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EXHIBIT 10.6
TECHNOLOGY ASSIGNMENT AND LICENSE AGREEMENT
THIS TECHNOLOGY ASSIGNMENT AND LICENSE AGREEMENT (the
"AGREEMENT") is made and entered into effective as of April 28, 2000 (the
"EFFECTIVE DATE") by and between AXYS PHARMACEUTICALS, INC., a Delaware
corporation with offices at 000 Xxxxxxx Xxx, Xxxxx Xxx Xxxxxxxxx, XX 00000
("AXYS"), and AXYS ADVANCED TECHNOLOGIES, INC., a Delaware corporation with
offices at 000 Xxxxxxx Xxx, Xxxxx Xxx Xxxxxxxxx, XX 00000 ("AAT"). Each of Axys
and AAT may be referred to herein individually as a "Party" and jointly as the
"Parties."
RECITALS
WHEREAS, AAT is a wholly-owned subsidiary of Axys, and Axys is
willing to assign to AAT all its right, title and interest in and to certain
Axys proprietary technology, intellectual property and other business assets
useful for the practice of combinatorial chemistry, and AAT is willing to grant
to Axys a limited license under such technology and intellectual property solely
for Axys' internal drug discovery, development and commercialization business
activities, all on the terms set forth below; and
WHEREAS, Axys intends, forthwith after entering into this
Agreement, to sell AAT to Discovery Partners International, Inc. ("DPII") via a
reverse triangular merger;
NOW, THEREFORE, in consideration of the foregoing and the
covenants and promises contained herein, the Parties hereby agree as follows:
1. DEFINITIONS
1.1 "AAT CONTRACTS" means the agreements set forth on Schedule
1.1 hereto.
1.2 "ADDITIONAL CHEMISTRY ASSETS" means the tangible assets owned
by Axys that are being used by AAT as of the Effective Date and/or had
heretofore been used in Axys' or AAT's combinatorial chemistry business and that
were not previously assigned or otherwise transferred to AAT, all of which are
rlisted in Schedule 1.2 attached hereto.
1.3 "AFFILIATE" means, with respect to a particular Party,
another corporation, partnership or similar entity that controls, is controlled
by or is under common control with such Party, but in any case, only for the
duration of the period that such other corporation, partnership or similar
entity controls, is controlled by or is under common control with such Party.
For the purposes of the definition in this Section 1.3, the word "control"
(including, with correlative meaning, the terms "controlled by" or "under the
common control with") means the ownership of at least fifty percent (50%) of the
voting stock (or voting or membership interest, if not a corporation) of such
entity. For the purposes of clarification, it is the parties' intent that if a
corporation, partnership or similar entity ceases to control, be controlled by
or be under common control with a particular Party, such entity shall, at the
time such control relationship ceases, cease to have any rights under this
Agreement, including, without limitation, any license rights
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granted pursuant to this Agreement. Notwithstanding the foregoing, Axys and AAT
shall be deemed not to be Affiliates of each other.
1.4 "ASSIGNED CONTRACTS" means the agreements set forth on
Schedule 1.4 hereto, which are assigned to AAT by Axys pursuant to Section
2.1(c).
1.5 "ASSIGNED KNOW-HOW" means the Information that is Controlled
by Axys as of the Effective Date, including, without limitation, the Information
identified generally in Schedule 1.5 attached hereto, which is necessary to or
used by AAT in its current combinatorial chemistry business, but excluding the
Assigned Protocols and Licensed Technology.
1.6 "ASSIGNED PATENTS" means those patents and patent
applications set forth in Schedule 1.6 hereto, and including any and all rights
that are Controlled by Axys as of the Effective Date with respect to such
patents and patent applications, including without limitation the rights to
enforce and file divisional, continuation, continuation-in-part, substitution,
reissue, reexamination, and extension and foreign equivalent applications
thereof.
1.7 "ASSIGNED PROTOCOLS" means the Protocols Controlled by Axys
that are set forth in Schedule 1.7 hereto, and all trade secret and other
intellectual property rights in such Protocols that are Controlled by Axys as of
the Effective Date.
1.8 "ASSIGNED SOFTWARE" means the computer software programs, in
object code and, to the extent Controlled by Axys, source code forms, that are
either owned by Axys or licensed to Axys and are described generally in Schedule
1.8 hereto, and all documentation for such programs in Axys' possession as of
the Effective Date, and all copyright and other intellectual property rights in
any of the foregoing that are Controlled by Axys as of the Effective Date. In
addition, for purposes of Section 2.2 and Article 6, "Assigned Software" (and
therefore also "Assigned Technology" and "Confidential Information") shall
include the Post-Effective-Date computer software programs, in object code form,
and all documentation for such programs (other than source code), and all
copyright and other intellectual property rights, pertaining to the improved
user interface which AAT currently proposes to develop between the Effective
Date and December 31, 2000 for free delivery to counterparties under the AAT
Contracts.
1.9 "ASSIGNED TECHNOLOGY" means the Assigned Patents, the
Assigned Know-How, the Assigned Protocols, and the Assigned Software.
1.10 "COLLABORATION" means a collaboration agreement or similar
agreement establishing a strategic alliance between Axys (or its Affiliate) and
a third party corporate (or other business) entity, where the primary goal of
such agreement is the collaborative discovery and/or development of drug
candidates based on research directed at one or more particular targets or
disease areas and where it is anticipated that the role of Axys (or its
Affiliate):
(a) will not involve only the provision of compounds and/or
Protocols received under this Agreement or the Compound Purchase Agreement; and
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(b) will involve a significant application of other Axys (or
its Affiliate's) technology or drug discovery expertise and/or significant
efforts by Axys (or its Affiliate's) employees.
1.11 "COLLABORATION EXCEPTION" means use of combinatorial
chemistry technology to design and synthesize compounds as part of a
Collaboration and use of such compounds within the scope of such Collaboration.
1.12 "CONTROLLED" means, with respect to any material,
Information or intellectual property right, that Axys owns or has a license to
such material, Information or intellectual property right with the right to
assign or license (as applicable) such material, Information or intellectual
property right as provided herein without violating any agreement with a third
party.
1.13 "INFORMATION" means information and data of any type and in
any tangible or intangible form, including without limitation inventions, works
of authorship, plans, designs, practices, methods, techniques, specifications,
production technical operating procedures, standard operating procedures,
protocols under development, formulations, software, formulae, knowledge,
know-how, skill, experience, test data, analytical and quality control data,
stability data, results of studies and patent and other legal information or
descriptions.
1.14 "LICENSED GENERAL KNOW-HOW" means Information that is
Controlled by Axys as of the Effective Date which is now being used by Axys in
areas other than combinatorial chemistry, as well as being used in AAT's
combinatorial chemistry business.
1.15 "LICENSED PATENTS" means those patents and patent
applications (if any) that are Controlled by Axys as of the Effective Date
(including divisional, continuation, continuation-in-part, substitution,
reissue, reexamination, and extension and foreign equivalent applications
thereof) and are now being used by Axys in areas other than combinatorial
chemistry, as well as being used in AAT's combinatorial chemistry business.
1.16 "LICENSED SOFTWARE" means the computer software programs (if
any), in object code and, to the extent Controlled by Axys, source code forms,
that are Controlled by Axys (and including all documentation for such programs
in Axys' possession as of the Effective Date, and all copyright and other
intellectual property rights in any of the foregoing that are Controlled by Axys
as of the Effective Date), and are now being used by Axys in areas other than
combinatorial chemistry, as well as being used in AAT's combinatorial chemistry
business.
1.17 "LICENSED TECHNOLOGY" means the Licensed Patents, the
Licensed General Know-How and the Licensed Software. It is intended that the
difference between items identified as Assigned Technology and the items
assigned as Licensed Technology is that the patents, software, and Information
within the Licensed Technology are those now being used by Axys in areas other
than combinatorial chemistry, as well as being used in AAT's combinatorial
chemistry business.
1.18 "LIMITATION" means that Axys (and its Affiliates and
permitted sublicensees) shall be entitled to use the Assigned Technology and
(within the combinatorial chemistry field of use) the Licensed Technology for,
but only for, work performed by Axys and
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its Affiliates within their respective facilities (or, in the case of a
permitted sublicense under Section 2.2, by the permitted sublicensee within the
permitted sublicensee's facilities) as part of Axys' (or its Affiliates')
internal research and/or development work in the area of drug discovery,
development and commercialization or by Axys or its Affiliates and/or one of
their Collaboration partners within the scope of the Collaboration Exception. It
is understood and agreed the scope of the Limitation does not permit Axys (or
its Affiliate or sublicensee) to transfer to any third party any library or
collection of compounds created in connection with Axys' or a permitted
sublicensee's use of the Assigned Technology or the Licensed Technology, except
to a Collaboration partner in connection with the Collaboration Exception, or to
the successor in interest of Axys pursuant to assignment of this Agreement under
Section 7.4. Included within the Limitation are the restrictions on sublicensing
included in Section 2.2 and the restrictions on use included in Section 2.3(b).
It is understood that any drug or pharmaceutical or diagnostic compound
developed based on the foregoing use may be commercialized for any and all
prophylactic, therapeutic and diagnostic uses, with the further understanding
that such commercial use is not as part of a library or collection of compounds
sold or otherwise transferred to a third party for screening or other similar
discovery uses.
1.19 "PROTOCOL" means a detailed set of combinatorial chemistry
synthetic methods and standard operating procedures designed to be used for
synthesizing a set of related compounds using combinatorial chemistry
techniques.
2. TECHNOLOGY LICENSES AND ASSET TRANSFER
2.1 ASSIGNMENT OF ASSETS.
(a) Axys hereby assigns to AAT all its right, title and
interest in and to the Assigned Technology and the Additional Chemistry Assets.
Axys assigns the Assigned Technology and the Additional Chemistry Assets to AAT,
and AAT hereby accepts such assets as of the Effective Date, "AS IS" and "WHERE
IS" and without any warranty and expressly subject to Sections 4.2 and 4.3.
(b) The assignment of assets under subsection (a) is pursuant
to an executed Xxxx of Sale, Assignment of Patents and Patent Applications,
Assignment of Trademark Applications and Assignment of Copyrights, each in the
form attached hereto as Schedule 2.1(b) and delivered by Axys to AAT
simultaneously with the execution and delivery of this Agreement. Axys further
agrees to undertake all additional actions and execute and deliver all
additional documents and instruments reasonably requested by AAT from time to
time to perfect AAT's title in and to the Assigned Technology and the Additional
Chemistry Assets.
(c) Effective as of and after the Effective Date, Axys hereby
assigns to AAT all of Axys' rights, claims and benefits (except as otherwise
provided in subsection (d)), and delegates all its obligations, responsibilities
and liabilities under the Assigned Contracts, and AAT hereby assumes and agrees
to perform all Axys' obligations, responsibilities and liabilities and agrees to
accept all Axys' rights, claims and benefits (except as otherwise provided in
subsection (d)), under the Assigned Contracts. If the counterparty's consent is
required but not obtained, Axys shall enforce and receive all rights, claims and
benefits in trust for AAT, and deliver over any cash or assets arising therefrom
to AAT upon request.
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(d) The rights in the Assigned Technology assigned to AAT
under Section 2.1(a) are expressly subject to any and all license rights that
Axys has previously granted to third parties identified on Schedule 2.1(d),
under the contracts specified on Schedule 2.1(d), with respect to such
technology and intellectual property rights, to the extent and so long as such
license rights remain in force.
(e) All notebooks, documents, memoranda, reports, files,
books, correspondence, lists and other written and graphic records relating to
the combinatorial chemistry business, which Axys or its employees, agents or
consultants prepared, used or constructed directly in the course of and pursuant
to the conduct of Axys' combinatorial chemistry business prior to the Effective
Date (collectively, "Business Materials") shall be AAT's exclusive property, and
Axys hereby agrees to deliver all Business Materials promptly to AAT at AAT's
request.
2.2 LICENSE GRANT TO AXYS.
(a) AAT hereby grants to Axys and Axys' Affiliates the
non-exclusive, world-wide, fully paid-up, irrevocable, perpetual, royalty-free
license, with the limited right to grant sublicenses as provided below, to use,
practice and commercially exploit the Assigned Technology within the scope of
the Limitation and not otherwise.
(b) Neither Axys nor its Affiliates may sublicense to third
parties the rights licensed under this Section 2.2, except (i) to third party
contractors for the performance of work, within the scope of the Limitation and
not otherwise, paid for by Axys (or its Affiliate) and on Axys' (or its
Affiliate's) behalf or (ii) to one or more Collaboration partners of Axys (or
its Affiliate) for the performance of work pursuant to the applicable
Collaboration within the Collaboration Exception, and not otherwise, in either
case pursuant to appropriate written non-disclosure and limitation-of-use
agreements.
(c) The license rights under this Section 2.2 may be assigned
to a successor in interest of Axys pursuant to assignment of this Agreement by
Axys as permitted under Section 7.4, but may not otherwise be assigned. Axys and
its Affiliates and permitted sublicensees shall not transfer to any third party
any library or collection of compounds made by practicing the Assigned
Technology as permitted hereunder except in connection with a Collaboration
Exception or to the successor in interest of Axys pursuant to assignment of this
Agreement under Section 7.4.
2.3 LICENSE GRANT TO AAT.
(a) Axys hereby grants to AAT the non-exclusive (subject to
subsection 2.3(b)), world-wide, fully-paid-up, irrevocable, perpetual,
royalty-free, assignable, sublicensable license to use, practice and
commercially exploit the Licensed Technology solely in the field of
combinatorial chemistry and not otherwise. It is understood that Axys and its
Affiliates retain the non-exclusive rights under the Licensed Technology within
the field of combinatorial chemistry solely for use within the scope of the
Limitation, and retain exclusively all rights to the Licensed Technology outside
the field of combinatorial chemistry.
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(b) During the "Term," as such term is defined in that
certain Non-Competition and Non-Disclosure Agreement of even date herewith
between Axys and DPII, Axys agrees not to use, practice or commercially exploit
the Licensed Technology in the field of combinatorial chemistry except within
the scope of the Limitation. AAT agrees not to use, practice or commercially
exploit the Licensed Technology except within the field of combinatorial
chemistry.
2.4 USER INTERFACE TECHNOLOGY TRANSFER. At the same time as AAT
delivers to the counterparties under the AAT Contracts the improved user
interface program (and documentation) described in the last sentence of Section
1.8, it shall also deliver the items described in such last sentence of Section
1.8 to Axys (subject to Section 2.2 and Article 6).
2.5 COMPOUND TRANSFER. AAT covenants that it shall provide to
Axys, promptly after its request, at least six micromoles of each compound
produced by AAT prior to the Effective Date, without further charge, but
excluding any compounds for which Axys has already received at least six
micromoles prior to the Effective Date. Such compounds shall be included within
the scope of the license rights granted to Axys under Section 2.2 hereof. The
Parties agree that in the event that any such requested compounds are not
available in the inventory of AAT, AAT will supply to Axys at least six
micromoles of other compounds produced by AAT, such compounds to be selected by
the good faith discussion of the Parties, such that AAT is not obligated to
resynthesize any of the earlier-created compounds.
3. INTELLECTUAL PROPERTY MATTERS
3.1 INFRINGEMENT BY THIRD PARTIES. AAT shall have the sole and
exclusive right to bring and control any action or proceeding with respect to
infringement of any patents owned by AAT, including without limitation the
Assigned Patents, at its own expense and by counsel of its own choice.
3.2 ALLEGATION OF INFRINGEMENT BY THIRD PARTIES. Each Party shall
be solely responsible for responding to any claim or allegation of infringement
made by a third party against such Party based on its post-Effective-Date
actions or activities.
4. REPRESENTATIONS AND WARRANTIES
4.1 MUTUAL REPRESENTATIONS AND WARRANTIES. Each Party hereby
represents and warrants to the other Party that, as of the Effective Date:
(a) such Party is duly organized and validly existing under
the laws of the state of its incorporation and has full corporate power and
authority to enter into this Agreement and to carry out the provisions hereof;
(b) such Party has taken all corporate action necessary to
authorize the execution and delivery of this Agreement and the performance of
its obligations under this Agreement; and such execution, delivery and/or
performance does not violate any law, regulation, permit held by such Party, or
contract to which such Party is a party;
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(c) this Agreement is a legal and valid obligation of such
Party, binding upon such Party and enforceable against such Party in accordance
with the terms of this Agreement, except as such enforcement may be limited by
applicable bankruptcy, insolvency, reorganization, arrangement, moratorium or
other similar laws affecting creditors' rights, and subject to general equity
principles and to limitations on availability of equitable relief, including
specific performance; and
(d) it has the right to enter into this Agreement and to
grant the rights granted herein.
4.2 DISCLAIMER. AAT hereby accepts and assumes title to all the
Assigned Technology and the Additional Chemistry Assets, and a license to the
Licensed Technology, "AS IS" and "WHERE IS" without any warranties of any kind,
either express or implied. AXYS HEREBY DISCLAIMS ANY AND ALL WARRANTIES, EITHER
EXPRESS OR IMPLIED, WITH RESPECT TO THE ADDITIONAL CHEMISTRY ASSETS, THE
ASSIGNED TECHNOLOGY AND THE LICENSED TECHNOLOGY, INCLUDING WITHOUT LIMITATION
ANY WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND
NON-INFRINGEMENT.
