Exhibit 10.127 November 16, 2000 Mr. David M. Mott c/o MedImmune, Inc. 35 W. Watkins Mill Road Gaithersburg, MD 20878 Dear David: Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with...

Exhibit 10.127












                                                     November 16, 2000


Xx. Xxxxx X. Xxxx
c/o MedImmune, Inc.
00 X. Xxxxxxx Xxxx Xxxx
Xxxxxxxxxxxx, XX 00000


Dear Xxxxx:

                  Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with
MedImmune, Inc. (the "Company").

                  This letter agreement will confirm that the Employment Agreement was amended, effective as of October 1, 2000, to
reflect your new position as Vice Chairman and Chief Executive Officer and your new annual base salary of $600,000.  In addition, the
Employment Agreement is hereby amended so that the Employment Period referred to in Section 2 thereof is extended to November 1,
2002.  All other provisions of the Employment Agreement remain unchanged.

                                                     Very truly yours,

                                                     MEDIMMUNE, INC.


                                                     By: /s/ Xxxxx X. Xxxxxxxxx
                                                            Xxxxx X. Xxxxxxxxx
                                                             Chairman of the Board

Accepted and agreed to by:



/s/ Xxxxx X. Xxxx
Xxxxx X. Xxxx

Date:     11/22/00