1 EXHIBIT 4.10 AMENDED WARRANTS (Cancellable above $5.00 Liquidity Event) FOR GOOD AND VALUABLE CONSIDERATION, the receipt of which is hereby acknowledged, Genomic Solutions, Inc., a Delaware corporation, 4355 Varsity Drive, Suite E, Ann Arbor,...

   1
                                                                    EXHIBIT 4.10

                                AMENDED WARRANTS
                    (Cancellable above $5.00 Liquidity Event)

                  FOR GOOD AND VALUABLE CONSIDERATION, the receipt of which is
hereby acknowledged, Genomic Solutions, Inc., a Delaware corporation, 0000
Xxxxxxx Xxxxx, Xxxxx X, Xxx Xxxxx, Xxxxxxxx 00000, hereinafter referred to as
the "Company", grants to      hereinafter referred to as "Optionee", or assigns,
the right to purchase      shares of common stock of the Company at an initial
exercise price per share of one cent, subject to termination in whole or in part
in accordance with subsection (M) of this Warrant. The Warrants will expire on
April 23, 2009.

                  (A) Stock Dividends. In the event that the Company shall issue
any shares of common stock as a dividend upon its common stock before these
Warrants are exercised, Optionee upon exercising these Warrants after the date
of record when said stock dividends are payable, shall be entitled to receive,
in addition to the shares of common stock purchased hereunder, without the
payment of further consideration, the number of shares of the common stock which
it would have been entitled to receive if it had been a holder of record on such
record date of the number of shares of the common stock then purchasable under
these Warrants (increased proportionately on account of any prior common stock
dividends).

                  (B) Splits. In the event that the Company by amendment of its
Articles of Incorporation or otherwise shall split up its outstanding shares of
common stock into a greater number of shares, or decrease the outstanding shares
by combination or otherwise, the number of shares of common stock called for by
these Warrants shall be increased or decreased correspondingly on account of
each such stock split or combination without any increase or decrease in the
total purchase price (for all shares).

                  (C) Adjustment for Reclassification, Exchange, or
Substitution. If the Common Stock purchasable upon exercise of this Warrant
shall be changed into the same or a different number of shares of any class or
classes of stock, whether by capital reorganization, reclassification, or
otherwise (other than a subdivision or combination of shares or stock dividend
provided for above, or a reorganization, merger, consolidation or sale of assets
provided for below), then and in each such event the holder of this Warrant
shall have the right thereafter to be issued upon the exercise of this Warrant
the kind and amounts of shares of stock and other securities and property
receivable upon such reorganization, reclassification or other change, by
holders of the number of shares of Common Stock purchasable upon exercise of the
Warrant immediately prior to such reorganization, reclassification, or change,
all subject to further adjustment as provided herein.

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                  (D) Reorganization, Mergers, Consolidations, or Sales of
Assets. If at any time or from time to time there shall be a capital
reorganization of the Common Stock (other than a subdivision, combination,
reclassification, or exchange of shares provided for above) or a merger or
consolidation of the Company with or into another corporation, or the sale of
all or substantially all of the Company's properties and assets to any other
person, then:

                  1.  If in any such transaction, the shareholders of Company
receive cash or Freely Marketable Securities (as hereinafter defined), or a
combination thereof, this Warrant shall be exercised immediately prior to the
consummation of any such transaction (but such exercise may be conditioned upon
the consummation of such transaction) and thereafter, the holder of this Warrant
shall be entitled to receive, upon the surrender of this Warrant and payment of
the applicable purchase price, only the cash or the Freely Marketable Securities
to which a holder of common stock deliverable upon exercise of this Warrant
immediately prior to the consummation of such transaction would have been
entitled to received on account of such transaction.

                  2.  If the provisions of subsection (D) (1) are not
applicable, provision shall be made so that as a part of such reorganization,
merger, consolidation, or sale, the holders of this Warrant shall thereafter be
entitled to receive upon exercise of this Warrant the number of shares of stock
or other securities or property of the Company, or of the successor
corporation resulting from such merger or consolidation or sale, to which a
holder of Common Stock deliverable upon exercise would have been entitled on
such capital reorganization, merger, consolidation, or sale.

