” wherein the Parties agree to their shared, mutual interest in the outcome of such potential dispute. Absent any agreement to the contrary, and subject to claims for indemnification under Article 12, each Party may defend itself from any such Third Party claim at its own cost and expense, provided, however, that the provisions of Section ‎10.3 shall govern the right of Grifols to assert a counterclaim of infringement of any Rigel Patents.

10.5 Patents Licensed From Third Parties. Each Party’s rights under this Article 10 with respect to the prosecution and enforcement of any Rigel Patent shall be subject to the rights (a) retained by any upstream licensor to prosecute and enforce such Patent Right, if such Patent is subject to an upstream license agreement; and (b) granted to any Third Party prior to such Patent becoming subject to the license grant under this Agreement.

10.6 Parties Cooperation. Further to the above, in the event of a Product Infringement or a Third Party intellectual property right infringement set forth in Section ‎10.3 and ‎10.4, the Parties shall meet to consider the impact of such infringements on Grifols’ rights pursuant to this Agreement.

10.7 Trademarks.

(a) Product Trademarks. Grifols shall utilize Rigel’s trade names, trade dresses, branding, and logos, to be used for the Product in the Field in the Grifols Territory, which are included in Exhibit C attached herein (the “Rigel Product Marks”); provided, however, that if any Product ▇▇▇▇ is not approved for use in a country in the Grifols Territory, Grifols shall be responsible for identifying a trademark for the Product for use in such country (“Grifols Product Marks”). Rigel shall own all Rigel Product Marks and Grifols shall own all Grifols Product Marks. Each Party shall be responsible for the registration, maintenance, defense, and enforcement of its respective Product Marks at its own cost and using counsel of its own choice. Rigel shall keep Grifols informed of material progress with regard to the registration, prosecution, maintenance, and defense, if any, of any Rigel Product Marks in the Grifols Territory, including content, timing, and jurisdiction of the filing of such Rigel Product Marks in the Grifols Territory.

(b) Trademark License. Grifols shall use the Rigel Product Marks and Grifols Product Marks, as applicable, to Commercialize the Product in the Field in the Grifols Territory. In addition, unless prohibited by Applicable Laws in any country of the Grifols Territory, Rigel’s corporate trademark shall be included in the on the packaging and product information of the Products sold in the Field in the Grifols Territory to indicate that the Product is licensed from Rigel. Rigel hereby grants to Grifols a limited (as to the Term of this Agreement), royalty-free license to use Rigel’s corporate trademark and Rigel Product Marks solely in connection with the Commercialization of the Product in the Field in the Grifols Territory under this Agreement. All use of the Rigel Product Marks and Rigel’s corporate trademark shall comply with Applicable Laws and shall be subject to Rigel’s review and approval. For clarity, Grifols may also include its (or its Affiliate’s or Sublicensee’s, as applicable) corporate trademarks and logo in the Product sold in the Grifols Territory.

11.

Representations and Warranties

11.1 Mutual Representations and Warranties. Each Party represents and warrants to the other that, as of the Effective Date: (a) it is duly organized and validly existing under the laws of its jurisdiction of incorporation or formation, and has full corporate or other power and authority to enter into this Agreement and to carry out the provisions hereof, (b) it is duly authorized to execute and deliver this Agreement and to perform its obligations hereunder, and the person or persons executing this Agreement on its behalf has been duly authorized to do so by all requisite corporate or partnership action, (c) this Agreement is legally binding upon it, enforceable in accordance with its terms, and does not conflict with any agreement, instrument, or understanding, oral or written, to which it is a Party or by which it may be bound, nor violate any material law or regulation of any court, governmental body, or administrative or other agency having jurisdiction over it, and (d) it has the right to grant the licenses granted by it under this Agreement.

11.2 Covenants.

(a) Debarment. Each Party represents, warrants, and covenants to the other Party that it is not debarred or disqualified under the U.S. Federal Food, Drug and Cosmetic Act, as may be amended, or comparable laws in any country or jurisdiction other than the U.S., and it does not, and will not during the Term, employ or use the services of any person who is debarred or disqualified, in connection with activities relating to any Product. In the event that either Party becomes aware of the debarment or disqualification or threatened debarment or disqualification of any person providing services to such Party, including the Party itself or its Affiliates or sublicensees, that directly or indirectly relate to activities contemplated by this Agreement, such Party shall immediately notify the other Party in writing and such Party shall cease employing, contracting with, or retaining any such person to perform any such services.

(b) Compliance. Each Party covenants as follows:

(i) In the performance of its obligations under this Agreement, each Party shall comply and shall cause its and its Affiliates’ employees and contractors to comply with all Applicable Laws.

(i) Each Party and its and its Affiliates’ employees and contractors shall not, in connection with the performance of their respective obligations under this Agreement, directly or indirectly through Third Parties, pay, promise, or offer to pay, or authorize the payment of, any money or give any promise or offer to give, or authorize the giving of anything of value to a Public Official or Entity or other person for purpose of obtaining or retaining business for or with, or directing business to, any person, including, such Party (and such Party represents and warrants that as of the Effective Date, such Party, and to its knowledge, its and its Affiliates’ employees and contractors, have not directly or indirectly promised, offered, or provided any corrupt payment, gratuity, emolument, bribe, kickback, illicit gift, or hospitality or other illegal or unethical benefit to a Public Official or Entity or any other person in connection with the performance of such Party’s obligations under this Agreement, and such Party covenants that it and its Affiliates’ employees and contractors shall not, directly or indirectly, engage in any of the foregoing).

(i) Each Party and its Affiliates, and their respective employees and contractors, in connection with the performance of their respective obligations under this Agreement, shall not violate or cause the violation of the FCPA, Export Control Laws, or any other Applicable Laws, or otherwise cause any reputational harm to the other Party.

(i) Each Party shall immediately notify the other Party if such Party has any information or suspicion that there may be a violation of the FCPA, Export Control Laws, or any other Applicable Laws in connection with the performance of this Agreement or the Development, manufacture, or Commercialization of any Product.

(i) In connection with the performance of its obligations under this Agreement, each Party shall comply and shall cause its and its Affiliates’ employees and contractors to comply with such Party’s own anti-corruption and anti-bribery policy, a copy of which will be provided to the other Party upon request.

(i) Each Party will have the right, upon reasonable prior written notice and during the other Party’s regular business hours, to conduct at its own cost and expenses inspections of and to audit such other Party’s books and records in the event of a suspected violation or to ensure compliance with the representations, warranties, and covenants of this Section ‎11.2(b); provided, however, that in the absence of good cause for such inspections and audits, Rigel exercise this right no more than annually.

(i) In the event that a Party has violated or been suspected of violating any of the representations, warranties, or covenants in this Section ‎11.2(b), such Party will cause its or its

Affiliates’ personnel or others working under its direction or control to submit to periodic training that such Party will provide on anti-corruption law compliance.

(i) Each Party will, at the other Party’s prior written request, annually certify to such other Party in writing its compliance, in connection with the performance of its obligations under this Agreement, with the representations, warranties, or covenants in Section ‎11.2(b), which certification shall be issued by such Party’s representative with sufficient authority.

(i) Each Party shall have the right to suspend or terminate this Agreement in its entirety where there is a credible finding, after a reasonable investigation, that the other Party, its Affiliates, or its Sublicensees, in connection with performance of its obligations under this Agreement, has engaged in chronic or material violations of the FCPA.

