EXHIBIT 10.9
THIRD AMENDMENT TO SUBLEASE BETWEEN
REGEN BIOLOGICS, INC.
AND GENITOPE CORPORATION
THIS THIRD AMENDMENT TO SUBLEASE (this "THIRD AMENDMENT") is made and
entered into as of the 16th day of May, 2003, by and between REGEN BIOLOGICS,
INC., a Delaware corporation ("REGEN"), and GENITOPE CORPORATION, a Delaware
corporation ("SUBTENANT").
RECITALS
This Third Amendment is made and entered into with reference to the
following recitals:
A. Regen and Subtenant entered into a Sublease dated August 3,
1999, which was amended by a Second Amendment to Sublease Agreement dated
October 1, 2000, which amendment was styled as a "second amendment" because
Subtenant and Regen previously agreed to extend the term of the Sublease and
such extension was treated as a "first amendment", as further amended by a
Second Amendment to Sublease dated February 25, 2002 (collectively, as amended,
the "SUBLEASE"), for the sublease of approximately 7,655 square feet of rentable
area and 603 square feet of rentable common area (i.e. Subtenant's share of
common area between Regen and Subtenant that is rentable area under the Master
Lease) (the "SUBLEASED PREMISES") in the building commonly known as "Building
12" of Seaport Center, and located at 000 Xxxxxxxxx Xxxxx, Xxxxxxx Xxxx,
Xxxxxxxxxx 00000.
B. Regen and Subtenant wish to execute this Third Amendment to
provide for an extension of the term of the Sublease and to modify the base
rent, operating expense and other related provisions of the Sublease.
NOW, THEREFORE, in consideration of the foregoing, the sum of Ten
Dollars ($10.00) and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Regen and Subtenant agree as
follows:
1. DEFINED TERMS. All defined terms herein shall have the meaning
given to such term in the Sublease or the Master Lease, as applicable, unless
specifically defined herein.
2. INCORPORATION OF RECITALS. The foregoing recitals are
incorporated by reference into this Section 2 as if set forth in this Paragraph
2 in full.
3. TERM. The term of the Sublease is extended and will expire on
May 31, 2006, unless sooner terminated in accordance with the terms of the
Sublease. In no event will the term of the Sublease extend beyond the term of
the Master Lease.
4. RENT. Notwithstanding anything to the contrary in the
Sublease, commencing on June 1, 2003 (the "MODIFIED RENT COMMENCEMENT DATE"),
and continuing through the term of the Sublease (as extended by the terms of
this Third Amendment), Subtenant shall pay base monthly rent ("RENT") in advance
on the first day of each calendar month to Regen in the amounts specified below:
1.
Monthly Rate Per Rentable
Period Square Foot Base Monthly Rent
------------------- ------------------------- -----------------
06/01/03 - 05/31/04 $1.90 $15,690.20
06/01/04 - 05/31/05 $1.96 $16,185.68
06/01/05 - 05/31/06 $2.02 $16,681.16
If the Modified Rent Commencement Date and/or the last day of the
Sublease term do not fall on the first day of a month or the last day of a
month, as applicable, the rent payable hereunder will be pro-rated on a per day
basis based on the actual number of days in such month. Commencing on the
Modified Rent Commencement Date, the foregoing rent payable by Subtenant under
the terms of the Sublease (as modified by the terms of this Third Amendment)
shall be payable on a triple-net basis and will not include any costs for real
property taxes, Operating Expenses (as defined in the Master Lease), janitorial
services, utilities, garbage removal and the like, which costs will be paid by
Subtenant in accordance with the terms of Section 5 below.
5. EXPENSES. As of the Modified Rent Commencement Date, the
pro-rata share of Operating Expenses payable by Subtenant to Regen (the
"EXPENSE") shall be calculated pursuant to Section 5(a) of this Third Amendment,
wherein Subtenant's prorata share is based on the ratio of: (i) the total square
feet subleased by Subtenant pursuant to the Sublease to (ii) the total square
feet leased by Regen pursuant to the Master Lease.
(a) EXPENSE CALCULATION. The expense shall be calculated
by Regen, and Subtenant's pro rata share shall be invoiced to Subtenant on a
monthly basis. Subject to the abatement described in Subsection (b) immediately
below, Subtenant shall owe and pay to Regen its pro-rata share of the Expense,
such Expense to be calculated as follows: actual monthly Operating Expenses
billed to Regen by the Master Landlord, plus actual monthly operating expenses
incurred by Regen (including, without limitation, all Operating Expenses
actually incurred by Regen), but not billed by the Master Landlord, in relation
to the Master Premises rented by Regen pursuant to the Master Lease.
Notwithstanding anything to the contrary contained in this Third Amendment,
Subtenant shall not be obligated to pay any monthly operating expenses or
Operating Expense not applicable to the Subleased Premises. The monthly expenses
referred to herein will include estimates of expenses reasonably anticipated to
be incurred by Regen but not billed by Master Lessor and Operating Expenses for
such period, which will be adjusted at the end of each year according to the
Master Lease. Once the adjustments are received from the Master Landlord, Regen
shall provide a revised statement to Subtenant showing such adjustments,
together with, as appropriate, (i) an invoice for the remaining amount due from
Subtenant to Regen or (ii) a check for the refund amount due from Regen to
Subtenant. All such monthly invoices will be paid by Subtenant, together with
the next monthly Rent payment, and in no event later than thirty (30) days after
receipt by Subtenant of such invoices.