4.3 EXPLANATION. It is understood that, in connection with the
sale of AAT by Axys to DPII, Axys will make, in certain other agreements
relating to such sale, certain representations, warranties and covenants for the
benefit of DPII with respect to (among other things) the Assigned Contracts, the
Assigned Technology, the Additional Chemistry Assets and the Licensed
Technology, and grant DPII certain indemnification and other rights and remedies
with respect to such representations, warranties and covenants. This Agreement's
disclaimers, limitations, quitclaim provisions and "AS IS, WHERE IS" provisions
are not intended to affect or diminish such representations, warranties,
covenants, rights and remedies set forth in such other agreements, but merely to
ensure that any liability of Axys to DPII after such sale shall arise primarily
under and to the extent defined in such agreements between Axys and DPII instead
of under this Agreement. Nonetheless, any liability of Axys to AAT under the
express terms of this Agreement may also be enforced by AAT after a sale to
DPII.
5. TERM AND TERMINATION
5.1 TERM. The Agreement shall commence on the Effective Date and
continue in force thereafter indefinitely.
6. CONFIDENTIALITY
6.1 LIMITATIONS ON CONFIDENTIAL INFORMATION. As used herein,
"Confidential Information" means (a) confidential and proprietary Information
within the Assigned Technology that is or has been transferred or disclosed by
Axys to AAT plus any confidential and proprietary Information that AAT may
subsequently disclose to Axys hereunder and (b) the Compound Information as such
term is defined in the Compound Purchase Agreement between the Parties of even
date herewith. Axys understands that maintenance of the confidential nature of
the Confidential Information may be important to AAT's future use, practice and
commercial exploitation of the rights granted to AAT under this Agreement, and
thus Axys agrees that it
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shall use reasonable efforts to preserve the confidentiality of such
Confidential Information and not to publish it, or otherwise disclose it to
third parties except under appropriate written confidentiality and
limitation-of-use agreements for the purposes of exercising its limited
sublicense rights under Section 2.2 of this Agreement or Sections 2.2, 2.3 and
4.1 of the Compound Purchase Agreement.
6.2 EXCEPTIONS. The obligations set forth in Section 6.1 shall
not apply to any Information that Axys can demonstrate by competent written
evidence:
(a) is or becomes generally available to the public or
otherwise part of the public domain other than through any act or omission of
Axys in breach of this Agreement;
(b) is independently developed by Axys or its Affiliate
without using any of the Confidential Information or any other Information
previously transferred by Axys to AAT; or
(c) is disclosed to Axys by a third party that has no
obligation not to disclose such Information to Axys.
6.3 PERMITTED DISCLOSURE. Notwithstanding the limitations in this
Article 6, Axys may disclose Confidential Information to the extent such
disclosure is reasonably necessary in the following instances, but solely for
the limited purpose of such necessity:
(a) filing or prosecuting patent applications which Axys is
allowed to file or prosecute;
(b) regulatory and tax filings;
(c) defending litigation or (subject to AAT's prior written
consent) prosecuting litigation; and
(d) complying with applicable governmental laws or
regulations or valid court orders.
Notwithstanding the foregoing, in the event Axys is required to
make a disclosure of the Confidential Information pursuant to subsections 6.3(a)
- (d), it will give reasonable advance notice to AAT of such disclosure and
endeavor in good faith to secure confidential treatment of such information. In
any event, the Parties agree to take all reasonable action to limit or avoid
disclosure of Confidential Information hereunder. Further, the Parties agree to
consult with one another on the provisions of this Agreement to be redacted in
any filings made by a Party with the United States Securities and Exchange
Commission or as otherwise required by law.
7. MISCELLANEOUS
7.1 GOVERNING LAW. This Agreement shall be governed by the laws
of the State of California that apply to contracts negotiated, executed and
performed within the State of California.
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7.2 ENTIRE AGREEMENT. This Agreement constitutes the entire,
final and complete agreement and understanding between the Parties with respect
to the subject matter hereof, and replaces and supersedes all prior discussions
and agreements between the Parties with respect to such subject matter. In
particular, but without limiting the foregoing, the Parties hereby agree that
the Limited Technology and License Agreement, dated as of June, 1999, between
the Parties is hereby terminated. No amendment, modification or waiver of any
terms or conditions hereof shall be effective unless made in writing and signed
by a duly authorized officer of each Party.
7.3 FURTHER AGREEMENTS. Each Party agrees to execute, acknowledge
and deliver such further instruments and to do all such other acts as may be
necessary or appropriate in order to carry out the purposes and intent of this
Agreement.
7.4 SUCCESSORS AND ASSIGNS. This Agreement shall be binding upon
each of the Parties, their successors and assigns. Axys shall not be entitled to
assign the benefits of this Agreement to any Party without the prior
post-Effective-Date written consent of AAT, which consent shall not be
unreasonably withheld; provided, however, such consent shall not be required for
an assignment to the successor in interest of Axys in connection with the
merger, acquisition, or consolidation of Axys or the sale of all or
substantially all of the assets of Axys. Any assignment in contravention of this
Section 7.4 shall be null, void and of no effect.
7.5 HEADINGS. The headings of the several sections are inserted
for convenience of reference only and are not intended to be a part of or to
affect the meaning or interpretation of this Agreement.
7.6 NOTICE. All notices required or permitted to be given under
this Agreement shall be in writing and shall be mailed by registered or
certified mail, or delivered by a nationally recognized overnight courier, or
delivered by hand to the address set forth in the first paragraph of this
Agreement, to the attention of the party's President. All notices shall be
deemed to have been given two (2) business days after such notice is mailed, as
evidenced by the postmark at the point of mailing, or on the date of personal
delivery, if not mailed.
7.7 COUNTERPARTS. This Agreement may be executed in counterparts,
each of which shall be an original and all of which shall constitute together
the same document.
7.8 SEVERABILITY. If a court of competent jurisdiction declares
any provision of this Agreement invalid or unenforceable, or if any government
or other agency having jurisdiction over either AAT or Axys deems any provision
to be contrary to any laws, then that provision shall be severed and the
remainder of the Agreement shall continue in full force and effect. The Parties
further agree to negotiate in good faith with the intention of agreeing to and
implementing an amendment to replace such void, invalid, unenforceable, or
unlawful provision with a valid and enforceable provision that will achieve, to
the extent possible, the economic, business and other purposes of such void,
invalid, unenforceable or unlawful provision.
7.9 FURTHER AGREEMENT. Neither Party is obligated by this
Agreement to enter into any further agreement of any kind with the other Party.
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7.10 INDEPENDENT CONTRACTORS. Each Party shall act solely as an
independent contractor, and nothing in this Agreement shall be construed to give
either Party the power or authority to act for, bind or commit the other Party
in any way. Nothing herein shall be construed to create the relationship of
partnership, principal and agent or joint venture between the Parties.
IN WITNESS WHEREOF, the Parties have executed and delivered this
Technology Assignment and License Agreement on the Effective Date.
AXYS PHARMACEUTICALS, INC.
By: /s/ Xxxxxxx X. Xxxxxx
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Name: Xxxxxxx X. Xxxxxx
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Title: Senior Vice President
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AXYS ADVANCED TECHNOLOGIES, INC.
By: /s/ Xxxxxxx X. Xxxxxx
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Name: Xxxxxxx X. Xxxxxx
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Title: Vice President and Secretary
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[SIGNATURE PAGE TO TECHNOLOGY ASSIGNMENT AND LICENSE AGREEMENT]
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SCHEDULE 1.1
AAT CONTRACTS
Combinatorial Chemistry Agreement with Daiichi Pharmaceutical Co., Ltd. dated
June 30, 1999.
Combinatorial Chemistry Agreement with Allergan, Inc. dated September 27, 1999
Combinatorial Chemistry Agreement with Elitra Pharmaceuticals Inc., dated
September 30, 1999
Combinatorial Chemistry Agreement with Novartis Institute for Functional
Genomics, Inc., dated December 8, 1999
Combinatorial Chemistry Agreement with L'Oreal Group, dated December 20, 1999
Combinatorial Chemistry Agreement with Monsanto, dated December 21, 1999
Combinatorial Chemistry Agreement with Cephalon, Inc., dated December 21, 1999
Combinatorial Chemistry Agreement with Xxxxxxx-Xxxxx Squibb Company, dated
December 31, 1999
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SCHEDULE 1.2
ADDITIONAL CHEMISTRY ASSETS
(see attached)
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AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
COMPUTER 2/28/93 112 Tag: A2077 1 Indigo 16 27,000.00
10/31/93 120 Tag: A1641 INDIGO 2 19,157.50
10/31/93 123 Tag: A1470 INDIGO 15,010.00
1/31/94 172 Tag: A1654 1 CPU Mac Q 4,290.00
12/31/94 197 Tag: Al747 1 HPLaserj 2,159.59
1/31/95 198 Tag: Al754 Computer - A 3,342.20
5/31/95 203 Tag: A4994 Computer - P 4,883.15
12/31/95 220 Tag: A4826 1 COMPUTER 1,052.12
6/30/96 241 Tag: A4075 2 computer 3,692.14
6/30/96 248 Tag: A2248 2 Powermac 10,630.55
6/30/96 251 Tag: A2349 3 Powermac 11,590.13
9/30/96 266 Tag: A5443 Monitor 2,110.64
12/1/96 728 Tag: A8067 POWERMAC 76 3,214.48
1/1/97 765 Tag: A2352 PDWERMAC 72 3,145.64
1/1/97 766 Tag: A9070 POWERMAC 76 13,548.05
2/1/97 794 Tag: A2712 DELLDIMENS 2,134.69
2/1/97 804 Tag: A2231 MONITOR SM 936.27
3/1/97 859 Tag: A4996 4PCS spare 26,785.79
3/1/97 860 Tag: A2452 APPLE POWER 7,794.36
3/1/97 880 Tag: A2709 2 PCS DELL 8,963.14
5/1/97 922 Tag: A2852 DELL 6200-O 3,841.38
9/1/97 1011 Tag: A2313 5 PCS POWER 13,848.60
4/1/98 1192 Tag: A6162 POWERMAC G3 1,977.93
4/1/98 1193 Tag: A6163 MONITOR SON 833.35
4/1/98 1194 Tag: A6161 HP DESKJET 1,425.01
4/1/98 1195 Tag: A6296 POWERBOOK G 3,935.18
7/1/98 1295 Tag A7027 HP LASERJET 895.57
9/1/98 1383 Tag: A6814 DELLXPS 26 885.54
9/1/98 1405 Tag: A7059 4000N PRINT 645.60
9/1/98 1406 Tag: A7060 4000N PRINT 645.59
10/1/98 1438 Tag: A7080 POWERBOOK G 3,219.66
3/1/97 2434 Tag: 1769 Server U2-2 12,212.52
7/1/96 3259 Tag: 1501 Computer -
3/31/98 4587 Tag: 3756 Server Sun 21,310.71
11/30/98 4772 Tag: 2929 Unipack B 560.48
11/30/98 4773 Tag: 2928 Unipack B 560.48
1/22/99 4979 Tag: A6978 CompEq Son 183.12
1/22/99 4980 Tag: A6975 CompEq Pow 1,007.39
8/27/99 5286 Tag: A8028 Computer PI 547.89
ADDT'L
DEPR FR
IN SERVIC GL BALANCE ACCUM DEPR GL BALANCE 10/31/99
DATE 3/31/00 10/31/99 10/31/99 TO 3/31/2000
COMPUTER 2/28/93 27,000.00
10/31/93 19,157.50 -
10/31/93 15,010.00 -
1/31/94 4,290.00 -
12/31/94 2,159.59 -
1/31/95 3,342.20 -
5/31/95 4,883.15 -
12/31/95 1,052.12 -
6/30/96 3,290.82 401.32
6/30/96 9,475.06 1,155.49
6/30/96 10,330.34 1,259.79
9/30/96 2,110.64 -
12/1/96 3,125.19 89.29
1/1/97 2,970.89 174.75
1/1/97 12,785.38 752.67
2/1/97 1,956.80 177.69
2/1/97 858.25 78.02
3/1/97 23,809.00 2,976.79
3/1/97 6,928.32 866.04
3/1/97 7,967.24 995.90
5/1/97 3,292.61 548.77
9/1/97 11,614.96 2,233.64
4/1/98 1,565.86 412.07
4/1/98 659.74 173.61
4/1/98 1,128.13 286.88
4/1/98 3,115.35 819.83
7/1/98 682.33 213.24
9/1/98 726.18 259.36
9/1/98 475.71 169.89
9/1/98 475.70 169.89
10/1/98 2,325.31 894.35
3/1/97 10,582.18 1,650.34 [text illegible]
7/1/96 4,958.00 (4,958.00) NOT TRANSFERRED TO
[AXY]
3/31/98 16,870.97 4,439.74 [text illegible]
11/30/98 385.33 175.15 [text illegible]
11/30/98 385.33 175.15 [text illegible]
1/22/99 102.77 80.35
1/22/99 566.36 442.03
8/27/99 156.54 391.35
2.
14
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
8/27/99 5287 Tag: A8029 Computer PI 547.89
8/27/99 5288 Tag: A8028 Computer 17 92.39
8/27/99 5289 Tag: A8029 Computer 17 92.39
9/14/99 5299 Tag: A6811 Computer De 1,884.26
10/20/99 5331 Tag: A8044 SSF Compute 211.65
3/10/00 5764 Tag: A6111 Comp Eq21" monitor
3/10/00 5765 Tag: A8100 Comp Eq Powermac G4
3/10/00 5766 Tag: A8110 Comp Eq Powermac G4
3/21/00 5768 Tag: A8112 Comp Eq Monitor TMX 412
3/21/00 5769 Tag: A8113 Comp Eq Monitor TMX 412
LAB EQUIPMENT 1/31/91 305 Tag: A2052 1Sola Power 3,900.00
9/30/92 308 Tag: A2380 1Pelicon Ca 4,454.85
9/30/93 313 Tag: A3939 1Portion No 4,000.00
6/30/95 323 Tag: A4874 TOMTEC DILU 21,222.41
6/30/95 325 Tag: A2341 Vacuum Pump 1,299.00
3/31/95 326 Tag: A2206 Freezer not 1,928.82
10/31/95 331 Tag: A2841 Vacuum pump 1,407.25
3/31/96 335 Tag: A1239 Turbo Pump 6,000.00
3/31/96 340 Tag: A3941 GeneAmp-Oth 113.00
11/30/95 343 Tag: A3940 1Fumehoods 31,216.52
11/30/95 349 Tag: A1920 Rotary evap 3,254.89
11/30/95 354 Tag: A2757 Balance el 1,175.72
11/30/95 358 Tag: A3252 2 HTS lab r 171,765.70
1/31/94 376 Tag: A2585 Conoentralo 1,950.00
1/31/94 380 Tag: SF592 HPLCSystem 9,280.00
1/31/94 389 Tag: A4764 Balance BA 945.10
1/31/94 394 Tag: A1610 Parbal Bea 28,316.00
1/31/94 398 Tag: A4988 Shaker- env 5,722.25
1/31/94 400 Tag: A4903 Adapter gl 170.00
5/31/92 416 Tag: SF631 1HPLC Semi 54,745.51
5/31/92 417 Tag: A2228 1Fenups un 16,602.56
8/31/92 422 Tag: A3286 Vertishear 1,076.75
8/31/92 433 Tag: A2489 Chromatogre 776.00
2/28/93 437 Tag: A2515 2Roller Rac 7,002.00
12/31/93 454 Tag: A2705 Environment 5,727.00
12/31/93 463 Tag: A2603 Pipeltor - 8 704.95
1/31/95 477 Tag: Al184 Pump - Vacuum 1,840.00
6/30/95 483 Tag: A2005 Vacuum Oven 2,730.00
6/30/95 497 Tag: A1991 SAMPLER DIL 14,522.80
6/30/95 499 Tag: SF717 HP1090 HPLC 62,002.77
ADDT'L
DEPR FR
IN SERVICE GL BALANCE ACCUM DEPR GL BALANCE 10/31/99
DATE 3/31/00 10/31/99 10/31/9 TO 3/31/2000
8/27/99 156.54 391.35
8/27/99 26.40 65.89
8/27/99 26.40 65.99
9/14/99 314.04 1,570.22
10/20/99 211.65
3/10/00 -
3/10/00 -
3/10/00 -
3/21/00 -
3/21/00 242,905.02 223,084.2
LAB EQUIPMENT 1/31/91 3,900.00 -
9/30/92 4,454.85 -
9/30/93 4,000.00 -
6/30/95 21,222.41 -
6/30/95 1,299.00 -
3/31/95 1,928.82 -
10/31/95 1,407.25 -
3/31/96 5,500.00 500.00
3/31/96 103.58 9.42
11/30/95 31,216.52 -
11/30/95 3,254.89 -
11/30/95 1,175.72 -
11/30/95 171,765.70 -
1/31/94 1,950.00 -
1/31/94 9,230.00 -
1/31/94 945.10 -
1/31/94 28,316.00 -
1/31/94 5,722.25 -
1/31/94 170.00 -
5/31/92 54,745.51 -
5/31/92 16,602.56 -
8/31/92 1,076.75 -
8/31/92 776.00 -
2/28/93 7,002.00 -
12/31/93 5,727.00 -
12/31/93 704.95 -
1/31/95 1,840.00 -
6/30/95 2,730.00 -
6/30/95 14,522.80 -
6/30/95 62,002.77 -
3.