11.3 Additional Rigel Representations, Warranties, and Covenants. Rigel represents, warrants, and covenants, as applicable, to Grifols that, as of the Effective Date:

(a) Exhibit B lists all Rigel Patents in the Grifols Territory and the Option Territory as of the Effective Date that claim the composition of matter or method of use or manufacture of the Compound and have been filed, prosecuted, and maintained in a manner consistent with Rigel’s standard practice, and in each applicable jurisdiction in which such Patent has been filed no official final deadlines with respect to prosecution thereof have been missed and all applicable fees have been paid on or before the due date for payment;

(b) All inventors of Inventions claimed in the Rigel Patents listed on Exhibit B have assigned their entire right, title, and interest in and to such inventions to Rigel and the inventors listed are correct and there are no claims or assertions in writing received by Rigel regarding the inventorship of such Patent alleging that additional or alternative Inventors ought to be listed;

(c) Rigel has the right to grant all rights and licenses it purports to grant to Grifols with respect to the Rigel Technology and the Rigel Product Marks under this Agreement;

(d) Rigel has not granted any liens or security interests on the Rigel Technology;

(e) to Rigel’s knowledge, Rigel has not received any written notice from a Third Party that the commercialization of the Product prior to the Effective Date has infringed any Patents of any Third Party within the Grifols Territory;

(f) Rigel has not as of the Effective Date, and will not during the Term, grant any right to any Third Party under the Rigel Technology that would conflict with the rights granted to Grifols hereunder;

(g) no claim or action has been brought or, to Rigel’s knowledge, threatened in writing, by any Third Party alleging that the Rigel Patents are invalid or unenforceable, and no Rigel Patent is the subject of any interference, opposition, cancellation, or other protest proceeding;

(h) to Rigel’s knowledge, no Third Party is infringing or misappropriating or has materially infringed or misappropriated the Rigel Technology and Rigel Product ▇▇▇▇ in the Grifols Territory;

(i) to Rigel’s knowledge, it has disclosed to Grifols the clinical and non-clinical data in Rigel’s Control that is material to the evaluation of the safety, efficacy, and manufacturing process of the Product;

(j) to Rigel’s knowledge, there are no issues or information, which to Rigel’s knowledge and reasonable opinion, are reasonably likely to have a material impact on the Product that have not been fully disclosed to Grifols in the course of Grifols’ due diligence; and

(k) Rigel shall at all times throughout the Term of this Agreement maintain Rigel Patents in force in the Grifols Territory that are deemed by Rigel as necessary for Grifols to Commercialize the Product in the Field in the Grifols Territory in accordance with the Commercialization Plan and as sole market supplier of the Product to customers under the Rigel Patents in the Field in the Grifols Territory.

11.4 Disclaimer. Except as expressly set forth in this Agreement, THE TECHNOLOGY AND INTELLECTUAL PROPERTY RIGHTS PROVIDED BY EACH PARTY HEREUNDER ARE PROVIDED “AS IS” AND EACH PARTY EXPRESSLY DISCLAIMS ANY AND ALL OTHER WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, INCLUDING THE WARRANTIES OF DESIGN, MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES, OR ARISING FROM A COURSE OF DEALING, USAGE OR TRADE PRACTICES, IN ALL CASES WITH RESPECT THERETO. Without limiting the foregoing, (a) neither Party represents or warrants that any Data obtained from conducting clinical trials in one country or jurisdiction will comply with the laws and regulations of any other country or jurisdiction, and (b) neither Party represents or warrants the success of any study or test conducted pursuant to this Agreement or the safety or usefulness for any purpose of the technology it provides hereunder.

12.

Indemnification

12.1 Indemnification by Rigel. Rigel hereby agrees to defend, indemnify, and hold harmless Grifols and its Affiliates and their respective directors, officers, employees, and agents (each, a “Grifols Indemnitee”) from and against any and all liabilities, expenses, and losses including any product liability, personal injury, property damage, including reasonable legal expenses and attorneys’ fees (collectively, “Losses”), to which any Grifols Indemnitee may become subject as a result of any claim, demand, action, or other proceeding by any Third Party to the extent such Losses arise out of or result from: (a) the Development, use, handling, storage, Commercialization, or other disposition of any Compound or Product by Rigel or its Affiliates or licensees or the contractors of any of them (excluding any activities by or on behalf of Grifols or its Affiliates or Sublicensees), (b) the Commercialization of the Products under the Rigel Patents in accordance with the terms and conditions of this Agreement in the Field constitutes an infringement, violation or misappropriation of any Third Party's rights, including the promotion, offer, use, marketing, distribution, sale and/or otherwise Commercialization of the Products in the Grifols Territory, (c) the negligence or willful misconduct of any Rigel Indemnitee, or (d) the breach by Rigel of any warranty, representation, covenant, or agreement made by Rigel in this Agreement, except, in each case (a)-(d), to the extent such Losses arise out of any activities set forth in Section ‎12.2(a), (b), or (c) for which Grifols is obligated to indemnify any Rigel Indemnitee(s) under Section ‎12.2.

12.2 Indemnification by Grifols. Grifols hereby agrees to defend, indemnify, and hold harmless Rigel, its Affiliates, and licensees and their respective directors, officers, employees, and agents (each, a “Rigel Indemnitee”) from and against any and all Losses to which any Rigel Indemnitee may become subject as a result of any claim, demand, action, or other proceeding by any Third Party to the extent such Losses arise out of: (a) the use, handling, storage, Commercialization, or other disposition of any Compound or Product by Grifols or its Affiliates or Sublicensees or the contractor of any of them, (b) the negligence or willful misconduct of any Grifols Indemnitee, or (c) the breach by Grifols of any warranty, representation, covenant, or agreement made by Grifols in this Agreement; except, in each case (a)-(c), to the extent such Losses arise out of any activities set forth in Section ‎12.1(a), (b), (c), or (d) for which Rigel is obligated to indemnify any Grifols Indemnitee(s) under Section ‎12.1.

12.3 Procedure. A party that intends to claim indemnification under this Article 12 (the “Indemnitee”) shall promptly notify the indemnifying Party (the “Indemnitor”) in writing of any Third Party claim, demand, action, or other proceeding (each, a “Claim”) in respect of which the Indemnitee intends to claim such indemnification, and the Indemnitor shall have sole control of the defense or settlement thereof. The Indemnitee may participate at its expense in the Indemnitor’s defense of and settlement negotiations for any Claim with counsel of the Indemnitee’s own choice. The indemnity arrangement in this Article ‎12 shall not apply to amounts paid in settlement of any action with respect to a Claim if such settlement is effected without the consent of the Indemnitor, which consent shall not be unreasonably withheld or delayed. The failure to deliver written notice to the Indemnitor within a reasonable time

after the commencement of any action with respect to a Third Party Claim shall only relieve the Indemnitor of its indemnification obligations under this Article ‎12 if and to the extent the Indemnitor is actually prejudiced thereby. The Indemnitee shall cooperate fully with the Indemnitor and its legal representatives in the investigation of any action with respect to a Claim covered by this indemnification.

