EMPLOYMENT AGREEMENT

EXHIBIT 10.8

EMPLOYMENT AGREEMENT

THIS EMPLOYMENT AGREEMENT (the “Agreement”), dated as of June 16, 2006 (the “Effective Date”), is hereby entered into in the State of Maryland by and between SUCAMPO PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and XXXXXXX XXXX, Ph.D. (“Executive”).

WHEREAS, Executive is one of the founders of the Company and has been employed by the Company for some time, most recently pursuant to the terms of an Amended and Restated Employment Agreement effective as of July 1, 2004;

WHEREAS, Executive and her spouse own a controlling interest in Sucampo AG, which will enter into an Amended and Restated Patent Access Agreement with Company to be executed on or about the date hereof (the “Patent Access Agreement”) pursuant to which Sucampo AG has licensed certain of its patented technology and know-how to the Company on an exclusive basis in the Company’s Territory;

WHEREAS, Executive possesses certain skills, experience or expertise which will be of continued value to the Company;

WHEREAS, the parties acknowledge that Executive’s abilities and services are unique and will continue to significantly enhance the business prospects of the Company; and

WHEREAS, in light of the foregoing, the Company desires to continue to employ Executive as its Chief Executive Officer and President, and Executive desires to remain in such employment.

NOW, THEREFORE, in consideration of the promises and the mutual covenants and agreements herein contained, the Company and Executive hereby agree as follows:

Article 1. Employment Agreement

1.1 Employment and Duties

The Company offers and Executive hereby accepts employment with the Company for the Term (as hereinafter defined) as its Chief Executive Officer and President, and in connection therewith, agrees to perform such duties as Executive shall reasonably be assigned by the Company’s Board of Directors. Executive hereby warrants and represents that Executive has no contractual commitments or other obligations to third parties inconsistent with Executive’s acceptance of this employment and performance of the obligations set forth in this Agreement. Executive shall perform such duties and carry out Executive’s responsibilities hereunder faithfully and to the best of Executive’s ability, and shall devote Executive’s full business time and best efforts to the business and affairs of the Company during normal business hours (exclusive of periods of vacation, sickness, disability, or other leaves to which Executive is entitled). Notwithstanding the foregoing, it is understood and agreed that Executive may devote a reasonable amount of her business time to the affairs of the Sucampo Group Companies (i.e., Sucampo AG, S&R Technology Holdings LLC, S&R Foundation, R-Tech Ueno, Ltd., Sucampo Pharma, Ltd. and Sucampo Pharma Europe, Ltd.) in which she is currently engaged as a director, officer, manager, member or employee, as the case may be, and that such activities shall be permitted under this Agreement insofar as they do not materially interfere with Executive’s performance of her responsibilities and duties under this Agreement. Executive will perform all of Executive’s responsibilities in compliance with all applicable laws and will ensure that the operations that Executive manages are in compliance with all applicable laws.

Article 2. Employment Term

2.1 Term

The term of Executive’s employment hereunder (the “Term”) shall be deemed to commence on the Effective Date and shall end on the third anniversary of the Effective Date, unless sooner terminated as hereinafter provided; provided, however, that the Term shall be automatically renewed and extended for an additional period of one (1) year on each anniversary thereafter unless either party gives a Notice of Termination (as defined below) to the other party at least sixty (60) days prior to such anniversary.

2.2 Survival on Merger or Acquisition

In the event the Company is acquired during the Term, or is the non-surviving party in a merger, or sells all or substantially all of its assets, this Agreement shall not automatically be terminated, and the Company agrees to use its best efforts to ensure that the transferee or surviving company shall assume and be bound by the provisions of this Agreement.

Article 3. Compensation and Benefits

3.1 Compensation

(a) Base Salary. The Company shall pay Executive a salary at an annual rate that is not less than Three Hundred Eighty Thousand Dollars ($380,000.00), to be paid in bi-weekly installments, in arrears (the “Base Salary”). Thereafter, the Base Salary will be reviewed by the Compensation Committee of the Board of Directors (the “Compensation

Committee”) at least annually, and its recommendations shall be reviewed and approved by the independent members of the Board. Base Salary may, in the sole discretion of the independent Directors, be increased, but not decreased (unless mutually agreed by Executive and the Company).

(b) Stock Compensation. Following the occurrence of the Equity Eligibility Date, Executive shall be eligible for consideration to receive restricted stock grants, incentive stock options or other awards in accordance with the 2006 Stock Incentive Plan. Recommendations concerning the decision to make an award pursuant to that Plan and the amount of any award are entirely discretionary, and shall be made by the Compensation Committee, subject to review and approval by the independent members of the Board. In the event that, during the Term (i) the Company is acquired or is the non-surviving party in a merger, or (ii) the Company sells all or substantially all of its assets, or (iii) in the event of the death of Executive, all unvested restricted stock awards and incentive stock options having previously been awarded to Executive shall immediately vest and may be exercised in accordance with the terms of the Plan and the Executive’s grant award. For purposes of this Agreement, the “Equity Eligibility Date” shall be the date upon which the equity ownership in the Company of Executive, when combined with that of Xx. Xxxxx Xxxx, shall cease to represent at least fifty percent (50%) of the Company’s total equity.

(c) Bonuses. Executive shall be eligible to receive an annual bonus award in recognition of Executive’s contributions to the success of the Company pursuant to the Company’s management incentive bonus program as it may be amended or modified from time to time. The bonus award shall be based on an annual incentive target of fifty

percent (50%) of Executive’s Base Salary, and determined by the Compensation Committee’s assessment of Executive’s achievement of annual objectives. The Compensation Committee’s recommendation shall be reviewed and approved by the independent members of the Board. The decision to make an award and the amount of any award shall be determined by the independent Directors, in their sole discretion.

(d) Withholding Taxes. All compensation due to Executive shall be paid subject to withholding by the Company to ensure compliance with all applicable laws and regulations.

3.2 Participation in Benefit Plans

Executive shall be entitled to participate in all employee benefit plans or programs of the Company offered to other employees to the extent that Executive’s position, tenure, salary, and other qualifications make Executive eligible to participate in accordance with the terms of such plans. The Company does not guarantee the continuance of any particular employee benefit plan or program during the Term, and Executive’s participation in any such plan or program shall be subject to all terms, provisions, rules and regulations applicable thereto. Executive will be entitled to four (4) weeks of vacation per year, to be used and administered in accordance with the Company’s vacation policy as it may change from time to time.