15
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
4/30/94 517 Tag: Al137 Freezer Rel 6,099.00
4/30/94 521 Tag: A2722 Freezer Exp 1,500.00
4/30/94 537 Tag: A4881 Racks for C 5,450.00
3/31/96 539 Tag: A4883 Composite R 9,300.00
6/30/96 502 Tag: A8942 BioSafety 7,658.00
6/30/96 564 Tag: A4754 4 306 pump 46,381.38
6/30/96 565 Tag: A4879 4 306 pump 45,203.17
6/30/96 567 Tag: A3948 215Sampler 12,373.88
6/30/96 569 Tag: A3923 Environment 5,525.80
6/30/96 584 Tag: A3238 Fluoslar re 22,583.59
6/30/96 586 Tag: A3243 Column The 3,263.52
6/30/96 591 Tag: A3943 Analytical 4,662.49
8/31/96 595 Tag: A3251 Saw-Isomer 2,782.79
8/31/96 599 Tag: A1708 Computer - C 2,667.61
8/31/96 601 Tag: X0000 XXXXXX 0XX 1,218.69
8/31/96 604 Tag: A2016 Powetmac 75 2,517.21
8/31/96 606 Tag: A2038 Powermac 76 14,775.06
8/31/96 609 Tag: A2222 Powermac 76 10,612.73
8/31/96 632 Tag: A2200 Rotary Evap 2,750.63
8/31/96 637 Tag: A2484 Oven-Vacuum 1,429.60
9/30/95 644 Tag: A1173 Fraction Co 3,150.74
10/31/93 646 Tag: A4901 Temperature 1,034.14
10/31/93 656 Tag: A3983 Vacuum Pump 6,442.00
10/31/93 658 Tag: A4765 Xxxxxxx Xxx 3,030.00
7/31/93 665 Tag: A4068 Vacuum Pump 1,030.40
7/31/93 668 Tag: A2706 Shekel- env 1,022.58
9/30/96 676 Tag: A4880 Pumphead 1,084.49
12/1/96 734 Tag: A4753 PUMPHEAD M 1,008.83
12/1/96 738 Tag: A2612 BALANCE XXX 1,810.68
12/1/96 739 Tag: A2613 ANALYTICAL 1,810.68
12/1/96 742 Tag: A2610 EVAPORATOR 2,185.94
12/1/96 743 Tag: A2621 EVAPORATOR 2,185.94
12/1/96 746 Tag: A3982 PUMP22 I-W 1,671.87
12/1/96 747 Tag: A3231 HYDRA 96 MI 13,350.83
12/1/96 753 Tag: A2635 ANALYTICAL 1,809.94
12/1/96 754 Tag: A2636 ROTARY EVAP 2,332.18
12/1/96 755 Tag: A2637 ROTARY EVAP 2,332.18
12/1/96 756 Tag: A2676 ISOGRATI C P 3,680.49
1/1/97 774 Tag: 42719 SHAKER- REC 2,602.72
1/1/97 778 Tag: Al829 BUCHI XXXXX 2,618.18
ADDT'L
DEPR FR
IN SERVICE GL BALANCE ACCUM DEPR GL BALANCE 10/31/99
DATE 3/31/00 10/31/99 10/31/99 TO 3/31/2000
4/30/94 6,099.00 -
4/30/94 1,500.00 -
4/30/94 5,450.00 -
3/31/96 8,525.00 775.00
6/30/96 6,626.15 832.46
6/30/96 41,339.92 5,041.46
6/30/96 40,289.78 4,913.39
6/30/96 11,028.88 1,344.99
6/30/96 4,925.16 600.64
6/30/96 20,128.85 2,454.74
6/30/96 2,908.78 854.74
6/30/96 4,155.70 508.79
8/31/96 2,466.56 316.23
8/31/96 2,364.47 303.14
8/31/96 1,080.20 138.49
8/31/96 2,231.17 286.04
8/31/96 13,096.07 1,678.99
8/31/96 9,406.74 1,205.99
8/31/96 2,438.05 312.58
8/31/96 1,267.14 162.46
9/30/95 3,150.74 -
10/31/93 1,034.14 -
10/31/93 6,442.00 -
10/31/93 3,030.00 -
7/31/93 1,030.40 -
7/31/93 1,022.58 -
9/30/96 958.38 126.11
12/1/96 882.72 126.11
12/1/96 1,584.34 226.34
12/1/96 1,584.34 226.34
12/1/96 1,912.70 273.24
12/1/96 1,912.70 273.24
12/1/96 1,462.88 208.99
12/1/96 11,681.97 1,668.86
12/1/96 1,583.70 226.24
12/1/96 2,040.65 291.53
12/1/96 2,040.65 291.53
12/1/96 3,220.43 460.06
1/1/97 2,269.03 338.69
1/1/97 2,282.52 335.86
4.
16
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
1/1/97 779 Tag: A2749 XXXXXXX TOL 1,116.65
2/1/97 806 Tag: A2717 XXXXXX 215 9,115.35
2/1/97 808 Tag: A2746 BALANCE XXX 4,640.57
2/1/97 810 Tag: A2755 BALANCE XXX 1,038.98
2/1/97 817 Tag: A4884 2 HPLC 1100 70,746.73
2/1/97 818 Tag: A2776 FREEZER EXP 1,224.45
2/1/97 819 Tag: A2782 DISPENSER W 1,736.48
2/1/97 822 Tag: A2804 PUMPVACUUM 3,009.22
2/1/97 823 Tag: A2803 PUMPVACUUM 1,504.62
2/1/97 827 Tag: A2718 SYRINGE PUM 982.43
2/1/97 839 Tag: A3924 SHAKER RECI 959.91
2/1/97 841 Tag: X0000 000X-00 XX 46,348.88
3/1/97 844 Tag: A2774 UPRIGHT F RE 4,154.45
3/1/97 845 Tag: A2775 UPRIGHT F RE 4,154.45
3/1/97 846 Tag: A2810 UPRIGHT FRE 4,154.45
3/1/97 849 Tag: A2747 MODULINE 12 2,556.28
3/1/97 852 Tag: A4991 XXXXXX PREP 39,743.64
3/1/97 881 Tag: A2901 SPEEDVAC EV 7,322.27
5/1/97 901 Tag: A2999 SHIMADZU HP 14,000.75
5/1/97 908 Tag: A3004 COMPLETE 11 30,809.28
6/1/97 933 Tag: A3083 PS API150 M 91,119.23
6/1/97 939 Tag: A3081 HYDRA-96 RB 13,801.88
6/1/97 944 Tag: A3090 BALANCE MET 2,600.79
6/1/97 945 Tag: A4733 VACUUM DONT 766.77
7/1/97 952 Tag: A3088 CONTROLLER 1,182.42
7/1/97 954 Tag: A2907 HP 8453 UV 7,275.54
8/1/97 977 Tag: A8131 VACUUM PUMP 1,267.57
9/1/97 997 Tag: A4890 4 SETS SURG 4,650.05
10/l/97 1036 Tag: A4824 ROLIFT WALK 3,867.49
11/l/97 1049 Tag: X0000 XXXXX-00 XX 10,870.01
12/1/97 1081 Tag: A3229 2 PCS VAGUU 2,097.00
12/1/97 1083 Tag: A3201 215GILSON 8,299.56
12/1/97 1086 Tag: A3240 REFRIGERATO 785.54
12/1/97 1087 Tag: A3227 2 PCS XXXXX 3,798.84
12/1/97 1088 Tag: A3223 4 PCS MODIF 2,061.08
12/1/97 1089 Tag: A3218 4 PCS CUXTO 5,770.56
12/1/97 1090 Tag: A3232 2 PCS DIAPH 1,082.08
12/1/97 1094 Tag: A3235 MASTERPRO B 1,060.86
12/1/97 1096 Tag: A3944 ANALYTICAL 1,433.66
1/1/98 1103 Tag: A3236 PUMPRV 5 T 635.23
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
973.49 143.18
7,915.98 1,199.38
4,203.66 636.97
902.27 136.71
61,437.94 9,308.79
1,063.34 161.11
1,507.99 228.49
2,613.27 395.95
1,306.64 197.98
853.17 129.26
833.60 126.31
40,250.35 6,088.54
3,593.04 561.41
3,593.04 561.41
3,593.04 561.41
2,210.82 345.44
34,372.88 5,370.76
6,332.78 989.49
12,000.64 2,000.11
26,407.95 4,401.33
77,714.22 13,399.01
11,712.19 2,029.69
2,218.32 382.47
654.01 112.76
1,003.26 179.16
6,173.18 1,102.36
1,069.51 198.05
3,900.04 750.01
3,222.90 644.59
8,995.87 1,874.14
1,722.54 374.46
6,817.50 1,482.06
645.27 140.27
3,120.48 678.86
1,693.03 368.05
4,740.10 1,030.46
838.84 193.24
871.42 189.44
1,177.65 256.01
517.59 117.64
5.
17
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
1/1/98 1109 Tag: OT137 TREEZEMOBIL 6,409.45
1/1/98 1118 Tag: N/A GENEVAC HT 30,133.64
2/1/98 1122 Tag: A3251 FLEXCHEM RO 4,174.84
2/1/98 1123 Tag: A3249 FLEXCHEM RO 5,863.54
2/1/98 1124 Tag: A3252 TECAN GENES 43,137.58
2/1/98 1129 Tag: A3253 DELLOPTIFL 1,486.06
3/1/98 1150 Tag: A3272 HYDRA - 96 R 9,336.56
4/1/98 1159 Tag: A6018 RECIPROCAL 487.99
4/1/98 1160 Tag: A6019 RECIPROCAL 487.99
4/1/98 1183 Tag: A6160 RECIPROCAL 487.99
2/6/97 1196 Tag: SF146 Xxxxx for c 31,48l.24
5/1/98 1200 Tag: A7055 API150 MAS 55,391.72
5/1/98 1201 Tag: A6297 215LIQUID 7,265.17
5/1/98 1203 Tag: A6307 HYDRA-96R 8,589.63
5/1/98 1206 Tag: A6732 ENHANCED DA 886.77
5/1/98 1207 Tag: A6731 SYSTEM CONT 4,082.23
5/1/98 1212 Tag: A6450 SEDEX 55 E. 6,390.75
5/1/98 1213 Tag: A6595 SEDEX 55 E. 6,390.75
5/1/98 1214 Tag: A6584 HP BINARY P 4,926.73
5/1/98 1215 Tag: A6585 HP BINARY P 4,926.72
5/1/98 1216 Tag: A6586 HP 1100 VAC 966.02
5/1/98 1217 Tag: A6585 HP 1100 VAC 966.02
5/1/98 1218 Tag: A6588 HP 1100 THE 1,616.07
5/1/98 1219 Tag: A6589 HP 1100 THE 1,616.07
5/1/98 1220 Tag: A6590 HP 1100 DIOD 4,926.72
5/1/98 1221 Tag: A6591 HP 1100 DIOD 4,926.72
5/1/98 1222 Tag: A6440 HP 1100 BINA 4,926.72
5/1/98 1223 Tag: A6441 HP 1100 VAC 966.02
5/1/98 1224 Tag: A6442 HP 1100 AUT 3,703.09
5/1/98 1225 Tag: A6444 HP 110 DIOD 5,423 83
5/1/98 1226 Tag: A6443 HP 1100 THE 972.05
5/1/98 1227 Tag: A6445 SINGLE lNST 5,960.38
8/1/98 1375 Tag: A7032 RAININ GRAD 19,562.29
9/1/98 1381 Tag: A7011 SERIAL TEAC 382.23
10/1/98 1414 Tag: A7067 Pump corrosion resistant 813.43
10/1/98 1431 Tag: A7074 HYDRA 96 FL 6,941.53
10/1/98 1432 Tag: A7069 RECIPROCAL 353.16
10/1/98 1433 Tag: A7070 RECIPROCAL 353.16
10/1/98 1434 Tag: A7071 RECIPROCAL 353.17
10/1/98 1440 Tag: N/A IMPACRT 2-8 704.32
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
5,211.41 1,196.04
24,553.33 5,580.31
3,371.98 802.86
4,735.93 1,127.61
34,841.89 8,295.69
1,200.27 285.79
7,469.25 1,867.31
386.33 101.66
386.33 101.66
386.33 101.66
27,338.98 4,142.26
43,350.03 12,041.69
5,685.78 1,579.39
6,722.32 1,867.31
693.99 192.78
3,194.79 887.44
5,001.46 1,389.29
5,001.46 1,389.29
3,855.69 1,071.04
3,855.69 1,071.03
756.01 210.01
756.01 210.01
1,264.75 351.32
1,264.75 351.32
3,855.69 1,071.03
3,855.69 1,071.03
3,855.69 1,071.03
756.01 210.01
2,898.07 805.02
4,244.74 1,179.09
760.74 211.31
4,664.64 1,295.74
14,871.71 4,890.58
281.64 100.59
587.47 225.96
5,013.32 1,928.21
255.06 98.10
255.06 98.10
255.06 98.11
508.68 195.64
6.
18
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00 0
10/1/98 1441 Tag: N/A IMPACT 2-12 773.11
10/1/98 1442 Tag: A7078 TOWDOOR RE 534.26
10/1/98 1443 Tag: A7081 HYDRA 96 DI 6,941.53
11/1/98 1449 Tag: A7066 HP 35900E A 857.59
11/1/98 1459 Tag: A7087 Reciprocal 336.45
12/1/98 1488 Tag: A7099 BUCHI MODEL 879.71
12/1/98 1489 Tag: A7100 BUCHI MODEL 879.71
12/1/98 1490 Tag: A7101 BUCHI MODEL 879.71
12/1/98 1491 Tag: A7102 BUCHI MODEL 879.71
12/1/98 1493 Tag: A7103 BALANCE-S 732.67
12/1/98 1496 Tag: A7094 HT 12EVAPOR 28,292.51
12/1/98 1497 Tag: A7470 DIGITAL VAC 327.26
12/1/98 1498 Tag: A7108 DIGITAL VAC 327.25
1/1/99 1508 Tag: A7109 WORKSTATION 592.08
1/1/99 1511 Tag: A7114 MODULINE 12 446.28
12/7/98 4902 Tag. A7117 LabEq Ove 546.07
11/18/98 4905 Tag: A7110 Reciprocal 294.80
2/5/99 4908 Tag: A7155 LabEq-Frz 1,289.09
2/5/99 4909 Tag: A7156 LabEq Frz 1,289.09
2/23/99 5024 Tag: A7160 LabEq Free 3,230.79
2/23/99 5025 Tag: A7161 LabEq Unit 4,970.32
2/23/99 5026 Tag: LabEq Gene 2,680.22
2/24/99 5027 Tag: LabEq Fume 4,233.18
3/9/99 5039 Tag: A7162 LabEq Auto 4,421.39
3/24/99 5054 Tag: A7168 LabEq Acqu 2,844.78
3/24/99 5055 Tag: X0000 XxxXx XXX 2,938.66
3/24/99 5056 Tag: A7168 LabEq Jus 283.54
3/15/99 5079 Tag: LabEq HPLC 16,428.58
6/11/99 5088 Tag: A7202 LabEq Flex 7,250.05
5/28/99 5095 Tag: A7198 LabEq Lang 264.87
1/19/99 5204 Tag: 7163 LabEq HPLC 13,471.66
7/19/99 5227 Tag: A8020 LabEq HPLC 7,403.76
5/18/99 5229 Tag: A7170 LabEq Rel 289.59
7/21/99 5239 Tag: LabEq Auto 6,902.01
12/15/98 5252 Tag: A7110 LabEq Shak 577.22
1/7/99 5254 Tag: A7128 LabEq Vacu 593.17
1/7/99 5255 Tag: A7124 LabEq Auto 2,264.11
1/7/99 5256 Tag: A7125 LabEq Ther 596.84
1/7/99 5257 Tag: A7126 LabEq Vari 1,379.65
8/25/99 5297 Tag: A2026 LabEq Bala 412.59
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
558.35 214.76
385.85 148.41
5,013.32 1,928.21
605.35 252.24
237.49 98.96
604.80 274.91
604.80 274.91
604.80 274.91
604.80 274.91
503.71 228.96
16,013.60 7278.91
224.99 102 27
224.98 102.27
394.72 197.36
297.52 148.76
318.05 228.02
171.70 123.10
708.30 580.79
708.30 580.79
1,775.16 1,455.63
2,730.95 2,239.37
1,472.65 1,207.57
2,325 92 1,907.26
2,368 60 2,052.79
1,524.00 1,320.78
1,574.28 1,364.38
151.80 131.64
8801.02 7,627.56
3,222.24 4,027.81
132.43 132.44
7,031.33 6,440.53
2,776.41 4,627.35
135.41 154.45
2,588.25 4,313.76
284.31 292.91
279.63 313.54
1,067.37 1,196.74
281.37 315.47
650.40 729.25
117.88 294.71
7.
19
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
10/4/99 5322 Tag: A8033 Impact Exp 112.32
10/4/99 5323 Tag: A8034 Impact Exp 112.32
10/4/99 5324 Tag A8035 Impact 2-12 111.15
10/4/99 5325 Tag: A8036 Impact 2-12 111.15
10/4/99 5326 Tag: A8037 Impact 2-12 111.15
10/5/99 5327 Tag: A8038 Impact 2 8 101.65
10/5/99 5328 Tag: A8039 Impact 2 8 101.65
10/5/99 5329 Tag: A8040 Impact 2 8 101.65
9/29/99 5338 Tag: A8032 LabEq Isop 4,877.46
9/21/99 5339 Tag: LabEq Isop 4,877.81
12/1/99 5349 Tag: RECV LabEq Fume 7,943.94
11/29/99 5355 Tag: A8057 LabEq Serf 130.47
12/6/99 5356 Tag: A8059 LabEq Chro 301.20
12/10/99 5637 Tag: A8063 Lab Funn 95.22
12/17/99 5638 Tag: A8064 LabEq RS23 100.29
12/30/99 5639 Tag: A8073 LabEq Save 1,147.17
12/30/99 5640 Tag: A8074 LabEq Save 1,147.17
1/13/00 5642 Tag: A8077 LabEq Save 770.70
1/13/00 5643 Tag: A8078 LabEq Save 770.70
12/2/99 5645 Tag: A8060 LabEq Pon 165.57
12/7/99 5647 Tag: A8061 LabEq Oxyg 132.84
1/11/00 5648 Tag: A8079 LabEq Save 752.96
1/10/00 5649 Tag: A8065 LabEq Free 65.14
12/1/99 5650 Tag: A8057 LabEq Recip 62.27
12/1/99 5651 Tag: A8058 LabEq Recl 62.27
2/2/00 5692 Tag: A3238 LabEq Fast Stack 130.00
Microlrlre
1/4/00 5693 Tag: A8066 LabEq H B 1,290.78
11/16/99 5694 Tag: A8042 2000 Lab Eq HP B 1,139.80
1/26/00 5695 Tag: A2228 2000 Lab Eq Optx 578.82
2/5/00 5713 A8064 Lab Eq RS232 Interface 40.83
1/17/00 5719 Tag: A8082 2000 Speedvac sy 413.21
2/22/00 5720 A8097 Lab Eq Oven frg micro 94.57
vacuum
3/17/00 5767 A8115 Lab Eq Advanced Video
Microsoft
Furniture 9/30/93 32 Tag: A3912 6 Flexion I 2,321.00
5/30/94 35 Tag A2853 1 Modular F 9,905.61
6/30/96 55 Tag SEE C 40 Concert 13,776.61
7/31/96 58 Tag: A3973 6 Superior 2,221.50
9/1/97 1013 Tag: SEE C 4 PCS TASK 536.92
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
112.32
112.32
111.15
111.15
111.15
101.65
101.65
101.65
812.91 4,064.55
812.91 4,064.90
7,943.94
130.47
301.20
95.22
100.29
1,147.17
1,147.17
770.70
770.70
165.57
132.84
752.96
65.14
62.27
62.27
130.00
1,290.76
1,139.80
413.21
40.83
413.21
94.57
1,597,063.05 1,368,647.24 -
Furniture 2,321.00 -
9,905.61 -
12,279.15 1,497.45
1,974.66 246.84
450.32 86.60
8.