                  3.  For purposes of this Warrant, "Freely Marketable
Securities" shall mean securities of a class registered under Section 12(b) or
Section 12(g) of the Securities Exchange Act of 1934 (or if not so registered,
with respect to which an underwritten public offering of such securities shall
have been completed pursuant to a Registration Statement filed under the
Securities Act of 1933 and as a consequence of the distribution of securities
pursuant to such offering will necessitate registration of such class of
securities under the Securities Exchange Act of 1934), which may be resold by
the holder thereof without a requirement for any registration under federal or
state securities laws, provided however, that underwriter lock-up provisions not
exceeding 180 days or limitations on the manner in which such securities may be
sold or the quantity of such securities which may be sold in any three month
period under Rule 145 of the rules and regulations promulgated under the
Securities Act of 1933 (but not a delay in the time at which such securities may
be sold other than resulting from the foregoing) shall not be considered to
render otherwise Freely Marketable Securities not freely marketable.

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                  (E) Successive Application of Provisions. Appropriate
adjustment shall be made in the application of these provisions with respect to
the rights of the holders of the Warrant after a stock dividend, stock split,
reclassification, exchange, substitution, reorganization, merger, consolidation,
or sale to the end that these provisions (including adjustment of the Minimum
Company Value then in effect and the number of shares purchasable upon exercise
of the Warrant) shall be applicable after that event as nearly equivalent as may
be practicable.

                  Sale of Shares Below Minimum Company Value. The provisions of
this subsection ("F") shall apply to the issue or sale of Additional Shares of
Common Stock (as hereinafter defined) or Convertible Securities as defined in
subsection "F-3".

                  1.  If at any time or from time to time after April 23, 1999
the Company shall issue or sell Additional Shares of Common Stock, other than as
a dividend as provided above, and other than upon a subdivision as provided
above, for a consideration per share less than $5.00 (the "Minimum Company
Value") (or, if an adjusted Minimum Company Value shall be in effect by reason
of a previous adjustment, then less than such adjusted Minimum Company Value)
then and in each such case, as of the opening of business on the date of such
issue or sale, Optionee shall have the right to purchase upon exercise of this
Warrant the number of shares of common stock of the Company as results from
dividing the number of shares of common stock of Company which were purchasable
upon exercise of this Warrant as of the close of business the preceding day by a
fraction (i) the numerator of which shall be (a) the number of shares of Common
Stock outstanding (including any Additional Shares of Common Stock and the
shares subject to outstanding options or warrants excluded from the definition
of Additional Shares of Common Stock hereunder immediately prior to such issue
or sale), plus (b) the number of shares of Common stock which the aggregate
consideration received by the Company for the total number of Additional Shares
of Common Stock so issued would purchase at such Minimum Company Value, and (ii)
the denominator of which shall be the number of shares of Common Stock
outstanding (including any Additional Shares of Common Stock and the shares
subject to outstanding options or warrants excluded from the definition of
Additional Shares of Common Stock hereunder) immediately prior to such issue or
sale plus the number of such Additional Shares of Common Stock so issued.

                  2.  For the purpose of making any adjustment in the number of
shares of Common Stock purchasable on exercise of this Warrant as provided
above, the consideration received by the Company for any issue or sale of
securities shall, (a) to the extent it consists of cash, be computed at the net
amount of cash received by the Company after deduction of any underwriting or
similar commissions, concessions, or compensation paid or allowed by the Company
in connection with such issue or sale, (b) to



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the extent it consists of property other than cash, be computed at the fair
value of that property as determined in good faith by the Board; and (c) if
Additional Shares of Common Stock, Convertible Securities (as hereinafter
defined), or rights or options to purchase either Additional Shares of Common
Stock or Convertible Securities are issued or sold together with other stock
or securities or other assets of the Company for a consideration that covers
both, be computed as the portion of the consideration so received that may be
reasonably determined in good faith by the Board to be allocable to such
Additional Shares of Common Stock, Convertible Securities or rights or
options.