3.3 Expenses

The Company will pay or reimburse Executive for all reasonable and necessary out-of-pocket expenses incurred by Executive in the performance of Executive’s duties under this Agreement. Executive shall provide to the Company detailed and accurate records of such

expenses for which payment or reimbursement is sought, and Company payments shall be in accordance with the regular policies and procedures maintained by the Company from time to time.

3.4 Professional Organizations

During the Term, Executive shall be reimbursed by the Company for the annual dues payable for membership in professional societies associated with subject matter related to the Company’s interests. New memberships for which reimbursement will be sought shall be approved by the Company in advance.

3.5 Parking

During the Term, the Company shall either provide parking for Executive’s automobile at the Company’s expense or reimburse Executive for such expense.

Article 4. Termination of Employment

4.1 Definitions

As used in Article 4 of this Agreement, the following terms shall have the meaning set forth for each below:

(a) “Benefit Period” shall mean the eighteen (18) month period commencing on the Date of Termination which occurs in connection with a termination of employment described in the first sentence of Section 4.4(a).

(b) “Cause” shall mean any of the following:

(i) the gross neglect or willful failure or refusal of Executive to perform Executive’s duties hereunder (other than as a result of Executive’s death or Disability);

(ii) perpetration of an intentional and knowing fraud against or affecting the Company or any customer, supplier, client, agent or employee thereof;

(iii) any willful or intentional act that could reasonably be expected to injure the reputation, financial condition, business or business relationships of the Company or Executive’s reputation or business relationships;

(iv) conviction (including conviction on a nolo contendere plea) of a felony or any crime involving fraud, dishonesty or moral turpitude;

(v) the material breach by Executive of this Agreement (including, without limitation, the Employment Covenants set forth in Article 5 of this Agreement); or

(vi) the failure or continued refusal to carry out the directives of the Board of Directors that are consistent with Executive’s duties and responsibilities under this Agreement which is not cured within thirty (30) days after receipt of written notice from the Company specifying the nature of such failure or refusal; provided, however, that Cause shall not exist if such refusal arises from

Executive’s reasonable, good faith belief that such failure or refusal is required by law.

(c) “Date of Termination” shall mean the date specified in the Notice of Termination (as hereinafter defined) (except in the case of Executive’s death, in which case the Date of Termination shall be the date of death); provided, however, that if Executive’s employment is terminated by the Company other than for Cause, the date specified in the Notice of Termination shall be at least thirty (30) days from the date the Notice of Termination is given to Executive.

(d) “Notice of Termination” shall mean a written notice from the Company to Executive that indicates Section 2 or the specific provision of Section 4 of this Agreement relied upon as the reason for such termination or nonrenewal, the Date of Termination, and, in the case of termination or non-renewal by the Company for Cause, in reasonable detail, the facts and circumstances claimed to provide a basis for termination or nonrenewal.

(e) “Good Reason” shall mean:

(i) Company effects a material diminution of Executive’s position, authority or duties;

(ii) any requirement that Executive, without her consent, move her regular office to a location more than fifty (50) miles from Company’s executive offices;

(iii) the material failure by Company, or its successor, if any, to pay compensation or provide benefits or perquisites to Executive as and when required by the terms of this Agreement; or

(iv) any material breach by Company of this Agreement.

The Executive shall have Good Reason to terminate Executive’s employment if (i) within twenty-one (21) days following Executive’s actual knowledge of the event which Executive determines constitutes Good Reason, Executive notifies the Company in writing that Executive has determined a Good Reason exists and specifies the event creating Good Reason, and (ii) following receipt of such notice, the Company fails to remedy such event within twenty-one (21) days. If either condition is not met, Executive shall not have a Good Reason to terminate Executive’s employment.

(f) “Change in Control” shall mean:

(i) the acquisition by any person of beneficial ownership of fifty percent (50%) or more of the outstanding shares of the Company’s voting securities; or

(ii) the Company is the non-surviving party in a merger; or

(iii) the Company sells all or substantially all of its assets; provided, however, that no “Change in Control” shall be deemed to have occurred merely as the result of a refinancing by the Company or as a result of the Company’s insolvency or the appointment of a conservator; or

(iv) the Compensation Committee of the Company, in its sole and absolute discretion determines that there has been a sufficient change in the share ownership or ownership of the voting power of the Company’s voting securities to constitute a change of effective ownership or control of the Company.

4.2 Termination Upon Death or Disability

This Agreement, and Executive’s employment hereunder, shall terminate automatically and without the necessity of any action on the part of the Company upon the death of Executive. In addition, if at any time during the Term, Executive shall become physically or mentally disabled (as determined by an independent physician competent to assess the condition at issue), whether totally or partially, so that Executive is unable substantially to perform Executive’s duties and services hereunder, with or without reasonable accommodation, for either (i) a period of sixty (60) consecutive calendar days, or (ii) ninety (90) consecutive or non-consecutive calendar days during any consecutive five (5) month period (the “Disability Date”), the Company may terminate this Agreement and Executive’s employment hereunder by written notice to Executive after the Disability Date (but before Executive has recovered from such disability).

4.3 Company’s and Executive’s Right to Terminate

This Agreement and Executive’s employment hereunder may be terminated at any time by the Company for Cause or, if without Cause, upon thirty (30) days prior written notice to Executive. In the event the Company should give Executive notice of termination without Cause, the Company may, at its option, elect to provide Executive with thirty (30) days’ salary in lieu of Executive’s continued active employment during the notice period. This Agreement and

Executive’s employment hereunder may be terminated by Executive at any time for Good Reason and, if without Good Reason, upon thirty (30) days prior written notice to the Company.

4.4 Compensation Upon Termination

(a) Severance. In the event the Company terminates (or elects not to renew) this Agreement without Cause or pursuant to Section 4.2 due to the disability of Executive, or in the event Executive terminates this Agreement for Good Reason, Executive shall be entitled to receive: (i) Executive’s Base Salary through the Date of Termination, (ii) reimbursement of any COBRA continuation premium payments made by Executive for the Benefit Period, and (iii) a lump sum severance payment equal to twenty-four (24) months of Executive’s then current Base Salary to be made not later than ten (10) business days following the expiration of the revocation period in Executive’s release (as provided in Section 4.4(c) below) without any revocation having occurred. Notwithstanding the foregoing, the Company shall, to the extent necessary and only to the extent necessary, modify the timing of delivery of severance benefits to Executive if the Company reasonably determines that the timing would subject the severance benefits to any additional tax or interest assessed under Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”). In such event, the payments will be made as soon as practicable without causing the severance benefits to trigger such additional tax or interest under Section 409A of the Code In the event this Agreement is terminated (or not renewed) for any reason other than by the Company without Cause or pursuant to Section 4.2 due to the disability of Executive or by Executive for Good Reason, Executive shall not be entitled to the continuation of any compensation, bonuses or

benefits provided hereunder, or any other payments following the Date of Termination, other than Base Salary earned through such Date of Termination.

