[Ixion Letterhead]
December 20, 1995
Xxxxx X. XxXxxxxx, PH. D.
Director, Office of Technology Licensing
000 Xxxxxxx Xxxx
Xxxxxxxxxxx, XX 00000-0000
AMENDMENT NUMBER ONE
Re: Oxalate Patent Licenses between UFRFI and Ixion
Dear Xxxxx:
I refer to the Patent License Agreement between the University of Florida
Research Foundation, Inc., ("UFRFI") and Ixion Biotechnology, Inc. ("Ixion" or
the "Company"), dated January 11, 1995, relating to USSN 08/262,424 (the
"Oxalate License"). Such license requires Ixion to develop a working model
of an urine oxalate detection kit by January 11, 1996. We have determined that
a more promising product is a molecular probe to detect the presence or absence
of Oxalobacter formigenes in the human gut. We expect to have a working model
of that probe by January 11, 1996, and would like to substitute that probe for
the urine oxalate kit referred to in Section 3.2(b) of the Oxalate License.
If this meets with your approval, please sign and return a copy of this
letter.
Best wishes for the holiday season.
Sincerely yours,
/S/
Xxxxxx X. Xxxxxx
Accepted and agreed to:
/s/ Xxxxx X. XxXxxxxx
_____________________
