Amendment #1
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By this Amendment, Duke University ("DUKE"), and CISTRON
Biotechnology, Inc. ("SPONSOR") agree to amend the terms of the Clinical
Study and Research Agreement entered into by the parties effective
September 1, 1998, ("Agreement") as follows:
1. The parties agree that Article 5, Period of Performance, is revised
so that the research will be conducted in an ten-month period
commencing on September 1, 1998, and concluding on or before June
30, 1999.
2. All other terms of the Agreement are unchanged and remain in full
force and effect.
AGREED:
DUKE UNIVERSITY SPONSOR:
By: /s/XXXXX XXXXXXXXX, M.D. By: /s/XXXXX X. XXXXXX
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Xxxxx Xxxxxxxxx, MD Printed Name: Xxxxx X. Xxxxxx
Chancellor for Health Affairs Title: Chairman & CEO
Date executed: 12/18/98 Date executed: 12-16-98
Acknowledged:
/s/XXXXXX X. XXXXXX
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Xxxxxx X. Xxxxxx
Principal Investigator
