FIRST AMENDMENT TO SEVENTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT

Exhibit 4.7

FIRST AMENDMENT TO

SEVENTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT

This First Amendment (this “Amendment”) amends that certain Seventh Amended and Restated Stockholders Agreement, dated as of January 25, 2007 (the “Agreement”), and is entered into as of April 6, 2007, by and among NimbleGen Systems, Inc., a Delaware corporation, the individuals and entities listed on Exhibit A who have executed a counterpart signature page hereto (each individually a “Common Stockholder” and collectively the “Common Stockholders”), the individuals and entities listed on Exhibit B who have executed a counterpart signature page hereto (each individually a “Series E Stockholder” and collectively the “Series E Stockholders”), and the individuals and entities listed on Exhibit C who have executed a counterpart signature page hereto (each individually a “Series F Stockholder” and collectively the “Series F Stockholders”).

R E C I T A L S

WHEREAS, the Common Stockholders are the holders of more than fifty percent (50%) of the Common Stock held by those stockholders who or which are parties to the Agreement, and by their execution of this Amendment, they are consenting, separately as a single class, hereto;

WHEREAS, the Series E Stockholders are the holders of more than fifty percent (50%) of the Series E Preferred Stock held by those stockholders who or which are parties to Agreement, and by their execution of this Amendment, they are consenting, separately as a single class, hereto;

WHEREAS, the Series F Stockholders are the holders of more than fifty percent (50%) of the Series F Preferred Stock held by those stockholders who or which are parties to Agreement, and by their execution of this Amendment, they are consenting, separately as a single class, hereto; and

WHEREAS, the parties have determined it is their respective best interests to amend the Agreement as set out below.

A G R E E M E N T

NOW, THEREFORE, in consideration of the mutual promises set forth herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto mutually agree as follows:

1. Amendment of the Agreement.

(a) Section 5.1 of the Agreement hereby is deleted in its entirety and replaced with the following:

“5.1. Election of Directors. On all matters relating to the election of directors of the Company, each of the Stockholders agrees to vote all Shares which constitute voting stock now held or hereafter acquired by such Stockholder

(or the holders thereof shall consent pursuant to an action by written consent) so as to elect and maintain in office the following members to the Company’s Board of Directors and to remove from office from time to time individuals not satisfying the indicated criteria:

(a) one (1) individual nominated by vote of the holders of a majority of the outstanding Common Stock;

(b) two (2) individuals nominated by Tactics II LLC;

(c) two (2) individuals nominated by Xxxxxx;

(d) one (1) individual nominated by Skyline Venture Management II LLC;

(e) one (1) individual nominated by Xxxxx Venture Partners Management Company I, LLC;

(f) one (1) individual nominated by Venture Investors LLC;

(g) one (1) individual nominated by Xxxxxxx, Xxxxxxxxxxxx;

(h) the individual serving from time to time, if any, as the full-time Chief Executive Officer or Chief Operating Officer, as the case may be, of the Company; and

(i) up to two (2) other individuals designated (which designation may be changed from time to time) by the affirmative vote of a majority of the members of the Company’s Board of Directors then in office.

Notwithstanding any term or implication above in this Section 5.1 or in Section 9.2 to the contrary, any of the Stockholders named in Subsections 5.1(a)-(g) above from time to time may waive their or its right to nominate an individual as a director by a written waiver delivered to the Company (to the attention of its Secretary) which shall be irrevocably and unconditionally effective for the one hundred eighty (180) day period commencing on the date of delivery of such waiver to the Company (or such longer period as may be specified in any such written waiver) in which event, during the period the waiver is effective, the individual that such Stockholder(s), absent such waiver, would be entitled to nominate pursuant to whichever is applicable of Subsections 5.1(a)-(g) above instead shall be an individual who (in addition to the two individuals specified in Subsection 5.1(i) as being subject to such designation) may be designated by the Company’s Board of Directors then in office in accordance with Subsection 5.1(i) above and who, if so designated, shall be considered for all purposes hereof to be an individual designated by the Company’s Board of Directors then in office in accordance with Subsection 5.1(i) above. Further notwithstanding any term or implication above in this Section 5.1 to the contrary, in the event that any of the Stockholders named in Subsections 5.1(b)-(g) above, together with such Stockholder’s Affiliates, shall at any time cease to own any of the then issued and outstanding shares of Common Stock or Preferred Stock, the holders of a majority of the outstanding Series E Preferred Stock shall thereafter assume the rights previously granted to such Stockholder pursuant to this Section 5.1.”