12.4 Insurance. Each Party, at its own expense, for a period until [ * ] after expiration or termination of this Agreement, shall maintain commercial general liability insurance, including public and product liability and other appropriate insurance (e.g., contractual liability, bodily injury, property damage, business interruption insurance, and personal injury coverage) (or self-insure for Grifols and a reputable insurance company for Rigel) in an amount consistent with sound business practice and reasonable in light of its obligations under this Agreement during the Term, at a minimum equivalent to [ * ] for any one claim or in the aggregate. Each Party shall be an additional insured on any and all insurance policies of the other Party pertaining to this Agreement. Each Party shall provide a certificate of insurance evidencing such coverage to the other Party upon request. It is understood that such insurance shall not be construed to create any limit of either Party’s obligations or liabilities with respect to its indemnification obligations hereunder. In the event of use by either Party of subcontractors, sublicensees, or any Third Party in the performance of such Party’s obligations under the Agreement, such Party shall ensure that its subcontractor, sublicensee, or Third Party has a proper and adequate general liability insurance to cover its risks with respect to the other Party for damages mentioned above, and each Party shall remain liable at all times for their sublicensees’ or subcontractors’ conduct. Additionally, certificates of insurance shall be provided within [ * ] after renewal of any and all applicable policies of insurance, and each Party shall notify the other Party within [ * ] before cancellation of any such policies of insurance.

12.5 Limitation of Liability. EXCEPT IN THE EVENT OF NEGLIGENCE, FRAUD OR WILLFUL MISCONDUCT, NEITHER PARTY SHALL BE ENTITLED TO RECOVER FROM THE OTHER PARTY ANY SPECIAL, INCIDENTAL, CONSEQUENTIAL, OR PUNITIVE DAMAGES, INCLUDING LOST PROFITS IN CONNECTION WITH THIS AGREEMENT OR ANY LICENSE GRANTED HEREUNDER, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES; provided, however, that this Section ‎12.5 shall not be construed to limit either Party’s indemnification obligations under this Article ‎12 or damages available as a result of a breach of a Party’s non-compete obligations under Sections 2.1 and 2.7 or confidentiality obligations under Article ‎13.

13.

Confidentiality

13.1 Confidential Information. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing by the Parties, the Parties agree that, during the Term and for [ * ] thereafter, the receiving Party shall keep confidential and shall not publish or otherwise disclose and shall not use for any purpose other than as expressly provided for in this Agreement any Confidential Information of the other Party, and both Parties shall keep confidential and, subject to the remainder of this Article ‎13, shall not publish or otherwise disclose the terms of this Agreement. Each Party may use the other Party’s Confidential Information only to the extent required to accomplish the purposes of this Agreement, including exercising its rights or performing its obligations under this Agreement. Each Party will use at least the same standard of care as it uses to protect proprietary or confidential information of its own (but no less than reasonable care) to ensure that its employees, agents, consultants, contractors, and other representatives do not disclose or make any unauthorized use of the Confidential Information of the other Party. Each Party will promptly notify the other upon discovery of any unauthorized use or disclosure of the Confidential Information of the other Party.

13.2 Exceptions. The obligations of confidentiality and restriction on use under Section ‎13.1 will not apply to any information that the receiving Party can prove by competent written evidence: (a) is at the time of disclosure, or thereafter becomes, through no act or failure to act on the part of the receiving Party, generally known or available to the public; (b) is known by the receiving Party at the time of receiving such information, other than by previous disclosure of the disclosing Party, or its Affiliates, employees, agents, consultants, or contractors; (c) is disclosed to the receiving Party without restriction by a Third Party who has no obligation of confidentiality or limitations on use with respect thereto; or (d) is independently discovered or developed by the receiving Party without the use of or reference to the Confidential Information belonging to the disclosing Party.

13.3 Authorized Disclosure. Each Party may disclose Confidential Information belonging to the other Party as expressly permitted by this Agreement or if and to the extent such disclosure is reasonably necessary in the following instances:

(a) filing, prosecuting, or maintaining Patents as permitted by this Agreement;

(b) Regulatory Filings for Products that such Party has a license or right to Develop or Commercialize under this Agreement in a given country or jurisdiction;

(d) complying with applicable court orders or governmental regulations, including regulations promulgated by securities exchanges; and

(e) disclosure to its and its Affiliates’ employees, consultants, contractors, and agents, to its licensees and sublicensees, in each case on a need-to-know basis in connection with the Commercialization of the Product in accordance with the terms of this Agreement, in each case under written obligations of confidentiality and non-use at least as stringent as those herein.

(f) disclosure to actual and bona fide potential investors, acquirors, licensees, and other financial or commercial partners solely for the purpose of evaluating or carrying out an actual or potential investment, acquisition, or collaboration, in each case under written obligations of confidentiality and non-use at least as stringent as those herein, provided that the disclosing Party redacts the financial terms and other provisions of this Agreement that are not reasonably required to be disclosed in connection with such potential investment, acquisition, or collaboration, which redaction shall be prepared in consultation with the other Party.

Notwithstanding the foregoing, in the event a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to Section ‎13.3(c) or ‎13.3(d), it will, except where impracticable, give reasonable advance notice to the other Party of such disclosure and use the same diligent efforts to secure confidential treatment of such Confidential Information as such Party would use to protect its own confidential information, but in no event less than reasonable efforts. In any event, the Parties agree to take all reasonable action to avoid disclosure of Confidential Information hereunder. Any information disclosed pursuant to Section ‎13.3(c) or ‎13.3(d) shall remain Confidential Information and subject to the restrictions set forth in this Agreement, including the foregoing provisions of this Article 13.

13.4 Publicity; Public Disclosures. The Parties agree to issue a press release substantially in a form agreed by the Parties and attached to this Agreement as Exhibit D announcing the signature of this Agreement at or shortly after the Effective Date within the time-period as required by relevant securities laws. It is understood that each Party may desire or be required to issue subsequent press releases relating to this Agreement or activities hereunder. The Parties agree to consult with each other reasonably and in good faith with respect to the text and timing of such press releases prior to the issuance thereof, to the extent practicable, provided that a Party may not unreasonably withhold, condition, or delay consent to such releases by more than [ * ], and that either Party may issue such press releases or make such disclosures to the SEC, the Spanish securities and exchange commission (Comisión Nacional del ▇▇▇▇▇▇▇ de Valores – "CNMV") or other applicable agency as it determines is reasonably necessary to comply with Applicable Laws or for appropriate market disclosure. Each Party shall provide the other Party with advance notice of legally required disclosures to the extent practicable. The Parties will consult with each other on the provisions of this Agreement to be redacted in any filings made by a Party with the SEC, the CNMV or as otherwise required by Applicable Laws; provided that each Party shall have the right to make any such filing as it reasonably determines necessary under Applicable Laws. In addition, following the initial joint press release announcing this Agreement, either Party shall be free to disclose, without the other Party’s prior written consent, the existence of this Agreement, the identity of the other Party and those terms of the Agreement which have already been publicly disclosed in accordance with this Section 13.4.

13.5 Prior Confidentiality Agreement. As of the Effective Date, the terms of this Article ‎13 shall supersede any prior non-disclosure, secrecy, or confidentiality agreement between the Parties (or their Affiliates) relating to the subject of this Agreement, including the Confidentiality Agreement. Any information disclosed pursuant to any such prior agreement shall be deemed Confidential Information under this Agreement.

13.6 Equitable Relief. Given the nature of the Confidential Information and the competitive damage that a Party would suffer upon unauthorized disclosure, use, or transfer of its Confidential Information to any Third Party, the Parties agree that monetary damages may not be a sufficient remedy for any breach of this Article ‎13. In addition to all other remedies, a Party shall be entitled to seek specific performance and injunctive and other equitable relief as a remedy for any breach or threatened breach of this Article ‎13.

14.

Term and Termination

14.1 Term. This Agreement shall commence on the Effective Date and, unless terminated earlier as provided in this Article ‎14 or by mutual written agreement of the Parties, shall continue until the expiration of the last Royalty Term in the Grifols Territory (the “Term”).