(b) Change in Control. In the event that Executive is terminated other than for “Cause” within eighteen (18) months following the occurrence of a “Change in Control” of the Company, then Executive shall be entitled to a severance payment in an amount that is two (2) times the amount specified in Section 4.4(a), clause (iii) above (the “Change in Control Severance Payment”). In the event that Executive shall become entitled to a Change in Control Severance Payment as provided herein, the Company shall cause its independent auditors promptly to review, at the Company’s sole expense, the applicability to those payments of Sections 280G and 4999 of the Code. If the auditors determine that any payment of the Change in Control Severance Payment would be subject to the excise tax imposed by Section 4999 of the Code or any interest or penalties with respect to such excise tax, then such payment owed to Executive shall be reduced by an amount calculated to provide to Executive the maximum Change in Control Severance Payment which will not trigger application of Sections 280G and 4999 of the Code.

(c) Release. Anything to the contrary contained herein notwithstanding, as a condition to Executive receiving severance benefits to be paid pursuant to this Section 4.4, Executive shall execute and deliver to the Company a general release in the form attached hereto as Exhibit A. The Company shall have no obligation to provide any severance benefits to Executive until it has received the general release from Executive and any revocation or rescission period applicable to the Release shall have expired without revocation or rescission.

Article 5. Employment Covenants

5.1 Definitions

As used in this Article 5 of the Agreement, the following terms shall have the meaning set forth for each below:

(a) “Affiliate” shall mean a person or entity that directly, or indirectly through one or more intermediaries, controls or is controlled by, or under common control with another person or entity, including current and former directors and officers of such an entity.

(b) “Confidential Information” shall mean all confidential and proprietary information of the Company, its Predecessors and Affiliates, whether in written, oral, electronic or other form, including but not limited to trade secrets; technical, scientific or business information; processes; works of authorship; Inventions; discoveries; developments; systems; chemical compounds; computer programs; code; algorithms; formulae; methods; ideas; test data; know how; functional and technical specifications; designs; drawings; passwords; analyses; business plans; information regarding actual or demonstrably anticipated business, research or development; marketing, sales and pricing strategies; and information regarding the Company’s current and prospective consultants, customers, licensors, licensees, investors and personnel, including their names, addresses, duties and other personal characteristics. Confidential Information does not include information that (i) is in the public domain, other than as a result of an act of misappropriation or breach of an obligation of confidentiality by any person; (ii)

Executive can verify by written records kept in the ordinary course of business was in Executive’s lawful possession prior to its disclosure to Executive; (iii) is received by Executive from a third party without a breach of an obligation of confidentiality owed by the third party to the Company and without the requirement that Executive keep such information confidential; or (iv) Executive is required to disclose by applicable law, regulation or order of a governmental agency or a court of competent jurisdiction. If Executive is required to make disclosure pursuant to clause (iv) of the preceding sentence as a result of the issuance of a court order or other government process, Executive shall (a) promptly, but in no event more than 72 hours after learning of such court order or other government process, notify, pursuant to Section 6.1 below, the Company; (b) at the Company’s expense, take all reasonable necessary steps requested by the Company to defend against the enforcement of such court order or other government process, and permit the Company to intervene and participate with counsel of its choice in any proceeding relating to the enforcement thereof; and (c) if such compelled disclosure is required, Executive shall disclose only that portion of the Confidential Information that is necessary to meet the minimum legal requirement imposed on Executive.

(c) “Executive Work Product” shall mean all Confidential Information and Inventions conceived of, created, developed or prepared by Executive (whether individually or jointly with others) before or during Executive’s entire course of employment with the Company, during or outside of working hours, which relate in any manner to the actual or demonstrably anticipated business, research or development of the Company, or result from or are suggested by any task assigned to Executive or any work performed by Executive for or on behalf of the Company or any of its Affiliates.

(d) “Invention” shall mean any apparatus, biological processes, cell line, chemical compound, creation, data, development, design, discovery, formula, idea, improvement, innovation, know-how, laboratory notebook, manuscript, process or technique, whether or not patentable or protectable by copyright, or other intellectual property in any form.

(e) “Predecessor” shall mean an entity, the major portion of the business and assets of which was acquired by another entity in a single transaction or in a series of related transactions.

(f) “Trade Secrets,” as used in this Agreement, will be given its broadest possible interpretation under the law applicable to this Agreement.

5.2 Nondisclosure and Nonuse

Executive acknowledges that prior to and during Executive’s entire course of employment with the Company, Executive has had and will have occasion to create, produce, obtain, gain access to or otherwise acquire, whether individually or jointly with others, Confidential Information. Accordingly, during the term of Executive’s employment with the Company and at all times thereafter, Executive shall keep secret and shall not, except for the Company’s benefit, disclose or otherwise make available to any person or entity or use, reproduce or commercialize, any Confidential Information, unless specifically authorized in advance by the Company in writing.

5.3 Other Confidentiality Obligations

Executive acknowledges that the Company may, from time to time, have agreements with other persons or entities or with the U.S. Government or governments of other countries, or

agencies thereof, which impose confidentiality obligations or other restrictions on the Company. Executive hereby agrees to be bound by all such obligations and restrictions and shall take all actions necessary to discharge the obligations of the Company thereunder, including, without limitation, signing any confidentiality or other agreements required by such third parties.

5.4 Return of Confidential Information

At any time during Executive’s employment with the Company, upon the Company’s request, and in the event of Executive’s termination of employment with the Company for any reason whatsoever, Executive shall immediately surrender and deliver to the Company all records, materials, notes, equipment, drawings, documents and data of any nature or medium, and all copies thereof, relating to any Confidential Information (collectively the “the Company Materials”) which is in Executive’s possession or under Executive’s control. Executive shall not remove any of the Company Materials from the Company’s business premises or deliver any of the Company Materials to any person or entity outside of the Company, except as required in connection with Executive’s duties of employment. In the event of the termination of Executive’s employment for any reason whatsoever, Executive shall promptly sign and deliver to the Company a Termination Certificate in the form of Exhibit B attached hereto.