2

(b) Section 7.4 of the Agreement hereby is deleted in its entirety and replaced with the following:

“7.4 Directors’ Expenses. The Company shall not pay any compensation to any member of the Company’s Board of Directors in connection with the performance of his or her duties as a director; provided, however, that, as of and after January 30, 2007, the Company may pay such compensation (including for service on a committee established by the Board of Directors) to any director who is an individual designated in accordance with Subsection 5.1(i) as is approved by the Company’s Board of Directors; and provided, further, the Company shall reimburse the reasonable out of pocket expenses of each member of the Company’s Board of Directors in connection with the performance of his or her duties as director.”

2. Agreement Otherwise Unaffected. The Agreement, as amended by this Amendment, shall remain in full force and effect.

3. Counterparts; Facsimile Signatures. This Amendment may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument. This Amendment may be executed by facsimile and each facsimile signature will have the same effect as an original signature.

[Remainder of this page intentionally left blank.]

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IN WITNESS WHEREOF, the parties hereto have executed this FIRST AMENDMENT TO SEVENTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT as of the date set forth in the first paragraph hereof.

COMPANY:
NIMBLEGEN SYSTEMS, INC.
By:		/s/ Xxxxxxx X. Xxxx
Print Name:		Xxxxxxx X. Xxxx
Title:		CEO
STOCKHOLDER:
SKYLINE VENTURE PARTNERS II, L.P.
By:		Skyline Venture Management II LLC,
		its General Partner
By:		/s/ Xxxx X. Xxxxxx
		Xxxx X. Xxxxxx, Managing Director
SKYLINE VENTURE PARTNERS QUALIFIED PURCHASER FUND II, L.P.
By:		Skyline Venture Management II LLC, its General Partner
By:		/s/ Xxxx X. Xxxxxx
		Xxxx X. Xxxxxx, Managing Director

4

SKYLINE EXPANSION FUND, L.P.
By:		Skyline Expansion Fund Management, LLC
Its:		General Partner
By:		Skyline Venture Management III, LLC
Its:		Managing Member
By:		/s/ Xxxx X. Xxxxxx
		Xxxx X. Xxxxxx, Managing Director
TACTICS II LLC
By:		/s/ Xxxxxx X. Xxxxx
Print Name:		Xxxxxx X. Xxxxx
Title:		Member
NIMBLEGEN, INC.
By:		/s/ Xxxxxx Xxxxxxx
Print Name:		Xxxxxx Xxxxxxx
Title:		Treasurer/Secretary
TACTICS II INVESTMENTS LLC
By:		/s/ Xxxxxx X. Xxxxx
Print Name:		Xxxxxx X. Xxxxx
Title:		Member
780 PARTNERS
By:		/s/ Xxxxxxx X. Xxxxx
Print Name:		Xxxxxxx X. Xxxxx
Title:		Managing Partner

5

FHF PARTNERS
By:		/s/ Xxxxxxxx X. Xxxxxxxxx
Print Name:		Xxxxxxxx X. Xxxxxxxxx
Title:		General Partner
WISCONSIN ALUMNI RESEARCH FOUNDATION
By:
Print Name:
Title:
ICE NINE INVESTMENTS, LLC
By:
Print Name:
Title:
Xxxxxxxxx X. Xxxxxxxx
/s/ Xxxxx X. Xxxx
Xxxxx X. Xxxx
Xxxxxx Xxxxx
Xxxxx Xxxxxxxx