20
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
9/1/97 1027 Tag: A3150 6 PCS CHAIR 593.97
11/1/97 1047 Tag: SEE C 20 PCS OFFI 2,320.96
11/1/97 1048 Tag: SEE C 10 GUEST CH 636.75
7/1/98 1051 Tag: SEE C 10 pcs office chair 1,160.49
burgundy
10/1/98 1271 Tag: N/A BOBREED's 3,809.54
4/1/99 1428 Tag: N/A FURNITURE F 1,460.30
12/1/99 5057 Tag: Fn Glassware 679.80
Fixture 4/12/99 5350 Tag: Retrofit Ex 447.66
7/1/96 5096 Tag: Fx Frames I 396.44
5/31/93 3258 Tag: 1501 Storage Ser 67,312.50
5/31/93 1581 Tag: A1035 800Per Mon 155.00
6/30/93 1592 Tag: A4078 Chromatogra 2,441.00
6/30/93 1630 Tag: A5408 6 Tables 221.39
6/30/93 1631 Tag: A5000 6 Tables 221.39
6/30/93 1632 Tag: A3867 6 Tables 221.39
6/30/93 1633 Tag: A3871 5 Tables 202.67
6/30/93 1640 Tag: A2995 LaserWriter 2,597.99
7/31/93 1652 Tag: A2080 Rotary Cull 430.10
7/31/93 1661 Tag: A4777 Tekmar Spee 298.00
7/31/93 1662 Tag: A4778 Electrophor 785.00
7/31/93 1675 Tag: A4779 604U-R Auto 3,137.00
7/31/93 1677 Tag: A4780 Rotor Horiz 561.00
7/31/93 1678 Tag: A2229 VacGage w- 273.27
7/31/93 1679 Tag: A4781 Rotor- Hori 329.00
7/31/93 1680 Tag: A4782 Trunnion Ri 52.00
7/31/93 1681 Tag: A4783 Trunnion Ri 52.00
7/31/93 1682 Tag: A4784 Shield - Sea 289.76
7/31/93 1691 Tag: A2243 AirSensor 1,013.60
7/31/93 1701 Tag: A1174 Retriever 5 950.00
7/31/93 1713 Tag: A4872 Omnigene Th 5,290.00
7/31/93 1716 Tag: A4787 GenePulser 920.00
7/31/93 1734 Tag: A4882 Pre-Filter 211.20
7/31/93 1736 Tag: A4752 HR Flow Cel 1,352.00
9/30/93 1763 Tag: A3284 Diluter 799 2,771.00
9/30/93 1770 Tag: A5479 Sony CB-0008 2,310.00
12/31/93 1796 Tag: A1748 Water Aspir 1,618.76
12/31/93 1802 Tag: A2753 110gBalanc 1,420.00
4/30/94 1852 Tag: A2724 Bio Pilot 55,128.22
4/30/94 1856 Tag: A3979 LaserWriter 4,371.00
4/30/94 1862 Tag: A3945 Computers 2,780.00
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
498.16 95.81
1,920.80 400.16
526.96 109.79
960.40 200.09
2,802.50 907.04
1,054.66 405.64
353.15 326.65
Fixture 39,930.51 35,208.77 447.66
396.44 205.44 205.44 191.00
67,312.50 59,833.33 59,833.33 7,479.17 Transfer GLI
155.00 -
2,441.00 -
221.39 -
221.39 -
221.39 -
202.67 -
2,597.99 -
430.10 -
298.00 -
785.00 -
3,137.00 -
561.00 -
273.27 -
329.00 -
52.00 -
52.00 -
289.76 -
1,013.60 -
950.00 -
5,290.00 -
920.00 -
211.20 -
1,352.00 -
2,771.00 -
2,310.00 -
1,618.76 -
1,420.00 -
55,128.22 -
4,371.00 -
2,780.00 -
9.
21
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
IN SERVICE SYSTEM LTD DEPR
DATE ASSET # TAG # DESCRIPTION 3/31/00
4/30/94 1870 Tag: A3933 Laminar Flo 11,952.44
4/30/94 1871 Tag: A3937 PD pumps 3,309.25
4/30/94 1873 Tag: A1825 Ultraliter 13,898.50
4/30/94 1876 Tag: A3931 Nalgene Tan 11,444.50
4/30/94 1877 Tag: A3946 Flowmeters 11,313.00
8/31/94 1883 Tag: A3913 Osmometer 4,236.00
7/31/95 1902 Tag: KH558 NMR-270 195,000.00
Leased Furniture 4/30/93 1545 Tag: A5442 Corner Tabl 59.00
5/31/93 1550 Tag: A5568 Holga 5 Dra 3,935.65
5/31/93 1557 Tag: A4080 8 Xxxxxx Xx 1,776.00
6/30/93 1558 Tag: A1351 Desk Chair- 458.25
6/30/93 1561 Tag: A4082 Desk Chair- 458.25
6/30/93 1562 Tag: A4083 Desk Chair- 458.25
8/31/93 1570 Tag: A3865 5-5 Table 1,013.35
8/31/93 1573 Tag: A1705 36562WorksI 424.68
Leasehold Impr Bd 3/31/94 279 Tag: A3934 Vacuum For 2,918.00
1/31/95 284 Tag: A4073 Hood-Peptide Lab 7,462.00
2/28/95 285 Tag: A3938 Exhaust Hoo 2,320.00
4/30/94 70 Tag: A1951 42 Round ch 982.55
8/31/91 71 Tag: SEE C 12 Ergon Mg 2,971.80
8/31/91 74 Tag: A5343 12 Ergon Mg 2,971.80
8/31/91 75 Tag: SEE C 00 Xxxxx Xx 2,670.00
9/30/91 81 Tag: A5431 2 30x60 Sin 1,074.00
7/1/97 967 Tag: A4873 KODAK EKTAG 620.24
9/1/97 1024 Tag: A4072 4 PCS OVERH 713.65
9/1/97 1025 Tag: A3400 3 PCS EKTAG 1,122.50
10/1/97 1031 Tag: A3145 2 PCS XEROX 2,261.36
Leasehold Impr Bd 10/31/99 various various Oyster Point LI (55% of 2,198,350.41
54114
3/31/00 Oyster Point LI (55% of
5415877.38)
SOFTWARE 9/30/95 9 Tag: A4786 1 BIOSYM 43,253.56
3/5/99 5099 Tag: Software Mi 1,203.57
--------------
4,570,643.82
==============
AXYS ADVANCED TECHNOLOGY
FIXED ASSET DEPRECIATION ADDITIONS
FROM 10/31/99 TO 3/31/2000
ADDT'L
DEPR FR
ADDT'L DEPR
GL BALANCE ACCUM DEPR GL BALANCE FR 10/31/99
3/31/00 10/31/99 10/31/99 TO 3/31/2000
11,952.44 -
3,309.25 -
13,898.50 -
11,444.50 -
11,313.00 -
4,236.00 -
343,557.43 195,000.00 343,557.43 -
Leased Furniture 59.00 -
3,935.65 -
1,776.00 -
458.25 -
458.25 -
458.25 -
1,013.35 -
8,583.43 424.68 8,583.43 -
Leasehold Impr Bd 2,918.00 -
7,462.00
12,700.00 2,320.00 12,700.0 -
982.55 -
2,971.80 -
2,971.80 -
2,670.00 -
1,074.00 -
526.26 93.98
598.54 115.11
941.46 181.04
15,387.90 1,884.47 14,620.88 376.89
Leasehold Impr Bd 2,198,350.41 2,050,748.85 2,050,748.85 147,601.55
SOFTWARE 43,253.56 -
44,457.13 644.76 43,898.32 558.81
----------------------------------------------------------------------
4,570,643.82 4,161,085.92 4,161,085.92 409,557.90
======================================================================
10.
22
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
COMPUTER 2/28/93 112 Tag: A2077 1 Indigo 16 27,000.00 27,000.00
----------------------------------------------------------------------------------------------------------------------------------
10/31/93 120 Tag: A1641 INDIGO 2 19,157.50 19,157.50
----------------------------------------------------------------------------------------------------------------------------------
10/31/93 123 Tag: A1470 INDIGO 15,010.00 15,010.00
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 172 Tag: A1654 1 CPU Mac O 4,290.00 4,290.00
----------------------------------------------------------------------------------------------------------------------------------
12/31/94 197 Tag: A1747 1 HPLaserj 2,159.59 2,159.59
----------------------------------------------------------------------------------------------------------------------------------
1/31/95 198 Tag: A1754 Computer - A 3,342.20 3,342.20
----------------------------------------------------------------------------------------------------------------------------------
5/31/95 203 Tag: A4994 Computer - P 4,883.15 4,883.15
----------------------------------------------------------------------------------------------------------------------------------
12/31/95 229 Tag: A4826 1 COMPUTER 1052.12 1052.12
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 241 Tag: A4075 2 computer 3,852.67 3,852.67
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 248 Tag: A2248 2 Powermac 11,092.74 11,092.74
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 251 Tag: A2349 3 Powermac 12,094.05 12,094.05
----------------------------------------------------------------------------------------------------------------------------------
9/30/96 266 Tag: A5443 Monitor 2,110.64 2,110.64
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 728 Tag: A3067 POWERMAC 76 3,214.48 3,214.48
----------------------------------------------------------------------------------------------------------------------------------
1/1/97 765 Tag: A2352 POWERMAC 72 3,145.64 3,145.64
----------------------------------------------------------------------------------------------------------------------------------
1/1/97 766 Tag: A3070 POWERMAC 76 13,548.05 13,548.05
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 794 Tag: A2712 DELLDIMENS 2,134.69 2,134.69
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 804 Tag: A2231 MONITOR SM 936.27 936.27
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 859 Tag: A4996 4PCS sparc 26,785.79 26,785.79
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 860 Tag: A2452 APPLE POWER 7,794.36 7,794.36
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 880 Tag: A2709 2 PCS DELL 8,963.14 8,963.14
----------------------------------------------------------------------------------------------------------------------------------
5/1/97 922 Tag: A2852 DELL6200-O 3,951.13 3,951.13
----------------------------------------------------------------------------------------------------------------------------------
9/1/97 1011 Tag: A2313 5 PCS POWER 16,082.24 16,082.24
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1192 Tag: A6162 POWERMAC G3 2,966.90 2,966.90
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1193 Tag: A6163 MONITOR SON 1,250.04 1,250.04
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1194 Tag: A6161 HP DESKJET 2,137.50 2,137.50
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1195 Tag: A6296 POWERBOOK G 5,902.76 5,902.76
----------------------------------------------------------------------------------------------------------------------------------
7/1/98 1295 Tag: A7027 HP LASERJET 1,535.24 1,535.24
----------------------------------------------------------------------------------------------------------------------------------
9/1/98 1383 Tag: A6814 DELLXPS 26 1,867.34 1,867.34
----------------------------------------------------------------------------------------------------------------------------------
9/1/98 1405 Tag: A7059 4000N PRINT 1,223.23 1,223.23
----------------------------------------------------------------------------------------------------------------------------------
9/1/98 1406 Tag: A7060 4000N PRINT 1,223.22 1,223.22
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1438 Tag: A7080 POWERBOOK G 6,439.33 6,439.33
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 2434 Tag: 1769 Server U2-2 19,804.08 19,804.08
----------------------------------------------------------------------------------------------------------------------------------
7/1/96 3259 Tag: 1501 Computer 5,914.50 (5,914.50)
----------------------------------------------------------------------------------------------------------------------------------
3/31/98 4587 Tag: 3736 Server Sun 53,276.74 53,276.74
----------------------------------------------------------------------------------------------------------------------------------
11/30/98 4772 Tag: 2929 Unipack B 1,261.09 1,261.09
----------------------------------------------------------------------------------------------------------------------------------
11/30/98 4773 Tag: 2928 Unipack 9 1,281.09 1,281.09
----------------------------------------------------------------------------------------------------------------------------------
1/22/99 4979 Tag: A6978 CompEq Son 470.89 470.89
----------------------------------------------------------------------------------------------------------------------------------
1/22/99 4980 Tag: A6975 CompEq Pow 2,590.42 2,590.42
----------------------------------------------------------------------------------------------------------------------------------
11.
23
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
8/27/99 5286 Tag. A8028 Computer PI 2,817.75 2,817.75
----------------------------------------------------------------------------------------------------------------------------------
8/27/99 5287 Tag: A8029 Computer PI 2,817.75 2,817.75
----------------------------------------------------------------------------------------------------------------------------------
8/27/99 5288 Tag: A8028 Computer 17 475.11 475.11
----------------------------------------------------------------------------------------------------------------------------------
8/27/99 5289 Tag: A8029 Computer 17 475.12 475.12
----------------------------------------------------------------------------------------------------------------------------------
9/14/99 5299 Tag: A6811 Computer De 11,305.58 11,305.58
----------------------------------------------------------------------------------------------------------------------------------
10/20/99 5331 Tag: A8044 SSFCompute 1,523.82 1,523.82
----------------------------------------------------------------------------------------------------------------------------------
3/10/00 5764 Tag: A8111 Comp Eq 21" monitor 768.58 768.58
----------------------------------------------------------------------------------------------------------------------------------
3/10/00 5765 Tag: A8109 Comp Eq Powermac G4 2,676.98 2,676.98
----------------------------------------------------------------------------------------------------------------------------------
3/10/00 5766 Tag: A8110 Comp Eq Powermac G4 2,676.98 2,676.98
----------------------------------------------------------------------------------------------------------------------------------
3/21/00 5768 Tag: A8112 Comp Eq Monitor TMX 412 1,980.32 1,980.32
----------------------------------------------------------------------------------------------------------------------------------
3/21/00 5769 Tag: A8113 Comp Eq Monitor TMX 412 321,139.95 1,980.32 325,308.63 1,980.32
----------------------------------------------------------------------------------------------------------------------------------
LAB EQUIPMENT 1/31/91 305 Tag: A2052 1 Sola Power 3,900.00 3,900.00
----------------------------------------------------------------------------------------------------------------------------------
9/30/92 306 Tag: X0000 0 Xxxxxxx Xx 4,454.85 4,454.85
----------------------------------------------------------------------------------------------------------------------------------
8/30/93 313 Tag: A3939 1 Portion No 4,000.00 4,000.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/95 323 Tag: A4874 TOMTEC DILU 21,222.41 21,222.41
----------------------------------------------------------------------------------------------------------------------------------
6/30/95 325 Tag: A2341 Vacuum Pump 1,299.00 1,299.00
----------------------------------------------------------------------------------------------------------------------------------
3/31/95 326 Tag: A2206 Freezer not 1,928.82 1,928.82
----------------------------------------------------------------------------------------------------------------------------------
10/31/95 331 Tag: A2841 Vacuum pump 1,407.25 1,407.25
----------------------------------------------------------------------------------------------------------------------------------
3/31/96 335 Tag: A1239 Turbo Pump 6,000.00 6,000.00
----------------------------------------------------------------------------------------------------------------------------------
3/31/96 340 Tag: A3941 GeneAmp-Oth 113.00 113.00
----------------------------------------------------------------------------------------------------------------------------------
11/30/95 343 Tag: A3940 1 Fumehoods 31,216.52 31,216.52
----------------------------------------------------------------------------------------------------------------------------------
11/30/95 349 Tag: A1920 Rotary evap 3,254.89 3,254.89
----------------------------------------------------------------------------------------------------------------------------------
11/30/95 354 Tag: A2757 Balance el 1,175.72 1,175.72
----------------------------------------------------------------------------------------------------------------------------------
11/30/95 358 Tag: A3252 2 HTS lab r 171,765.70 171,765.70
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 376 Tag: A2585 Concentralo 1,950.00 1,950.00
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 380 Tag: SF592 HPLCSystem 9,280.00 9,280.00
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 389 Tag: A4764 Balance BA 945.10 945.10
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 394 Tag: A1610 Parbal Bea 28,316.00 28,316.00
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 398 Tag: A4988 Shaker- env 5,722.25 5,722.25
----------------------------------------------------------------------------------------------------------------------------------
1/31/94 400 Tag: A4903 Adapter gl 170.00 170.00
----------------------------------------------------------------------------------------------------------------------------------
5/31/92 416 Tag: SF631 1HPLC Semi 54,745.51 54,745.51
----------------------------------------------------------------------------------------------------------------------------------
5/31/92 417 Tag: A2228 1Fenups un 16,602.56 16,602.56
----------------------------------------------------------------------------------------------------------------------------------
8/31/92 422 Tag: A3286 Vertishear 1,076.75 1,076.75
----------------------------------------------------------------------------------------------------------------------------------
8/31/92 433 Tag: A2489 Chromatogre 776.00 776.00
----------------------------------------------------------------------------------------------------------------------------------
2/28/93 437 Tag: A2515 2Roller Rac 7,002.00 7,002.00
----------------------------------------------------------------------------------------------------------------------------------
12/31/93 454 Tag: A2705 Environment 5,727.00 5,727.00
----------------------------------------------------------------------------------------------------------------------------------
12/31/93 463 Tag: A2603 Pipeltor e 704.95 704.95
----------------------------------------------------------------------------------------------------------------------------------
1/31/95 477 Tag: A1184 Pump - Vacuum 1,840.00 1,840.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/95 483 Tag: A2005 Vacuum Oven 2,730.00 2,730.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/95 497 Tag: A1991 SAMPLER DIL 14,522.80 14,522.80
----------------------------------------------------------------------------------------------------------------------------------
12.
