JOINT FILING AGREEMENT
EXHIBIT 1
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JOINT FILING AGREEMENT
Each of the undersigned hereby acknowledges and agrees, in
compliance with the provisions of Rule 13d-1(k)(1) promulgated under the
Securities Exchange Act of 1934, as amended, that the Schedule 13D to which this
Agreement is attached as an Exhibit (the "Schedule 13D"), and any amendments
thereto, will be filed with the Securities and Exchange Commission jointly on
behalf of the undersigned. This Agreement may be executed in one or more
counterparts.
Dated: January 5, 2004
PERSEUS-▇▇▇▇▇ BIOPHARMACEUTICAL FUND, LP
By: Perseus-▇▇▇▇▇ Partners, LLC,
General Partner
By: SFM Participation, L.P.,
Managing Member
By: SFM AH LLC
General Partner
By: ▇▇▇▇▇ Fund Management LLC,
Managing Member
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇
Title: Assistant General Counsel
PERSEUS-▇▇▇▇▇ PARTNERS, LLC
By: SFM Participation, L.P.
Managing Member
By: SFM AH LLC
General Partner
By: ▇▇▇▇▇ Fund Management LLC,
Managing Member
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇
Title: Assistant General Counsel
CUSIP NO. ▇▇▇▇▇▇▇▇▇ PAGE 2
PERSEUS BIOTECH FUND PARTNERS, LLC
By: Perseuspur EC, L.L.C.
Managing Member
By: Perseuspur, LLC
Member
By: /s/ ▇▇▇▇ ▇▇▇▇▇▇▇
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Name: ▇▇▇▇ ▇▇▇▇▇▇▇
Title: Secretary and Treasurer
PERSEUS EC, L.L.C.
By: Perseuspur, LLC
Member
By: /s/ ▇▇▇▇ ▇▇▇▇▇▇▇
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Name: ▇▇▇▇ ▇▇▇▇▇▇▇
Title: Secretary and Treasurer
PERSEUSPUR, LLC
By: /s/ ▇▇▇▇ ▇▇▇▇▇▇▇
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Name: ▇▇▇▇ ▇▇▇▇▇▇▇
Title: Secretary and Treasurer
▇▇. ▇▇▇▇▇ ▇. ▇▇▇▇▇
By: /s/ ▇▇▇▇ ▇▇▇▇▇▇▇
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Name: ▇▇▇▇ ▇▇▇▇▇▇▇
Title: Attorney-in-Fact
SFM PARTICIPATION, L.P.
By: SFM AH LLC
General Partner
By: ▇▇▇▇▇ Fund Management LLC,
Managing Member
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇
Title: Assistant General Counsel
SFM AH LLC
By: ▇▇▇▇▇ Fund Management LLC,
Managing Member
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇
Title: Assistant General Counsel
CUSIP NO. ▇▇▇▇▇▇▇▇▇ PAGE 3
MR. ▇▇▇▇▇▇ ▇▇▇▇▇
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇ (1)
Title: Attorney-in-Fact
▇▇▇▇▇ FUND MANAGEMENT LLC
By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇
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Name: ▇▇▇▇ ▇. ▇▇▇▇▇
Title: Assistant General Counsel
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(1) A Power of Attorney authorizing ▇▇▇▇ ▇. ▇▇▇▇▇, et. al. to act on behalf of
▇▇▇▇▇▇ ▇▇▇▇▇ has been filed with the Securities and Exchange Commission