EXHIBIT 10.50
CONFIDENTIAL
March 31, 1999
Xx. Xxxxxx Xxxxxxxx
Executive Director
Veterans Medical Research Foundation
VA Medical Center (151A)
0000 Xx Xxxxx Xxxxxxx Xxxxx
Xxx Xxxxx, XX 00000
Dear Xxxxxx:
Collateral Therapeutics, Inc. (hereinafter "CTI") proposes that this letter be
the written agreement which sets forth the understanding and obligations of the
parties regarding the research conducted by Xx. Xxxx Xxxxxxx in the field of
cardiovascular disease (hereinafter, the "Studies").
1. Xxxx Xxxxxxx, M.D. (hereinafter "Investigator") and the Veterans
Medical Research Foundation (hereinafter "VMRF" or the "Foundation")
agree to utilize their best efforts to conduct the Studies. Further
details concerning the Studies will be discussed in confidence by the
Investigator with CTI representatives. If during the term of this
agreement, the Investigator shall cease to conduct the studies,
and/or no longer be employed by the Veterns' Affairs Healthcare
System, then VMRF shall promptly so notify CTI and CTI shall have
the option to terminate the funding of the studies. CTI will
promptly advise VMRF in writing if CTI so elects.
2. The Investigator agrees to comply with the federal regulations relating
to the Animal Welfare Act (7. U.S.C. 2131, et seq) and the United
States Department of Agriculture regulations as set forth in 9 C.F.R.
parts 1, 2, and 3.
3. The Investigator will render periodic confidential reports as may be
requested to CTI.
4. In preparation for and during the course of these Studies, it may be
necessary for CTI to disclose to the Investigator or to VMRF certain
technical and business information; all such information, as well as
the results of the research, subject to the restriction in paragraph #5
of this agreement, is considered to be highly confidential by CTI. It
is understood that VMRF may disclose the amount of this research
funding in any routine disclosure as required by VMRF policy, but shall
not use or disclose the subject matter of the research. The
Investigator and the Foundation agree to take all reasonable
precautions to prevent disclosure of this and other
Veterans Medical Research Foundation
March 19, 1999
Page 2
confidential information to others and to not use confidential
information without the prior express written consent of CTI. These
restrictions upon disclosure of said information shall extend beyond
the term of this contract for a period of ten (10) years, but shall
cease to apply as to any specific portion of the information which is
or becomes available to the public other than by the Investigator or
the Foundation's fault.
5. The text of any oral or written disclosure of the results of the
Studies shall be submitted to CTI at least sixty (60) days prior to any
and all such disclosures. The Investigator and the Foundation shall
consider any suggestions from CTI concerning said disclosure, but are
not bound to incorporate such suggestions in any oral or written
publications. CTI may request addition of a sponsor's representative to
authorship on documents submitted for publication. The Investigator and
the Foundation agree to delay any such disclosure for up to six (6)
months following notification of CTI, at CTI's request, to allow for
completion of development and filing of patent applications.
6. The Investigator and VMRF agree to disclose promptly and fully to an
authorized representative of CTI all ideas, developments and
inventions, whether or not patentable, conceived or reduced to practice
by the Investigator and/or VMRF as a result of the Studies provided for
herein. All of such ideas, developments and inventions shall be the
property of CTI. Accordingly, the Investigator and VMRF agree to assign
outright to CTI the entire right, title and interest, both in the
United States and abroad, to such ideas, developments and inventions
and any resulting patent applications and patents, without payment
other than the fees provided for herein. The Investigator and VMRF
further agree to execute any and all documents and take such other
steps which CTI determines are necessary or convenient to fully
implement its proprietary rights in such ideas, developments and
inventions, such as, including but not limited to executing assignment
documents, filing and obtaining patents, and fully cooperating in the
prosecution of such property rights, but at no expense to them. CTI
will have the above-mentioned patent documents drafted, prosecuted and
maintained at its own expense. The Investigator and VMRF warrant that
it has appropriate ownership rights in such ideas, developments and
inventions to carry out its obligations under this paragraph. Both
parties acknowledge that in so far as U.S. government facilities or
resources are utilized in this work, the U.S. Government may have
rights in any invention and may choose to exercise these rights.
7. Both parties also acknowledge that the Department of Veterans Affairs
has informed the VMRF that VMRF has waived all patent rights that may
develop in connection with this agreement.