14.2 Termination for Cause.

(a) For Regulatory Reasons. If by the [ * ] anniversary of the Effective Date the EMA has not approved the MAA for the Product for ITP, Grifols shall have the right to terminate this Agreement in its entirety within [ * ] after such [ * ] anniversary by providing Rigel with at least [ * ] written notice from the date of issuance thereof. Within [ * ] as of the effective date of termination only pursuant to this Section Error! Reference source not found., Rigel shall refund to Grifols the twenty-five million dollar ($25,000,000)-payment made by Grifols to Rigel pursuant to Section ‎8.1(b).

(b) For Manufacturing and Supply Reasons. The termination of the Commercial Supply Agreement at any time during its term and due to a breach by Rigel of its representations, warranties and/or covenants therein, shall result in the automatic termination of this Agreement.

(c) Material Breach. Each Party shall have the right to terminate this Agreement immediately in its entirety upon written notice to the other Party if such other Party materially breaches this Agreement and has not cured such breach to the reasonable satisfaction of the other Party within [ * ] ([ * ] with respect to any payment breach) after notice of such breach from the non-breaching Party.

(d) Bankruptcy. Each Party shall have the right to terminate this Agreement immediately in its entirety upon written notice to the other Party if such other Party makes a general assignment for the benefit of creditors, files an insolvency petition in bankruptcy, petitions for or acquiesces in the appointment of any receiver, trustee, or similar officer to liquidate or conserve its business or any substantial part of its assets, commences under the laws of any jurisdiction any proceeding involving its insolvency, bankruptcy, reorganization, adjustment of debt, dissolution, liquidation, or any other similar proceeding for the release of financially distressed debtors, or becomes a party to any proceeding or action of the type described above and such proceeding is not dismissed within [ * ] after the commencement thereof.

(e) Patent Challenge. Rigel shall have the right to terminate this Agreement immediately in its entirety upon written notice to Grifols if Grifols or any of its Affiliates or Sublicensees directly, or indirectly through any Third Party, commences any interference or opposition proceeding with respect to, challenges the validity or enforceability of, or opposes any extension of or the grant of a supplementary protection certificate with respect to, any Rigel Patent.

(f) Safety Reasons. Either Party shall have the right to terminate this Agreement in its entirety upon written notice to the other Party if the terminating Party reasonably determines, based upon additional information that becomes available or an analysis of the existing information at any time, that the medical risk/benefit

of the Product is so unfavorable that it would be incompatible with the welfare of patients to Develop or Commercialize or to continue to Develop or Commercialize such Product. Prior to any such termination, the terminating Party shall comply with such internal review and management approval processes as it would normally follow in connection with the termination of the development and commercialization of its own products for safety reasons. The terminating Party shall document the decisions of such committees or members of management and the basis therefor and shall make such minutes and documentation available to the other Party promptly upon written request.

(g) Manufacturing and Supply related obligations. Grifols shall have the right to terminate this Agreement in its entirety upon written notice to Rigel and without penalty, under any of the following events:

(i) within a period of [ * ] as of the Effective Date (or such longer term as the Parties may agree to in writing), Grifols has not been able to identify and negotiate a satisfactory agreement with a Third Party for the provision of pharmacovigilance services within the scope of this Agreement and the Commercial Supply Agreement; and/or

(ii) within a period of [ * ] as of the Effective Date (or such longer term as the Parties may agree to in writing), Grifols has not been able to identify and negotiate a satisfactory agreement with a Third Party for the provision of testing, labeling and packaging services within the scope of this Agreement and the Commercial Supply Agreement; and/or

(iii) within a period of [ * ] as of the Effective Date (or such longer term as the Parties may agree to in writing), Grifols or a Grifols' Affiliate, has not been able to obtain approval from the Spanish or other Regulatory Authorities to amend its license and/or permits in order to include the Products; and/or

(iv) within a period of [ * ] as of the Effective Date (or such longer term as the Parties may agree to in writing), if the Parties have not executed the Commercial Supply Agreement.

14.3 Termination for Convenience. Following the [ * ] anniversary of the date of receipt of the first MAA Approval for the Product in the Grifols Territory, Grifols shall have the right to terminate this Agreement in its entirety without cause upon [ * ] written notice to Rigel. For clarity, termination under this Section 14.3 shall not trigger Rigel’s refund obligation under Section 14.2(a).

14.4 Termination due to Acquisition of Rigel by a Competing Company. In the case Rigel is acquired by a Competing Company and Grifols has not provided its consent to an assignment or transfer of this Agreement to such Competing Company during the Consent Process, this Agreement shall terminate upon closing of such an acquisition of Rigel by such a Competing Company and [ * ] written notice, and Rigel or the acquiring party shall pay Grifols a one-time payment of [ * ], within [ * ] from the closing date of such acquisition. The “Consent Process” shall be [ * ]. Upon [ * ], Grifols will have [ * ] to provide Rigel with Grifols’ written consent to assign or otherwise transfer this Agreement should such discussions result in an acquisition of Rigel. [ * ]. As used herein, a “Competing Company” means a company and/or its affiliated entities which [ * ].

14.5 Effects of Termination. Upon any termination of this Agreement by either Party, the following subsections (a)-(g) will apply. For clarity, during the pendency of any termination notice period, all of the terms and conditions of this Agreement shall remain in effect and the Parties shall continue to perform all of their respective obligations hereunder. For further clarity, if this Agreement is terminated only with respect to one or more countries pursuant to Section ‎5.1, the following shall apply only with respect to such terminated countries.

(a) Licenses. The licenses granted by Rigel to Grifols will automatically terminate, including all sublicenses granted by Grifols to any Sublicensee.

(b) Regulatory Materials; Data. Within [ * ] after the effective date of such termination, Grifols shall transfer and assign to Rigel all Regulatory Filings and Regulatory Approvals for the Product, Data from all preclinical, non-clinical, and clinical studies of the Product conducted by or on behalf of Grifols, its Affiliates, or Sublicensees, and all pharmacovigilance data (including all adverse event data) on the Product. Such transfer shall be [ * ] and shall be [ * ]. In addition, at Rigel’s request, Grifols shall provide Rigel with reasonable assistance with any inquiries and correspondence with Regulatory Authorities regarding the Product in the Grifols Territory, such assistance shall be limited to a period of [ * ] after such termination.

(c) Development Wind-Down. Grifols shall either, as directed by Rigel, (i) wind-down any ongoing Development activities (including any Clinical Trials) of Grifols or its Affiliates and Sublicensees with respect to the Product in the Grifols Territory in an orderly fashion or (ii) promptly transfer such Development activities to Rigel or its designee, in each case in compliance with all Applicable Laws.

(d) Commercial Wind-Down. Grifols shall, as directed by Rigel and except when this Agreement has been terminated under Sections ‎14.2(a), (b), (c) (material breach by Rigel), (d) (insolvency of Rigel), and/or (f) , (i) continue certain ongoing Commercial activities of Grifols and its Affiliates and Sublicensees with respect to the Product in the Grifols Territory for a period of up to [ * ] after the effective date of termination, as determined by Rigel, and (ii) handoff such Commercial activities to Rigel or its designee, on a timetable to be set by Rigel, not to exceed [ * ] after the effective date of termination, and in compliance with all Applicable Laws. Except as necessary to conduct the foregoing activities as directed by Rigel, Grifols shall immediately discontinue its (and shall ensure that its Affiliates and Sublicensees immediately discontinue their) promotion, marketing, offering for sale, and servicing of the Product and its use of all Product Marks. If Grifols books any sales during such transition period, Grifols shall continue to pay Rigel royalties on such sales on the same terms as if this Agreement has not been terminated.

