Amendment 1.3 to Agreement dated 26th Dec ’08 signed by and between Dr. Reddy’s Laboratories Limited Bollaram Road, Miyapur, Hyderabad 500 049 India (Hereinafter referred to as “Dr. Reddy’s”) And Prana Biotechnology Ltd Level 2, 369 Royal Parade,...

Exhibit 4.23

Amendment 1.3 to Agreement dated 26^th Dec ’08 signed by and between

Xx. Xxxxx’x Laboratories Limited

Xxxxxxxx Xxxx, Xxxxxxx,

Xxxxxxxxx 000 000

Xxxxx

(Hereinafter referred to as “Xx. Xxxxx’x”)

And

Prana Biotechnology Ltd

Xxxxx 0, 000 Xxxxx Xxxxxx, Xxxxxxxxx Xxxxxxxx, 0000

Xxxxxxxxx

(Hereinafter referred to as “Prana”)

Xx. Xxxxx’x and Prana are collectively referred to as the “PARTIES”

This amendment will include the following additional and amended clauses in the above mentioned Agreement (plus amendments) and will be in effect from 14 February 2012 onwards.

1.	Terms to be included
i.	The following new clause-12 in Appendix A of the Agreement:

“12. Sub-Project 4A: Qualification of Xx Xxxxx’x Reference Standard in comparison with IDT Reference Standard

	a)	Xx. Xxxxx’x will analyse the Xx Xxxxx’x Reference Standard (CDDQ5RS1101) and the IDT Reference Standard (DA102301.1) side-by-side using Xx Xxxxx’x methods.
	b)	This will include:
		i.		Description, per Method of Analysis AR&D-GTP-001.
		ii.		Identification by FT-IR, Mass, NMR(13C and 1 H NMR), Elemental composition by HR-MS, per Method of Analysis AR&D-GTP-003
		iii.		Chloride content, per Method of Analysis MF/CDDQ5-002/02
		iv.		Identification, Assay and Related substances by HPLC, per Method of Analysis MF/CDDQ5-001/05
		v.		Related substances by LC-MS, per Methods of Analysis MF/CDDQ5-004/0/3 and MF/CDDQ5-003/02
		vi.		Residue on ignition, per Method of Analysis AR&D-GTP-0010
		vii.		Water content by KF, per Method of Analysis AR&D-GTP-005
		viii.		Heavy metals, per Method of Analysis AR&D-GTP-0011
		ix.		Residual solvents by GC, per Method of Analysis MF/CDDQ5-007/02 (excluding Methanol)
	c)	Related Substances analysis to be performed in one sequence. Same tests to be performed on same day or in same sequence for reference standards of Xx. Xxxxx’x and IDT.

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d) Report containing all raw data and comments on comparability of the two Reference Standards to be provided. This should be an addendum to the existing Reference Standard report titled “Report on PBT2 reference standard preparation (I-CDDQ-10-0318)”.

ii.	The following description of new Sub-Project 4A under Sub-Project Pricing in clause 3 of the Agreement
	“Sub-Project 4A: Qualification of Xx Xxxxx’x Reference Standard in comparison with IDT Reference Standard – USD 4,000/-”
iii.	The following description of new Sub-Project payment terms in clause 3 of the Agreement
	“Sub-Project 4A:
	●	100% upon sharing the final report to Prana (USD 4,000/-)”
2.	Terms to be varied
i.	The current numbering of the following clause heading in Appendix A of the Agreement, as amended in Amendment 10:

“12. Sub-Project 6: Stability Study (48 months)”

is amended as follows

“13. Sub-Project 6: Stability Study (48 months)”

All other terms and conditions of the original Agreement dated 26^th Dec’08 and those included in Amendments 1 to 12 remain unchanged.

In witness whereof, the parties hereto have signed this Agreement

Signed for and on behalf of		Signed for and on behalf of
Xx. Xxxxx’x Laboratories Limited		Prana Biotechnology Ltd.
Signature		Signature
Name: Xxxxx Xxxxxxxx		Name: Xxxxxx Xxxxx
Witness Signature		Witness Signature
Witness Name: Xxxxx Xxxxxxxx		Witness Name: Xxxxxxxxx Xxxxxxx

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