(b) Regen shall xxxxx the first amounts due and payable
by Subtenant during the Term under this Section 5 for the Expense up to an
amount equal to Twenty-Seven Thousand Seven Hundred One and 46/100 Dollars
($27,701.46) (the "EXPENSE ABATEMENT"). From time to time as amounts are first
due and payable by Subtenant to Regen for its pro-rata share of the
2.
Expense in accordance with the terms of this Section 5, Regen shall xxxxx such
amounts up to the amount of the Expense Abatement.
(c) Notwithstanding anything to the contrary contained in
the Sublease, this Third Amendment or the Master Lease, within ninety (90) days
after receipt by Subtenant of Regen's statement of the Expense for any prior
calendar year during the Term, Subtenant shall have the right, at Subtenant's
sole cost and expense, upon ten (10) business days prior written notice, to
inspect the applicable books of Regen during the business hours of Regen at
Regen's office in the Building, or, at Regen's option, such other location as
Regen reasonably may specify, for the purpose of verifying the information
contained in the statement, provided that the party inspecting such books is an
employee of a reputable accounting firm that provides a full range of accounting
services that is hired on a per-hour basis (and not on a contingency basis), and
Subtenant uses reasonable efforts to maintain the confidentiality of such audit
and the results thereof. Unless Subtenant asserts specific errors within ninety
(90) days after receipt of the statement, the statement shall be deemed correct
as between Regen and Subtenant.
6. NO ALLOWANCE. Regen and Subtenant agree that Regen will not be
obligated to provide any tenant improvement allowances whatsoever, or perform
any work in the Premises, in connection with the execution of this Third
Amendment.
7. APPROVALS; EFFECTIVENESS. Regen and Subtenant acknowledge that
Regen is negotiating the terms of an amendment to the Master Lease with Master
Landlord to extend the term of the Lease until May 31, 2006 (the "PRIME LEASE
AMENDMENT"). Regen and Subtenant agree that the effectiveness of this Third
Amendment is expressly conditioned on (i) Regen and Master Landlord executing
and delivering the Prime Lease Amendment and (ii) Regen's receipt of Master
Landlord's written consent to the terms of this Third Amendment (collectively
(i) and (ii) are the "APPROVALS"). Regen shall use good faith reasonable efforts
to obtain the Approvals by May 31, 2003. If the Approvals are not obtained by
Regen on or before May 31, 2003 this Third Amendment will automatically
terminate and be of no further force and effect. If the Prime Lease Amendment is
executed by Regen and Master Landlord, the following provisions of the Prime
Lease Amendment shall not be incorporated into the Sublease, as amended by this
Third Amendment: Section 3, 7, and 9.
8. RECAPTURE. Commencing on May 31, 2005, Regen will have the
ongoing right to terminate the Sublease with respect to all or any portion of
the Subleased Premises, provided that Regen has delivered written notice to
Subtenant (the "RECAPTURE NOTICE") of such termination at least six (6) months
prior to the date of such termination. The Recapture Notice shall specify the
date of termination (the "RECAPTURE TERMINATION DATE") and the applicable
portion (or all) of the Subleased Premises being recaptured by Regen and
terminated under the Sublease (the "RECAPTURED PREMISES"). If the Recaptured
Premises does not constitute the entire Subleased Premises and Regen elects to
terminate the Sublease with respect to the Recaptured Premises then (a)
Subtenant shall vacate and tender the Recaptured Premises to Regen on the
Recapture Termination Date as if the Recapture Termination Date had been
originally set forth in the Sublease as the expiration date of the term of the
Sublease with respect to the Recaptured Premises, and (b) as to all portions of
the Subleased Premises other than the Recaptured Premises, this Sublease shall
remain in full force and effect except that the Rent, additional rent and the
Expense payable pursuant to Section 5 of this Third Amendment shall be reduced
3.
proportionately. If the Recaptured Premises does not constitute the entire
Subleased Premises, Regen shall pay all expenses of construction reasonably
required to permit the operation of the Recaptured Premises separate from the
balance of the Subleased Premises. If the Recaptured Premises constitutes the
entire Subleased Premises and Regen elects to terminate the Sublease, then (1)
Subtenant shall vacate and tender the entire Subleased Premises to Regen on the
Recapture Termination Date, and (2) the term of the Sublease shall terminate on
the Recapture Termination Date as if the Recapture Termination Date had been
originally set forth in the Sublease as the expiration date of the term of the
Sublease.
9. MASTER LANDLORD'S OBLIGATIONS. Notwithstanding anything to the
contrary contained in the Sublease (as amended by this Third Amendment), the
following provisions of the Master Lease hereby are incorporated into the
Sublease, except that (i) references to "Landlord" shall mean only Master
Landlord, and (ii) "Landlord's" obligations thereunder shall remain "Master
Landlord Obligations" as defined in Section 20(a) of the Sublease: Paragraphs
3(c), 3(d), 3(e), 3(f) and 3(g): Paragraph 6(a); Paragraph 13; and Paragraph 14.