(e) Transition Assistance. Grifols shall use Commercially Reasonable Efforts to seek an orderly transition of the Development and Commercialization of the Product to Rigel or its designee as follows: (1) Grifols shall provide reasonable consultation and assistance for a period of no more than [ * ] after the effective date of termination for the purpose of transferring or transitioning to Rigel all Grifols Know-How not already in Rigel’s possession and, at Rigel’s request, all then-existing commercial arrangements relating to the Product that Grifols is able, using Commercially Reasonable Efforts, to transfer or transition to Rigel or its designee, in each case, to the extent reasonably necessary for Rigel to continue the Development or Commercialization of the Product in the Grifols Territory. (2) If any such contract between Grifols and a Third Party is not assignable to Rigel or its designee (whether by such contract’s terms or because such contract does not relate specifically to the Product) but is otherwise reasonably necessary for Rigel to continue the Development or Commercialization of the Product in the Grifols Territory, or if Grifols is performing such work for the Product itself (and thus there is no contract to assign), then Grifols shall reasonably cooperate with Rigel to negotiate for the continuation of such services for Rigel from such entity, or Grifols shall continue to perform such work for Rigel, as applicable, for a reasonable period (not to exceed [ * ]) after the effective date of termination at Rigel’s cost until Rigel establishes an alternate, validated source of such services. It is understood that (1) and (2) as set forth within this Section 14.4 (e) is subject to good faith negotiations among the Parties to set forth the terms and conditions applicable to these transition assistance activities.

(f) Remaining Inventories. Rigel shall acquire from Grifols any or all of the inventory of the Product held by Grifols as of the date of termination that has at least [ * ] of remaining shelf life and at the same price Grifols paid for it according to the terms of the Commercial Supply Agreement.

(g) Trademarks. Grifols shall transfer and assign to Rigel, upon Rigel's request, all or part of the Grifols Product Marks, under the terms and conditions that the Parties may agree to at that time.

14.6 Confidential Information. Upon expiration or termination of this Agreement in its entirety, except to the extent that a Party obtains or retains the right to use the other Party’s Confidential Information, each Party shall promptly return to the other Party, or delete or destroy, all relevant records and materials in such Party’s possession

or control containing Confidential Information of the other Party; provided that such Party may keep one copy of such materials for archival purposes only subject to continuing confidentiality obligations. All Grifols Data and Regulatory Filings assigned to Rigel upon termination of this Agreement will be deemed Rigel’s Confidential Information and no longer Grifols’ Confidential Information.

14.7 Survival. Expiration or termination of this Agreement shall not relieve the Parties of any obligation or right accruing prior to such expiration or termination. Except as set forth below or elsewhere in this Agreement, the obligations and rights of the Parties under the following provisions of this Agreement shall survive expiration or termination of this Agreement: Sections 2.5, 10.1, 11.4, 13.1, 13.2, 13.3, 13.6, 14.4, 14.5, 14.6, 14.7, 14.8 and 14.9, and Articles 1, 8 (solely to the extent any payment obligation has accrued prior to the effective date of termination), 9 (solely to the extent any payment obligation has accrued prior to the effective date of termination or as part of the transition activities pursuant to the terms and conditions under this Article 14), 12, 15 and 16.

14.8 Exercise of Right to Terminate. All rights and obligations of a Party accrued prior to the effective date of a termination (including the rights to receive reimbursement for costs incurred prior to the effective date of such termination and payments accrued or due prior to the effective date of such termination) shall survive such termination.

14.9 Rights in Bankruptcy. All rights and licenses granted under or pursuant to this Agreement by one Party to the other Party are, and will otherwise be deemed to be, for purposes of Section 365(n) of the U.S. Bankruptcy Code or comparable provision of applicable bankruptcy or insolvency laws, licenses of right to “intellectual property” as defined under Section 101 of the U.S. Bankruptcy Code or comparable provision of applicable bankruptcy or insolvency laws. The Parties agree that a Party that is a licensee of such rights under this Agreement will retain and may fully exercise all of its rights and elections under the U.S. Bankruptcy Code or comparable provision of applicable bankruptcy or insolvency laws. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party to this Agreement under the U.S. Bankruptcy Code or comparable provision of applicable bankruptcy or insolvency laws, the other Party will be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, and same, if not already in its possession, will be promptly delivered to it (a) upon any such commencement of a bankruptcy or insolvency proceeding upon its written request therefor, unless the bankrupt Party elects to continue to perform all of its obligations under this Agreement, or (b) if not delivered under (a) above, following the rejection of this Agreement by or on behalf of the bankrupt Party upon written request therefor by the other Party.

15.

Dispute Resolution

15.1 Objective. The Parties recognize that disputes as to matters arising under or relating to this Agreement or either Party’s rights and obligations hereunder may arise from time to time. It is the objective of the Parties to establish procedures to facilitate the resolution of such disputes in an expedient manner by mutual cooperation and without resort to litigation. To accomplish this objective, the Parties agree to follow the procedures set forth in this Article ‎15 to resolve any such dispute if and when it arises.

15.2 Executive Mediation. The Parties shall attempt to settle any dispute, controversy, or claim that arises out of, or relates to, any provision of the Agreement (“Disputed Matter”) by first referring the Disputed Matter to the Executive Officers (or their respective designees having the authority to settle such Disputed Matter). Either Party may initiate such informal dispute resolution by sending written notice of the Disputed Matter to the other Party, and, within [ * ] after such notice, the Executive Officers (or their respective designees) shall meet for attempted resolution by good faith negotiations. If the Executive Officers (or their respective designees) are unable to resolve such dispute within [ * ] of their first meeting for such negotiations, either Party may seek to have such dispute resolved in accordance with Section ‎15.3 below.

15.3 Dispute Resolution.

(a) If the Parties are unable to resolve a Disputed Matter using the process described in Section ‎15.2, then a Party seeking further resolution of the Disputed Matter will submit the Disputed Matter to resolution by final and binding arbitration. Whenever a Party will decide to institute arbitration proceedings, it will give written notice to that effect to the other Party. Arbitration will be held in [ * ] and administered by the American Arbitration Association (“AAA”) pursuant to its Rules then in effect (the “Rules”), except as otherwise provided herein and applying the substantive law specified in Section ‎16.1. The arbitration will be conducted by a panel of three (3) arbitrators appointed in accordance with the Rules; provided that each Party will, within [ * ] after the institution of the arbitration proceedings, appoint an arbitrator, and such arbitrators will together, within [ * ], select a third (3rd) arbitrator as the chairperson of the arbitration panel. Each arbitrator must have significant business or legal experience in the pharmaceutical business. If the two (2) initial arbitrators are unable to select a third (3rd) arbitrator within such [ * ] period, the third (3rd) arbitrator will be appointed in accordance with Rules. After conducting any hearing and taking any evidence deemed appropriate for consideration, the arbitrators will be requested to render their opinion within [ * ] of the final arbitration hearing. No panel of arbitrators will have the power to award damages excluded pursuant to Section ‎12.5 under this Agreement and any arbitral award that purports to award such damages is expressly prohibited and void ab initio. Decisions of the panel of arbitrators that conform to the terms of this Section ‎15.3 will be final and binding on the Parties and judgment on the award so rendered may be entered in any court of competent jurisdiction. The losing Party, as determined by the panel of arbitrators, will pay all of the AAA administrative costs and fees of the arbitration and the fees and costs of the arbitrators, and the arbitrators will be directed to provide for payment or reimbursement of such fees and costs by the losing Party. If the panel of arbitrators determines that there is no losing Party, the Parties will each bear one-half of those costs and fees and the arbitrators’ award will so provide. Notwithstanding the foregoing, the prevailing Party in any legal action shall be entitled to its reasonable attorneys’ fees, expert or witness fees, and any other fees and costs.