24
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
6/30/95 499 Tag: SF717 HP1090 HPLC 62,002.77 62,002.77
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 517 Tag: A1137 Freezer Rel 6,099.00 6,099.00
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 521 Tag: A2722 Freezer Exp 1,500.00 1,500.00
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 537 Tag: A4881 Racks for C 5,450.00 5,450.00
----------------------------------------------------------------------------------------------------------------------------------
3/31/96 539 Tag: A4883 Composite R 9,300.00 9,300.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 562 Tag: A3942 BioSafety 9,989.51 9,989.51
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 564 Tag: A4754 4 306 pump 60,497.45 60,497.45
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 565 Tag: A4879 4 306 pump 58,960.65 58,960.65
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 567 Tag: A3948 215Sampler 16,139.83 16,139.83
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 569 Tag: A3923 Environment 7,207.56 7,207.56
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 584 Tag: A3238 Fluoslar re 29,456.84 29,456.84
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 586 Tag: A3243 Column The 4,256.75 4,256.75
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 591 Tag: A3943 Analytical 6,081.49 6,081.49
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 595 Tag: A3251 Saw-Isomer 3,794.71 3,794.71
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 599 Tag: A1708 Computer - C 3,637.63 3,637.63
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 601 Tag: X0000 XXXXXX 0XX 1,661.83 1,661.83
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 604 Tag: A2016 Powermac 75 3,432.56 3,432.56
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 606 Tag: A2039 Powermac 76 20,147.80 20,147.80
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 609 Tag: A2222 Powermac 76 14,471.89 14,471.89
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 632 Tag: A2200 Rotary Evap 3,750.86 3,750.86
----------------------------------------------------------------------------------------------------------------------------------
8/31/96 637 Tag: A2484 Oven-Vacuum 1,949.46 1,949.46
----------------------------------------------------------------------------------------------------------------------------------
9/30/95 644 Tag: A1173 Fraction Co 3,150.74 3,150.74
----------------------------------------------------------------------------------------------------------------------------------
10/31/93 646 Tag: A4901 Temperature 1,034.14 1,034.14
----------------------------------------------------------------------------------------------------------------------------------
10/31/93 656 Tag: A3983 Vacuum Pump 6,442.00 6,442.00
----------------------------------------------------------------------------------------------------------------------------------
10/31/93 658 Tag: A4765 Xxxxxxx Bat 3,030.00 3,030.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 665 Tag: A4068 Vacuunm Pump 1,030.40 1,030.40
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 668 Tag: A2706 Xxxxxx- env 1,022.58 1,022.58
----------------------------------------------------------------------------------------------------------------------------------
9/30/96 676 Tag: A4880 Pumphead 1,513.24 1,513.24
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 734 Tag: A4753 PUMPHEAD M 1,513.24 1,513.24
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 738 Tag: A2612 BALANCE XXX 2,715.99 2,715.99
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 739 Tag: A2613 ANALYTICAL 2,716.00 2,716.00
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 742 Tag: A2610 EVAPORATOR 3,278.89 3,278.89
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 743 Tag: A2621 EVAPORATOR 3,278.89 3,278.89
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 746 Tag: A3982 PUMP22 I-W 2,507.78 2,507.78
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 747 Tag: A3231 HYDRA 96 MI 20,026.25 20,026.25
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 753 Tag: A2635 ANALYTICAL 2,714.91 2,714.91
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 754 Tag: A2636 ROTARY EVAP 3,498.27 3,498.27
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 755 Tag: A2637 ROTARY EVAP 3,498.27 3,498.27
----------------------------------------------------------------------------------------------------------------------------------
12/1/96 756 Tag: A2676 ISOCRATIC P 5,520.75 5,520.75
----------------------------------------------------------------------------------------------------------------------------------
1/1/97 774 Tag: A2719 SHAKER- REC 4,004.17 4,004.17
----------------------------------------------------------------------------------------------------------------------------------
13.
25
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
1/1/97 778 Tag: A1829 BUCHI XXXXX 4,027.98 4,027.98
----------------------------------------------------------------------------------------------------------------------------------
1/1/97 779 Tag: A2749 XXXXXXX TOL 1,717.93 1,717.93
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 806 Tag: A2717 XXXXXX 215 14,392.65 14,392.65
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 808 Tag: A2748 BALANCE XXX 7,643.02 7,643.02
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 810 Tag: A2755 BALANCE XXX 1,640.51 1,640.51
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 817 Tag: A4884 2 HPLC 1100 111,705.35 111,705.35
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 818 Tag A2776 FREEZER EXP 1,933.35 1,933.35
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 819 Tag: A2782 DISPENSER W 2,741.80 2,741.80
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 822 Tag: A2804 PUMPVACUUM 4,751.40 4,751.40
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 823 Tag: A2803 PUMPVACUUM 2,375.70 2,375.70
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 827 Tag: A2718 SYRINGE PUM 1,551.22 1,551.22
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 839 Tag: A3924 SHAKER RECI 1,515.66 1,515.66
----------------------------------------------------------------------------------------------------------------------------------
2/1/97 841 Tag: X0000 000X-00 XX 73,182.45 73,182.45
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 844 Tag: A2774 UPRIGHT FRE 6,736.95 6,736.95
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 845 Tag: A2775 UPRIGHT FRE 6,736.95 6,736.95
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 846 Tag: A2810 UPRIGHT FRE 6,736.95 6,736.95
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 849 Tag: A2747 MODULINE 12 4,145.28 4,145.28
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 852 Tag: A4991 XXXXXX PREP 54,449.17 54,449.17
----------------------------------------------------------------------------------------------------------------------------------
3/1/97 881 Tag: A2901 SPEEDVAC EV 11,873.94 11,873.94
----------------------------------------------------------------------------------------------------------------------------------
5/1/97 901 Tag: A2999 SHIMADZU HP 24,001.30 24,001.30
----------------------------------------------------------------------------------------------------------------------------------
5/1/97 908 Tag: A3004 COMPLETE 11 52,815.89 52,815.89
----------------------------------------------------------------------------------------------------------------------------------
6/1/97 933 Tag: A3083 PS API150 M 160,788.07 160,788.07
----------------------------------------------------------------------------------------------------------------------------------
6/1/97 939 Tag: A3081 HYDRA-96 RB 24,356.25 24,356.25
----------------------------------------------------------------------------------------------------------------------------------
6/1/97 944 Tag: A3090 BALANCE MET 4,589.63 4,589.63
----------------------------------------------------------------------------------------------------------------------------------
6/1/97 945 Tag: A4733 VACUUM CONT 1,353.13 1,353.13
----------------------------------------------------------------------------------------------------------------------------------
7/1/97 952 Tag: A3088 CONTROLLER 2,149.86 2,149.86
----------------------------------------------------------------------------------------------------------------------------------
7/1/97 954 Tag: A2907 HP 8453 UV 13,228.25 13,228.25
----------------------------------------------------------------------------------------------------------------------------------
8/1/97 977 Tag: A3131 VACUUM PUMP 2,376.70 2,376.70
----------------------------------------------------------------------------------------------------------------------------------
9/1/97 997 Tag: A4890 4 SETS SURG 9,000.11 9,000.11
----------------------------------------------------------------------------------------------------------------------------------
10/1/97 1036 Tag: A4824 ROLIFT WALK 7,734.95 7,734.95
----------------------------------------------------------------------------------------------------------------------------------
11/1/97 1049 Tag: A3204 HYDRA-96 FL 22,489.65 22,489.65
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1081 Tag: A3229 2 PCS VACUU 4,493.60 4,493.60
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1083 Tag: A3201 215GILSON 17,784.80 17,784.80
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1086 Tag: A3240 REFRIGERATO 1,683.29 1,683.29
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1087 Tag: A3227 2 PCS XXXXX 8,140.40 8,140.40
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1088 Tag: A3223 4 PCS MODIF 4,416.60 4,416.60
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1089 Tag: A3219 4 PCS CUXTO 12,365.50 12,365.50
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1090 Tag: A3232 2 PCS DIAPH 2,318.72 2,318.72
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1094 Tag: A3235 MASTERPRO B 2,273.25 2,273.25
----------------------------------------------------------------------------------------------------------------------------------
12/1/97 1096 Tag: A3944 ANALYTICAL 3,072.14 3,072.14
----------------------------------------------------------------------------------------------------------------------------------
14.
26
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
1/1/98 1103 Tag: A3236 PUMPRV 5 T 1,411.58 1,411.58
----------------------------------------------------------------------------------------------------------------------------------
1/1/98 1109 Tag: SF137 FREEZEMOBIL 14,376.56 14,376.56
----------------------------------------------------------------------------------------------------------------------------------
1/1/98 1118 Tag: N/A GENEVAC HT 66,963.63 66,963.63
----------------------------------------------------------------------------------------------------------------------------------
2/1/98 1122 Tag: A3251 FLEXCHEM RO 9,634.25 9,634.25
----------------------------------------------------------------------------------------------------------------------------------
2/1/98 1123 Tag: A3249 FLEXCHEM RO 13,531.25 13,531.25
----------------------------------------------------------------------------------------------------------------------------------
2/1/98 1124 Tag: A3252 TECAN GENES 99,548.25 99,548.25
----------------------------------------------------------------------------------------------------------------------------------
2/1/98 1129 Tag: A3253 DELLOPTIFL 3,429.35 3,429.35
----------------------------------------------------------------------------------------------------------------------------------
3/1/98 1150 Tag: A3272 HYDRA-96 R 22,407.75 22,407.75
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1159 Tag: A6018 RECIPROCAL 1,219.98 1,219.98
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1160 Tag: A6019 RECIPROCAL 1,219.98 1,219.98
----------------------------------------------------------------------------------------------------------------------------------
4/1/98 1183 Tag: A6160 RECIPROCAL 1,219.98 1,219.98
----------------------------------------------------------------------------------------------------------------------------------
2/6/97 1196 Tag: SF146 Xxxxx for C 49,707.23 49,707.23
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1200 Tag: A7055 API150 MAS 144,500.12 144,500.12
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1201 Tag: A6297 215LIQUID 18,952.58 18,952.58
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1203 Tag: A6307 HYDRA 96R 22,407.75 22,407.75
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1206 Tag: A6732 ENHANCED DA 2,313.30 2,313.30
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1207 Tag: A6731 SYSTEM CONT 10,649.28 10,649.28
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1212 Tag: A6450 SEDEX 55 E. 16,671.50 16,671.50
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1213 Tag: A6595 SEDEX 55 E. 16,671.50 16,671.50
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1214 Tag: A6584 HP BINARY P 12,852.32 12,852.32
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1215 Tag: A6585 HP BINARY P 12,852.31 12,852.31
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1216 Tag: A6586 HP 1100 VAC 2,520.06 2,520.06
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1217 Tag: A6585 HP 1100 VAC 2,520.06 2,520.06
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1218 Tag: A6688 HP 1100 THE 4,215.85 4,215.85
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1219 Tag: A6589 HP 1100 THE 4,215.85 4,215.85
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1220 Tag: A6590 HP 1100 DIOD 12,852.31 12,852.31
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1221 Tag: A6591 HP 1100 DIOD 12,852.31 12,852.31
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1222 Tag: A6440 HP 1100 BINA 12,852.31 12,852.31
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1223 Tag: A6441 HP 1100 VAC 2,520.06 2,520.06
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1224 Tag: A6442 HP 1100 AUT 9,660.23 9,660.23
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1225 Tag: A6444 HP 110 DIOD 14,149.09 14,149.09
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1226 Tag: A6443 HP 1100 THE 2,535.80 2,535.80
----------------------------------------------------------------------------------------------------------------------------------
5/1/98 1227 Tag: A6445 SINGLE lNST 15,548.78 15,548.78
----------------------------------------------------------------------------------------------------------------------------------
8/1/98 1375 Tag: A7032 RAININ GRAD 58,686.87 58,686.87
----------------------------------------------------------------------------------------------------------------------------------
9/1/98 1381 Tag: A7011 SERIAL TEAC 1,206.99 1,206.99
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1414 Tag: A7067 Pump corrosion resistant 2,711.47 2,711.47
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1431 Tag: A7074 HYDRA 96 FL 23,138.44 23,138.44
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1432 Tag: A7069 RECIPROCAL 1,177.22 1,177.22
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1433 Tag: A7070 RECIPROCAL 1,177.22 1,177.22
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1434 Tag: A7071 RECIPROCAL 1,177.23 1,177.23
----------------------------------------------------------------------------------------------------------------------------------
15.
27
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1440 Tag: N/A IMPACT 2-8 2,347.72 2,347.72
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1441 Tag: N/A IMPACT 2-12 2,577.03 2,577.03
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1442 Tag: A7078 TOWDOOR RE 1,780.88 1,780.88
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1443 Tag: A7081 HYDRA 96 DI 23,138.44 23,138.44
----------------------------------------------------------------------------------------------------------------------------------
11/1/98 1449 Tag: A7066 HP 3590E A 3,026.77 3,026.77
----------------------------------------------------------------------------------------------------------------------------------
11/1/98 1459 Tag: A7087 Reciprocal 1,187.52 1,187.52
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1488 Tag. A7099 BUCHI MODEL 3,298.95 3,298.95
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1489 Tag: A7100 BUCHI MODEL 3,298.95 3,298.95
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1490 Tag: A7101 BUCHI MODEL 3,298.95 3,298.95
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1491 Tag: A7102 BUCHI MODEL 3,298.96 3,298.96
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1493 Tag: A7103 BALANCE-S 2,747.54 2,747.54
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1496 Tag: A7094 HT 12EVAPOR 87,346.93 87,346.93
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1497 Tag: A7470 DIGITAL VAC 1,227.23 1,227.23
----------------------------------------------------------------------------------------------------------------------------------
12/1/98 1498 Tag: A7108 DIGITAL VAC 1,227.22 1,227.22
----------------------------------------------------------------------------------------------------------------------------------
1/1/99 1508 Tag: A7109 WORKSTATION 2,368.34 2,368.34
----------------------------------------------------------------------------------------------------------------------------------
1/1/99 1511 Tag: A7114 MODULINE 12 1,785.15 1,785.15
----------------------------------------------------------------------------------------------------------------------------------
12/7/98 4902 Tag: A7117 LabEq Ove 2,226.28 2,226.28
----------------------------------------------------------------------------------------------------------------------------------
11/18/98 4905 Tag: A7110 Reciprocal 1,201.92 1,201.92
----------------------------------------------------------------------------------------------------------------------------------
2/5/99 4908 Tag: A7155 LabEq-Frz 5,949.67 5,949.67
----------------------------------------------------------------------------------------------------------------------------------
2/5/99 4909 Tag: A7156 LabEq Frz 5,949.67 5,949.67
----------------------------------------------------------------------------------------------------------------------------------
2/23/99 5024 Tag: A7160 LabEq Free 14,911.39 14,911.39
----------------------------------------------------------------------------------------------------------------------------------
2/23/99 5025 Tag: A7161 LabEq Unit 22,940.00 22,940.00
----------------------------------------------------------------------------------------------------------------------------------
2/23/99 5026 Tag LabEq Gene 12,370.23 12,370.23
----------------------------------------------------------------------------------------------------------------------------------
2/24/99 5027 Tag LabEq Fume 19,537.74 19,537.74
----------------------------------------------------------------------------------------------------------------------------------
3/9/99 5039 Tag: A7162 LabEq Auto 22,106.92 22,106.92
----------------------------------------------------------------------------------------------------------------------------------
3/24/99 5054 Tag: A7168 LabEq Acqu 14,223.88 14,223.88
----------------------------------------------------------------------------------------------------------------------------------
3/24/99 5055 Tag: X0000 XxxXx XXX 14,693.27 14,693.27
----------------------------------------------------------------------------------------------------------------------------------
3/24/99 5056 Tag: A7168 LabEq Jus 1,417.65 1,417.65
----------------------------------------------------------------------------------------------------------------------------------
3/15/99 5079 Tag: LabEq HPLC 82,142.85 82,142.85
----------------------------------------------------------------------------------------------------------------------------------
6/11/99 5088 Tag: A7202 LabEq Flex 48,333.63 48,333.63
----------------------------------------------------------------------------------------------------------------------------------
5/28/99 5095 Tag: A7198 LabEq Larg 1,589.17 1,589.17
----------------------------------------------------------------------------------------------------------------------------------
1/19/99 5204 Tag: 7163 LabEq HPLC 57,736.51 57,736.51
----------------------------------------------------------------------------------------------------------------------------------
7/19/99 5227 Tag: A8020 LabEq HPLC 55,528.19 55,528.19
----------------------------------------------------------------------------------------------------------------------------------
5/18/99 5229 Tag: A7170 LabEq Ref/ 1,737.56 1,737.56
----------------------------------------------------------------------------------------------------------------------------------
7/21/99 5239 Tag: LabEq Auto 51,765.15 51,765.15
----------------------------------------------------------------------------------------------------------------------------------
12/15/98 5252 Tag: A7110 LabEq Shak 2,369.21 2,369.21
----------------------------------------------------------------------------------------------------------------------------------
1/7/99 5254 Tag A7123 LabEq Vacu 2,542.13 2,542.13
----------------------------------------------------------------------------------------------------------------------------------
1/7/99 5255 Tag: A7124 LabEq Auto 9,703.34 9,703.34
----------------------------------------------------------------------------------------------------------------------------------
1/7/99 5256 Tag: A7125 LabEq Ther 2,557.89 2,557.89
----------------------------------------------------------------------------------------------------------------------------------
1/7/99 5257 Tag: A7126 LabEq Vari 5,912.74 5,912.74
----------------------------------------------------------------------------------------------------------------------------------
16.
