THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT Dated 08 January 2004

                                                                   Exhibit 10.25

                                 AMENDMENT No. 9

                                       to

                        THE DEVELOPMENT AND MANUFACTURING
                               SERVICES AGREEMENT

                              Dated 08 January 2004

                                     Between

                               LONZA BIOLOGICS ***

                                       and

                          TRUBION PHARMACEUTICALS, INC.



     THIS AMENDMENT No. 9 ("Ninth Amendment") is made the 31st day of October
2005

     BETWEEN

     LONZA BIOLOGICS *** of *** (hereinafter referred to as "LB"), and

     TRUBION PHARMACEUTICALS, INC., of 0000 0xx Xxxxxx, Xxxxx 0000, Xxxxxxx, XX
00000, XXX (herein after referred to as the "Customer")

     WHEREAS

     A.   LB and the Customer entered into a development and manufacturing
          services agreement (the "Agreement") dated 08 January 2004, pursuant
          to which LB agreed to provide Services to the Customer, and,

     B.   The Customer now wishes LB to perform additional services under the
          Agreement, and,

     C.   LB is willing to perform such additional services on the terms set out
          in the Agreement, and

     D.   The parties wish to amend the Agreement in accordance with Clause 13.5
          thereto.

     NOW THEREFORE IT IS HEREBY AGREED as follows:

     1.0 XXXXX 00, XXXXX XX ADDED TO SCHEDULE 2 OF THE AGREEMENT TO READ AS
FOLLOWS:

     STAGE 31 ***

     BACKGROUND

     ***.

     31.1 OBJECTIVES

     ***

     31.2 ACTIVITIES

     ***

     31.3 DELIVERABLES

          31.3.1 A copy of the summary report as prepared in activity 31.2.11

     31.4 TIMESCALE



     Stage 31 commenced at Customer's request ***.

     It is estimated that Stage 31 will be complete approximately *** from
commencement.


                                       -2-



     SCHEDULE 3 TO THE AGREEMENT SHALL BE AMENDED TO INCLUDE PROVISION FOR
PAYMENT FOR THE ABOVE MENTIONED ADDITIONAL SERVICES, AS SET OUT BELOW HERETO.
INVOICES FOR THESE ADDITIONAL SERVICES SHALL BE ISSUED, AND CUSTOMER PAYMENTS
SHALL BE MADE ***

     "1.  PRICE

          ***

     2.   PAYMENT

          FOR STAGE 31

          *** upon commencement of Stage 31.
          *** upon completion of Stage 31."


                                       -3-



     SAVE AS HEREIN PROVIDED ALL OTHER TERMS AND CONDITIONS OF THE AGREEMENT
SHALL REMAIN IN FULL FORCE AND EFFECT.

     AS WITNESS the hands of the duly authorised representatives of the parties
hereto the day and year first above written.


Signed for and on behalf of             ***
LONZA BIOLOGICS ***                     ----------------------------------------

                                        ***
                                        ----------------------------------------
                                        TITLE


Signed for and on behalf of             /s/ Xxxxxxx Xxxxxx
TRUBION PHARMACEUTICALS, INC            ----------------------------------------
                                        Senior VP, Reseach & Development
                                        TITLE