                  3.  For the purpose of the adjustment provided above, if at
any time or from time to time after April 23, 1999, the Company shall issue any
rights or options for the purchase of, or stock or other securities convertible
into Additional Shares of Common Stock (such convertible stock or securities
being hereinafter referred to as "Convertible Securities"), then, in each case,
if the Effective Price (as hereinafter defined) of such rights, options, or
Convertible Securities shall be less than the then existing Minimum Company
Value, the Company shall be deemed to have issued at the time of the issuance of
such rights or options or Convertible Securities the maximum number of
Additional Shares of Common Stock issuable upon exercise or conversion thereof
and to have received as consideration for the issuance of such shares an amount
equal to the total amount of the consideration, if any, received by the Company
for the issuance of such shares, rights or options or Convertible Securities,
plus in the case of such options or rights, the minimum amounts of
consideration, if any, payable to the Company upon exercise or conversion of
such options or rights.

              If any such rights or options or the conversion privilege
represented by any such Convertible Securities shall expire or be cancelled
without having been exercised, the number of shares of common stock which may be
purchased upon exercise of this Warrant shall be readjusted to the number of
shares of common stock that would have been applicable had any adjustment been
made on the basis that the only Additional Shares of Common Stock so issued were
the Additional Shares of Common Stock, if any, actually issued or sold on the
exercise of such rights or options or rights of conversion of such Convertible
Securities, and such Additional Shares of Common Stock, if any, were issued or
sold for the consideration actually received by the Company upon such exercise,
plus the consideration, if any, actually received by the Company for the
granting of all such rights or options, whether or not exercised, plus the
consideration received for issuing or selling the convertible Securities
actually converted plus the consideration, if any, actually received by the
Company on the conversion of such Convertible Securities.

                  4.  For the purpose of the adjustment provided for above, if
at any time or from time to time after April 23, 1999,


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the Company shall issue any rights or options for the purchase of Convertible
Securities, then, in each such case, if the Effective Price thereof is less than
the then current Minimum Company Value, the Company shall be deemed to have
issued at the time of the issuance of such rights or options the maximum number
of Additional Shares of Common Stock issuable upon conversion of the total
amount of Convertible Securities covered by such rights or options and to have
received as consideration for the issuance of such Additional Shares of Common
Stock an amount equal to the amount of consideration, if any, received by the
Company for the issuance of such rights or options, plus the minimum amounts
of consideration, if any, payable to the Company upon exercise of such rights or
options plus the minimum amounts of consideration, if any, payable to the
Company upon the conversion of such Convertible Securities.

              The provisions above for the readjustment of the number of shares
of common stock which may be purchased upon exercise of this Warrant after the
expiration of rights or options or the rights of conversion of Convertible
Securities, shall apply mutatis mutandis to the rights, options and Convertible
Securities referred to in this subsection.

                  5.  "Effective Price" for purposes hereof shall mean the
quotient determined by dividing the total of all of such consideration by such
maximum number of Additional Shares of Common Stock. No further adjustment in
the number of shares of common stock which may be purchased upon exercise of
this Warrant shall be made as a result of the actual issuance of Additional
Shares of Common Stock or Convertible Securities on the exercise of any such
rights or options or on the conversion of any such Convertible Securities.

                  (G) Definition. The term "Additional Shares of Common Stock"
as used herein shall mean all shares of Common Stock issued by the Company after
April 23, 1999 whether or not subsequently reacquired or retired by the Company,
other than (i) up to (x) 2,162,020 shares of common stock issued upon exercise
of outstanding incentive or non-qualified stock options, and (y) 968,751 shares
of common stock issued upon exercise of incentive or non-qualified options
hereafter granted with an exercise price of not less than $2.00 per share, to
employees, consultants or non-employee directors pursuant to the existing stock
option plans adopted by the Board, (ii) 5,093,576 shares of common stock issued
upon conversion of the outstanding shares of Series B Preferred Stock, (iii)
4,070,339 shares of common stock issued upon conversion of the outstanding
shares of Series C Preferred Stock, (iv) 1,100,000 shares of common stock
issued upon conversion of the outstanding shares of Series D Preferred Stock,
(v) 270,027 shares of common stock issued upon conversion of the outstanding
shares of Series M Preferred Stock, and (vi) shares of common stock issued upon
exercise of any Warrants issued pursuant to the terms of the Business Loan
Agreement between Company, White Pines Limited Partnership I, Pacific