28
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
8/25/99 5297 Tag: A2026 LabEq Bala 3,536.53 3,536.53
----------------------------------------------------------------------------------------------------------------------------------
10/4/99 5322 Tag: A8033 Impact Exp 1,347.85 1,347.85
----------------------------------------------------------------------------------------------------------------------------------
10/4/99 5323 Tag: A8034 Impact Exp 1,347.85 1,347.85
----------------------------------------------------------------------------------------------------------------------------------
10/4/99 5324 Tag: A8035 Impact 2-12 1,333.64 1,333.64
----------------------------------------------------------------------------------------------------------------------------------
10/4/99 5325 Tag: A8036 lmpact 2-12 1,333.63 1,333.63
----------------------------------------------------------------------------------------------------------------------------------
10/4/99 5326 Tag: A8037 lmpact 2-12 1,333.63 1,333.63
----------------------------------------------------------------------------------------------------------------------------------
10/5/99 5327 Tag: A8038 lmpact 2 B 1,219.76 1,219.76
----------------------------------------------------------------------------------------------------------------------------------
10/5/99 5328 Tag: A8039 Impact 2 B 1,219.77 1,219.77
----------------------------------------------------------------------------------------------------------------------------------
10/5/99 5329 Tag: A8040 Impact 2 B 1,219.77 1,219.77
----------------------------------------------------------------------------------------------------------------------------------
9/29/99 5338 Tag: A8032 LabEq Isop 48,774.65 48,774.65
----------------------------------------------------------------------------------------------------------------------------------
9/21/99 5339 Tag LabEq Isop 48,778.00 48,778.00
----------------------------------------------------------------------------------------------------------------------------------
12/1/99 5349 Tag: REC V LabEq Fume 158,878.80 158,878.80
----------------------------------------------------------------------------------------------------------------------------------
11/29/99 5355 Tag: A8057 LabEq Seri 2,609.34 2,609.34
----------------------------------------------------------------------------------------------------------------------------------
12/6/99 5356 Tag: A8059 LabEq Chro 6,023.79 6,023.79
----------------------------------------------------------------------------------------------------------------------------------
12/10/99 5637 Tag: A8063 LabEq Funn 1,904.43 1,904.43
----------------------------------------------------------------------------------------------------------------------------------
12/17/99 5638 Tag: A8064 LabEq RS23 2,005.89 2,005.89
----------------------------------------------------------------------------------------------------------------------------------
12/30/99 5639 Tag: A8073 LabEq Sava 22,943.56 22,943.56
----------------------------------------------------------------------------------------------------------------------------------
12/30/99 5640 Tag: A8074 LabEq Sava 22,943.56 22,943.56
----------------------------------------------------------------------------------------------------------------------------------
1/13/00 5642 Tag: A8077 LabEq Sava 23,120.95 23,120.95
----------------------------------------------------------------------------------------------------------------------------------
1/13/00 5643 Tag: A8078 LabEq Sava 23,120.95 23,120.95
----------------------------------------------------------------------------------------------------------------------------------
12/2/99 5645 Tag: A8060 LabEq Port 3,311.37 3,311.37
----------------------------------------------------------------------------------------------------------------------------------
12/7/99 5647 Tag: A8061 LabEq Oxyg 2,656.91 2,656.91
----------------------------------------------------------------------------------------------------------------------------------
1/11/00 5648 Tag: A8079 LabEq Save 22,588.80 22,588.80
----------------------------------------------------------------------------------------------------------------------------------
1/10/00 5649 Tag: A8065 LabEq Free 1,953.91 1,953.91
----------------------------------------------------------------------------------------------------------------------------------
12/1/99 5650 Tag: A8057 LabEqRecip 1,245.32 1,245.32
----------------------------------------------------------------------------------------------------------------------------------
12/1/99 5651 Tag: A8058 LabEq Reci 1,245.31 1,245.31
----------------------------------------------------------------------------------------------------------------------------------
2/2/00 5692 Tag: A3238 Lab Eq Fast Stack Microlitre 7,820.00 7,820.00
----------------------------------------------------------------------------------------------------------------------------------
1/4/00 5693 Tag: A8066 2000 LabEq HPB 38,723.33 38,723.33
----------------------------------------------------------------------------------------------------------------------------------
11/16/99 5694 Tag: A8042 2000 LabEq HP B 31,344.47 31,344.47
----------------------------------------------------------------------------------------------------------------------------------
1/26/00 5695 Tag: A2228 2000 LabEq Optx 17,364.72 17,364.72
----------------------------------------------------------------------------------------------------------------------------------
2/5/00 5713 Tag: A8064 Lab Eq RS232 Interface 2,450.00 2,450.00
----------------------------------------------------------------------------------------------------------------------------------
1/17/00 5719 Tag: A8082 2000 Speedvac sy 22,538.80 22,538.80
----------------------------------------------------------------------------------------------------------------------------------
2/22/00 5720 Tag: A8097 Lab Eq Oven lrg micro vacu 5,674.03 5,674.03
----------------------------------------------------------------------------------------------------------------------------------
3/17/00 5767 Tag: A8115 Lab Eq Advaned Video Microsco 3,119,410.60 2,330.50 3,385,330.54 2,330.50
----------------------------------------------------------------------------------------------------------------------------------
FURNITURE 9/30/93 32 Tag: A3912 6 Felxion I 2,321.00 2,321.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/94 36 Tag: A1962 1 Modules F 9,965.01 9,965.01
----------------------------------------------------------------------------------------------------------------------------------
6/30/96 55 Tag: SEE C 40 Concert 14,375.60 14,375.60
----------------------------------------------------------------------------------------------------------------------------------
7/31/96 58 Tag: A3973 6 Superior 2,369.59 2,369.59
----------------------------------------------------------------------------------------------------------------------------------
9/1/97 1013 Tag: SEE C 4 PCS TASK 1,039.20 1,039.20
----------------------------------------------------------------------------------------------------------------------------------
9/1/97 1027 Tag: A3150 6 PCS CHAIR 1,149.62 1,149.62
----------------------------------------------------------------------------------------------------------------------------------
17.
29
----------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
----------------------------------------------------------------------------------------------------------------------------------
11/1/97 1047 Tag: SEE C 20 PCS OFFI 4,801.99 4,801.99
----------------------------------------------------------------------------------------------------------------------------------
11/1/97 1048 Tag: SEE C 10 GUEST CH 1,317.41 1,317.41
----------------------------------------------------------------------------------------------------------------------------------
11/1/97 1051 Tag: SEE C 10 pcs office chair burgundy 2,401.00 2,401.00
----------------------------------------------------------------------------------------------------------------------------------
7/1/98 1271 Tag: N/A BOBREED'S 10,884.34 10,884.34
----------------------------------------------------------------------------------------------------------------------------------
10/1/98 1428 Tag: N/A FURNlTURE F 4,857.65 4,867.65
----------------------------------------------------------------------------------------------------------------------------------
4/1/99 5057 Tag: Fn Glasswar 3,708.00 3,708.00
----------------------------------------------------------------------------------------------------------------------------------
12/1/89 5350 Tag. Retrohr Ex 8,953.06 68,153.47 8,953.06 68,153.47
----------------------------------------------------------------------------------------------------------------------------------
FIXTURE 4/12/99 5096 Tag: Fx Frames I 2,162.38 2,162.38 2,162.38 2,162.38
----------------------------------------------------------------------------------------------------------------------------------
Leased CP 7/1/96 3258 Tag: 1501 Storage Ser 71,800.00 71,800.00 71,800.00 71,800.00
----------------------------------------------------------------------------------------------------------------------------------
Leased Lab Eq 5/31/93 1581 Tag: A1036 800per Mon 155.00 155.00
----------------------------------------------------------------------------------------------------------------------------------
5/31/93 1592 Tag: A4078 Chromatogra 2,441.00 2,441.00
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1630 Tag: A5408 6 Tables 221.39 221.39
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1631 Tag: A5000 6 Tables 221.39 221.39
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1632 Tag: A3867 6 Tables 221.39 221.39
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1633 Tag: A3871 5 Table 202.67 202.67
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1640 Tag. A2995 LaserWriter 2,597.99 2,597.99
----------------------------------------------------------------------------------------------------------------------------------
6/30/93 1652 Tag: A2080 Rotary Cull 430.10 430.10
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1661 Tag: A4777 Tekmar Spee 298.00 298.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1662 Tag: A4778 Electrophor 785.00 785.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1675 Tag: A4779 604U-R Auto 3,137.00 3,137.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1677 Tag: A4780 Rotor Horiz 561.00 561.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1678 Tag: A2229 VacGage w 273.27 273.27
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1679 Tag: A4781 Rotor-Hon 329.00 329.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1680 Tag: A4782 Trunnion Ri 52.00 52.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1681 Tag: A4783 Trunnion Ri 52.00 52.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1682 Tag: A4784 Shield Sea 289.76 289.76
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1691 Tag: A2243 AirSensor 1,013.60 1,013.60
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1701 Tag: A1174 Retriever 5 950.00 950.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1713 Tag: A4872 Omnigene Th 5,290.00 5,290.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1716 Tag: A4787 GenePulser 920.00 920.00
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1734 Tag: A4882 Pre-Filter 211.20 211.20
----------------------------------------------------------------------------------------------------------------------------------
7/31/93 1736 Tag: A4752 HR Flow Cel 1,352.00 1,352.00
----------------------------------------------------------------------------------------------------------------------------------
9/30/93 1763 Tag: A3284 Diluter 799 2,771.00 2,771.00
----------------------------------------------------------------------------------------------------------------------------------
9/30/93 1770 Tag: A5479 Sony CB 0003 2,310.00 2,310.00
----------------------------------------------------------------------------------------------------------------------------------
12/31/93 1796 Tag: A1748 Waler Aspir 1,616.76 1,616.76
----------------------------------------------------------------------------------------------------------------------------------
12/31/93 1802 Tag: A2753 110gBalanc 1,420.00 1,420.00
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 1852 Tag: A2724 BioPilot 55,128.22 55,128.22
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 1856 Tag: A3579 Laserwriter 4,371.00 4,371.00
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 1862 Tag: A3945 Computers 2,780.00 2,780.00
----------------------------------------------------------------------------------------------------------------------------------
4/30/94 1870 Tag: A3933 Laminat Flo 11,952.44 11,952.44
----------------------------------------------------------------------------------------------------------------------------------
18.
30
------------------------------------------------------------------------------------------------------------------------------------
IN ADDITIONS FR
SERVICE SYSTEM GL BALANCE COST GL BALANCE 10/31/99
DATE ASSET # TAG # DESCRIPTION 10/31/00 10/31/99 3/31/2000 3/31/00 TO 3/31/00
------------------------------------------------------------------------------------------------------------------------------------
4/30/94 1871 Tag: A3937 PD pumps 3,309.25 3,309.25
------------------------------------------------------------------------------------------------------------------------------------
4/30/94 1873 Tag: A1825 Ultrafilter 13,898.50 13,898.50
------------------------------------------------------------------------------------------------------------------------------------
4/30/94 1876 Tag: A3931 Nalgene Tan 11,444.50 11,444.50
------------------------------------------------------------------------------------------------------------------------------------
4/30/94 1877 Tag: A3946 Flowmeters 11,313.00 11,313.00
------------------------------------------------------------------------------------------------------------------------------------
8/31/94 1883 Tag: A3913 Osmometer 4,236.00 4,236.00
------------------------------------------------------------------------------------------------------------------------------------
7/31/95 1902 Tag: XX000 XXX-000 195,000.00 343,557.43 195,000.00 343,557.43
------------------------------------------------------------------------------------------------------------------------------------
leased 4/30/93 1545 Tag: A5442 Corner Tabl 59.00 59.00
Furniture
------------------------------------------------------------------------------------------------------------------------------------
5/31/93 1550 Tag: A5568 Holga 5 Dra 3,935.65 3,935.65
------------------------------------------------------------------------------------------------------------------------------------
5/31/93 1557 Tag: A4080 8 Brevel Ch 1,776.00 1,776.00
------------------------------------------------------------------------------------------------------------------------------------
6/30/93 1558 Tag: A1351 DeskChair 458.25 458.25
------------------------------------------------------------------------------------------------------------------------------------
6/30/93 1561 Tag: A4082 DeskChair 458.25 458.25
------------------------------------------------------------------------------------------------------------------------------------
6/30/93 1562 Tag: A4083 DeskChair 458.25 458.25
------------------------------------------------------------------------------------------------------------------------------------
8/31/93 1570 Tag: A3865 5-5 Table 1,013.35 1,013.35
------------------------------------------------------------------------------------------------------------------------------------
8/31/93 1573 Tag: A1705 36562Worksl 424.68 8,583.43 424.68 8,583.43
------------------------------------------------------------------------------------------------------------------------------------
Leasehold 3/31/94 279 Tag: A3934 Vacuum For 2,918.00 2,918.00
Impr Bd
------------------------------------------------------------------------------------------------------------------------------------
1/31/95 284 Tag: A4073 Hood-Peptide Lab 7,462.00 7,462.00
------------------------------------------------------------------------------------------------------------------------------------
2/28/95 285 Tag: A3938 ExHaust hpp 2,320.00 12,700.00 2,320.00 12,700.00
------------------------------------------------------------------------------------------------------------------------------------
Ofc 4/30/94 70 Tag: A1951 42 Round ch 982.55 982.55
Equipment
------------------------------------------------------------------------------------------------------------------------------------
8/31/91 71 Tag: SEE C 12 Ergon Mg 2,971.80 2,971.80
------------------------------------------------------------------------------------------------------------------------------------
8/31/91 74 Tag: A5343 12 Ergon Mg 2,971.80 2,971.80
------------------------------------------------------------------------------------------------------------------------------------
8/31/91 75 Tag: SEE C 12 Ergon Si 2,670.00 2,670.00
------------------------------------------------------------------------------------------------------------------------------------
9/30/91 81 Tag: A5431 2 30x60 Sin 1,074.00 1,074.00
------------------------------------------------------------------------------------------------------------------------------------
7/1/97 967 Tag: A4873 KODAK EKTAG 1,127.71 1,127.71
------------------------------------------------------------------------------------------------------------------------------------
9/1/97 1024 Tag: A4072 4 PCS OVERH 1,381.27 1,381.27
------------------------------------------------------------------------------------------------------------------------------------
9/1/97 1025 Tag: A3400 3 PCS EKTAG 2,172.58 2,172.58
------------------------------------------------------------------------------------------------------------------------------------
1-/1/97 1031 Tag: A3145 2 PCS XEROX 4,522.69 19,874.40 4,522.69 19,874.40
------------------------------------------------------------------------------------------------------------------------------------
Leasehold various various 10/31/99 Oysler Point LI 2,976,277.36 2,976,277.36 2,978,732.56 2,978,732.56 2,455.20
Impr Bd. (55% of 54114
------------------------------------------------------------------------------------------------------------------------------------
3/31/00 Oysler Poinl Ll(55%
of 5415B77.38)
------------------------------------------------------------------------------------------------------------------------------------
SOFTWARE 9/30/95 9 Tag: A4786 1 BIOSYM 43,253.56 43,253.56
------------------------------------------------------------------------------------------------------------------------------------
3/5/99 5099 Tag: SOFTWARE Mi 3,610.69 46,864.25 3,610.69 46,864.25
------------------------------------------------------------------------------------------------------------------------------------
6,990,523.27 6,990,523.27 7,263,067.09 7,263,067.09 272,543.82
-------------------------------------------------------------=======================================================================
19.
31
SCHEDULE 1.4
ASSIGNED CONTRACTS
Research Agreement with Pharmacia & Upjohn dated February 29, 1996, as amended.
Combinatorial Chemistry Agreement with Xxxxxx-Xxxxxxx Company dated May 15,
1998.
Combinatorial Chemistry Agreement with Signal Pharmaceuticals, Inc. dated July
6, 1998.
Combinatorial Chemistry Agreement with Xxxxx-Xxxxxxx Xxxxx dated December 22,
1998.
Combinatorial Chemistry Agreement with Protein Design Labs, Inc. dated December
28, 1998.
Combinatorial Chemistry Agreement with Novalon Pharmaceutical Corporation dated
June 28, 1999.
1.
32
SCHEDULE 1.5
GENERAL DESCRIPTION OF ASSIGNED KNOW-HOW
All know-how pertaining to the protocols set forth in Schedule 1.7
1.
33
SCHEDULE 1.6
ASSIGNED PATENTS
(see attached)
1.