Veterans Medical Research Foundation
March 19, 1999
Page 3
8. CTI shall have the right to use the results and data of the Studies in
any manner deemed appropriate to CTI's business interests. Such uses
may include but are not limited to, disclosure as may be useful to meet
legal and business obligations, such as to support patent applications,
both foreign and domestic, or satisfy the requirements of any
government agency. In the event that work resulting from the Studies is
published in the scientific literature by CTI, acknowledgement will be
made to the Investigator and the Department of Veterans Affairs in the
accepted style, as appropriate. CTI will not use the name of the
Investigator or VMRF for advertising, other commercial purposes, in
publications or otherwise without appropriate written permission,
unless required by law or government regulations. CTI agrees that the
investigator shall have priority publication rights over data generated
from these studies subject to paragraph #5.
9. In consideration for the Studies, during the term of this agreement CTI
agrees to pay VMRF direct reimbursement for all expenditures made by
VMRF in connection with the Studies as directed by the Investigator,
and pay reimbursement for certain direct costs based on the formula as
set forth below. In this regard, CTI agrees to pay VMRF the following:
(i) a $5,000 primary monthly payment (hereafter the "Primary Monthly
Payment"); (ii) a supplemental monthly payment (hereafter the
"Supplemental Monthly Payment") equal to all other expenditures made by
VMRF in connection with the Studies during each month of the term of
this agreement in excess of the Primary Monthly Payment; and (iii) a
monthly payment covering the allocable indirect costs associated with
all amounts expended by VMRF for the Studies which shall be computed by
multiplying the sum of the Primary Monthly Payment and the Supplemental
Payment by a 40% indirect overhead factor.
The amount of the Supplemental Monthly Payment will be computed based
on the overall level of expenditures by VMRF for the Studies each
month, less the Primary Monthly Payment. VMRF shall agree to provide
CTI with sufficient information for it to compute the Supplemental
Monthly Payment. Following the term of the agreement, VMRF shall agree
to promptly return any amounts advanced to VMRF by CTI for which there
is not any corresponding expenditure in connection with the Studies.
CTI shall have the right to review any and all financial records of
VMRF relating solely to these Studies on a quarterly basis, to
determine the sufficiency of the Supplemental Payment. Annually VMRF
shall provide CTI with a financial statement and account reconciliation
covering all amounts expended by VMRF for the Studies during the term
of this agreement.
Veterans Medical Research Foundation
March 19, 1999
Page 4
10. This contract will become effective on March 31, 1999, and will
terminate three years from that date unless otherwise extended by
mutual consent of CTI and the Foundation and Investigator, evidenced
by written agreement.
11. The parties agree to take all other action necessary to effect the
rights of the parties herein.
12. Only VMRF or CTI, or an assignee or affiliate of VMRF or CTI, shall
have rights to enforce any obligation under this Agreement. No other
persons or entities shall be deemed an intended beneficiary under this
Agreement.
13. The parties acknowledge that Xx. Xxxxxx X. Xxxxxx may have a conflict
of interest regarding this agreement and Xx. X. Xxxxxxxxxx shall serve
in his place for VMRF on all matters relating to this agreement.
14. If any provision of this Agreement is held to be unenforceable for any
reason, it shall be adjusted if possible rather than voided in order to
achieve the intent of the parties to the greatest extent possible. In
any event, other provisions of the Agreement shall be deemed valid and
enforceable to the greatest extent possible.
If the terms of this agreement meet with the approval of the Veterans Medical
Research Foundation, please sign and date two copies and return one to CTI at
your earliest convenience.
Most Sincerely,
COLLATERAL THERAPEUTICS, INC.
/s/ Xxxxxxxxxxx X. Xxxxxxxx
-------------------------------
Xxxxxxxxxxx X. Xxxxxxxx
Chief Financial and Operating Officer
ACCEPTED AND AGREED TO:
VETERANS MEDICAL RESEARCH FOUNDATION
/s/ Xxxxxx Xxxxxxxx 4/12/99
-------------------------------- ---------------------------------
Xxxxxx Xxxxxxxx Date
PRINCIPLE INVESTIGATOR
/s/ Dr. X. Xxxx Xxxxxxx 4/15/99
-------------------------------- ---------------------------------
Dr. X. Xxxx Xxxxxxx Date