                                        5


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Capital L.P., Chase Venture Capital Associates, L.P., American Healthcare Fund
II, Xxx X. X. Bund Xxxxx Xxxxxx Prototype PS Plan Account #000-00000-00000,
Xxxxx Consulting Associates, Inc., Volunteer Healthcare Associates, L.L.C.,
McDonald Investments Inc. Custodian FBO X. Xxxxxxxx XxXxxxxx III IRA Rollover
Account #00000000, X. Xxxxxxx Xxxxxxxxx, Xxxxxx X. Xxxxxxx, Xxxx X. Xxxxxxxxx,
Grove Investment Partners, Xxxxxx X. Xxxxxx Living Trust u/a/d September 9,
1997, Xxxx X. Xxxxxx, XxXxxxxx Investments Inc. Custodian FBO Xxxxxx X. Xxxxx
XXX Rollover Account #00000000, National City Bank of MI/IL, Custodian FBO
Xxxxxxx X. Xxxxxx XXX Rollover Account dated June 12, 1991 Account
#MI-1491-00-4, Xxxxxxx and Associates Profit Sharing Plan u/a/d January 1, 1991
and Xxxxxxx X. Xxxxxxxx dated April 23, 1999 (hereinafter referred to as the
"Loan Agreement").

                  (H) Accountants' Certificate of Adjustment. In each case of an
adjustment or readjustment of the Minimum Company Value or the number of shares
of Common Stock or other securities issuable upon exercise of the Warrant, the
Company shall compute such adjustment or readjustment in accordance herewith and
prepare a certificate showing such adjustment or readjustment, and shall mail
such certificate, by first class mail, postage prepaid, to the registered holder
hereof at the holder's address as shown in the Company's books. The certificate
shall set forth such adjustment or readjustment, describing in detail the facts
upon which such adjustment or readjustment is based including a statement of the
Minimum Company Value at the time in effect, and the number of additional shares
of Common Stock and the type and amount, if any, of other property which at the
time would be received upon exercise of the Warrant.

                  (I) Exercise.

                      1. OPTIONAL. This Warrant may not be exercised with
respect to that portion of the shares for which the right to subscribe for and
purchase such shares may be terminated in accordance with the provisions of
subsection (M) below except for the exercise of this Warrant in accordance with
subsection (D)(1) above by reason of a transaction described therein which does
not effect the termination of this Warrant in accordance with such subsection
(M). This Warrant may be exercised at any time in whole or part with respect to
the number of shares of common stock with respect to which the rights to
purchase such shares of common stock are no longer subject to termination in
accordance with the provisions of subsection (M) by delivering to the Company
(a) the form of Exercise Notice attached hereto duly completed and executed by
the holder of this Warrant, (b) this Warrant certificate for notation thereon of
such exercise, and (c) either payment of the applicable purchase price or the
election to exercise this Warrant in accordance with "4" below. Upon any
exercise of this Warrant only in part, new Warrants shall be executed and
delivered by Company to the holder of this Warrant in accordance with subsection
(M)(3) hereof.

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                      2. MANDATORY. This Warrant shall be exercised concurrent
with the consummation of the sale by Company of its common stock in a firm
commitment underwriting pursuant to a registration statement on Form S-1, Form
SB-1, Form SB-2, or their then equivalents, filed under the Securities Act of
1933, as amended, and resulting in an aggregate offering price to the public of
at least $20,000,000, and where the offering price to the public is not less
than $8.00 per share.

                      3. EFFECT OF EXERCISE. The holder will be deemed to be
the holder of record of the shares of common stock as to which this Warrant was
exercised in accordance with this Warrant, effective at the close of business on
the date (a) such exercise is completed and all documents specified in "(1)"
above are delivered to the Company, or (b) the later of (x) the consummation of
the sale contemplated by "(2)" above, or (y) the surrender thereafter of this
Warrant to the Company together with either payment of the applicable purchase
price or the election to exercise this Warrant in accordance with "41" below.
The holder hereof, upon such surrender, and payment or election, shall become
entitled as of such date to all dividends, subscription and other rights of a
holder of record of such shares of the common stock. When issued, said shares
shall be fully paid and nonassessable and free from any liens and charges.

                      4. NET EXERCISE. Instead of payment of the applicable
purchase price, the Optionee may exercise this Warrant by electing to receive,
without the payment by the Optionee of any additional consideration, shares of
common stock equal to the value of this Warrant by the surrender of all or part
of this Warrant to the Company with the Exercise Notice specifying reliance on
this subsection I (4). Thereupon, the Company shall issue to the Optionee such
number of fully paid and nonassessable shares of common stock as is computed
using the following formula:

                           X = Y (A-B)
                               --------
                                  A

where

X =  the number of shares to be issued to the Optionee pursuant to this
     subsection I(4).