6

VENTURE INVESTORS EARLY STAGE
FUND III LIMITED PARTNERSHIP
By:		Venture Investors LLC, its General Partner
By:		/s/ Xxxx Xxxx
		Xxxx Xxxx, Member
BAIRD VENTURE PARTNERS I LIMITED PARTNERSHIP
By:		Xxxxx Venture Partners Management
		Company I, LLC, its General Partner
By:		/s/ Xxxxx X. Xxxxxxx
Title:		Director
BVP I AFFILIATES FUND LIMITED PARTNERSHIP
By:		Xxxxx Venture Partners Management
		Company I, LLC, its General Partner
By:		/s/ Xxxxx X. Xxxxxxx
Title:		Director
STATE OF WISCONSIN INVESTMENT BOARD
By:		/s/ Xxxxxxxxxxx X. Xxxxxxxxxxxxx
Print Name:		Xxxxxxxxxxx X. Xxxxxxxxxxxxx
Title:		Portfolio Manager
XXXXXX XX
By:		/s/ Xx. Xxxxxxx Xxxxxxxx //s/ Xx. Xxxxxx Xxxxx
Print Name:		Xx. Xxxxxxx Xxxxxxxx / Xx. Xxxxxx Xxxxx
Title:		VP Corp. Strategy/M&A / General Counsel

7

Xxxxxxx X. Treble
/s/ Xxxxx Xxxxxxx
Xxxxx Xxxxxxx
ITX INTERNATIONAL EQUITY CORPORATION
By:		/s/ Takehito Jimbo
Print Name:		Takehito Jimbo
Title:		President
THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEMS
By:		/s/ Xxxx X. Xxxx
Print Name:		Xxxx X. Xxxx
Title:		Executive VP for Business Affairs
TEXAS INSTRUMENTS, INCORPORATED
By:
Print Name:
Title:
Xxxxxx Xxxxxxx
/s/ Xxxxx Xxxxxx
Xxxxx Xxxxxx
J. Xxxxxx Xxxx

8

Xxxxx X. Xxxxxxxx

STARTech EARLY VENTURES, LLC

By:

Print Name:

Title:

STARTech SEED FUND II, L.P.

By:

Print Name:

Title:

Xxxxxx Xxxxxx

Xxx Xxxxxxx

Xxxxxx Xxxxx

/s/ Xxxxxxx X. Xxxx

Xxxxxxx X. Xxxx

XXXXXXX INCORPORATED

By:

Print Name:

Title:

9

TOPSPIN PARTNERS, L.P.
By:
Print Name:
Title:
TOPSPIN ASSOCIATES, L.P.
By:
Print Name:
Title:
BROOKSIDE CAPITAL PARTNERS FUND, L.P.
By:		/s/ Xxxx XxXxxxxxx
Print Name:		Xxxx XxXxxxxxx
Title:		Managing Director
ADAGE CAPITAL PARTNERS, L.P.
By:		/s/ Xxx Xxxxx
Print Name:		Xxx Xxxxx
Title:		Chief Operating Officer
XXXXX MASTER FUND LTD.
By:
Print Name:
Title:

10

BBT FUND, L.P.
By:		BBT Genpar, L.P.
Its:		General Partner
By:		FFT-FW, Inc.
Its:		General Partner
By:
Print Name:
Title:
CAP FUND, L.P.
By:		Cup Genpar, L.P
Its:		General Partner
By:		CAP-FW, Inc.
Its:		General Partner
By:
Print Name:
Title:
SRI FUND, L.P.
By:		SRI Genpar, L.P.
Its:		General Partner
By:		BBT-FW, Inc.
Its:		General Partner
By:
Print Name:
Title:

11

QVT FUND LP
By:		QVT Associates GP LLC
Its:		General Partner
By:		/s/ Xxxxx Xx
Print Name:		Xxxxx Xx
Title:		Managing Member
By:		/s/ Xxxx Xxxxx
Print Name:		Xxxx Xxxxx
Title:		Managing Member
THE BOARD OF TRUSTEES OF THE XXXXXX XXXXXXXX JUNIOR UNIVERSITY (SBST-LS)
By:
		Xxxxxxx Xxxxxx, Director – Separate Investments

