EXHIBIT 1 TO SCHEDULE 13D
JOINT FILING AGREEMENT
Each of the undersigned hereby agrees and consents that the Schedule
13D filed herewith (this "Schedule 13D") by Glaxo Wellcome plc ("Glaxo
Wellcome") is filed on behalf of each of them pursuant to the authorization
of each of them to Glaxo Wellcome to make such filing and that such Schedule
13D is filed jointly on behalf of each of them, pursuant to Sections 13(d)
and 13(g) of the U.S. Securities Exchange Act of 1934, as amended, and the
rules promulgated thereunder. Each of these persons is not responsible for
the completeness or accuracy of the information concerning the other persons
making this filing unless such person knows or has reason to believe that
such information is inaccurate. This agreement may be signed in counterparts.
GLAXO WELLCOME PLC GLAXO GROUP LIMITED
By: /s/ X. X. XXXXXX By: /s/ X. X. XXXXXX
---------------------- ------------------------------
Title: Secretary Title: Secretary
GLAXO VENTURE LIMITED GLAXO WELLCOME
AMERICAS INC.
By: /s/ X. X. XXXXXX By: /s/ X. X. XXXXXX
------------------------ ------------------------------
Title: Director Title: Director
AFFYMAX N.V. AFFYMAX TECHNOLOGIES N.V.
By: /s/ XXXXXXXX XXXXXXXXX By: /s/ XXXXXXXX XXXXXXXXX
---------------------------- -------------------------------
Title: Company Secretary Title: Company Secretary
Page 26 of 102
XX. XXXXXXX X. XXXX XX. XXXXX X. XXXX
By: /s/ XXXXXXX X. XXXX By: /s/ XX. XXXXX X. XXXX
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Dated: February 16, 1999
Page 27 of 102