Y =  the number of shares of common stock subject to issuance upon exercise of
     the portion of the Warrant the Optionee elects to exercise pursuant to this
     subsection I(4).

A =  the "Fair Market Value" of one share of common stock on the date the net
     exercise election is made pursuant to this subsection I(4) as agreed to by
     Company and Optionee within ten days of the date of such exercise, or in
     the absence of such an agreement, as determined by appraisal in the manner
     provided in subsection K below.

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B =  the Exercise Price in effect under this Warrant at the time the net
     exercise election is made pursuant to this subsection I(4).

                      5. FRACTIONAL SHARES. No fractional shares shall be
issued upon the exercise of this Warrant. In lieu of fractional shares, the
Company shall pay the holder a sum in cash equal to the fair market value of the
fractional shares (if "Fair Market Value" was determined as contemplated by
"4" above, then such amount; otherwise as determined by the Board) on the date
of exercise.

                  (J) Shares Reserved. The Company shall at all times authorize
and reserve unissued, a number of shares of its common stock sufficient to
satisfy the rights of the holders of these Warrants, and shall keep the transfer
agent supplied with sufficient stock certificates to provide for the exercise of
all outstanding warrants.

                  (K) Put. Optionee may require the Company to redeem these
Warrants or the shares of common stock issued upon exercise of the Warrants at
any time beginning April 23, 2004 and prior to the date on which Company shall
have completed an "Initial Public Offering" as defined in the Registration
Rights Agreement dated April 23, 1999 between the parties. The price per share
shall be the greater of (i) "Fair Market Value" as agreed to by Company and
Optionee, or in the absence of such an agreement, as determined by appraisal as
hereinafter provided, or (ii) based on a value of the Company determined in
accordance with the following formula:

                  Value = (EBITDA + Extraordinary Expense-Extraordinary Income)
                  times seven plus cash and cash equivalents minus Long Term
                  Debt

                  EBITDA shall be defined as the earnings of the Company before
                  interest, taxes, depreciation and amortization. The EBITDA
                  utilized for determining the value of the Company shall be the
                  greater of (i) EBITDA for the last fiscal year immediately
                  preceding the redemption of the Warrants or shares, or (ii)
                  one-half of the aggregate EBITDA for the two fiscal years
                  immediately preceding the redemption of the Warrants or
                  shares.

If "Fair Market Value" is to be determined by appraisal, Company and Optionee
shall each appoint one independent appraiser who is a regionally or nationally
recognized investment banking firm, or an independent appraiser who is a member
of a recognized professional organization, within ten days of notice by either
Company or Optionee to the other that appraisal is being demanded. Within 20
days of appointment, each appraiser shall determine the price at which the
shares would exchange between a willing buyer and a willing seller, when the
former is not under

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any compulsion to buy and the latter is not under any compulsion to sell, both
having reasonable knowledge of the relevant facts. For purposes of determining
the value of the shares, it shall be assumed that the business of the Company is
ongoing. The mean of the values determined in each such appraisal shall
constitute "Fair Market Value". The cost of the appraisals shall be borne by the
Company.

No adjustment shall be made to the price per share determined pursuant to the
foregoing for any discounts, including, but not limited to, discounts based
upon a lack of marketability or shares constituting a minority interest in the
stock of the Company.

All computations and determinations for the purpose of the foregoing
determination of value shall be made in accordance with generally accepted
principles of accounting consistently applied.

                  (L)  Payment of Redemption Price. The redemption price
applicable under the provisions of subsection (K) shall be determined within 30
days of the date on which Optionee shall notify Company that Optionee is
requiring a redemption of this Warrant or the shares. The redemption price shall
be paid to Optionee in cash within ten days thereafter upon surrender by
Optionee of this Warrant or the shares, provided however, that such payment of
the redemption price shall be subject to the ability of Company reasonably to
obtain debt or equity financing which may be necessary to fund such payment. In
the event that Company shall be unable to pay the redemption price solely for
the reason specified in the preceding sentence within 90 days of when due,
Optionee shall have the right, at Optionee's sole discretion, to either:

                  (i)  rescind the demand for the redemption of this Warrant or
the shares whereupon all rights of Optionee to require redemption of this
Warrant or the shares at any future date in accordance with the terms and
provisions of subsection K and this subsection (L) shall remain in full force
and effect, or

                  (ii) accept payment of the redemption price by the execution
and delivery by Company to Optionee of a Promissory Note in the amount of the
redemption price, in the form of the Promissory Note attached as Exhibit A to
the Loan Agreement, except that such Promissory Note would be payable in two
equal consecutive annual installments commencing one year after the redemption
of the Warrants or the shares. Any such Promissory Note would thereafter
constitute a "Note" for all purposes under the Loan Agreement, including without
limitation, that payment of the indebtedness represented by such Promissory Note
would be secured by the Collateral subject to the Security Agreement.

              (M)   Cancellation. The right of the holder of this Warrant to
subscribe for and purchase shares of common stock may

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terminate, in whole or in part, in accordance with the following provisions:

                     1. For purposes of this subsection (M) "Liquidity Event"
shall mean (x) the merger or consolidation of Company with, or sale or transfer
of all or substantially all of the outstanding capital stock or assets of
Company to, any other entity in which transaction the shareholders of Company
receive cash or Freely Marketable Securities, or a combination thereof, or (y)
the consummation of the sale of Company's common stock in a firm commitment
underwriting pursuant to a registration statement on Form S-1, Form SB-1, Form
SB-2, or their then equivalents, filed under the Securities Act of 1933, as
amended, and resulting in an aggregate offering price to the public of at least
$20,000,000.



                     2. (a) If a Liquidity Event shall occur prior to April 24,
2000, and if the price per share of common stock of Company applicable in such
Liquidity Event shall exceed 120% of the Minimum Company Value, the right to
subscribe for and purchase the shares of common stock purchaseable under the
terms of this Warrant shall terminate concurrently with the completion of the
Liquidity Event.

                        (b) If a Liquidity Event shall occur after April 23,
2000 but prior to April 24, 2001, and if the price per share of common stock of
Company applicable in such Liquidity Event shall exceed 150% of the Minimum
Company Value, the right to subscribe for and purchase sixty-six and two-thirds
(66 2/30%) percent of the shares of common stock purchaseable under the terms
of this Warrant shall terminate concurrently with the completion of the
Liquidity Event.

                        (c) If a Liquidity Event shall occur after April 23,
2001 but prior to April 24, 2002, and if the price per share of common stock of
Company applicable in such Liquidity Event shall exceed 180% of the Minimum
Company Value, the right to subscribe for and purchase thirty-three and
one-third (33 1/3%) percent of the shares of common stock purchaseable under
the terms of this Warrant shall terminate concurrently with the completion of
the Liquidity Event.

                     3. Within ten days of the surrender of this Warrant by the
registered holder at the office of the Company at any time, the Company shall
execute and deliver to the holder in exchange for this Warrant:

                        (i) a Warrant in the form attached to the Loan
Agreement as Exhibit B-1 to subscribe for and purchase the number of shares of
common stock with respect to which such rights are no longer subject to
termination in accordance with the provisions of this subsection (M), and

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                        (ii) a Warrant of like tenor to this Warrant except for
substituting therein the appropriate subsection (M)(2) as set forth on the
Appendix attached hereto to subscribe for and purchase the balance of the number
of shares of common stock with respect to which such rights remain subject to
termination in accordance with this subsection (M).

          (N) Construction. The validity and interpretation of the terms and
provisions of this Warrant shall be governed by the laws of the State of
Delaware. The descriptive headings of the several sections of this Warrant are
inserted for convenience only and shall not control or affect the meaning or
construction of any of the provisions thereof.

          (0) Exchange of Warrant. This Warrant is exchangeable upon the
surrender hereof by the registered holder at the office of the Company for new
Warrants of like tenor representing in the aggregate the rights to subscribe for
and purchase the number of shares which may be subscribed for and purchased
hereunder, each of such new Warrants to represent the right to subscribe for and
purchase such number of shares as shall be designated by the holder at the time
of such surrender.