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Exhibit A

COMMON STOCKHOLDERS

Stockholder		Shares of Common Stock
NimbleGen, Inc. 0000 Xxxxxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxxxx.xxx		427,500
Xxxxxx Xxxxx 000 Xxxxx Xxxxx Xxxxxxx, XX 00000		67,500
Xxxxx Xxxxxxxx 0000 Xxxxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxxxx@xxxxxxxxx.xxx		10,000
Tactics II Investments LLC Attn: Xxxxxx Xxxxx 0 Xxxxxx Xxxxx, Xxxxx 000 Xxxxxxxxxx, XX 00000 xxxxxx@xxxxxxxxx.xxx		405,000
Wisconsin Alumni Research Foundation Attn: Xxxxxx X. Xxxxxx 000 Xxxxxx Xxxxxx, 00xx Xxxxx Xxxxxxx, XX 00000 xxxxxx@xxxx.xxx		100,000
Skyline Venture Partners II, L.P. Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		7,906

1

Stockholder		Shares of Common Stock
Skyline Venture Partners Qualified Purchaser Fund Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		92,094
The Board of Regents of The University of Texas System c/o UT Southwestern Medical Center at Dallas Attention: Director for Technology Transfer 0000 Xxxxx Xxxxx Xxxxxxxxx Xxxxxx, XX 00000		39,667
Xxxxxx Xxxxxx 0000 Xxxx Xxx Xxxx Xxxxxx Xxxxx, XX 00000		39,667
STARTech Seed Fund II, L.P. 0000 Xxxx Xxxxxxx Xxxx Xxxxxxxxxx, XX 00000 Attn: CFO, STARTech Early Ventures		16,221
STARTech Early Ventures, LLC 0000 Xxxx Xxxxxxx Xxxx Xxxxxxxxxx, XX 00000 Attn: CFO, STARTech Early Ventures		10,058
J. Xxxxxx Xxxx 0000 Xxxxxxx Xxxxx Xxxxxxxxx, XX 00000		15,605
Xxxxx X. Xxxxxxxx c/o CenterPoint Ventures 00000 Xxxx Xxxx, Xxxxx 0000 Xxxxxx, XX 00000		7,783

2

Stockholder		Shares of Common Stock
Xxxxx Xxxxxx 000 Xxxxxxxx Xxxxx Xxxxxxx, XX 00000		2,999
Texas Instruments Incorporated Attn: Xxxxxxx X. Xxxxx 0000 Xxxxxxxxx Xxx, XX 0000 Xxxxxx, XX 00000		66,000
Total		1,308,000

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Exhibit B

SERIES E PREFERRED STOCKHOLDERS

Stockholder		Shares of Series E Preferred Stock
780 Partners Attn: Xxxxxxx Xxxxx 000 Xxxxx Xxxxx Xxxxxx Xxxxxxxxx, XX 00000 xxxxxx@xxxxx.xxx		250,298
Baird Venture Partners, L.P. Attn: Xxxxx X. Xxxxxxx 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxx.xxx		171,565
Xxxxxxxxx Xxxxxxxx Genetics Building, B10 000 Xxxxx Xxxx Xxxxxxx, XX 00000 xxxxxxxxxxxx@xxxxxxxxxxxxxx.xxx		112,672
BVP I Affiliates Fund L.P. Attn: Xxxxx X. Xxxxxxx 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxx.xxx		120,145
FHF Partners Attn: Xxxxxxxx Xxxxxxxxx 0000 X. Xxxxxxxx Xxxx, Xxxxx #000 Xxxxxxxx, XX 00000		248,331

1

Stockholder		Shares of Series E Preferred Stock
Ice Nine Investments, LLC c/o Quarles & Xxxxx, LLP Attn: Xxxxxxxx Xxxx 0 Xxxxx Xxxxxxxx Xxxxxx, Xxxxx 000 Xxxxxxx, XX 00000 xxx@xxxxxxx.xxx		12,543
ITX International Equity Corporation Attn: Takehita Jimbo 000 X. Xx Xxxxxx Xxxx, Xxxxx 000 Xxxxxxxx Xxxx, XX 00000		714,286
Xxxxx Xxxxxxxx 0000 Xxxxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxxxx@xxxxxxxxx.xxx		3,673
Xxxxx Xxxx c/o Menemsha Capital Partners, Ltd c/o Tailwind Capital 000 Xxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000		249,521
Skyline Venture Partners Qualified Purchaser Fund Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		1,010,155
Skyline Venture Partners II, L.P. Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		86,716