5.5 Confidential Information of Others

Executive represents that Executive’s performance of all the terms of this Agreement and Executive’s employment with the Company do not and will not breach any agreement to keep in confidence proprietary information, knowledge or data with regard to which Executive has obligations of confidentiality or nonuse, and Executive shall not disclose to the Company or cause the Company to use any such confidential proprietary information, knowledge or data

belonging to any previous employer of Executive or other person, except as such disclosure or use may be authorized in writing by the previous employer or other person. Executive represents that Executive has not brought and will not bring to the Company or use at the Company any confidential materials or documents of any former employer or other person that are not generally available to the public, unless express written authorization for their possession and use has been obtained from such former employer or other person. Executive agrees not to enter into any agreement, whether written or oral, that conflicts with these obligations.

5.6 Other Obligations

The terms of this Section 5 are in addition to, and not in lieu of, any statutory or other contractual or legal obligation to the Company to which Executive may be subject relating to the protection of Confidential Information.

5.7 Assignment of Confidential Information and Inventions; Works Made for Hire

Executive hereby assigns to the Company all right, title and interest in all intellectual property, including any patent applications, trade secrets, know how, copyrights, software, or trademarks associated with the Executive Work Product and Confidential Information. Executive hereby acknowledges and agrees that all Executive Work Product subject to copyright protection constitutes “work made for hire” under United States copyright laws (17 U.S.C. § 101) and is owned exclusively by the Company. To the extent that title to any Executive Work Product subject to copyright protection does not constitute a “work for hire,” and to the extent title to any other Executive Work Product does not, by operation of law or otherwise, vest in the Company, all right, title, and interest therein, including, without limitation, all copyrights, patents and trade secrets, and all copyrightable or patentable subject matter, are

hereby irrevocably assigned to the Company. Executive shall promptly disclose to the Company in writing all Executive Work Product. Executive shall, without any additional compensation, execute and deliver all documents or instruments and give the Company all assistance it requires to transfer all right, title, and interest in any Executive Work Product to the Company; to vest in the Company good, valid and marketable title to such Executive Work Product; to perfect, by registration or otherwise, trademark, copyright and patent protection of the Company with respect to such Executive Work Product; and otherwise to protect the Company’s trade secret and proprietary interest in such Executive Work Product. Executive hereby irrevocably designates and appoints the Company and its duly authorized officers and agents as Executive’s agents and attorneys-in-fact to act for and on Executive’s behalf, and to execute and file any documents and to do all other lawfully permitted acts to further the purposes of this Section 5.7 with the same legal force and effect as if executed by Executive.

5.8 Representations

Executive represents that, to the best of her knowledge, none of the Inventions will violate or infringe upon any right, patent, copyright, trademark or right of privacy, or constitute libel or slander against or violate any other rights of any person, firm or corporation, and that Executive will not knowingly create any Invention which causes any such violation.

5.9 Inventions, Intellectual Property and Equipment Not Transferred

Executive has set forth on Exhibit C attached hereto a complete list and brief description of all Inventions, intellectual property and equipment located at the Company which is owned directly or indirectly by Executive and which shall not be transferred to the Company pursuant to this Agreement. Except as so listed, Executive agrees that she will not assert any rights under

any intellectual property as having been made or acquired by Executive prior to being employed by the Company. The Company may, at its discretion, require detailed disclosures and materials demonstrating ownership of the intellectual property so listed.

5.10 Effect of Patent Access Agreement

Pursuant to the Patent Access Agreement among Sucampo AG (“SAG”), Sucampo Pharmaceuticals, Inc. (“SPI”), Sucampo Pharma, Ltd. (“SPL”), and Sucampo Pharma Europe, Ltd. (“SPE”), SAG has licensed certain of its patented technology and know-how to SPI, SPL, and SPE on an exclusive basis in their respective Territories (as that term is defined in the Patent Access Agreement). The Patent Access Agreement contains provisions pursuant to which patented technology or know-how owned by SAG is either (i) not licensed to SPI, SPL, or SPE, or (ii) if licensed by SAG to SPI, SPL, or SPE, will be transferred back or revert to SAG under certain circumstances. In the event that the provisions of this Agreement and the Patent Access Agreement conflict with respect to the transfer of or right to use any patented technology or know-how covered by the Patent Access Agreement, the parties agree that the provisions of the Patent Access Agreement shall control.

5.11 Exclusivity of Employment

During the Term, and without prior approval of the Board of Directors, Executive shall not directly or indirectly engage in any activity competitive with or adverse to the Company’s business or welfare or render a material level of services of a business, professional or commercial nature to any other person or firm, whether for compensation or otherwise; provided, however, that Executive may devote a reasonable amount of her business time to the affairs of Sucampo Group Companies in which she is currently engaged as a director, officer, manager,

member or employee, as the case may be, and may participate in charitable and civic undertakings, provided that such activities do not materially interfere with the performance of Executive’s duties and responsibilities to the Company.

5.12 Covenant Not to Compete

Executive agrees to be bound and abide by the following covenant not to compete:

(a) Term and Scope. During Executive’s employment with the Company and for a period of twelve (12) months after Executive’s separation from employment for any reason whatsoever, Executive will not render to any Conflicting Organization (as hereinafter defined), services, directly or indirectly, anywhere in the world in connection with any Conflicting Product (as hereunder defined), except that Executive may accept employment with a Conflicting Organization whose business is diversified (and which has separate and distinct divisions) if Executive first certifies to the Company in writing that such prospective employer is a separate and distinct division of the Conflicting Organization and that Executive will not render services directly or indirectly in respect of any Conflicting Product. Such twelve (12) month time period shall be tolled during any period that Executive is engaged in activity in violation of this covenant.

(b) Judicial Construction. Executive and the Company agree that, if the period of time or the scope of this Covenant Not to Compete shall be adjudged unreasonably overbroad in any court proceeding, then the period of time and/or scope shall be modified accordingly, so that this covenant may be enforced with respect to such services or geographic areas and during such period of time as is judged by the court to be reasonable.

“Conflicting Product” means any product, method or process, system or service of any person or organization other than the Company that is the same as, similar to or interchangeable with any product, method or process, system or service involving prostones, prostone compounds or derivates, or any prostone-related technology.

“Conflicting Organization” means any person or organization which is engaged in research on or development, production, marketing, licensing, selling, servicing or other commercialization of any Conflicting Product.

5.13 Non-Solicitation

For twelve (12) months after termination of employment with the Company for any reason, Executive shall not directly or indirectly solicit or hire, or assist any other person in soliciting or hiring, any person employed by the Company (as of the date of Executive’s termination) or any person who, as of the date of Executive’s termination, was in the process of being recruited by the Company, or induce any such employee to terminate his or her employment with the Company.