34
PATENTS AND PATENT APPLICATIONS:
1. U.S. Patent No. 5,703,792
THREE DIMENSIONAL MEASUREMENT OF MOLECULAR DIVERSITY
Issued 12/30/97
2. U.S. Patent No. 5,526,281
MACHINE LEARNING APPROACH TO MODELING BIOLOGICAL ACTIVITY FOR MOLECULAR
DESIGN AND TO MODELING OTHER CHARACTERISTICS Issued 6/11/96
3. US. Patent No. 5,576,220
THIN FILM HPMP MATRIX SYSTEMS AND METHODS FOR CONSTRUCTION AND
DISPLAYING LIGANDS
Issued 11/19/96
4. U.S. Patent No. 5,585,275
PILOT APPARATUS FOR PEPTIDE SYNTHESIS AND SCREENING
Issued 12/17/96
5. U.S. Patent No. 5,591,646
METHOD AND APPARATUS FOR PEPTIDE SYNTHESIS AND SCREENING
Issued 1/7/97
6. U.S. Patent Application Serial No. 08/989,204
NOVEL SOLID-PHASE SYNTHESIS TECHNIQUES FOR PREPARING MULTIPLE ANALOGOUS
COMPOUNDS
Filed 12/11/97
7. U.S. Patent Application Serial No. 09/353,158
PROCESS FOR SYNTHESIS OF BENZOPYRAN DERIVATIVES
Filed 7/14/99
8. U.S. Patent Application Serial No. 09/375,803
PROCESS FOR THE SYNTHESIS OF TRIAZOLOPYRIDIZINE COMPOUNDS
Filed 8/17/99
9 . U.S. Patent Application Serial No. 09/435,517
PROCESS FOR THE SYNTHESIS OF QUINAZOLINONES
Filed 11/8/99
10. U.S. Patent Application Serial No. 09/519,944
PROCESS FOR THE SYNTHESIS OF DIHYDROPYRIDONES
Filed 3/7/00
11. U.S. Patent Application Serial No. 09/527,626
SOLID PHASE SYNTHESIS OF BENZODIAZEPINES DIONES
Filed 3/16/00
12. U.S. Patent Application Serial No. 09/520,500
PROLINE DERIVATIVES AND SYNTHESIS THEREOF
Filed 3/10/00
1.
35
13. U.S. Patent Application Serial No. 60/142,202
PROCESS FOR SYNTHESIZING OXADIAZOLES
Filed 7/1/99
14. U.S. Patent Application Serial No. 60/142,163
INDOLE SYNTHESIS
Filed 7/1/99
15. US. Patent Application Serial No. 60/147,451
SOLID PHASE SYNTHESIS OF HETEROCYCLES
Filed 8/4/99
16. U.S. Patent Application Serial No. 60/148,169
SYNTHESIS OF PROTEASE SUBSTRATES
Filed 8/10/99
17. U.S. Patent Application Serial No. 60/152,005
PROCESS FOR SYNTHESIZING ISOXAZOLIDINES
Filed 9/1/99
18. U.S. Patent Application Serial No. 60/151,962
PROCESS FOR SYNTHESIZING ISOXAZOLINES AND ISOXAZOLES
Filed 9/1/99
19. U.S. Patent Application Serial No. 60/168,836
PROCESS FOR THE SYNTHESIS OF PYRAZOLINES
Filed 12/3/99
20. U.S. Patent Application Serial No. 60/189,067
QUINAZOLINE SYNTHESIS
Filed 3/13/00
21. U.S. Patent Application Serial No. 60/191,886
PROCESS FOR THE SYNTHESIS OF PYRAZOLE DIONES
Filed 3/23/00
22. U.S. Patent Application Serial No. 60/192,024
SYNTHESIS OF SOLID SUPPORTED DIHYROPRIDINES
Filed 3/24/00
23. U.S. Patent Application Serial No. 60/196,061
PROCESS FOR SYNTHESIZING ISOQUINOLONE INTERMEDIATES
Filed 4/10/00
2.
36
SCHEDULE 1.7
ASSIGNED PROTOCOLS
(see attached)
1.
37
AAT Library Protocols
1996-Present
--------------------------------
Library Group
--------------------------------
AMB001 Combi
--------------------------------
AMB002 Combi
--------------------------------
AMB003 Combi
--------------------------------
AMB004 Combi
--------------------------------
AMB006 Combi
--------------------------------
AMB101 Combi
--------------------------------
AMB102 Combi
--------------------------------
AMB103 Combi
--------------------------------
BAB003 Combi
--------------------------------
BAB005 Combi
--------------------------------
BAB006 Combi
--------------------------------
BAB007 Combi
--------------------------------
BAB009 Combi
--------------------------------
BAB011 Combi
--------------------------------
BAB106 Combi
--------------------------------
BAB206 Combi
--------------------------------
BRZ015-018 Combi
--------------------------------
BR2019 Combi
--------------------------------
BR2020 Combi
--------------------------------
BRZ021 Combi
--------------------------------
BRZ022 Combi
--------------------------------
BRZ023 Combi
--------------------------------
BRZ024 Combi
--------------------------------
BRZ122 Combi
--------------------------------
BRZ123 Combi
--------------------------------
BRZ124 Combi
--------------------------------
BRZ223 Combi
--------------------------------
CP3 Combi
--------------------------------
CP4 Combi
--------------------------------
CP5 Combi
--------------------------------
CP6 Combi
--------------------------------
CP7 Combi
--------------------------------
CQL001 Combi
--------------------------------
CQL002 Combi
--------------------------------
CQL003 Combi
--------------------------------
CQL004 Combi
--------------------------------
CQL005 Combi
--------------------------------
CQL006 Combi
--------------------------------
CQL101 Combi
--------------------------------
CQL104 Combi
--------------------------------
CQL105 Combi
--------------------------------
CQL201 Combi
--------------------------------
CQL204 Combi
--------------------------------
CQL006 Combi
--------------------------------
DC7 Combi
--------------------------------
DC2 Combi
--------------------------------
DR1 Combi
--------------------------------
DR2 Combi
--------------------------------
DR3 Combi
--------------------------------
DR5 Combi
--------------------------------
38
AAT Library Protocols
1996-Present
--------------------------------
DR6 Combi
--------------------------------
DR7 Combi
--------------------------------
DSC001 Combi
--------------------------------
DSC002 Combi
--------------------------------
DSC003 Combi
--------------------------------
DSC007 Combi
--------------------------------
DSC008 Combi
--------------------------------
DSC108 Combi
--------------------------------
EBK001 Combi
--------------------------------
FXW001 Combi
--------------------------------
FXW101 Combi
--------------------------------
HCH001 Combi
--------------------------------
HOE101 Combi
--------------------------------
UCP3 Combi
--------------------------------
UCP4 Combi
--------------------------------
UCP5 Combi
--------------------------------
UCP6 Combi
--------------------------------
UCP7 Combi
--------------------------------
UCP008 Combi
--------------------------------
UGB002 Combi
--------------------------------
UGB003 Combi
--------------------------------
UGB102 Combi
--------------------------------
UMD001 Combi
--------------------------------
UMD002 Combi
--------------------------------
KSY001 Combi
--------------------------------
KY1 Combi
--------------------------------
KY2 Combi
--------------------------------
KY3 Combi
--------------------------------
KY4 Combi
--------------------------------
KY5 Combi
--------------------------------
MDH1 Combi
--------------------------------
MDH2 Combi
--------------------------------
MDH003 Combi
--------------------------------
MDH019 Combi
--------------------------------
MDH020 Combi
--------------------------------
MDH021 Combi
--------------------------------
MDH11-14 Combi
--------------------------------
MDH11-15 Combi
--------------------------------
MDH24-10 Combi
--------------------------------
MJH002 Combi
--------------------------------
MJH101 Combi
--------------------------------
MJH201 Combi
--------------------------------
MJP001 Combi
--------------------------------
MJP002 Combi
--------------------------------
MJP004 Combi
--------------------------------
MJP104 Combi
--------------------------------
MJP204 Combi
--------------------------------
NAC001 Combi
--------------------------------
NAP001 Combi
--------------------------------
NAP101 Combi
--------------------------------
PPF001 Combi
--------------------------------
39
AAT Library Protocols
1996-Present
--------------------------------
PPF002 Combi
--------------------------------
PPF003 Combi
--------------------------------
PPF004 Combi
--------------------------------
PPF005 Combi
--------------------------------
PPF006 Combi
--------------------------------
PPF009 Combi
--------------------------------
PPF010 Combi
--------------------------------
PPF019 Combi
--------------------------------
PPF020 Combi
--------------------------------
PPF11-18 Combi
--------------------------------
PPF120 Combi
--------------------------------
P21 Combi
--------------------------------
P22 Combi
--------------------------------
P25 Combi
--------------------------------
P26 Combi
--------------------------------
SPT001 Combi
--------------------------------
SPT002 Combi
--------------------------------
SPT003 Combi
--------------------------------
SPT004 Combi
--------------------------------
SPT102 Combi
--------------------------------
SPT103 Combi
--------------------------------
SPT104 Combi
--------------------------------
SPT105 Combi
--------------------------------
SPT201 Combi
--------------------------------
SXL1 Combi
--------------------------------
SXL2 Combi
--------------------------------
SXL3 Combi
--------------------------------
SXL4 Combi
--------------------------------
SXL5 Combi
--------------------------------
SXL6 Combi
--------------------------------
SXL7 Combi
--------------------------------
SXL9 Combi
--------------------------------
SXL010 Combi
--------------------------------
SXL011 Combi
--------------------------------
SXL012 Combi
--------------------------------
SXL013 Combi
--------------------------------
SXL101 Combi
--------------------------------
TAK001 Combi
--------------------------------
TAK101 Combi
--------------------------------
TGL001 Combi
--------------------------------
TGL101 Combi
--------------------------------
TPH001 Combi
--------------------------------
TPH002 Combi
--------------------------------
TPH003 Combi
--------------------------------
TPH101 Combi
--------------------------------
TPH102 Combi
--------------------------------
TPH201 Combi
--------------------------------
TPH202 Combi
--------------------------------
TRK001 Combi
--------------------------------
ARG501 DISCO
--------------------------------
ARG502 DISCO
--------------------------------
40
AAT Library Protocols
1996-Present
--------------------------------
ARG503 DISCO
--------------------------------
ARG504 DISCO
--------------------------------
JES501 DISCO
--------------------------------
JIL401 DISCO
--------------------------------
JIL502 DISCO
--------------------------------
LIG-A01 DISCO
--------------------------------
41
Production Technical Operating Procedures
Rev. Code 8 Apr 1999 JMP
-----------------------------------------------------------------------------------------------------------
TITLE DESCRIPTION REV CODE SUB-FILE
-----------------------------------------------------------------------------------------------------------
100 SERIES: INSTRUMENTATION
-----------------------------------------------------------------------------------------------------------
CS Validation Validation of Computerized Systems 27 Jan 99 JMP
-----------------------------------------------------------------------------------------------------------
Sebastian Requirement Requirements Definition Doc. for Computer 1 Feb 99 JMP
Systems Validate
-----------------------------------------------------------------------------------------------------------
Sebastian I.Q. Sebastian Installation Qualification 27 Jan 99 ASL
-----------------------------------------------------------------------------------------------------------
Sebastian O.Q. Sebastian Operational Qualification 1 Feb 99 ASL
-----------------------------------------------------------------------------------------------------------
Sebastian P.Q. Sebastian Performance Qualification 7 Mar 99 ASL
-----------------------------------------------------------------------------------------------------------
Hydra Calibration Calibration of the Xxxxxxx Hydra 96 3 Feb 99 JMP
-----------------------------------------------------------------------------------------------------------
Hydra Operating the Xxxxxxx Hydra 96 6 March 1998 DG
-----------------------------------------------------------------------------------------------------------
Lyo/Condenser __ating the VirTis Unitop Iyophilizer and 5 May 1997 ZTN
FreezeMobile cond___
-----------------------------------------------------------------------------------------------------------
Matrix Operating the Matrix IMPACT multichannel 5 May 1997 ZTN
Pipettor
-----------------------------------------------------------------------------------------------------------
Moduline Washing with the Moduline Model A Dispenser 7 March 1998 DG
-----------------------------------------------------------------------------------------------------------
Savant ___rating the Savant Speedvac for concentrating 5 May 1997 ZTN
liquid san___
-----------------------------------------------------------------------------------------------------------
Tomtec vac box Operating the Tomtec vacuum box 10 April 1998 DGR
-----------------------------------------------------------------------------------------------------------
42
-----------------------------------------------------------------------------------------------------------
Moduline Carousel ___od for washing plates with the Moduline 4 March 1998 DGR
Automatic Car___
-----------------------------------------------------------------------------------------------------------
Supelco Visprep Operating the Supelco Visiprep vacuum manifold 11 Dec 1996 SPT
-----------------------------------------------------------------------------------------------------------
Tecan Genesis Operating the Tecan Genesis robot 12 Dec 1996 DR
-----------------------------------------------------------------------------------------------------------
Genevac I.Q/O.Q Genevac Installation/Operation Qualification 26 Nov 97 BAW
-----------------------------------------------------------------------------------------------------------
Genevac P.Q. Genevac Performance Qualification 3 Dec 97 BAW
-----------------------------------------------------------------------------------------------------------
Genevac Operating the Genevac 9 Dec 97 BAW
-----------------------------------------------------------------------------------------------------------
43
-----------------------------------------------------------------------------------------------------------
200 SERIES: LIBRARY TECHNIQUES
-----------------------------------------------------------------------------------------------------------
Clamping Clamping production plates 1 April 1998 DGP
-----------------------------------------------------------------------------------------------------------
N2 Drainage Product recovery via positive pressure 6 May 1997 ZTN
-----------------------------------------------------------------------------------------------------------
Cleaving from resins Method for cleaving compounds from resin in 27 May 1997 ZTN
PolyFil plate
-----------------------------------------------------------------------------------------------------------
Swirl and plate Transferring resin to Polyfilltronics plates 7 May 1997 ZTN
from tritted cartridge to ___
-----------------------------------------------------------------------------------------------------------
Protocol Handling Production Protocol handling procedure 2 March 1998 DG
-----------------------------------------------------------------------------------------------------------
Standard Replacement Returning products from QC Standard Analysis 6 March 1998 NGR
to xxxxx
-----------------------------------------------------------------------------------------------------------
TITLE DESCRIPTION REV CODE SUB-FILE
-----------------------------------------------------------------------------------------------------------
300 SERIES: PLATING
-----------------------------------------------------------------------------------------------------------
Plating prep Preparation for plating using the Xxxxxxx 15 May 1997 ZTN
Hydra 96
-----------------------------------------------------------------------------------------------------------
Resin prep using LAMPS Separation of 9 samples of bulk resin using 5 May 1997 EHL
LAMPS monitor
-----------------------------------------------------------------------------------------------------------
Resin transfer w/ Transfer via fritted Falcon Places to 88 xxxxx 20 April 1998 DGR
Falco_ of a deepwell
-----------------------------------------------------------------------------------------------------------
Kenner Resin Prep Preparation of Kenner Linker on Resin 13 Jan 1998 MRD
-----------------------------------------------------------------------------------------------------------
Kenner Resin Validation of Kenner resin 20 Jan 1998 MRD
Validation
-----------------------------------------------------------------------------------------------------------
Thiophenol Prep Preparation of Thiophenol Resin 13 Jan 1998 MRD
-----------------------------------------------------------------------------------------------------------
-----------------------------------------------------------------------------------------------------------
44
-----------------------------------------------------------------------------------------------------------
800 SERIES: SLE
-----------------------------------------------------------------------------------------------------------
SLE Packing Packing Hydromatrix material into 26 Feb 1998 DGP
Polyfilltronics places
-----------------------------------------------------------------------------------------------------------
PE/silica Polyfi. SPE in 96 well format using Hydromatrix 5 May 1997 SPT
hydrom__ material and Silica Gel 60 A in
Polyfilltronics plates
-----------------------------------------------------------------------------------------------------------
45
SCHEDULE 1.8
ASSIGNED SOFTWARE
NAMES OF SOFTWARE PROGRAMS
1. ICE PICK
2. COMPASS
3. HAMMERHAD
4. SIDEWINDER
5. MOLECULAR DOCKER
6. BAR CODING
7. COMBIGEN
DESCRIPTIONS OF SELECTED SOFTWARE PROGRAMS
ICEPICK is a system for computationally selecting diverse sets of
molecules. It computes the dissimilarity of the surface-accessible features of
two molecules, taking into account conformational flexibility. Then, the
intrinsic diversity of an entire set of molecules is calculated from spanning
tree over the pairwise dissimilarities. IcePick's dissimilarity measure is
compared against traditional 2D topological approaches, and the spanning tree
diversity measure is compared against commonly used variance techniques.
COMPASS allows for the building of predictive models for interactive
drug design in the absence of a known target protein structure, by removing
major obstacles to accurate prediction and automatically selecting conformations
and alignments of molecules without benefit of a characterized active site. The
technique combines explicit representation of molecular shape and neural network
learning methods to produce highly predictive models, even across chemically
distinct classes of molecules.
HAMMERHEAD can be successfully applied to dock a variety of ligands into
their cognate proteins, and is used for screening large databases of flexible
molecules for binding to a protein of known structure. It correctly docks
flexible ligands, spending an average of a few seconds on each compound during a
screen. Hammerhead is completely automated, including the elucidation of protein
building sites, through the docking of molecules, to the final selection of
compounds for assay.
SIDEWINDER performs directed sidechain selection given a protein
structure, ligand and binding hypothesis, and an array of potential sidechains.
Sidewinder computes predicted sets of the best sidechains at each specified
site. The software accurately generates sidechain conformations, attaches
sidechains at the designated scaffold point, refines and prunes the sidechains,
and finally refines and scores the entire ligand.
1.
46
MOLECULAR DOCKER aligns small molecules to a protein structure and
estimates their binding affinity. The algorithm represents a protein's binding
site in a way that is specifically sited to molecular docking applications.