2

Stockholder		Shares of Series E Preferred Stock
Skyline Expansion Fund, L.P. Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		22,222
Xxxxx Xxxxxxx 000 X. Xxxxxxxxxxx Xxxxx Xxxxxxx, XX 00000 xxxxxxxx@xxxxx.xxx		36,833
Xxxxxx XX Xxxxxx XX Attn: Xx. Xxxxx Xxxxxx Xxxxxxxxxxxxxxxxx 00 Xxxxx, Xxxxxxx D-55122 xxxxx.xxxxxx@xxxxxx.xxx Schott North America, Inc. Attn: Xxxxxxx Xxxxxx 000 Xxxxxx Xxxx Xxxxxxxx, Xxx Xxxx 00000 xxxxxxx.xxxxxx@xx.xxxxxx.xxx		2,690,477
State of Wisconsin Investment Board Attn: Xxxxx Xxxxxxxxxxxxx Wisconsin Private Equity Portfolio 000 Xxxx Xxxxxx Xxxxxx Xxxxxxx, XX 00000-0000 xxxxx.xxxxxxxxxxxxx@xxxx.xxxxx.xx.xx		278,862
Tactics II LLC Attn: Xxxxxx Xxxxx 0 Xxxxxx Xxxxx, Xxxxx 000 Xxxxxxxxxx, XX 00000 xxxxxx@xxxxxxxxx.xxx		250,299

3

Stockholder		Shares of Series E Preferred Stock
Xxxxxxx Treble 0000 Xxxxxx Xxxxxxx Xxxxxxxx, XX 00000 xxxxxxx@xxxxxxxxx.xxx		24,942
Venture Investors Early Stage Fund III, L.P. Attn: Xxxx Xxxx 000 Xxxxx Xxxx Xxxx Xxxxxxx, XX 00000 xxxx@xxxxxxxxxxxxxxxx.xxx		438,936
Wisconsin Alumni Research Foundation Attn: Xxxxxx X. Xxxxxx 000 Xxxxxx Xxxxxx, 00xx Xxxxx Xxxxxxx, XX 00000 xxxxxx@xxxx.xxx		252,540
Texas Instruments Incorporated Attn: Xxxxxxx X. Xxxxx 0000 Xxxxxxxxx Xxx, XX 0000 Xxxxxx, XX 00000		17,777
STARTech Seed Fund II, L.P. Attn: Xxxx Xxxxxxx 0000 Xxxx Xxxxxxx Xxxxxxxxx Xxxxxxxxxx, XX 00000		35,556
Xxxxxx Xxxxx 000 Xxxxx Xxxxx Xxxxxxx, XX 00000		407
Xxxxxx Xxxxxx 0000 Xxxx Xxx Xxxx Xxxxxx Xxxxx, XX 00000		1,000

4

Stockholder		Shares of Series E Preferred Stock
Xxxxxxx X. Xxxx Xxx Xxxxxxx Xxxxx Xxxxxxx, XX 00000 xxxxx@xxxxxxxxx.xxx		12,241
Xxxxxx Xxxxxxx 00000 Xxxxxxxxx Xxxx Xxxxxxxxx, XX 00000		000
Xxxxxx X. Xxxxx 0000 Xxxxxxxxxx Xxxxxx Xxxxxxxxx, XX 00000 xxxxxx@xxxxxxxxx.xxx		136
Xxxxxx Xxxxxxx NimbleGen Systems, Inc. Xxx Xxxxxxx Xxxxx Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxxxx.xxx		382
Xxxxxxx, Xxxxxxxxxxxx Attn: Xxxxx Xxxxx 0000 Xxxx Xxxxx, Xxxxx 000 Xxx Xxxxx, XX 00000		156,017
Topspin Partners, L.P. Attn: Xxxxx Xxxxxx 0 Xxxxxxxxxx Xxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxx@xxxxxxxxxxxxxxx.xxx		41,916
Topspin Associates, L.P. Attn: Xxxxx Xxxxxx 0 Xxxxxxxxxx Xxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxx@xxxxxxxxxxxxxxx.xxx		1,985
Total:		7,242,840