5.14 Judicial Enforcement

In the event of a breach or violation of any provision of this Article 5 by Executive, the parties agree that, in addition to any other remedies it may have, the Company shall be entitled to equitable relief for specific performance, and Executive hereby agrees and acknowledges that the

Company has no adequate remedy at law for the breach of the employment covenants contained herein.

Article 6. Miscellaneous

6.1 Notices

All notices or other communications which are required or permitted hereunder shall be deemed to be sufficient if contained in a written instrument given by personal delivery, air courier or registered or certified mail, postage prepaid, return receipt requested, addressed to such party at the address set forth below or such other address as may thereafter be designated in a written notice from such party to the other party:


	To Company:		Sucampo Pharmaceuticals, Inc.
			0000 Xxxxxxxx Xxxxxx, Xxxxx 000
			Xxxxxxxx, Xxxxxxxx 00000
			Attention: Chairperson, Board of Directors

	To Executive:		Xxxxxxx Xxxx, Ph.D.
			00000 Xxxxx Xxxx Xxxx
			Xx. Xxxxxxx, Xxxxxxxx 00000

All such notices, advances and communications shall be deemed to have been delivered and received (i) in the case of personal delivery, on the date of such delivery, (ii) in the case of air courier, on the business day after the date when sent and (iii) in the case of mailing, on the third business day following such mailing.

6.2 Headings

The headings of the articles and sections of this Agreement are inserted for convenience only and shall not be deemed a part of or affect the construction or interpretation of any provision hereof.

6.3 Modifications; Waiver

No modification of any provision of this Agreement or waiver of any right or remedy herein provided shall be effective for any purpose unless specifically set forth in a writing signed by the party to be bound thereby. No waiver of any right or remedy in respect of any occurrence or event on one occasion shall be deemed a waiver of such right or remedy in respect of such occurrence or event on any other occasion.

6.4 Entire Agreement

This Agreement, together with the Exhibits hereto and Executive’s Acknowledgement of Consideration, contains the entire agreement of the parties with respect to the subject matter hereof and supersedes all other agreements, oral or written, heretofore made with respect thereto including, without limitation, that certain agreement between Executive and the Company dated and effective as of July 21, 2004.

6.5 Severability

Any provision of this Agreement that may be prohibited by, or unlawful or unenforceable under, any applicable law of any jurisdiction shall, as to such jurisdiction, be ineffective without affecting any other provision hereof. To the full extent, however, that the provisions of such

applicable law may be waived, they are hereby waived, to the end that this Agreement be deemed to be a valid and binding agreement enforceable in accordance with its terms.

6.6 Controlling Law

This Agreement has been entered into by the parties in the State of Maryland and shall be continued and enforced in accordance with the laws of Maryland.

6.7 Arbitration

Any controversy, claim, or breach arising out of or relating to this Agreement or the breach thereof shall be settled by arbitration in the State of Maryland in accordance with the rules of the American Arbitration Association for commercial disputes and the judgment upon the award rendered shall be entered by consent in any court having jurisdiction thereof; provided, however, that this provision shall not preclude the Company from seeking injunctive or similar relief from the courts to enforce its rights under the Employment Covenants set forth in Article 5 of this Agreement. It is understood and agreed that, in the event the Company gives notice to Executive of termination for Cause and it should be finally determined in a subsequent arbitration that Executive’s termination was not for Cause as defined in this Agreement, then the remedy awarded to Executive shall be limited to such compensation and benefits as Executive would have received in the event of Executive’s termination other than for Cause at the same time as the original termination.

6.8 Assignments

Subject to obtaining Executive’s prior approval, which shall not be unreasonably withheld or delayed, the Company shall have the right to assign this Agreement and to delegate all rights,

duties and obligations hereunder to any entity that controls the Company, that the Company controls or that may be the result of the merger, consolidation, acquisition or reorganization of the Company and another entity. Executive agrees that this Agreement is personal to Executive and Executive’s rights and interest hereunder may not be assigned, nor may Executive’s obligations and duties hereunder be delegated (except as to delegation in the normal course of operation of the Company), and any attempted assignment or delegation in violation of this provision shall be void.

6.9 Read and Understood

Executive has read this Agreement carefully and understands each of its terms and conditions. Executive has sought independent legal counsel of Executive’s choice to the extent Executive deemed such advice necessary in connection with the review and execution of this Agreement.

IN WITNESS WHEREOF, the parties have executed this Agreement as of the Effective Date.


		SUCAMPO PHARMACEUTICALS, INC.

		By:		/s/ Kei X. Xxxxxxxx

				Kei X. Xxxxxxxx
		Its:		Secretary

		/s/ Xxxxxxx Xxxx

		XXXXXXX XXXX, Ph.D.

EXHIBIT A

GENERAL RELEASE

This General Release is made and entered into as of the ___ day of , 20___ (the “Separation Date”), by and between (hereinafter “Executive”) and Sucampo Pharmaceuticals, Inc. (“SPI”), a corporation organized under the laws of the State of Delaware, and its affiliates (hereinafter collectively referred to as the “Company”).

WHEREAS, Executive and SPI are parties to an Employment Agreement dated ___, 20___ (hereinafter, the “Agreement”);

WHEREAS, Executive and Company intend to settle any and all claims that Executive may have against Company as a result of any act, occurrence, decision, event or omission occurring at any time prior to the signing of this General Release, including, but not limited to, any matter or fact arising out of Executive’s employment with SPI, the termination of Executive’s employment pursuant to Section ___ of the Agreement [here specify the particular section invoked for the termination], or the events giving rise to the Agreement or this General Release;

WHEREAS, under the terms of the Agreement, Executive promised to enter into this General Release as a condition precedent to the separation payments and benefits to be provided under the Agreement;

NOW, THEREFORE, in consideration of the provisions and the mutual covenants contained herein, the parties agree as follows:

1. Release of Claims. Executive and the Company intend to settle any and all claims that Executive may have against the Company as a result of the hiring of Executive, Executive’s employment, Executive’s compensation while employed, and the termination of Executive’s employment. Executive agrees that in exchange for SPI’s promises in the Agreement and in exchange for the separation pay and benefits to be paid to Executive as described in the Agreement, Executive, on behalf of Executive and Executive’s heirs, successors and assigns, hereby releases and forever discharges the Company, its predecessors, successors, and assigns, and their respective officers, directors, shareholders, agents, employees, and insurers (the “Released Parties”), from all liability for damages and from all claims that Executive may have against the Released Parties arising from or relating to the hiring of Executive, Executive’s compensation while employed, Executive’s employment, the termination of Executive’s employment pursuant to Section ___ of the Agreement [here specify the particular section invoked for the termination], and any other actions, decisions, alleged omissions, or events occurring on or prior to the signing of this General Release.