In the event of a conflict between the provisions of the Master Lease (as
amended by the Prime Lease Amendment), to the extent incorporated into the
Sublease and this Third Amendment, and the provisions of the Sublease as
modified by this Third Amendment, the provisions of the Sublease as modified by
this Third Amendment shall control.
10. HAZARDOUS MATERIALS. Attached hereto as Exhibit A is a current
list of Subtenant's Permitted Hazardous Materials and Hazardous Materials Plans.
From time to time after the date of this Third Amendment, but in no event more
than two (2) times during each calendar year, Subtenant may submit a proposed
list of Subtenant's Permitted Hazardous Materials to Regen. Regen shall use
commercially reasonable efforts to promptly approve or disapprove such proposed
list, such approval not to be unreasonably withheld by Regen. In addition, Regen
shall promptly submit such proposed list to Master Landlord and request Master
Landlord's approval of same. Subtenant shall promptly reimburse Regen for all
costs and expenses incurred by Regen as a result of Regen submitting such
proposed list to Master Landlord for review. If Regen and Master Landlord
consent to the proposed list, then provided that Subtenant complies with the
terms of the Master Lease (as incorporated by the Sublease) related to such
Permitted Hazardous Materials, Subtenant shall have the right to bring such
listed materials onto the Subleased Premises. However, until Regen and Master
Landlord approve such proposed list in accordance with the terms of this Third
Amendment, Subtenant shall not have any right to bring any Hazardous Materials
onto the Subleased Premises. Regen shall not be liable or responsible for Master
Landlord's failure to review and/or approve any proposed list of Subtenant's
Permitted Hazardous Materials from Subtenant and if Master Landlord fails to
review or approve such list, the Sublease will continue in full force and effect
without offset or abatement of any sums payable by Subtenant. Notwithstanding
anything to the contrary contained in the Sublease, the Master Lease or this
Third Amendment, Regen shall protect, indemnify, defend upon demand with counsel
reasonably acceptable to Subtenant, and hold harmless Subtenant and its
officers, directors, employees and agents from and against any and all
liabilities, losses, claims, actual out-of-pocket damages (excluding punitive or
consequential damages (i.e., lost profits, lost business opportunity), interest,
penalties, fines, monetary sanctions, attorneys' fees, experts' fees, court
costs, remediation costs, investigation costs, and other expenses arising from
and after the commencement date of the Sublease to the extent
4.
caused solely by the use, storage, treatment, transportation, release or
disposal of Hazardous Materials on or about the Premises by Regen or Regen's
agents, employees or contractors.
11. SECURITY DEPOSIT. Regen and Subtenant acknowledge that as of
the date of this Third Amendment, Regen is holding Subtenant's security deposit
in the amount of $41,290.00. Provided that, as of June 1, 2003, no default on
the part of Subtenant under this Sublease shall then be in existence beyond
applicable notice and cure periods nor shall any default beyond any applicable
notice and cure periods have theretofore occurred, and further provided that,
within the immediately preceding thirty (30) days, Regen shall have reviewed
and, in Regen's reasonable discretion, approved Subtenant's then-most recent
audited financial statements (Subtenant hereby agreeing to deliver audited
financial statements for Subtenant, prepared within sixty (60) days of such
delivery, to Regen with Subtenant's request for Regen's review and approval of
same), Subtenant shall have the right to reduce the amount of the Security
Deposit to the sum of Fifteen Thousand Six Hundred Ninety and 20/100 Dollars
($15,690.20) upon written request to Regen. If all of the aforesaid conditions
are met, Regen shall so reduce the Security Deposit and shall return the excess
funds equal to the difference between the current security deposit and the
reduced security deposit or $25,599.80, to Subtenant within three business of
the date the aforesaid conditions have been met.
12. NO OTHER AMENDMENT. Except to the extent expressly set forth
in this Third Amendment, the Sublease remains in full force and effect, without
amendment, in accordance with its terms.
13. BROKERS. Each party hereto represents and warrants that it has
dealt with no broker in connection with this Third Amendment and the
transactions contemplated herein between Regen and Subtenant. Each party shall
indemnify, protect, defend and hold the other party harmless from all costs and
expenses (including reasonable attorneys' fees) arising from or relating to a
breach of the foregoing representation and warranty.
14. AUTHORIZATION. The undersigned warrant that they have been
authorized and directed to execute this Third Amendment on behalf of their
respective entities.
15. COUNTERPARTS. This Third Amendment may be signed in two or
more counterparts, each of which will be deemed an original and all of which
shall constitute one agreement.
16. TITLES. The titles of the sections and subsections of this
Third Amendment are for convenience of reference only and are not to be
considered in construing this Third Agreement.
(Signature Page Follows)
5.
IN WITNESS WHEREOF, the parties hereto have executed this Third
Amendment as of the day and year above written.
REGEN
REGEN BIOLOGICS, INC.,
a Delaware corporation
By: /s/ Xxxxx X. Varidi
------------------------------
Name: Xxxxx X. Varidi
Title: SVP and CFO
SUBTENANT
GENITOPE CORPORATION,
a Delaware corporation
By: /s/ Xxx X. Xxxxxx, Xx.