5

Exhibit C

SERIES F PREFERRED STOCKHOLDERS

Stockholder		Shares of Series F Preferred Stock
780 Partners Attn: Xxxxxxx Xxxxx 000 Xxxxx Xxxxx Xxxxxx Xxxxxxxxx, XX 00000 xxxxxx@xxxxx.xxx		276,014
Baird Venture Partners, L.P. Attn: Xxxxx X. Xxxxxxx 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxx.xxx		303,105
Xxxxxxxxx Xxxxxxxx Genetics Building, B10 000 Xxxxx Xxxx Xxxxxxx, XX 00000 xxxxxxxxxxxx@xxxxxxxxxxxxxx.xxx		141,870
BVP I Affiliates Fund L.P. Attn: Xxxxx X. Xxxxxxx 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxx.xxx		212,258
FHF Partners Attn: Xxxxxxxx Xxxxxxxxx 0000 X. Xxxxxxxx Xxxx, Xxxxx #000 Xxxxxxxx, XX 00000		263,182
Xxxxxx Xxxxx 000 Xxxxx Xxxxx Xxxxxxx, XX 00000		6,720

1

Stockholder		Shares of Series F Preferred Stock
Ice Nine Investments, LLC c/o Quarles & Xxxxx, LLP Attn: Xxxxxxxx Xxxx 0 Xxxxx Xxxxxxxx Xxxxxx, Xxxxx 000 Xxxxxxx, XX 00000 xxx@xxxxxxx.xxx		10,529
Xxxxx Xxxxxxxx 0000 Xxxxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxxxx@xxxxxxxxx.xxx		1,680
Xxxxx Xxxx c/o Menemsha Capital Partners, Ltd c/o Tailwind Capital 000 Xxxx Xxxxxx, 00xx Xxxxx Xxx Xxxx, XX 00000		335,268
Skyline Venture Partners Qualified Purchaser Fund Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		905,643
Skyline Venture Partners II, L.P. Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		77,742
Skyline Expansion Fund, L.P. Attn: Xxxx Xxxxxx 000 Xxxxxxxxxx Xxxxxx, #000 Xxxx Xxxx, XX 00000 Xxxx@XxxxxxxXxxxxxxx.xxx		666,667
Xxxxx Xxxxxxx 000 X. Xxxxxxxxxxx Xxxxx Xxxxx 000 Xxxxxxx, XX 00000 xxxxxxxx@xxxxx.xxx		18,455

2

Stockholder		Shares of Series F Preferred Stock
State of Wisconsin Investment Board Attn: Xxxxx Xxxxxxxxxxxxx Wisconsin Private Equity Portfolio 000 Xxxx Xxxxxx Xxxxxx Xxxxxxx, XX 00000-0000 xxxxx.xxxxxxxxxxxxx@xxxx.xxxxx.xx.xx		403,374
Tactics II LLC Attn: Xxxxxx Xxxxx 0 Xxxxxx Xxxxx, Xxxxx 000 Xxxxxxxxxx, XX 00000 xxxxxx@xxxxxxxxx.xxx		276,015
Xxxxxxx Treble 0000 Xxxxxx Xxxxxxx Xxxxxxxx, XX 00000 xxxxxxx@xxxxxxxxx.xxx		18,671
Venture Investors Early Stage Fund III, L.P. Attn: Xxxx Xxxx 000 Xxxxx Xxxx Xxxx Xxxxxxx, XX 00000 xxxx@xxxxxxxxxxxxxxxx.xxx		791,720
Wisconsin Alumni Research Foundation Attn: Xxxxxx X. Xxxxxx 000 Xxxxxx Xxxxxx, 00xx Xxxxx Xxxxxxx, XX 00000 xxxxxx@xxxx.xxx		312,987
Xxxxxx Xxxxxx 0000 Xxxx Xxx Xxxx Xxxxxx Xxxxx, XX 00000		24,538
Xxxxxxx X. Xxxx Xxx Xxxxxxx Xxxxx Xxxxxxx, XX 00000 xxxxx@xxxxxxxxx.xxx		201,980
Xxxxxx Xxxxxxx 00000 Xxxxxxxxx Xxxx Xxxxxxxxx, XX 00000		6,712