Initially, the protein's surface is coated with a collection of molecular
fragments that potentially interact with the protein. Each probe, serves as a
potential alignment point for atoms in a ligand, and is scored to represent that
probe's affinity for the protein. Probes are then clustered by accumulating
their affinities. High affinity clusters are identified as being the "stickiest"
portions of the protein surface. The stickiest cluster is used as a computation
binding pocket for docking.
COMBIGEN is Axys' proprietary in-house program for the enumeration of
library compound databases using a virtual chemistry approach. Presently Axys is
in the process of converting from this software to Afferent Structure(TM)
software from Afferent Systems, Inc.
BARCODING SOFTWARE
Axys' in-house intranet-based barcoding combines a
straightforward error checking interface with a chemical tracking database. The
interface minimizes the chances for operator error by taking barcoded input
directly from the barcoding scanner, and further reduces the chances for error
by requiring mutually corroborating input of catalog information and molecular
weight, which is checked for consistency from a database.
2.
47
SCHEDULE 2.1(b)
FORMS OF ASSIGNMENT
1.
48
XXXX OF SALE
This Xxxx of Sale dated as of April ___, 2000 is being made
pursuant to that certain Technology Assignment and License Agreement (THE
"TECHNOLOGY ASSIGNMENT AND LICENSE AGREEMENT") dated April ___, 2000 by and
between Axys Pharmaceuticals, Inc., a Delaware corporation (the "COMPANY") and
Axys Advanced Technologies, Inc., a Delaware corporation ("AAT").
NOW, THEREFORE, for good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the Company hereby agree as
follows:
1. Capitalized terms used herein but not defined herein shall
have the meanings assigned such terms in the Technology Assignment and License
Agreement.
2. Subject to the terms and conditions set forth in the
Technology Assignment and License Agreement, the Company does hereby sell,
transfer, assign and deliver to AAT, free and clear of all liens, claims,
charges and other encumbrances of any nature whatsoever, for AAT and AAT's
assigns to have and to hold forever, all of the Company's right, title and
interest in and to the assets, properties, rights and contracts set forth below,
as the same shall exist today, AS IS and WHERE IS (collectively, the "PURCHASED
ASSETS"):
(a) the tangible assets listed in Schedule 1.2 hereto;
(b) any and all Information that is Controlled by the Company
as of today, including, without limitation, the Information identified generally
in Schedule 1.5 attached hereto, which is necessary to or used by AAT in its
current combinatorial chemistry business, but excluding the Assigned Protocols
and Licensed Technology;
(c) the patents and patent applications set forth in Schedule
1.6 hereto, and including any and all rights that are Controlled by the Company
as of today with respect to such patents and patent applications, including
without limitation the rights to enforce and/or file any non-provisionals,
divisionals, continuations, continuations-in-part, substitutions, reissues,
reexaminations, extensions and foreign equivalents thereof.
(d) all of the Protocols Controlled by the Company that are
set forth in Schedule 1.7 hereto, and all trade secret and other intellectual
property rights in such Protocols that are Controlled by the Company as of
today;
(e) all of the computer software programs, in object code and,
to the extent Controlled by the Company, source code forms, that are either
owned by the Company or licensed to the Company and are described generally in
Schedule 1.8 hereto, and all documentation for such programs in the Company's
possession as of today, and all copyright and other intellectual property rights
in any of the foregoing that are Controlled by the Company as of today;
49
(f) notwithstanding the foregoing, all of the rights granted
under subsections (b), (c), (d) and (e) above are expressly subject to any and
all license rights that the Company has previously granted to third parties
identified on Schedule 2.1(d) to the Technology Assignment and License
Agreement, under the contracts specified in Schedule 2.1(d) to the Technology
Assignment and License Agreement, with respect to such technology and
intellectual property rights, to the extent and so long as such license rights
remain in force; and
(g) all of the Company's rights, claims and benefits (except
as otherwise provided in subsection (h)) under the Assigned Contracts.
3. AAT hereby waives compliance by the Company with the
provisions of the bulk transfer laws of any state. The Company covenants and
agrees to pay and discharge when due all claims of creditors which could be
asserted against AAT by reason of such noncompliance.
4. Notwithstanding any other provisions of this Xxxx of Sale to
the contrary, nothing contained in this Xxxx of Sale shall in any way supersede,
modify, replace, amend, change, rescind, waive, exceed, expand, enlarge or in
any way affect the provisions, including warranties, covenants, agreements,
conditions, representations or, in general any of rights and remedies, and any
of the obligations and indemnifications of the Company or AAT set forth in the
Technology Assignment and License Agreement nor shall this Xxxx of Sale expand
or enlarge any remedies under the Technology Assignment and License Agreement
including without limitation any limits on indemnification specified therein.
This Xxxx of Sale is intended only to effect the transfer of certain property to
be transferred pursuant to the Technology Assignment and License Agreement and
shall be governed entirely in accordance with the terms and conditions of the
Technology Assignment and License Agreement.
5. This Xxxx of Sale shall in all respects be construed in
accordance with and governed by the laws of the State of California without
giving effect to its conflicts-of-laws principles.
[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
50
IN WITNESS WHEREOF, the Company has caused this Xxxx of Sale to
be executed and delivered on the date and year first written above.
AXYS PHARMACEUTICALS, INC.,
a Delaware corporation
By: _____________________________
Name: _____________________________
Title: _____________________________
[SIGNATURE PAGE TO XXXX OF SALE]
51
SCHEDULE 1.2
ADDITIONAL CHEMISTRY ASSETS
(see attached)
See Schedule 1.2 to Technology Assignment and License Agreement.
52
SCHEDULE 1.5
GENERAL DESCRIPTION OF ASSIGNED KNOW-HOW
All know-how pertaining to the protocols set forth in Schedule 1.7
53
SCHEDULE 1.6
ASSIGNED PATENTS
(see attached)
See Schedule 1.6 to Technology Assignment and License Agreement.
54
SCHEDULE 1.7
ASSIGNED PROTOCOLS
(see attached)
See Schedule 1.7 to Technology Assignment and License Agreement.
55
SCHEDULE 1.8
ASSIGNED SOFTWARE
See Schedule 1.8 to Technology Assignment and License Agreement.
56
ASSIGNMENT OF PATENTS AND PATENT APPLICATIONS
This Assignment of Patents and Patent Applications Agreement (the
"ASSIGNMENT") dated as of April ___, 2000 (the "EFFECTIVE DATE"), is being made
pursuant to that certain Technology Assignment and License Agreement (the
"TECHNOLOGY ASSIGNMENT AND LICENSE AGREEMENT") dated April ___, 2000 by and
between Axys Pharmaceuticals, Inc., a Delaware corporation with offices at 000
Xxxxxxx Xxx, Xxxxx Xxx Xxxxxxxxx, XX 00000 (the "b") and Axys Advanced
Technologies, Inc., a Delaware corporation with offices at 000 Xxxxxxx Xxx,
Xxxxx Xxx Xxxxxxxxx, XX 00000 (the "ASSIGNEE").
For good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the Assignor makes the following assignment:
1. Assignment of Patent Rights to Assignee.
a. Under and in accordance with the Technology Assignment and
License Agreement, Assignor hereby assigns, transfers and conveys to the
Assignee all of the Assignor's right, title and interest throughout the world in
and to the patents and patent applications set forth in Schedule 1.6, which is
attached to and made a part of this Assignment, and in and to any and all U.S.,
or foreign equivalents thereof, including without limitation any extensions,
non-provisionals, continuations-in-part, divisionals, reissues and renewals
thereof, and in and to any and all U.S. or foreign patents that are granted from
such patent applications (collectively, the "ASSIGNED PATENTS"), and further,
all rights and privileges pertaining to the Assigned Patents including, without
limitation the right, if any, to xxx or bring other actions (including, but not
limited to, collection of damages) for past, present and future infringement
thereof. The assignments described in this Section 1 may be hereinafter referred
to as the "ASSIGNMENTS").
b. The Assignor agrees to assist the Assignee in every proper
way, at the Assignee's expense, to evidence and perfect the Assignments and to
apply for and obtain and from time to time enforce, maintain and defend the
Assigned Patents in any and all countries that the Assignee may designate from
time to time. The Assignor will execute all documents that the Assignee may
request for such purposes. If the Assignee is unable for any reason whatsoever
to secure the signature of a duly authorized officer of the Assignor to any
document that the Assignor is required to execute pursuant to the foregoing, the
Assignor hereby irrevocably designates and appoints the Assignee and its duly
authorized officers and agents, with full power of substitution, as its agents
and attorneys-in-fact to act for and in its behalf and instead of the Assignor,
to execute and file any such document and to do all other lawfully permitted
acts to further the purposes of the foregoing with the same legal force and
effect as if executed by the Assignor.
[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
57
IN WITNESS WHEREOF, the Assignor has signed this Agreement
effective as of the date first above written.
AXYS PHARMACEUTICALS, INC.,
By: _____________________________
Name: _____________________________
Title: _____________________________
STATE OF CALIFORNIA )
) ss
COUNTY OF __________________)
On ___________________, before me, ______________________, Notary
Public, personally appeared ________________________________, personally known
to me (or proved to me on the basis of satisfactory evidence) to be the
person(s) whose name(s) is/are subscribed to the within instrument and
acknowledged to me that he/she/they executed the same in his/her/their
authorized capacity(ies), and that by his/her/their signature(s) on the
instrument the person(s), or the entity upon behalf of which the person(s)
acted, executed the instrument.
WITNESS my hand and official seal.
____________________________________
Signature
[SEAL]
58
SCHEDULE 1.6
Assigned Patents Issued or Filed
---------------- ---------------
See Schedule 1.6 to Technology Assignment and License Agreement.
59
ASSIGNMENT OF TRADEMARKS AND SERVICEMARKS
This Trademark and Servicemark Assignment (the "ASSIGNMENT")
dated as of April ___, 2000 (the "EFFECTIVE DATE") is being made pursuant to
that certain Technology Assignment and License Agreement (the "TECHNOLOGY
ASSIGNMENT AND LICENSE AGREEMENT") dated April ___, 2000 by and between Axys
Pharmaceuticals, Inc., a Delaware corporation with offices at 000 Xxxxxxx Xxx,
Xxxxx Xxx Xxxxxxxxx, XX 00000 (the "ASSIGNOR") and Axys Advanced Technologies,
Inc., a Delaware corporation with offices at 000 Xxxxxxx Xxx, Xxxxx Xxx
Xxxxxxxxx, XX 00000 (the "ASSIGNEE").
WHEREAS, Assignor has adopted, used, is using and is the owner of
all trademarks and servicemarks and trademark and servicemark registrations and
applications for trademarks and servicemarks set forth in Exhibit A attached
hereto, and all other rights appurtenant thereto, including, but not limited to,
all common law rights, trade name rights and the right to recover for past
infringement throughout the world (the "TRADEMARKS");
WHEREAS, Assignor has acquired goodwill associated with and
symbolized by said Trademarks and has not abandoned the same;
WHEREAS, Assignee is desirous of acquiring all rights, title and
interest in and to the Trademarks throughout the world; and
WHEREAS, Assignor is willing to assign to Assignee all rights,
title and interest as Assignor may possess in and to the Trademarks throughout
the world.
NOW, THEREFORE, for good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, Assignor makes the following
assignment:
1. ASSIGNMENT.
a. Assignor hereby assigns to Assignee all of Assignor's
rights, title and interest in and to the Trademarks throughout the world,
together with the goodwill symbolized by said Trademarks; said rights, title and
interest include, without limitation, any and all causes of action heretofore
accrued in Assignor's favor for infringement of the aforesaid rights, to have
and to hold the same unto Assignee, its successors and assigns, for and during
the existence of the rights and all renewals thereof.
b. At any time, and from time to time hereafter, Assignor
shall forthwith, upon Assignee's written request and at the Assignee's expense,
take any and all steps to execute, acknowledge and deliver to Assignee any and
all further instruments and assurances necessary or expedient in order to vest
the aforesaid rights in Assignee and to facilitate Assignee's enjoyment and
enforcement of said rights and causes of action.
c. Assignor hereby constitutes and appoints Assignee as
Assignor's true and lawful attorney in fact, with full power of substitution in
Assignor's name and stead, to take any and all steps, including proceedings at
law, in equity or otherwise, to execute,
60
acknowledge and deliver any and all instruments and assurances necessary or
expedient in order to vest or perfect the aforesaid rights and causes of action
more effectively in Assignee or to protect the same or to enforce any claim or
right of any kind with respect thereto. This includes, but is not limited to,
any rights with respect to the Trademarks that may have accrued in Assignor's
favor from the respective date of first use of the Trademarks to the Effective
Date of this Assignment. Assignor hereby declares that the foregoing power is
coupled with an interest and as such is irrevocable.
[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]
61
IN WITNESS WHEREOF, the Assignor has executed this Assignment as
of the Effective Date first set forth above.
AXYS PHARMACEUTICALS, INC.
By: ___________________________
Name: ___________________________
Title: ___________________________
STATE OF CALIFORNIA )
) ss
COUNTY OF __________________)
On ___________________, before me, ______________________, Notary
Public, personally appeared ________________________________, personally known
to me (or proved to me on the basis of satisfactory evidence) to be the
person(s) whose name(s) is/are subscribed to the within instrument and
acknowledged to me that he/she/they executed the same in his/her/their
authorized capacity(ies), and that by his/her/their signature(s) on the
instrument the person(s), or the entity upon behalf of which the person(s)
acted, executed the instrument.
WITNESS my hand and official seal.
____________________________________
Signature
[SEAL]
62
EXHIBIT A
63
CONFIDENTIAL AND PROPRIETARY AXYS ADVANCE TECHNOLOGIES, INC INFORMATION
PENDING SERVICE XXXX APPLICATIONS
COMBIMED:
S.N.: 75/737109: Filed 6/23/99
COMBIMED CHEM:
S.N.: 75/737111: Filed 6/23/99
COMBIPHARM:
S.N.: 75/737116: Filed 6/23/99
Ref: CombiChemDockets\1_AAT.ddfoc2.doc
64
ASSIGNMENT OF COPYRIGHTS
This Assignment of Copyrights (the "ASSIGNMENT") dated as of
April __, 2000 (the "EFFECTIVE Date") is being made pursuant to that certain
Technology Assignment and License Agreement (the "TECHNOLOGY ASSIGNMENT AND
LICENSE AGREEMENT") dated April __, 2000 by and between Axys Pharmaceuticals,
Inc., a Delaware corporation with offices at 000 Xxxxxxx Xxx, Xxxxx Xxx
Xxxxxxxxx, XX 00000 (the "ASSIGNOR") and Axys Advanced Technologies, Inc., a
Delaware corporation with offices at 000 Xxxxxxx Xxx, Xxxxx Xxx Xxxxxxxxx, XX
00000 (the "ASSIGNEE").
For good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, Assignor makes the following assignment:
1. Under and in accordance with the Technology Assignment and
License Agreement, Assignor hereby assigns to Assignee all of Assignor's rights,
title and interest in and to the works described in Schedules 1.7 and 1.8
attached hereto and incorporated herein by this reference (the "WORKS"); said
rights, title and interest including, but not limited to, all copyrights,
copyright applications, copyright registrations, copyrightable subject matter in
the Works, rights of reproduction, distribution, performance and display, the
right to prepare derivative works and any and all causes of action heretofore
accrued in Assignor's favor for infringement of the aforesaid rights, to have
and to hold the same unto Assignee, its successors and assigns, for and during
the existence of the rights and all renewals and extensions thereof.
2. Assignor hereby assigns to Assignee and waives any and all
moral or other rights Assignor may have in and to the Works or any portion
thereof.
3. Assignor hereby constitutes and appoints Assignee as
Assignor's true and lawful attorney-in-fact, with full power of substitution in
Assignor's name and stead, to take any and all steps, including proceedings at
law, in equity or otherwise, to execute, acknowledge and deliver any and all
instruments and assurances necessary or expedient in order to vest or perfect
the aforesaid rights and causes of action more effectively in Assignee or to
protect the same or to enforce any claim or right of any kind with respect
thereto. This includes, but is not limited to, any rights with respect to the
Works that may have accrued in Assignor's favor from the respective date of
creation of the Works to the date of this Assignment. Assignor hereby declares
that the foregoing power is coupled with an interest and as such is irrevocable.
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65
IN WITNESS WHEREOF, Assignor has signed this Assignment effective
as of the date first above written.
AXYS PHARMACEUTICALS, INC.
By: _____________________________
Name: _____________________________
Title: _____________________________
STATE OF CALIFORNIA )
) ss
COUNTY OF __________________)
On ___________________, before me, ______________________, Notary
Public, personally appeared ________________________________, personally known
to me (or proved to me on the basis of satisfactory evidence) to be the
person(s) whose name(s) is/are subscribed to the within instrument and
acknowledged to me that he/she/they executed the same in his/her/their
authorized capacity(ies), and that by his/her/their signature(s) on the
instrument the person(s), or the entity upon behalf of which the person(s)
acted, executed the instrument.
WITNESS my hand and official seal.
____________________________________
Signature
[SEAL]
66
SCHEDULE 1.7
ASSIGNED PROTOCOLS
(see attached)
See Schedule 1.7 to Technology Assignment and License Agreement.
67
SCHEDULE 1.8
ASSIGNED SOFTWARE
See Schedule 1.8 to Technology Assignment and License Agreement.
68
SCHEDULE 2.1(d)
LICENSES-OUT
THIRD PARTY AGREEMENT
----------- ---------
1. Akkadix, Inc. License Agreement between Axys and Xyris
Corporation (the predecessor of Akkadix)
dated January 29, 1999, as amended.
2.
3.
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Document Number: 310957