(b) Notwithstanding the terms of and procedures set forth in Section ‎15.2 or 15.3(a), any applications, motions, or orders to show cause seeking temporary restraining orders, preliminary injunctions, or other similar preliminary or temporary legal or equitable relief (“Injunctive Relief”) concerning a Disputed Matter (including Disputed Matters arising out of a potential or actual breach of the confidentiality and non-use provisions in Article ‎13) may immediately be brought in the first instance and without invocation or exhaustion of the procedures set forth in subsections (a) and (b) for hearing and resolution in and by any court of competent jurisdiction. Alternatively, a party seeking Injunctive Relief may immediately institute arbitral proceedings without invocation or exhaustion of the procedures set forth in subsections (a) and (b), and any such Injunctive Relief proceedings will be administered by the AAA pursuant to its AAA emergency arbitration procedures then in effect and applying the substantive law specified in Section ‎16.1. In either event, once the Injunctive Relief proceedings have been conducted and a decision rendered thereon by the court or arbitral forum, the Parties shall, if the Disputed Matter is not finally resolved by the Injunctive Relief, proceed to resolve the Disputed Matter in accordance with the terms of Section ‎15.2 and ‎15.3(a).

(c) Notwithstanding the foregoing, this Section ‎15.3 shall not apply to any dispute, controversy, or claim that concerns (i) the validity, enforceability, or infringement of a patent, trademark, or copyright; or (ii) any antitrust, anti-monopoly, or competition law or regulation, whether or not statutory. Disputes regarding the foregoing shall be brought in a court of competent jurisdiction in which such patent or trademark or copyright was granted or arose, or in which such law or regulation applies, in each case as applicable.

16.

General Provisions

16.1 Governing Law. This Agreement, and all questions regarding the existence, validity, interpretation, breach, or performance of this Agreement, shall be governed by, and construed and enforced in accordance with, the laws of the State of New York, United States, without reference to its conflicts of law principles.

16.2 Entire Agreement; Modification. This Agreement, including the exhibits, is both a final expression of the Parties’ agreement and a complete and exclusive statement with respect to all of its terms. This Agreement supersedes all prior and contemporaneous agreements and communications, whether oral, written, or

otherwise, concerning any and all matters contained herein. This Agreement may only be modified or supplemented in a writing expressly stated for such purpose and signed by the Parties to this Agreement.

16.3 Relationship Between the Parties. The Parties’ relationship, as established by this Agreement, is solely that of independent contractors. This Agreement does not create any partnership, joint venture, or similar business relationship between the Parties. Neither Party is a legal representative of the other Party, and neither Party can assume or create any obligation, representation, warranty, or guarantee, express or implied, on behalf of the other Party for any purpose whatsoever.

16.4 Affiliates. Each Party may exercise its rights or fulfill its obligations under this Agreement through one or more of its Affiliates, provided that such Party shall remain primarily responsible to the other Party for the performance and action of such Affiliates.

16.5 Non-Waiver. The failure of a Party to insist upon strict performance of any provision of this Agreement or to exercise any right arising out of this Agreement shall neither impair that provision or right nor constitute a waiver of that provision or right, in whole or in part, in that instance or in any other instance. Any waiver by a Party of a particular provision or right shall be in writing, shall be as to a particular matter and, if applicable, for a particular period of time and shall be signed by such Party.

16.6 Assignment. Except as expressly provided hereunder, neither this Agreement nor any rights or obligations hereunder may be assigned or otherwise transferred by either Party without the prior written consent of the other Party (which consent shall not be unreasonably withheld); provided, however, that either Party may assign or otherwise transfer this Agreement and its rights and obligations hereunder without the other Party’s consent:

(a) in connection with the transfer or sale of all or substantially all of the business or assets of such Party relating to the Compound and Product to a Third Party, whether by merger, consolidation, divesture, restructure, sale of stock, sale of assets, or otherwise, provided that in the event of any such transaction (whether this Agreement is actually assigned or is assumed by the acquiring Party by operation of law (e.g., in the context of a reverse triangular merger)), the intellectual property rights of the acquiring Party to such transaction (if other than one of the Parties to this Agreement) shall not be included in the technology licensed hereunder; or

(b) to an Affiliate, provided that the assigning Party shall remain liable and responsible to the non-assigning Party hereto for the performance and observance of all such duties and obligations by such Affiliate, and provided further that if the entity to which this Agreement is assigned ceases to be an Affiliate of the assigning Party, the Agreement shall be automatically assigned back to the assigning Party or its successor.

The rights and obligations of the Parties under this Agreement shall be binding upon and inure to the benefit of the successors and permitted assigns of the Parties specified above, and the name of a Party appearing herein will be deemed to include the name of such Party’s successors and permitted assigns to the extent necessary to carry out the intent of this Section 16.6. Any assignment not in accordance with this Section 16.6 shall be null and void.

16.7 Severability. If, for any reason, any part of this Agreement is adjudicated invalid, unenforceable, or illegal by a court of competent jurisdiction, such adjudication shall not, to the extent feasible, affect or impair, in whole or in part, the validity, enforceability, or legality of any remaining portions of this Agreement. All remaining portions shall remain in full force and effect as if the original Agreement had been executed without the invalidated, unenforceable, or illegal part.

16.8 Notices. Any notice to be given under this Agreement must be in writing and delivered either in person, by (a) air mail (postage prepaid) requiring return receipt, (b) overnight courier, or (c) facsimile confirmed thereafter by any of the foregoing, to the Party to be notified at its address(es) given below, or at any address such Party may designate by prior written notice to the other in accordance with this Section ‎16.8. Notice shall be deemed sufficiently given for all purposes upon the earliest of: (i) the date of actual receipt, (ii) if air mailed, [ * ] after the date of postmark, (iii) if delivered by overnight courier, the next day the overnight courier regularly makes deliveries,

or (iv) if sent by facsimile, the date of confirmation of receipt if during the recipient’s normal business hours, otherwise the next business day.

If to Grifols, notices must be addressed to:

Grifols
Grifols Worldwide Operations Limited
Grange ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇
▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇ ▇▇, ▇▇▇▇▇▇▇
Attention: [ * ]
Facsimile: [ * ]

If to Rigel, notices must be addressed to:

Rigel Pharmaceuticals, Inc.
▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇.
▇▇▇▇▇ ▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇
▇▇▇
Attention: [ * ]

Facsimile: [ * ]

16.9 Force Majeure. Each Party shall be excused from liability for the failure or delay in performance of any obligation under this Agreement (other than failure to make payment when due) by reason of any event beyond such Party’s reasonable control including Acts of God, fire, flood, explosion, earthquake, pandemic flu, or other natural forces, war, civil unrest, acts of terrorism, accident, destruction or other casualty, or any other event similar to those enumerated above. Such excuse from liability shall be effective only to the extent and duration of the event(s) causing the failure or delay in performance and provided that the Party has not caused such event(s) to occur and uses reasonable efforts to overcome such event. Notice of a Party’s failure or delay in performance due to force majeure must be given to the other Party within [ * ] after its occurrence together with an estimate of its expected duration and impact on the performance of such Party’s obligations under this Agreement. The Party affected by such force majeure event shall exercise reasonable commercial efforts to overcome it and mitigate or limit damages to the non-affected Party. All delivery dates under this Agreement that have been affected by force majeure shall be tolled for the duration of such force majeure. In no event shall any Party be required to prevent or settle any labor disturbance or dispute.