3

Stockholder		Shares of Series F Preferred Stock
Xxxxxx Xxxxx 0000 Xxxxxxxxxx Xxxxxx Xxxxxxxxx, XX 00000 xxxxxx@xxxxxxxxx.xxx		2,237
Xxx Xxxxxxx NimbleGen Systems, Inc. Xxx Xxxxxxx Xxxxx Xxxxxxx, XX 00000 xxxxxxxx@xxxxxxxxx.xxx		6,310
Xxxxxxx, Xxxxxxxxxxxx Attn: Xxxxx Xxxxx 0000 Xxxx Xxxxx, Xxxxx 000 Xxx Xxxxx, XX 00000		2,674,277
Topspin Partners, L.P. Attn: Xxxxx Xxxxxx 0 Xxxxxxxxxx Xxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxx@xxxxxxxxxxxxxxx.xxx		691,619
Topspin Associates, L.P. Attn: Xxxxx Xxxxxx 0 Xxxxxxxxxx Xxxxx Xxxxxx Xxxxxxx, XX 00000 xxxxxxx@xxxxxxxxxxxxxxx.xxx		32,754
Brookside Capital Partners Fund, L.P. c/o Brookside Capital Attn: Xxx Xxxxxxxxxx 000 Xxxxxxxxxx Xxxxxx Xxxxxx, XX 00000		1,644,806
Adage Capital Partners, L.P. c/o Adage Capital Management, L.P. Attn: Xxx Xxxxx 000 Xxxxxxxxx Xxxxxx, 00xx Xxxxx Xxxxxx, XX 00000		600,000

4

Stockholder		Shares of Series F Preferred Stock
Xxxxx Master Fund Ltd. c/x Xxxxx Offshore Management LLC 0000 Xxxxx Xxxx Xxxxx Xx. Xxxxxxx, XX 00000		500,000
BBT Fund, L.P. c/o BBT Genpar, L.P. 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxx Xxxxx, XX 00000		147,500
CAP Fund, L.P. c/o BBT Genpar, L.P. 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxx Xxxxx, XX 00000		67,500
SRI Fund, L.P. c/o BBT Genpar, L.P. 000 Xxxx Xxxxxx, Xxxxx 0000 Xxxx Xxxxx, XX 00000		35,000
QVT Fund LP c/o QVT Associates GP LLC 0000 Xxxxxx xx xxx Xxxxxxxx, 0xx Xxxxx Xxx Xxxx, XX 00000 xxxxxxxxxxxx@xxx.xxx		200,000

5

Stockholder		Shares of Series F Preferred Stock
The Board of Trustees of Xxxxxx Xxxxxxxx Junior University The Board of Trustees of Xxxxxx Xxxxxxxx Junior University c/o Stanford Management Company Attn: Xxxxxxx Xxxxxx 0000 Xxxx Xxxx Xxxx Xxxxx Xxxx, XX 00000 xxxxxxxxxxxxx@xxxxxxxx.xxx The Board of Trustees of Xxxxxx Xxxxxxxx Junior University c/o Stanford Management Company Attn: Xxx Xx 0000 Xxxx Xxxx Xxxx Xxxxx Xxxx, XX 00000 xxxxx@xxxxxxxx.xxx		20,000
J. Xxxxxx Xxxx 0000 Xxxxxxx Xxxxx Xxxxxxxxx, XX 00000		3,337
Total:		11,880,470

6