------------------------------
Name: Xxx X. Xxxxxx, Xx.
Title: CEO
6.
EXHIBIT A
CHEMICAL INVENTORY MAY 12, 2003
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
"Big Dye" Applied Biosystems
----------------------------------------------------------------------------------------
0.5 M MgSO4 Genitope
----------------------------------------------------------------------------------------
0.5M EDTA Genitope
----------------------------------------------------------------------------------------
0.8% LE/TAE/EtBr gel Genitope
----------------------------------------------------------------------------------------
1 M Imidazol Genitope
----------------------------------------------------------------------------------------
1.2% LE/TAE/EtBr gel Genitope
----------------------------------------------------------------------------------------
1.8% LE/TAE/EtBr gel Genitope
----------------------------------------------------------------------------------------
10 mM Tris Cl Genitope
----------------------------------------------------------------------------------------
10% Bleach Genitope
----------------------------------------------------------------------------------------
100 base pair ladder Gibco
----------------------------------------------------------------------------------------
100% Ethanol Gold Shield
----------------------------------------------------------------------------------------
100% IPA XX Xxxxx
----------------------------------------------------------------------------------------
1000 base pair ladder Gibco
----------------------------------------------------------------------------------------
100mM CoCl2 Genitope
----------------------------------------------------------------------------------------
10mM GeneAmp dNTP blend Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
10mM Tris CI Genitope
----------------------------------------------------------------------------------------
10x Carbonate Buffer Genitope
----------------------------------------------------------------------------------------
10X PCR buffer for Tag Roche
----------------------------------------------------------------------------------------
10X PCR buffer II with MgCI2 Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
10X Sodium Citrate Genitope
----------------------------------------------------------------------------------------
1M CaCI2 Genitope
----------------------------------------------------------------------------------------
1M KCI Genitope
----------------------------------------------------------------------------------------
1M MgCI2 Genitope
----------------------------------------------------------------------------------------
1M MOPS Genitope
----------------------------------------------------------------------------------------
0X Xx0XX0 Genitope
----------------------------------------------------------------------------------------
1M Na-cacodylic acid in Tris-CI Genitope
----------------------------------------------------------------------------------------
1M NaHCO3 Genitope
----------------------------------------------------------------------------------------
1M TRIS CI ph7.8 Genitope
----------------------------------------------------------------------------------------
1M TRIS CI ph8.0 Genitope
----------------------------------------------------------------------------------------
1M TRIS CI ph8.5 Genitope
----------------------------------------------------------------------------------------
1M NaCI Mallinckrodt
----------------------------------------------------------------------------------------
1X Trypsin-EDTA Solution Cellgro
----------------------------------------------------------------------------------------
2% BSA/DPBS Genitope
----------------------------------------------------------------------------------------
2%BSA/PBS Genitope
----------------------------------------------------------------------------------------
2.2% LE/TAE/EtBr gel Genitope
----------------------------------------------------------------------------------------
2.5% MetaPhore/TBE gel Genitope
----------------------------------------------------------------------------------------
20X MOPS Running Buffer Genitope
----------------------------------------------------------------------------------------
25mM Mg(OAc)2 solution Applied Biosystems
----------------------------------------------------------------------------------------
2-Mercaptaethanol Sigma
----------------------------------------------------------------------------------------
25mM Dgtp-Na in H2O Genitope
----------------------------------------------------------------------------------------
2 propanol XX Xxxxx
----------------------------------------------------------------------------------------
3 M NaOAc
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
1
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
3 M Sodium Acetate Genitope
----------------------------------------------------------------------------------------
3M Tris Genitope
----------------------------------------------------------------------------------------
4X SAF Genitope
----------------------------------------------------------------------------------------
5% Nonfat Milk/DPBS Genitope
----------------------------------------------------------------------------------------
50 base pair ladder Gibco
----------------------------------------------------------------------------------------
50X TAE Genitope
----------------------------------------------------------------------------------------
5mM CoCl2 Genitope
----------------------------------------------------------------------------------------
5X TBE Genitope
----------------------------------------------------------------------------------------
5X XL Chelating Buffer Genitope
----------------------------------------------------------------------------------------
5X XL RT buffer for RT-PCR
----------------------------------------------------------------------------------------
70% Ethanol Genitope
----------------------------------------------------------------------------------------
95% Ethanol Genitope
----------------------------------------------------------------------------------------
ABTS Boehringer Mannheim
----------------------------------------------------------------------------------------
ABTS Bio-Rad
----------------------------------------------------------------------------------------
Acetic Acid, glacial XX Xxxxx
----------------------------------------------------------------------------------------
Acetone XX Xxxxx
----------------------------------------------------------------------------------------
Acetone Sigma
----------------------------------------------------------------------------------------
Agar Strips Hycon TC Biotest
----------------------------------------------------------------------------------------
Alcare Steris