A. Executive understands and agrees that Executive’s release of claims in this General Release includes, but is not limited to, any claims Executive may have under Title VII of the Federal Civil Rights Act of 1964, as amended; the Americans with Disabilities Act, the Equal Pay Act, the Fair Labor Standards Act, the Employee Retirement and Income Security Act, the Age Discrimination in Employment Act, the Family and Medical Leave Act, the Maryland Fair Employment Practices Act, or any other federal, state, or local statute, ordinance, or law.

B. Executive also understands that Executive is giving up all other claims, whether grounded in contract or tort theories, including, but not limited to, wrongful discharge, breach of contract, tortious interference with contractual relations, promissory estoppel,

detrimental reliance, breach of the implied covenant of good faith and fair dealing, breach of express or implied promise, breach of manuals or other policies, breach of fiduciary duty, assault, battery, fraud, invasion of privacy, intentional or negligent misrepresentation, defamation, including libel, slander, discharge defamation and self-publication defamation, discharge in violation of public policy, whistleblower, intentional or negligent infliction of emotional distress, or any other theory, whether legal or equitable.

C. Executive will not institute any lawsuit against the Released Parties arising from or relating to the hiring of Executive, Executive’s employment, Executive’s compensation while employed, the termination of Executive’s employment, or any other actions, decisions, alleged omissions, or events occurring prior to the signing of this General Release.

D. To the extent required by law, nothing contained in this General Release will be interpreted to prevent Executive from filing a charge with a governmental agency or participating in or cooperating with an investigation conducted by a governmental agency. However, Executive agrees that Executive is waiving the right to any monetary damages or other individual legal or equitable relief awarded as a result of any such proceeding related to any claim against the Released Parties arising from or relating to the hiring of Executive, Executive’s employment, Executive’s compensation while employed, the termination of Executive’s employment, or any other actions, decisions, alleged omissions, or events occurring on or prior to the signing of this General Release.

E. Notwithstanding any of the foregoing, this General Release shall not apply with respect to any rights or claims which Executive may have under the terms of Section ___ of the Agreement itself [same section as cited above] or to any rights or benefits Executive may

have related to vested accrued benefits under the terms of the Company’s benefit plans or to the Executive’s right to be indemnified by the Company pursuant to the terms of its bylaws and the law of the State of Delaware.

F. Executive may revoke this release of claims, insofar as it extends to potential claims under the Age Discrimination in Employment Act, by informing the Company of Executive’s intent to revoke this release within seven (7) calendar days following the execution of this General Release. Executive understands that any such revocation must be stated in writing and delivered by hand or by certified mail-return receipt requested within the seven (7) day period to [INSERT name and mailing address]. If Executive exercises this right to revoke or rescind, the Company shall have no obligation to provide severance pay or benefits to Executive as provided by the Agreement.

G. Executive acknowledges that the Company’s obligation to provide any severance pay or benefits pursuant to the Agreement shall not become effective or enforceable until the revocation period identified above has expired without notice of revocation having been made.

2. This General Release shall be binding upon, and insure to the benefit of, Executive and the Company and their respective successors and permitted assigns.

3. Executive hereby acknowledges and states that Executive has read this General Release and has been advised to consult with an attorney prior to signing this General Release. Executive further represents that Executive has had adequate time to consider the terms of this General Release, that it is written in language which is understandable to Executive, that

Executive fully appreciates the meaning of the terms of this General Release, and that Executive enters into this General Release freely and voluntarily.

IN WITNESS WHEREOF, Executive after due consideration and consultation, has authorized, executed, and delivered this General Release upon the date indicated below.


DATE:

						NAME

EXHIBIT B

TERMINATION CERTIFICATE

I hereby certify that I do not have in my possession or under my control, nor have I failed to return, any “Company Materials” as defined in that certain Employment Agreement (the “Agreement”) entered into between Sucampo Pharmaceuticals, Inc., a Delaware corporation, and me, dated .

I further certify that I have complied with and will continue to comply with all the terms of the Agreement.



		Executive’s Signature


		Print Name


		Date

EXHIBIT C
Inventions, Intellectual Property, and Equipment Not Transferred to Company

The inventions, intellectual property and/or equipment listed below are currently owned by Sucampo AG, and no rights with respect to the listed inventions, intellectual property and/or equipment are intended to be transferred or assigned to the Company by reason of the Employment Agreement.

Description

Patent No.

Application No.

Country

Status

METHOD FOR INHIBITING INFECTION OF HUMAN T-CELLS

4840941

144131

U.S.A. DIV2

Granted

METHOD FOR TOPICALLY CLEANSING THE HUMAN BODY

5100879

398318

U.S.A. CIP

Granted

CONDOM

4869270

196574

U.S.A.

Granted

TREATMENT OF SHOCK BY CYCLODEXTRINS AND THEIR DERIVATIVES

5071838

679864

U.S.A. CIP

Granted

IMPROVEMENT IN DIURESIS BY CYCLODEXTRINS AND THEIR DERIVATIVES

5132298

599607

U.S.A.

Granted

COMPOSITION FOR TREATMENT OF LIGHT-INJURED RETINAL DEGENERATION DISEASE

6248759

09/408562

U.S.A.

Granted

COMPOSITION FOR TREATMENT OF LIGHT-INJURED RETINAL DEGENERATION DISEASE

2000-573361

JAPAN

pending

AGENT FOR TREATING VISUAL CELL FUNCTION DISORDER

6864232

09/869129

U.S.A.

Granted

AGENT FOR TREATING VISUAL CELL FUNCTION DISORDER

200-590655

JAPAN

pending

AGENT FOR TREATING VISUAL CELL FUNCTION DISORDER

99959930.1

EPC

pending

AGENT FOR TREATING DRY EYE

09/926411

U.S.A.

Allowed

AGENT FOR TREATING DRY EYE

6872383

10/354083

U.S.A. CA

Granted

AGENT FOR TREATING DRY EYE

2001-615007

JAPAN

pending

AGENT FOR TREATING DRY EYE

1173177

00921047.7

EPC

Granted

COMPOSITION FOR TOPICAL ADMINISTRATION

7033604

10/187013

U.S.A.

