1
EXHIBIT 10.15
AMENDMENT AGREEMENT
The Letter Agreement of June 3, 1998 between Antigenics L.L.C. and Sigma-Tau
Industrie Farmaceutiche Riunite S.p.A. is hereby amended as follows:
-ON PAGE 1, THE INITIAL SIX LINES:
"Gentlemen:
We refer to our recent discussions regarding a potential scientific and business
cooperation between Antigenics L.L.C. ("Antigenics") and Sigma-Tau Industrie
Farmaceutiche Riunite S.p.A. (the "Company") in Italy (the "Territory") with
regard to Antigenics' proprietary technology on the use of Heat Shock Proteins
("HSP") for the use of HSP to boost and modulate the immune system against
cancer (the "Technology")."
are deleted and replaced by the following:
"Gentlemen:
We refer to our recent discussions regarding a potential scientific and business
cooperation between Antigenics L.L.C. ("Antigenics") and Sigma-Tau Industrie
Farmaceutiche Riunite S.p.A. (the "Company") in Italy, Spain, Portugal and
Switzerland (the "Territory") with regard to Antigenics' proprietary technology
on the use of Heat Shock Proteins ("HSP") for the use of HSP to boost and
modulate the immune system against cancer (the "Technology")."
-ON PAGE 1, PARAGRAPH 2, 10TH LINE:
"by the Company, within 12 (twelve) months from the date of this Letter
Agreement; it being"
is deleted and replaced by the following:
"by the Company, within 30 (thirty) months from the date of this Letter
Agreement; it being"
-ON PAGE 1, PARAGRAPH 3., 3RD LINE:
"parties, (ii) six months from the completion of the second Trial, if the
parties agree to only"
is deleted and replaced by the following:
"PARTIES, (ii) TWELVE MONTHS FROM THE COMPLETION OF THE SECOND TRIAL, IF THE
PARTIES AGREE TO ONLY"
2
IN WITNESS WHEREOF, the parties have executed this Amendment Agreement by their
duly authorized representatives in duplicate as of the day and year below
written.
ANTIGENICS, L.L.C. SIGMA-TAU INDUSTRIE
FARMACEUTICHE
RUINITE S.p.A.
By: /s/ Xxxx Xxxxx By: /s/ Xxxxxx Plate
-------------------------------- --------------------------------
Name/Title: Xxxx Xxxxx Name/Title: Xxxxxx Plate - Chief
-------------------------- --------------------------
Operating Officer
Date: 10/14/99 Date: 20-10-99
-------------------------------- --------------------------------