----------------------------------------------------------------------------------------
Algicide VWR
----------------------------------------------------------------------------------------
Ammonium Acetate Mallinckrodt
----------------------------------------------------------------------------------------
Ammonium Bifluoride, flake XX Xxxxx
----------------------------------------------------------------------------------------
Ammonium Hydroxide XX Xxxxx
----------------------------------------------------------------------------------------
AmpliTaq with MgCl2 and 10X rxn buffer II Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
Anti-Rat lgG Heavy and Light Calbiochem
----------------------------------------------------------------------------------------
ATCC Mycoplasma Detection Kit
----------------------------------------------------------------------------------------
Azaserine Sigma
----------------------------------------------------------------------------------------
Bacto Agar Difco Labs
----------------------------------------------------------------------------------------
Bacto EC Medium Difco Labs
----------------------------------------------------------------------------------------
Bacto Nzcym broth Difco Labs
----------------------------------------------------------------------------------------
Bacto Sabouraud Dextrose Agar Difco Labs
----------------------------------------------------------------------------------------
BCA Kit Xxxxxx
----------------------------------------------------------------------------------------
BCA Protein Assay Kit Xxxxxx
----------------------------------------------------------------------------------------
Bio-Rad Ready Gels Bio-Rad
----------------------------------------------------------------------------------------
BIS TRIS Sigma
----------------------------------------------------------------------------------------
Bis-Tris Sigma
----------------------------------------------------------------------------------------
Bleach Clorox
----------------------------------------------------------------------------------------
Boric Acid Granular XX Xxxxx
----------------------------------------------------------------------------------------
Brilliant Blue R Sigma
----------------------------------------------------------------------------------------
Brilliant Blue R 250 Sigma
----------------------------------------------------------------------------------------
Bromophenol Blue Sigma
----------------------------------------------------------------------------------------
BSA Mallinckrodt
----------------------------------------------------------------------------------------
BSA Hyclone
----------------------------------------------------------------------------------------
Buffer (Biphthalate) pH 4 XX Xxxxx
----------------------------------------------------------------------------------------
Buffer (Borate) pH 7 XX Xxxxx
----------------------------------------------------------------------------------------
Buffer (Phosphate) pH 10 XX Xxxxx
----------------------------------------------------------------------------------------
Buffer C1 Qiagen
----------------------------------------------------------------------------------------
Buffer P1 Qiagen
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
2
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
Buffer P3 Qiagen
----------------------------------------------------------------------------------------
Cacodylic Acid Sigma
----------------------------------------------------------------------------------------
Calcium Chloride Dihydrate EM Science
----------------------------------------------------------------------------------------
CCM-I Hyclone
----------------------------------------------------------------------------------------
Cell Culture Media Hyclone
----------------------------------------------------------------------------------------
Cellgro-FREE Media Mediatech
----------------------------------------------------------------------------------------
Chloroform XX Xxxxx
----------------------------------------------------------------------------------------
CiDecon Decon Labs, Inc.
----------------------------------------------------------------------------------------
Clear Bath Algicide VWR
----------------------------------------------------------------------------------------
Cloned pfu DNA polymerase Stratagene
----------------------------------------------------------------------------------------
Cloned pfu DNA Polymerase rxn buffer Stratagene
----------------------------------------------------------------------------------------
Cobalt Chloride Sigma
----------------------------------------------------------------------------------------
Cobalt Chloride rxn buffer Sigma
----------------------------------------------------------------------------------------
Coomasie Blue Staining Solution Genitope
----------------------------------------------------------------------------------------
Coomassie Plus Protein Assay Reagent Xxxxxx
----------------------------------------------------------------------------------------
CyQuant Molecular Probes
----------------------------------------------------------------------------------------
DEPC Sigma
----------------------------------------------------------------------------------------
Destaining Solution Genitope
----------------------------------------------------------------------------------------
Dextrose Anhydrous, Powder XX Xxxxx
----------------------------------------------------------------------------------------
dGTP, Na-salt, PCR grade rxn buffer
----------------------------------------------------------------------------------------
Diethyl Pyrocarbonate Sigma
----------------------------------------------------------------------------------------
Dimethy Sulfoxide Xxxxxx
----------------------------------------------------------------------------------------
DMEM Cellgro
----------------------------------------------------------------------------------------
DMSO Xxxxxxx Chemical
----------------------------------------------------------------------------------------
DMSO Amresco
----------------------------------------------------------------------------------------
DNA H2O Genitope
----------------------------------------------------------------------------------------
dNTP mix 10mM Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
dPBS Gibco/Cellgro
----------------------------------------------------------------------------------------
Dulbecco's PBS Cellgro
----------------------------------------------------------------------------------------
EDTA, Disodium Salt, Dehydrate, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
EGTA Sigma
----------------------------------------------------------------------------------------
ELISA Wash Buffer 10X Genitope