Granted

COMPOSITION FOR TOPICAL ADMINISTRATION

11/258914

U.S.A. DIV

pending

COMPOSITION FOR TOPICAL ADMINISTRATION

2003-510107

JAPAN

pending

COMPOSITION FOR TOPICAL ADMINISTRATION

02741390.5

EPC

pending

OPHTHALMIC COMPOSITION

6403598

09/485414

U.S.A.

Granted

OPHTHALMIC COMPOSITION

6476039

10/133450

U.S.A. DIV

Granted

OPHTHALMIC COMPOSITION

11-22996

JAPAN

pending

COMPOSITION FOR TREATMENT OF EXTERNAL SECRETION DISORDERS EXCEPT HYPOLACRIMATION

6339088

09/673563

U.S.A.

Granted

COMPOSITION FOR TREATMENT OF EXTERNAL SECRETION DISORDERS EXCEPT HYPOLACRIMATION

2000-599253

JAPAN

pending

- 1 -

Description

Patent No.

Application No.

Country

Status

METHOD OF TREATING OCULAR ALLERGIES WITH A MACROLIDE COMPOUND

10/523842

U.S.A.

pending

METHOD OF TREATING OCULAR ALLERGIES WITH A MACROLIDE COMPOUND

2004-527368

JAPAN

pending

METHOD FOR INHIBITING INFECTION OF HUMAN T-CELLS

4840941

144131

U.S.A. DIV2

Granted

METHOD FOR TOPICALLY CLEANSING THE HUMAN BODY

5100879

398318

U.S.A. CIP

Granted

METHOD FOR DIAGNOSIS OR PREDICTING SUSCEPTIBILITY TO PSYCHIATRIC DISORDERS

11/043959

U.S.A.

pending

METHOD FOR DIAGNOSIS OR PREDICTING SUSCEPTIBILITY TO PSYCHIATRIC DISORDERS

2005-021515

JAPAN

pending

METHOD FOR DIAGNOSIS OF OPTIC NEUROPATHY

PCT/JP05/005601

PCT

pending

METHOD FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA

10/429677

U.S.A.

Allowed

METHOD FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA

U.S.A. CA

pending

METHOD AND COMPOSITION FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA

2005-501572

JAPAN

pending

METHOD AND COMPOSITION FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA

2502437

Canada

pending

METHOD AND COMPOSITION FOR TREATING OCULAR HYPERTENSION AND GLAUCOMA

03758746.6

EPC

pending

PROSTAGLANDINS OF THE F SERIES

289349

8830931.5

EPC

Granted

OCULAR HYPOTENSIVE AGENTS

5001153

246059

U.S.A.

Granted

OCULAR HYPOTENSIVE AGENTS

5151444

584669

U.S.A. CA

Granted

OCULAR HYPOTENSIVE AGENTS

2209939

8821104.0

England

Granted

OCULAR HYPOTENSIVE AGENTS

308135

88308299.2

EPC

Granted

OCULAR HYPOTENSIVE AGENTS

455264

91108317.8

EPC DIV

Granted

OCULAR HYPOTENSIVE AGENTS

5194429

615515

U.S.A. DIV

Granted

OCULAR HYPOTENSIVE AGENTS

5236907

774750

U.S.A. CA

Granted

OCULAR HYPOTENSIVE AGENTS

2008226

63-248720

JAPAN

Granted

OCULAR HYPOTENSIVE AGENTS

2009965

63-248721

JAPAN

Granted

OCULAR HYPOTENSIVE AGENTS

366279

89310016.4

EPC

Granted

OCULAR HYPOTENSIVE AGENTS

580268

93202691.7

EPC DIV

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION FOR OCULAR ADMINISTRATION

458588

91304574.6

EPC

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

5166175

704570

U.S.A.

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

2511585

3-147793

JAPAN

Granted

- 2 -

Description

Patent No.

Application No.

Country

Status

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

2042937

2042937-2

Canada

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

109862

8273/91

Korea

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

60036

80103866

TAIWAN

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

458590

91304576.1

EPC

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION FOR OPHTHALMIC USE

5175189

899170

U.S.A. CA

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION FOR OPHTHALMIC USE

2042936

2042936-4

Canada

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION FOR OPHTHALMIC USE

59178

80103867

TAIWAN

Granted

TREATMENT OF OCULAR HYPERTENSION WITH AN OCULAR SYNERGISTIC COMBINATION

5397797

08/031875

U.S.A. CA

Granted

TREATMENT OF OCULAR HYPERTENSION WITH AN OCULAR SYNERGISTIC COMBINATION

2042934

2042934-8

Canada

Granted

TREATMENT OF OCULAR HYPERTENSION WITH AN OCULAR SYNERGISTIC COMBINATION

59100

80103868

TAIWAN

Granted

PROCESS OF PREPARING PROSTAGLANDIN INTERMEDIATES

2119050

3-223415

JAPAN

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

5547968

8/487637

U.S.A. CA3

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

2511611

4-43018

JAPAN

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

2061907

2061907-4

Canada

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

221369

3307/92

Korea

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

63244

81100863

TAIWAN

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

501678

92301412.0

EPC

Granted

INCREASING THE CHOROIDAL BLOOD FLOW

5221690

867359

U.S.A.

Granted

INCREASING THE CHOROIDAL BLOOD FLOW

2592196

4-263463

JAPAN

Granted

INCREASING THE CHOROIDAL BLOOD FLOW

2065889

2065889-4

Canada

Granted

TREATMENT OF OCULAR HYPERTENSION

5432174

8/162386

U.S.A. CA

Granted

TREATMENT OF OCULAR HYPERTENSION

5-56852

JAPAN

pending

TREATMENT OF OCULAR HYPERTENSION

0561073

92307700.2

EPC

Granted

PROCESS FOR PRODUCTION OF PROSTAGLANDIN INTERMEDIATES

5274130

07/937949

U.S.A.

Granted

PROCESS FOR PRODUCTION OF PROSTAGLANDIN INTERMEDIATES

2746800

4-233473

JAPAN

Granted

STABILIZATION OF A PROSTANOIC ACID COMPOUND

5523461

8/202132

U.S.A.

Granted

STABILIZATION OF A PROSTANOIC ACID COMPOUND

2839798

4-227047

JAPAN

Granted

- 3 -

Description

Patent No.

Application No.

Country

Status

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

5773471

08/613048

U.S.A.

