Nitec Pharma AG Kägenstrasse 17 CH-4153 Reinach Switzerland July 7, 2009 Dear Sirs: Exclusive Distribution Agreement between Nitec Pharma AG and Mundipharma International Corporation Ltd. dated March 24, 2009 (the “Agreement”)

Exhibit 10.18

Nitec Pharma AG

Xxxxxxxxxxxx 00

XX-0000 Xxxxxxx

Xxxxxxxxxxx

July 7, 2009

Dear Sirs:

Exclusive Distribution Agreement between Nitec Pharma AG and Mundipharma International Corporation Ltd. dated March 24, 2009 (the “Agreement”)

We refer to the Agreement subsisting between you and us and take this means to confirm the following amendment thereto agreed between you and us. Capitalised terms used in this letter without definition which are defined in the Agreement shall have the same meanings herein as therein.

1. With regard to the Asia Pacific Territory the Exclusive right of the Distributor and its Associates to enter into good faith negotiations with the Principal according to Clause 8 of the Agreement shall be extended through the close of business on August 15, 2009.

2. In all other respects the Agreement, as hereby amended, remains unchanged.

Please countersign this letter submitted to you in duplicate to indicate your agreement with its terms and return one copy to us for our files.

Yours sincerely,

Mundipharma International Corporation Ltd.

/s/ Xxxxxxx Xxxxxxxx

Xxxxxxx Xxxxxxxx

General Manager

Accepted and agreed to:

Nitec Pharma AG
By:		/s/ Xxxxxx Xxxxxxxxxx
Date:		9.7.2009
By:		/s/ Xxxxxx Xxxxxx
Date:		09.07.2009

MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED

Mundipharma House — 00, Xxx-xx-Xxxxx Xxxx — X.X. Xxx XX 0000 — Xxxxxxxx XX XX — Bermuda

Tel: (000) 000-0000 — Fax: (000) 000-0000

a member of the Mundipharma International Group