----------------------------------------------------------------------------------------
Ethanol (200 proof) Gold Shield
----------------------------------------------------------------------------------------
Ethidium Bromide Genitope
----------------------------------------------------------------------------------------
Ethylene Glycol Mallinckrodt
----------------------------------------------------------------------------------------
EZ-Link Sulfo-NHS-LC-Biotin Xxxxxx
----------------------------------------------------------------------------------------
Fetal Bovine Serum (FBS), characterized Hyclone
----------------------------------------------------------------------------------------
Fetal Bovine Serum (FBS), dialyzed Hyclone
----------------------------------------------------------------------------------------
Ferric Citrate Sigma
----------------------------------------------------------------------------------------
Ferric Nitrate Sigma
----------------------------------------------------------------------------------------
Ferrous Sulfate Sigma
----------------------------------------------------------------------------------------
Ficoll 400 Amersham Pharmacia
----------------------------------------------------------------------------------------
Ficoll-Paque Amersham Pharmacia
----------------------------------------------------------------------------------------
Fluorescien isothyocyanate Sigma
----------------------------------------------------------------------------------------
Formaldehyde (37%) XX Xxxxx
----------------------------------------------------------------------------------------
FuGENE Roche
----------------------------------------------------------------------------------------
Fyrite 7% CO2 Bacharach
----------------------------------------------------------------------------------------
Fyrite CO2 indicator refill Bacharach
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
3
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
Gel Drying Solution Invitrogen
----------------------------------------------------------------------------------------
Gel Extraction Kit (buffer EB,QG,PE) Qiagen
----------------------------------------------------------------------------------------
Gelatin Sigma
----------------------------------------------------------------------------------------
GeneAmp 25mM Mn(OAc)2 Roche
----------------------------------------------------------------------------------------
Gentamicin Gibco
----------------------------------------------------------------------------------------
Glucosamine Sigma
----------------------------------------------------------------------------------------
Glutaraldehyde Sigma
----------------------------------------------------------------------------------------
Glutaraldehyde (25%) Sigma/XX Xxxxx
----------------------------------------------------------------------------------------
Glycerol XX Xxxxx
----------------------------------------------------------------------------------------
Glycine XX Xxxxx
----------------------------------------------------------------------------------------
Goat Anti-Human lgG Biosource
----------------------------------------------------------------------------------------
Goat anti-human lgG gamma chain Biosource
----------------------------------------------------------------------------------------
Goat F(ab')2 anti-human kappa light chain Biosource
----------------------------------------------------------------------------------------
Goat F(ab')2 anti-human lambda light antibody Biosource
----------------------------------------------------------------------------------------
Growth check, microbial suspensions Becton Xxxxxxxxx?
----------------------------------------------------------------------------------------
Guanidine Sigma
----------------------------------------------------------------------------------------
Guanidium Isothyocyanate XX Xxxxx
----------------------------------------------------------------------------------------
Hand Soap SoftCide
----------------------------------------------------------------------------------------
HEPES Free Acid XX Xxxxx
----------------------------------------------------------------------------------------
Hi Trap Lectin Test Kit Sigma?
----------------------------------------------------------------------------------------
High Pure Plasmid isolation Kit Boehringer Mannheim
----------------------------------------------------------------------------------------
Hightrap G Protein Amersham Pharmacia
----------------------------------------------------------------------------------------
Hightrap SP Pharmacia Biotech
----------------------------------------------------------------------------------------
Horseradish Peroxidase Avidin D Vector Labs
----------------------------------------------------------------------------------------
Horseradish Peroxidase Substrate Kit Bio-Rad
----------------------------------------------------------------------------------------
Human lgC Kappa Sigma
----------------------------------------------------------------------------------------
Human lgC Lambda Sigma
----------------------------------------------------------------------------------------
Hybridoma SFM Invitrogen
----------------------------------------------------------------------------------------
Hydrochloric Acid XX Xxxxx
----------------------------------------------------------------------------------------
Hydrocyanic Acid XX Xxxxx
----------------------------------------------------------------------------------------
Hydrogen Peroxide 30% XX Xxxxx
----------------------------------------------------------------------------------------
Hypoxanthine Sigma
----------------------------------------------------------------------------------------
IEF Anode (lower) buffer Invitrogen
----------------------------------------------------------------------------------------
IEF Cathode Buffer pH 3-10 Invitrogen
----------------------------------------------------------------------------------------
IEF Sample Buffer pH 3-10 Invitrogen
----------------------------------------------------------------------------------------
Imidazole Sigma
----------------------------------------------------------------------------------------
Imject Mariculture KLH in PBS Xxxxxx
----------------------------------------------------------------------------------------
IPA XX Xxxxx
----------------------------------------------------------------------------------------
IPA (100%) XX Xxxxx
----------------------------------------------------------------------------------------
Isoamyl Alcohols
----------------------------------------------------------------------------------------
Isocetyl Alcohol
----------------------------------------------------------------------------------------
Isopropyl Alcohol (70%) BDG Inc.