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

3625946

8-53063

JAPAN

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

2171226

Canada

pending

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

96107319.5

China

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

399795

6237/96

Korea

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

127611

85102651

TAIWAN

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

701620

48003/96

Australia

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

286141

New Zealand

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

310178

19960974

Norway

Granted

TREATMENT OF OPTIC NERVE DISORDER WITH PROSTANOIC ACID COMPOUNDS

730866

96301637.3

EPC

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

149214

86105124

TAIWAN

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

6043213

08/981229

U.S.A.

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

6159930

09/450008

U.S.A. DIV

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

3058920

9-537910

JAPAN

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

2225398

Canada

pending

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

97190706.4

China

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

0455475

709546/97

Korea

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

725508

25761/97

Australia

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

320601

19975962

Norway

Granted

A PHARMACEUTICAL COMPOSITION CONTAINING ALBUMIN AS AN ACTIVE INGREDIENT

834320

97917418.2

EPC

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

6329426

09/220847

U.S.A. CIP

Granted

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

11-521457

JAPAN

pending

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

2274708

Canada

pending

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

98945530.8

EPC

pending

TREATMENT OF OCULAR HYPERTENSION WITH A SYNERGISTIC COMBINATION

00103455.2

Hong Kong

pending

DRUG COMPOSITIONS FOR THE TREATMENT OF OCULAR HYPERTENSION OR GLAUCOMA

2000-590641

JAPAN

pending

DRUG COMPOSITIONS FOR THE TREATMENT OF OCULAR HYPERTENSION OR GLAUCOMA

2356912

Canada

pending

- 4 -

Description

Patent No.

Application No.

Country

Status

COMPOSITION FOR APOPTOSIS INHIBITION

09/816655

U.S.A.

pending

COMPOSITION FOR APOPTOSIS INHIBITION

90107002

TAIWAN

pending

COMPOSITION FOR APOPTOSIS INHIBITION

2001-568431

JAPAN

pending

COMPOSITION FOR APOPTOSIS INHIBITION

2403086

Canada

pending

COMPOSITION FOR APOPTOSIS INHIBITION

01809737.5

China

pending

COMPOSITION FOR APOPTOSIS INHIBITION

2002-7012410

Korea

pending

COMPOSITION FOR APOPTOSIS INHIBITION

2001239551

Australia

Granted

COMPOSITION FOR APOPTOSIS INHIBITION

521464

New Zealand

Granted

COMPOSITION FOR APOPTOSIS INHIBITION

01914192.8

EPC

pending

TREATMENT OF OCULAR HYPERTENSION

6458836

09/900021

U.S.A. CIP3

Granted

TREATMENT OF OCULAR HYPERTENSION

P010101231

ARGENTINA

pending

TREATMENT OF OCULAR HYPERTENSION

90106162

TAIWAN

pending

TREATMENT OF OCULAR HYPERTENSION

2001-566636

JAPAN

pending

TREATMENT OF OCULAR HYPERTENSION

2402597

Canada

pending

TREATMENT OF OCULAR HYPERTENSION

01809339.6

China

pending

TREATMENT OF OCULAR HYPERTENSION

2002-7011970

Korea

pending

TREATMENT OF OCULAR HYPERTENSION

2001241143

Australia

Granted

TREATMENT OF OCULAR HYPERTENSION

521325

New Zealand

Granted

TREATMENT OF OCULAR HYPERTENSION

2002/7140

0000/0000

Xxxxx Xxxxxx

Granted

TREATMENT OF OCULAR HYPERTENSION

PI 0109192

Brazil

pending

TREATMENT OF OCULAR HYPERTENSION

233584

PA/A/2002/008967

Mexico

pending

TREATMENT OF OCULAR HYPERTENSION

IN/PCT/2002/01464

India

pending

TREATMENT OF OCULAR HYPERTENSION

000000

Xxxxxx

pending

TREATMENT OF OCULAR HYPERTENSION

PV2002-3092

Czech

pending

TREATMENT OF OCULAR HYPERTENSION

P0300391

Hungary

pending

TREATMENT OF OCULAR HYPERTENSION

20024381

Norway

pending

TREATMENT OF OCULAR HYPERTENSION

01912374.4

EPC

pending

- 5 -

Description

Patent No.

Application No.

Country

Status

CONTROL OF INTRAOCULAR PRESSURE DURING SURGERY

6414021

09/645361

U.S.A.

Granted

CONTROL OF INTRAOCULAR PRESSURE DURING SURGERY

2001-250329

JAPAN

pending

EYE DROP COMPOSITION

11/110698

U.S.A. CIP

pending

EYE DROP COMPOSITION

2005-513236

JAPAN

pending

EYE DROP COMPOSITION

2006-7003299

Korea

pending

EYE DROP COMPOSITION

Canada

pending

EYE DROP COMPOSITION

04720157.9

EPC

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

10/477359

U.S.A.

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

2002-589015

JAPAN

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

2003-7014707

Korea

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

2002255346

Australia

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

2444627

Canada

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

PI 0000000-0

Xxxxxx

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

PA/A/2003/010363

Mexico

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

20035043

Norway

pending

TREATMENT OF OCULAR HYPERTENSION AND GLAUCOMA

02724768.3

EPC

pending

METHOD FOR INHIBITING APOPTOSIS

6852687

10/132567

U.S.A.

Granted

METHOD FOR INHIBITING APOPTOSIS

2002-123755

JAPAN

pending

METHOD FOR INHIBITING APOPTOSIS

02009265.6

EPC

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

93124177

TAIWAN

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

10/567462

U.S.A.

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

Canada

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

2006-7002643

Korea

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

200480029804.9

China

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

2006-519266

JAPAN

pending

COMPOSITION FOR PROMOTING HAIR GROWTH

04771825.9

EPC

pending

COMPOSITION AND METHOD FOR SCARP AND HAIR TREATMENT

0000-000000

XXXXX

pending

- 6 -

Description

Patent No.

Application No.

Country

Status

COMPOSITION AND METHOD FOR SCARP AND HAIR TREATMENT

PCT/JP05/024276

PCT

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

10/550414

U.S.A.

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

2006-507702

JAPAN

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

2520957

Canada

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

00-0000-0000000

Korea

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

200480009070.8

China

pending

METHOD FOR TREATING VASCULAR HYPERPERMEABLE DISEASE

04724735.8

EPC

pending

ENDOTHELIN XXXXXXXXXX

0-000000

XXXXX

pending

HAIR GROWTH AGENT

3217293

9-100091

JAPAN

Granted

- 7 -

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Table of Contents

EMPLOYMENT AGREEMENT

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