Exhibit 10.123 November 16, 2000 Mr. Armando Anido c/o MedImmune, Inc. 35 W. Watkins Mill Road Gaithersburg, MD 20878 Dear Armando: Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with...

Exhibit 10.123












                                                     November 16, 2000


Xx. Xxxxxxx Xxxxx
c/o MedImmune, Inc.
00 X. Xxxxxxx Xxxx Xxxx
Xxxxxxxxxxxx, XX 00000


Dear Xxxxxxx:

                  Reference is made to your Employment Agreement, dated as of November 1, 1998 (the "Employment Agreement"), with
MedImmune, Inc. (the "Company").

                  The Employment Agreement is hereby amended so that the Employment Period referred to in Section 2 thereof is
extended to November 1, 2002.  All other provisions of the Employment Agreement remain unchanged.

                                                     Very truly yours,

                                                     MEDIMMUNE, INC.


                                                     By: /s/ Xxxxx X. Xxxx
                                                            Xxxxx X. Xxxx
                                                            Chief Executive Officer

Accepted and agreed to by:



/s/ Xxxxxxx Xxxxx
Xxxxxxx Xxxxx

Date:     12/4/00