----------------------------------------------------------------------------------------
ISP Medium 2 Difco Labs
----------------------------------------------------------------------------------------
Kanamycin Sigma
----------------------------------------------------------------------------------------
Kappa Control, characterized in-house lgG3 kappa conju Genitope
----------------------------------------------------------------------------------------
Kappa Standard Sigma
----------------------------------------------------------------------------------------
Kappa Standard Antibody, characterized in-house purifi Genitope
----------------------------------------------------------------------------------------
Keyhole Limpet Hemocyanin (KLH) Biosyn
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
4
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
Kinetic Endotoxin Detection LAL Kinetic QCL BioWhittaker/Cambrex
----------------------------------------------------------------------------------------
Lactose, monohydrate Sigma
----------------------------------------------------------------------------------------
Laemmli Sample Buffer Biorad
----------------------------------------------------------------------------------------
Lambda Control, Characterized in-house IgG3 lambda co Genitope
----------------------------------------------------------------------------------------
Lambda Standard Sigma
----------------------------------------------------------------------------------------
Lambda Standard Antibody, characterized in-house puri Genitope
----------------------------------------------------------------------------------------
LB Media Genitope
----------------------------------------------------------------------------------------
L-Glutamine Cellgro
----------------------------------------------------------------------------------------
Liquid Nitrogen Liquid Carbonic Indust
----------------------------------------------------------------------------------------
Lithium Chloride, Granular XX Xxxxx
----------------------------------------------------------------------------------------
Loading Dye Genitope
----------------------------------------------------------------------------------------
XxxXxxx Xxxxxx
----------------------------------------------------------------------------------------
macro-Prep High Q Support Bio-Rad
----------------------------------------------------------------------------------------
Magnesium Acetate Sigma
----------------------------------------------------------------------------------------
Magnesium Chloride, 6-Hydrate, Crystal XX Xxxxx/Mallinckrodt
----------------------------------------------------------------------------------------
Magnesium Sulfate XX Xxxxx
----------------------------------------------------------------------------------------
Maltose Sigma
----------------------------------------------------------------------------------------
Manganese Chloride AR Mallinckrodt
----------------------------------------------------------------------------------------
Mannopyranoside Sigma
----------------------------------------------------------------------------------------
MEM Amino Adds Cellgro
----------------------------------------------------------------------------------------
Mercaptoethanol Sigma
----------------------------------------------------------------------------------------
MetaPhor Agarose FMC Bioproducts
----------------------------------------------------------------------------------------
Methanol XX Xxxxx
----------------------------------------------------------------------------------------
Methotrexate in house
----------------------------------------------------------------------------------------
Methvl Mannopyranoside Sigma
----------------------------------------------------------------------------------------
MilliQH20 Genitope
----------------------------------------------------------------------------------------
Molecular weight Standard BioRad
----------------------------------------------------------------------------------------
Monoethanolamine XX Xxxxx
----------------------------------------------------------------------------------------
MOPS Sigma
----------------------------------------------------------------------------------------
Mycoplasma Kit ATCC
----------------------------------------------------------------------------------------
NaCl, 0.9% Xxxxxx
----------------------------------------------------------------------------------------
NanoOrange Protein Kit Molecular Probes
----------------------------------------------------------------------------------------
XxXX (0.0, 0, 00 X) XX Xxxxx
----------------------------------------------------------------------------------------
Nickel Sulfate Sigma
----------------------------------------------------------------------------------------
Ni-NTA Agarose Qiagen
----------------------------------------------------------------------------------------
Ni-NTA Resin Qiagen
----------------------------------------------------------------------------------------
NiSieve GTG Agarose FMC Bioproducts
----------------------------------------------------------------------------------------
Nonfat Dry Milk Nestle
----------------------------------------------------------------------------------------
NuPAGE Bis-Tris gels 4-12% Invitrogen
----------------------------------------------------------------------------------------
NuPAGE Bis-Tris Gels, 4-12% Novex
----------------------------------------------------------------------------------------
NuPAGE MES SDS Running Buffer Invitrogen
----------------------------------------------------------------------------------------
NuPAGE MOPS SDS Running Buffer Invitrogen
----------------------------------------------------------------------------------------
NuPAGE Sample Reducing Agent Novex
----------------------------------------------------------------------------------------
NuPAGE Transfer Buffer Invitrogen
----------------------------------------------------------------------------------------
NuPAGE Tris-Acetate Gels, 3.8% Novex
----------------------------------------------------------------------------------------
NuSieve GTG agarose FMC Bioproducts
----------------------------------------------------------------------------------------
O-Syl National Lab
----------------------------------------------------------------------------------------
PBS Cellgro
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
5
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
PCR Purification Kit (buffer EB,PB,PE) Qiagen
----------------------------------------------------------------------------------------
Pepsin Mallinckrodt
----------------------------------------------------------------------------------------
Phenol, equilibrated Sigma
----------------------------------------------------------------------------------------
Phosphate Buffered Saline (PBS) Cellgro
----------------------------------------------------------------------------------------
Phosphoric Acid XX Xxxxx
----------------------------------------------------------------------------------------
Pluronic L 121 BASF
----------------------------------------------------------------------------------------
Polyoxyethylenesorbital Monolaurate Sigma
----------------------------------------------------------------------------------------
Polysorbate 80 Mallinckrodt
----------------------------------------------------------------------------------------
Potassium Acetate, granular XX Xxxxx
----------------------------------------------------------------------------------------
Potassium Chloride, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
Potassium Hydroxide, Pellets XX Xxxxx
----------------------------------------------------------------------------------------
Potassium Phosphate Mallinckrodt
----------------------------------------------------------------------------------------
Precast Polyacrilamide Gel (Mini) Invitrogen
----------------------------------------------------------------------------------------
Pre-diluted Protein Assay (BGG) Xxxxxx
----------------------------------------------------------------------------------------
Protein A Elution Buffer Genitope
----------------------------------------------------------------------------------------
Protein A Wash Buffer Genitope
----------------------------------------------------------------------------------------
Protein G Column Amersham Pharmacia
----------------------------------------------------------------------------------------
Protein G Sepharose for Fast Flow Amersham Pharmacia
----------------------------------------------------------------------------------------
Pyrosperse BioWhittaker
----------------------------------------------------------------------------------------
Qiagen Protease Qiagen
----------------------------------------------------------------------------------------
QlAquick PCR Purification Kit Qiagen
----------------------------------------------------------------------------------------
Quanti-cult Chrisope Technologies
----------------------------------------------------------------------------------------
RNA H2O Genitope
----------------------------------------------------------------------------------------
RNAzol B Tel-test, Inc.