          (P) Lost Warrant Certificate. If this Warrant is lost, stolen,
mutilated or destroyed, the Company shall, upon request in writing from the
registered holder, issue a new Warrant of like denomination, tenor and date as
this Warrant, subject to the Company's right to require the holder to give the
Company a bond or other satisfactory security sufficient to indemnify the
Company against any claim that may be made against it (including any expense or
liability) on account of the alleged loss, theft, mutilation or destruction of
this Warrant or the issuance of such new Warrant.

          (Q) Waivers and Amendments. This Warrant or any provision hereof may
be changed, waived, discharged or terminated only by a statement in writing
signed by the party against which enforcement of the change, waiver, discharge
or termination is sought.

          (R) Notices. All notices or other communications required or permitted
hereunder shall be in writing and shall be delivered by personal delivery,
reputable overnight courier service, telecopier or mailed by United States mail,
first class postage prepaid, or by registered or certified mail with return
receipt requested, addressed as specified in the heading hereof. Each of the,
parties shall be entitled to specify a different address by giving five days'
advance written notice as aforesaid to the other parties.

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          IN WITNESS WHEREOF, these Warrants are issued this 21st day of
June, 1999.

                             GENOMIC SOLUTIONS, INC.


                             By: /s/ Xxxxxxx X. Xxxxxxxx
                                --------------------------------
                                Xxxxxxx X. Xxxxxxxx, President

      THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
      1933 OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD OR OFFERED FOR
      SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN
      EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT AND
      ANY APPLICABLE STATE SECURITIES LAW OR UNLESS THE CORPORATION HAS RECEIVED
      AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION
      IS NOT REQUIRED TO EFFECTUATE SUCH TRANSACTION.


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                               NOTICE OF EXERCISE

TO GENOMIC SOLUTIONS, INC.


     The undersigned hereby irrevocably elects to exercise the Warrant delivered
herewith as to   shares of common stock and requests that certificates for such
shares be issued in the name of and delivered to the undersigned at the address
stated below, and, if additional shares remain available for purchase pursuant
to the Warrant, the new Warrant evidencing the right to purchase the balance of
such shares shall be registered in the name of, and delivered to, the
undersigned at the address stated below. The undersigned hereby agrees with and
represents to the Company that said shares of common stock are acquired for
investment and not with a view to, or for sale in connection with, any
distribution or public offering thereof within the meaning of the Securities Act
of 1933, as amended.

[delete one of the following]

The undersigned elects to exercise the Warrant in accordance with subsection
I(4) thereof.

Payment is enclosed in the amount of $
                                      -------------
Dated:
      ---------------------------
By
  -------------------------------
Its
   ------------------------------
ADDRESS:

---------------------------------

---------------------------------

---------------------------------

PHONE:
      ---------------------------
FACSIMILE:
          -----------------------

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                                    APPENDIX

If the exchange of Warrants provided in subsection (M) (3) occurs after April
23, 2000 but prior to April 24, 2001, the following provisions shall be
substituted as subsection (M) (2) in the Warrant issued pursuant to subsection
(M)(3)(ii):
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           2. (a) If a Liquidity Event shall occur after April 23, 2000 but
prior to April 24, 2001, and if the price per share of common stock of Company
applicable in such Liquidity Event shall exceed 150% of the Minimum Company
Value, the right to subscribe for and purchase the shares of common stock
purchaseable under the terms of this Warrant shall terminate concurrently with
the completion of the Liquidity Event.

              (b) If a Liquidity Event shall occur after April 23, 2001 but
prior to April 24, 2002, and if the price per share of common stock of Company
applicable in such Liquidity Event shall exceed 180% of the Minimum Company
Value, the right to subscribe for and purchase fifty (500%) percent of the
shares of common stock purchaseable under the terms of this Warrant shall
terminate concurrently with the completion of the Liquidity Event.

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If the exchange of Warrants provided in subsection (M) (3) occurs after April
23, 2001 but prior to April 24, 2002, the following provisions shall be
substituted as subsection (M) (2) in the Warrant issued pursuant to subsection
(M)(3)(ii).
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           2. If a Liquidity Event shall occur after April 23, 2001 but prior to
April 24, 2002, and if the price per share of common stock of Company applicable
in such Liquidity Event shall exceed 180% of the Minimum Company Value, the
right to subscribe for and purchase of the shares of common stock purchaseable
under the terms of this Warrant shall terminate concurrently with the
completion of the Liquidity Event.

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