EXHIBIT 1
to Schedule 13G
JOINT FILING AGREEMENT PURSUANT TO RULE 13d-1(k)(1)
The undersigned acknowledge and agree that the foregoing
statement on Schedule 13G is filed on behalf of each of the undersigned and that
all subsequent amendments to this statement on Schedule 13G shall be filed on
behalf of each of the undersigned without the necessity of filing additional
joint filing statements. The undersigned acknowledge that each shall be
responsible for the timely filing of such amendments, and for the completeness
and accuracy of the information concerning him, her or it contained herein, but
shall not be responsible for the completeness and accuracy of the information
concerning the other entities or persons, except to the extent that he, she or
it knows or has reason to believe that such information is inaccurate.
Dated as of February 14, 2005
PERSEUS-XXXXX BIOPHARMACEUTICAL FUND, LP
By: Perseus-Xxxxx Partners, LLC
General Partner
By: SFM Participation, L.P.
Managing Member
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC
Managing Member
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Assistant General Counsel
PERSEUS-XXXXX PARTNERS, LLC
By: SFM Participation, L.P.
Managing Member
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC
Managing Member
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Assistant General Counsel
PERSEUS BIOTECH FUND PARTNERS, LLC
By: Perseuspur, LLC
Managing Member
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Secretary and Treasurer
SFM PARTICIPATION, L.P.
By: SFM AH LLC
General Partner
By: Xxxxx Fund Management LLC
Managing Member
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Assistant General Counsel
SFM AH LLC
By: Xxxxx Fund Management LLC
Managing Member
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Assistant General Counsel
PERSEUSPUR, LLC
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Secretary and Treasurer
XX. XXXXX X. XXXXX
By: /s/ Xxxx Xxxxxxx
---------------------------------------
Name: Xxxx Xxxxxxx
Title: Attorney-in-Fact (1)
MR. XXXXXX XXXXX
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Attorney-in-Fact (2)
XXXXX FUND MANAGEMENT LLC
By: /s/ Xxxxx Xxxxxxxxx
---------------------------------------
Name: Xxxxx Xxxxxxxxx
Title: Assistant General Counsel
(1) A Power of Attorney, dated April 9, 2003, appointing Xxxx Xxxxxxx to
act on behalf of Xxxxx Xxxxx has been filed with the Securities and
Exchange Commission.
(2) A Power of Attorney, dated October 30, 2002, appointing each of Xxxxxxx
X. Xxxxx, Xxxxx Xxxxxxxxx, Xxxx X. Xxxxx, Xxxxxxx Xxxxxxxx, Xxxxxxx X.
Xxxxxxx, Xx. and Xxxxxx Xxxxx to act on behalf of Xxxxxx Xxxxx has been
filed with the Securities and Exchange Commission.