----------------------------------------------------------------------------------------
RNeasy Maxi Kit Qiagen
----------------------------------------------------------------------------------------
RNeasy Midi Kit Qiagen
----------------------------------------------------------------------------------------
RNeasy Mini Kit Qiagen
----------------------------------------------------------------------------------------
Robane VWR
----------------------------------------------------------------------------------------
RO Water Genitope
----------------------------------------------------------------------------------------
RPMI 1640 Cellgro
----------------------------------------------------------------------------------------
rTth DNA polymerase with buffer pack Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
rTth XL DNA polymerase with buffer pack Xxxxxx Xxxxx
----------------------------------------------------------------------------------------
Sabouraud Dextrose Agar w/ Lecithin and Polysorbate 8 Becton Xxxxxxxxx
----------------------------------------------------------------------------------------
Saline (0.9%) Xxxxxx
----------------------------------------------------------------------------------------
Sargramostim Leukine Immunex
----------------------------------------------------------------------------------------
SeaKem LE Agarose BioWhittaker
----------------------------------------------------------------------------------------
SeaPlaque GTG Agarose FMC Bioproducts
----------------------------------------------------------------------------------------
SeaPlaque GTG Agarose FMC Bioproducts
----------------------------------------------------------------------------------------
SFX-MAB Hyclone
----------------------------------------------------------------------------------------
Silver Nitrate Invritrogen
----------------------------------------------------------------------------------------
Silver Xpress Silver Staining Kit Invritrogen
----------------------------------------------------------------------------------------
Sodium Acetate, Trihydrate, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Azide XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Bicarbonate, Powder XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Carbonate, Anyhdrous, Granular XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Carbonate, Monohydrate, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Chloride, Crystals EM Science
----------------------------------------------------------------------------------------
Sodium Citrate, Dihydrate, Granular XX Xxxxx
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
6
Exhibit A
Chemical Inventory May 12, 2003
REAGENT MANUFACTURER
----------------------------------------------------------------------------------------
Sodium Dodecyl Sulfate XX Xxxxx/Bio-Rad
----------------------------------------------------------------------------------------
Sodium Hydroxide XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Nitroprusside Sigma
----------------------------------------------------------------------------------------
Sodium Phosphate, Dibasic, 7-Hydrate, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Phosphate, Monobasic, Monohydrate, Crystal XX Xxxxx
----------------------------------------------------------------------------------------
Sodium Pyruvate Cellgro
----------------------------------------------------------------------------------------
Superblock Blocking Buffer in PBS Xxxxxx
----------------------------------------------------------------------------------------
TE Buffer Genitope
----------------------------------------------------------------------------------------
Terminal Transferase Boehringer Mannheim
----------------------------------------------------------------------------------------
TFBI Genitope
----------------------------------------------------------------------------------------
TFBII Genitope
----------------------------------------------------------------------------------------
Thymidine Sigma
----------------------------------------------------------------------------------------
TMB Microwell Peroxidase substrate Kirkegaard and Perry L
----------------------------------------------------------------------------------------
Trace Klean Xxxxxxx
----------------------------------------------------------------------------------------
Tricine Sigma
----------------------------------------------------------------------------------------
Tris Base EM Science or XX Xxxxx
----------------------------------------------------------------------------------------
TRIS Hydrochloride XX Xxxxx/EM Science
----------------------------------------------------------------------------------------
Tris-Base Genitope
----------------------------------------------------------------------------------------
Triton X-100 XX Xxxxx
----------------------------------------------------------------------------------------
Trypan blue Sigma
----------------------------------------------------------------------------------------
Trypsin Cellgro
----------------------------------------------------------------------------------------
Tryptic Soy Broth Difco Labs
----------------------------------------------------------------------------------------
Trypticase Soy Agar Becton Xxxxxxxxx
----------------------------------------------------------------------------------------
Trypticase Soy Agar Plates Becton Xxxxxxxxx
----------------------------------------------------------------------------------------
Trypticase Soy Agar Slants Becton Xxxxxxxxx
----------------------------------------------------------------------------------------
Tryptone Peptone Difco Labs
----------------------------------------------------------------------------------------
Uridine Sigma
----------------------------------------------------------------------------------------
WFI Abbott?
----------------------------------------------------------------------------------------
Yeast Extract Difco Labs
----------------------------------------------------------------------------------------
Zero Blunt TOPO PCR Cloning Kit Invitrogen
----------------------------------------------------------------------------------------
Exhibit A Sublease 525 Penobscot
7
