Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
Confidential
Exhibit 10.49
Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
This Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin, dated as of December 3, 2007 (“Effective Date”), is entered into by and between Patheon Italia S.p.A. (“Patheon”) and ZymoGenetics, Inc., a Washington corporation (“ZGEN”).
The parties hereby agree that the Manufacturing Services Agreement relating to rhThrombin, dated January 1, 2006 (the “Agreement”) shall be amended as follows:
| 1. | Territory |
Schedule H shall be replaced by the updated Schedule H attached hereto.
| 2. | Ratification of Agreement |
All other terms and obligations of the Agreement shall remain in full force and effect.
IN WITNESS WHEREOF, ZGEN and Patheon have executed this Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin as of the Effective Date.
| Patheon Italia S.p.A. | ZymoGenetics, Inc. | |||
| /s/ Xxxx Xxxxx | /s/ Xxxxxx X. Xxxxx | |||
| Xxxx Xxxxx | Xxxxxx X. Xxxxx, Ph.D. | |||
| Managing Director Patheon Italia S.p.A. – President Patheon Europe |
Senior Vice President, Technical Operations | |||
| Date: December 3, 2007 | Date: December 5, 0000 | |||
Xxxxxxxxxxxx
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Xxxxxx Xxxxxx of America
Countries within Europe
| • Albania |
• Andorra |
• Armenia | ||
| • Austria |
• Azerbaijan |
• Belarus | ||
| • Belgium |
• Bosnia and Herzegovina |
• Bulgaria | ||
| • Croatia |
• Cyprus |
• Czech Republic | ||
| • Denmark |
• Estonia |
• Finland | ||
| • France |
• Georgia |
• Germany | ||
| • Greece |
• Hungary |
• Iceland | ||
| • Ireland |
• Italy |
• Kazakhstan | ||
| • Kyrgyzstan |
• Latvia |
• Liechtenstein | ||
| • Lithuania |
• Luxembourg |
• Macedonia | ||
| • Malta |
• Moldova |
• Monaco | ||
| • Montenegro |
• Netherlands |
• Norway | ||
| • Poland |
• Portugal |
• Romania | ||
| • Russia |
• San Marino |
• Serbia | ||
| • Slovakia |
• Slovenia |
• Spain | ||
| • Sweden |
• Switzerland |
• Tajikistan | ||
| • Turkey |
• Turkmenistan |
• Ukraine | ||
| • United Kingdom |
• Uzbekistan |
• Vatican City | ||
Countries within Canada/Latin America Region
| • Canada |
• Mexico |
• Argentina | ||
| • Bolivia |
• Brazil |
• Chile | ||
| • Colombia |
• Dominican Republic |
• Ecuador | ||
| • El Salvador |
• Guatemala |
• Nicaragua | ||
| • Paraguay |
• Peru |
• Uruguay | ||
| • Venezuela |
• Costa Rica |
• Honduras | ||
| • Panama |
• Belize |
• Cuba | ||
| • French Guiana |
• Guadeloupe |
• Guyana | ||
| • Haiti |
• Suriname |
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Countries within Asia/Pacific Region
| • Australia |
• Cambodia |
• China | ||
| • Hong Kong |
• Indonesia |
• India | ||
| • Malaysia |
• New Zealand |
• Pakistan | ||
| • Philippines |
• Singapore |
• South Korea | ||
| • Vietnam |
• Taiwan |
• Thailand | ||
| • Bahrain |
• Bangladesh |
• Bhutan | ||
| • Brunei |
• Israel |
• Jordan | ||
| • Kuwait |
• Oman |
• Qatar | ||
| • Saudi Arabia |
• United Arab Emirates |
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Countries within Japan Region
| • Japan |