16.10 Interpretation. The headings of clauses contained in this Agreement preceding the text of the Sections, subsections, and paragraphs hereof are inserted solely for convenience and ease of reference only and shall not constitute any part of this Agreement, or have any effect on its interpretation or construction. All references in this Agreement to the singular shall include the plural where applicable. Unless otherwise specified, references in this Agreement to any Article shall include all Sections, subsections, and paragraphs in such Article, references to any Section shall include all subsections and paragraphs in such Section, and references in this Agreement to any subsection shall include all paragraphs in such subsection. The word “including” and similar words means including without limitation. The word “or” means “and/or” unless the context dictates otherwise because the subjects of the conjunction are, or are intended to be, mutually exclusive. The words “herein”, “hereof”, and “hereunder” and other words of similar import refer to this Agreement as a whole and not to any particular Section or other subdivision. All references to days in this Agreement mean calendar days, unless otherwise specified. Ambiguities and uncertainties in this Agreement, if any, shall not be interpreted against either Party, irrespective of which Party may be deemed to have caused the ambiguity or uncertainty to exist. This Agreement has been prepared in the English language and the English language shall control its interpretation. In addition, all notices required or permitted to be given hereunder, and all written, electronic, oral, or other communications between the Parties regarding this Agreement shall be in the English language.

16.11 Counterparts; Electronic or Facsimile Signatures. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument. This Agreement may be executed and delivered electronically or by facsimile and upon such delivery such electronic or facsimile signature will be deemed to have the same effect as if the original signature had been delivered to the other Party.

{Signature Page Follows}

In Witness Whereof, the Parties hereto have caused this Exclusive Commercialization License Agreement to be executed and entered into by their duly authorized representatives as of the Effective Date.

Rigel Pharmaceuticals, Inc.

By: /s/ ▇▇▇▇ ▇▇▇▇▇▇▇▇▇

Name: ▇▇▇▇ ▇▇▇▇▇▇▇▇▇

Title: CEO & President

Grifols Worldwide Operations Limited

By: /s/ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇

Name: ▇▇▇▇▇▇▇ ▇▇▇▇▇▇

Title: CFO

List of Exhibits:

Exhibit A:The Compound and Product

Exhibit B:Rigel Patents

Exhibit C:Product Marks

Exhibit D:Press Release

Exhibit A:

The Compound and Product

The chemical name for the Compound, fostamatinib disodium hexahydrate, is disodium [6-[[5-fluoro-2-(3,4,5-trimethoxyanilino) pyrimidin-4-yl]amino]-2,2-dimethyl-3-oxo-pyrido[3,2-b][1,4]oxazin-4-yl]methyl phosphate hexahydrate.

Fostamatinib disodium hexahydrate has the molecular formula C₂₃H₂₄FN₆Na₂O₉P·6H₂O, and the molecular weight is 732.52. The structural formula is:

The Product is an oral tablet containing fostamatinib disodium hexahydrate in the amount equivalent to 100 mg and 150 mg of fostamatinib free acid. The inactive ingredients are: (Tablet Core) mannitol, sodium bicarbonate, sodium starch glycolate, povidone, magnesium stearate, (Coating) polyvinyl alcohol, titanium dioxide, polyethylene glycol 3350, talc, iron oxide yellow and iron oxide red.

Exhibit B:

Rigel Patents

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{Redacted content comprises approximately 16 pages.}

Exhibit C:

Trademark Protection Status

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{Redacted content comprises approximately 2 pages.}

Exhibit D:

Press Release

Rigel Pharmaceuticals Enters Collaboration and License Agreement with Grifols, S.A. to Commercialize Fostamatinib in Europe

Grifols gains exclusive rights to fostamatinib in all potential indications in Europe and Turkey

Rigel to receive an upfront payment of $30 million, with the potential for $297.5 million in total regulatory and commercial milestones, including a $20 million payment upon EMA approval of fostamatinib in chronic immune thrombocytopenia (ITP), which is currently under review

Rigel to receive stepped royalty payments reaching 30% of net sales of fostamatinib

SOUTH SAN FRANCISCO, Calif., [ * ] /PRNewswire/ -- Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that it has entered into an exclusive license and supply agreement with Spain-based Grifols, S.A ( MCE: GRF, MCE: GRF.P, NASDAQ: GRFS) to commercialize fostamatinib disodium hexahydrate in all potential indications in Europe and Turkey. Grifols is a global healthcare company and a leading producer of plasma-derived medicines for the treatment of rare and chronic diseases, including intravenous immunoglobulin (IVIG) which is used in the treatment of ITP and AIHA. Fostamatinib is commercially available in the U.S. under the brand name TAVALISSE® (fostamatinib disodium hexahydrate) and is the first and only SYK inhibitor indicated for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment.

“Grifols has a broad presence in Europe and an established position in the hematology commercial landscape, which supports our goal of bringing fostamatinib to patients in these countries,” said ▇▇▇▇ ▇▇▇▇▇▇▇▇▇, president and CEO of Rigel. “Our marketing authorization application for fostamatinib in chronic ITP is currently under review by the European Medicines Agency, and we anticipate a decision by the end of 2019. This provides a potential opportunity for fostamatinib to begin generating revenue in the European market in 2020.”

Under terms of the agreement, Rigel will receive a $30 million upfront cash payment, with the potential for to $297.5 million in payments related to regulatory and commercial milestones, which includes a $20 million payment for EMA approval of fostamatinib for the treatment of chronic ITP. Rigel will receive significant stepped double-digit royalty payments based on tiered net sales which may reach 30% of net sales. In return, Grifols receives exclusive rights to fostamatinib in human diseases, including chronic ITP, autoimmune hemolytic anemia (AIHA), and IgA nephropathy (IgAN), in Europe and Turkey. Rigel retains the remaining global rights to fostamatinib outside the Grifols territories and those rights previously granted to Kissei Pharmaceuticals (in Japan, China, Taiwan and the Republic of Korea).

“Given our global leadership position as a manufacturer of plasma medicines and our in-depth knowledge and expertise in blood disorders, adding fostamatinib to our portfolio is a natural fit for Grifols,” said ▇▇▇▇ ▇▇▇▇▇▇▇, President, Bioscience Commercial Division of Grifols. “Its potential in multiple indications, including ITP, will provide significant benefit for patients and is a valuable addition to our portfolio.”

On October 4, 2018, the EMA validated the marketing authorization application for fostamatinib in adult chronic ITP, which was submitted by Rigel. The company anticipates a decision from the EMA’s Committee on Human Medicinal Products by the fourth quarter of 2019 and potential European approval by the end of 2019.

About ITP
In patients with ITP, the immune system attacks and destroys the body's own blood platelets, which play an active role in blood clotting and healing. Common symptoms of ITP are excessive bruising and bleeding. People suffering with chronic ITP may live with an increased risk of severe bleeding events that can result in serious medical

complications or even death. Current therapies for ITP include steroids, blood platelet production boosters (TPOs) and splenectomy. However, not all patients respond to existing therapies. As a result, there remains a significant medical need for additional treatment options for patients with ITP.

About TAVALISSE
Indication
TAVALISSE® (fostamatinib disodium hexahydrate) tablets is indicated in the US for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment.

Important Safety Information
Warnings and Precautions

Hypertension can occur with TAVALISSE treatment. Patients with pre-existing hypertension may be more susceptible to the hypertensive effects. Monitor blood pressure every 2 weeks until stable, then monthly, and adjust or initiate antihypertensive therapy for blood pressure control maintenance during therapy. If increased blood pressure persists, TAVALISSE interruption, reduction, or discontinuation may be required.

Elevated liver function tests (LFTs), mainly ALT and AST, can occur with TAVALISSE. Monitor LFTs monthly during treatment. If ALT or AST increase to >3 x upper limit of normal, manage hepatotoxicity using TAVALISSE interruption, reduction, or discontinuation.

Diarrhea occurred in 31% of patients and severe diarrhea occurred in 1% of patients treated with TAVALISSE. Monitor patients for the development of diarrhea and manage using supportive care measures early after the onset of symptoms. If diarrhea becomes severe (≥Grade 3), interrupt, reduce dose or discontinue TAVALISSE.

Neutropenia occurred in 6% of patients treated with TAVALISSE; febrile neutropenia occurred in 1% of patients. Monitor the ANC monthly and for infection during treatment. Manage toxicity with TAVALISSE interruption, reduction, or discontinuation.

TAVALISSE can cause fetal harm when administered to pregnant women. Advise pregnant women the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during treatment and for at least 1 month after the last dose. Verify pregnancy status prior to initiating TAVALISSE. It is unknown if TAVALISSE or its metabolite is present in human milk. Because of the potential for serious adverse reactions in a breastfed child, advise a lactating woman not to breastfeed during TAVALISSE treatment and for at least 1 month after the last dose.

Drug Interactions

Concomitant use of TAVALISSE with strong CYP3A4 inhibitors increases exposure to the major active metabolite of TAVALISSE (R406), which may increase the risk of adverse reactions. Monitor for toxicities that may require a reduction in TAVALISSE dose.

It is not recommended to use TAVALISSE with strong CYP3A4 inducers, as concomitant use reduces exposure to R406.

Concomitant use of TAVALISSE may increase concentrations of some CYP3A4 substrate drugs and may require a dose reduction of the CYP3A4 substrate drug.

Concomitant use of TAVALISSE may increase concentrations of BCRP substrate drugs (eg, rosuvastatin) and P-Glycoprotein (P-gp) substrate drugs (eg, digoxin), which may require a dose reduction of the BCRP and P-gp substrate drug.

Adverse Reactions

Serious adverse drug reactions in the ITP double-blind studies were febrile neutropenia, diarrhea, pneumonia, and hypertensive crisis, which occurred in 1% of TAVALISSE patients. In addition, severe adverse reactions occurred including dyspnea and hypertension (both 2%), neutropenia, arthralgia, chest pain, diarrhea, dizziness, nephrolithiasis, pain in extremity, toothache, syncope, and hypoxia (all 1%).

Common adverse reactions (≥5% and more common than placebo) from the FIT-1 and FIT-2 phase 3 clinical trials included: diarrhea, hypertension, nausea, dizziness, ALT and AST increased, respiratory infection, rash, abdominal pain, fatigue, chest pain, and neutropenia.

Please see ▇▇▇.▇▇▇▇▇▇▇▇▇.▇▇▇ for full Prescribing Information.

To report side effects of prescription drugs to the FDA, visit ▇▇▇.▇▇▇.▇▇▇/▇▇▇▇▇▇▇▇ or call ▇-▇▇▇-▇▇▇-▇▇▇▇ (▇▇▇-▇▇▇-▇▇▇▇).

TAVALISSE is a trademark of Rigel Pharmaceuticals, Inc.

About Rigel (▇▇▇.▇▇▇▇▇.▇▇▇)
Rigel Pharmaceuticals, Inc., is a biotechnology company dedicated to discovering, developing and providing novel small molecule drugs that significantly improve the lives of patients with immune and hematologic disorders, cancer and rare diseases. Rigel's pioneering research focuses on signaling pathways that are critical to disease mechanisms. The company's first FDA approved product is TAVALISSE™ (fostamatinib disodium hexahydrate), an oral spleen tyrosine kinase (SYK) inhibitor, for the treatment of adult patients with chronic immune thrombocytopenia who have had an insufficient response to a previous treatment. Rigel's current clinical programs include an upcoming Phase 3 study of fostamatinib in autoimmune hemolytic anemia and an ongoing Phase 1 study of R835, a proprietary molecule from its interleukin receptor associated kinase (IRAK) program. In addition, Rigel has product candidates in clinical development with partners BerGenBio AS, Daiichi Sankyo, and Aclaris Therapeutics.

About Grifols

Grifols is a global healthcare company with more than 75 years of legacy dedicated to improving the health and well-being of people around the world. Grifols produces essential plasma-derived medicines for patients, and provides hospitals and healthcare professionals with the tools, information and services they need to help them deliver expert medical care.

Grifols’ three main divisions – Bioscience, Diagnostic and Hospital – develop, produce and market innovative products and services that are available in more than 100 countries.

With a network of 250 plasma donation centers, Grifols is a leading producer of plasma-derived medicines used to treat rare, chronic and, at times, life-threatening conditions. As a recognized leader in transfusion medicine, Grifols offers a comprehensive portfolio of diagnostic products designed to support safety from donation through transfusion. The Hospital Division provides intravenous (IV) therapies, clinical nutrition products and hospital pharmacy systems, including systems that automate drug compounding and control drug inventory.

Grifols is headquartered in Barcelona, Spain, and has 20,000 employees in 30 countries. In 2017, sales exceeded 4,300 million euros. Grifols demonstrates its strong commitment to advancing healthcare by allocating a significant portion of its annual income to research, development and innovation.

The company’s class A shares are listed on the Spanish Stock Exchange, where they are part of the Ibex-35 (MCE:GRF). Grifols non-voting class B shares are listed on the ▇▇▇▇▇▇▇ Continuo (MCE:GRF.P) and on the US NASDAQ via ADRs (NASDAQ:GRFS).

For more information, visit ▇▇▇.▇▇▇▇▇▇▇.▇▇▇

Forward Looking Statements
This release contains forward-looking statements relating to, among other things, Rigel's partnership with Grifols; Rigel’s partnership with Kissei; Rigel's ability to achieve regulatory and commercial milestone payments under its agreement with Grifols; the potential opportunity for fostamatinib to begin generating revenue in the European market in 2020; Rigel's interactions with the EMA; and the timing of the EMA's MAA review process and when Rigel expects a decision. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as "planned," "will," "may," "expect," "anticipate," and

similar expressions are intended to identify these forward-looking statements. These forward-looking statements are based on Rigel's current expectations and inherently involve significant risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in such forward looking statements as a result of these risks and uncertainties, which include, without limitation, risks and uncertainties associated with the commercialization and marketing of TAVALISSE; risks that the FDA, EMA or other regulatory authorities may make adverse decisions regarding fostamatinib; risks that TAVALISSE clinical trials may not be predictive of real-world results or of results in subsequent clinical trials; risks that TAVALISSE may have unintended side effects, adverse reactions or incidents of misuses; the availability of resources to develop Rigel's product candidates; market competition; as well as other risks detailed from time to time in Rigel's reports filed with the Securities and Exchange Commission, including its Quarterly Report on Form 10-Q for the period ended September 30, 2018. Rigel does not undertake any obligation to update forward-looking statements and expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein.

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EXCLUSIVE COmmercialization LICENSE Agreement

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