Innovation and Northwestern University Phone 847-467-2097 Northwestern |INVO New Ventures Office 1800 Sherman Ave, Suite 504 invo.northwestern.edu Innovation and New Ventures Evanston, IL 60201

Exhibit 10.22

Innovation and	Northwestern University	Phone 000-000-0000	Northwestern |INVO
New Ventures Office	0000 Xxxxxxx Xxx, Xxxxx 000	xxxx.xxxxxxxxxxxx.xxx	Innovation and New Ventures
	Xxxxxxxx, XX 00000

     November 30, 2017

Xxxxx X Xxxxxxxxx, Ph.D.

Chief Executive Officer

Exicure, Inc.

0000 Xxxxx Xxx.

Xxxxxx, XX 00000

Re: Amendment Two to the Amended Restated License Agreement effective December 12, 2011 between Exicure, Inc. ("Exicure") and Northwestern University ("Northwestern') (the "Agreement").

Dear Xxxxx:

This letter agreement memorializes the understanding reached between Northwestern and Exicure regarding the Second Amendment to the Agreement ("Amendment Two). Unless otherwise defined In this Amendment Two, capitalized terms shall have the meaning assigned to them in the Agreement.

Subject to the terms and conditions of the Agreement and Exicure's compliance therewith, the parties hereby agree as follows:

1. Appendix A of the Agreement is amended and incorporated herein by reference.

2. All other terms and conditions of the Agreement shall remain in full force and effect as amended hereby.

By signing below, the parties hereby execute this valid and binding agreement effective as of the date listed above.

NORTHWESTERN UNIVERSITY		EXICURE, INC.
/s/ Xxxxxx Xxxxxxx, Ph.D.		/s/ Xxxxx X. Xxxxxxxxx, Ph.D.
Xxxxxx Xxxxxxx, Ph.D.		Xxxxx X. Xxxxxxxxx, Ph.D.
Associate Vice President for Research		Chief Executive Officer
and Executive Director, INVO

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.

Innovation and	Northwestern University	Phone 000-000-0000	Northwestern |INVO
New Ventures Office	0000 Xxxxxxx Xxx, Xxxxx 000	xxxx.xxxxxxxxxxxx.xxx	Innovation and New Ventures
	Xxxxxxxx, XX 00000

Exhibit A:

NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
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*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.

Innovation and	Northwestern University	Phone 000-000-0000	Northwestern |INVO
New Ventures Office	0000 Xxxxxxx Xxx, Xxxxx 000	xxxx.xxxxxxxxxxxx.xxx	Innovation and New Ventures
	Xxxxxxxx, XX 00000

NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
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*****	*****	*****	*****	*****	*****	*****	*****
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*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.

Innovation and	Northwestern University	Phone 000-000-0000	Northwestern |INVO
New Ventures Office	0000 Xxxxxxx Xxx, Xxxxx 000	xxxx.xxxxxxxxxxxx.xxx	Innovation and New Ventures
	Xxxxxxxx, XX 00000

NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
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*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.

Innovation and	Northwestern University	Phone 000-000-0000	Northwestern |INVO
New Ventures Office	0000 Xxxxxxx Xxx, Xxxxx 000	xxxx.xxxxxxxxxxxx.xxx	Innovation and New Ventures
	Xxxxxxxx, XX 00000

NU ID	Filing Date	Application Number	Patent Number	Type	Country	Status	Title
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****
*****	*****	*****	*****	*****	*****	*****	*****
*****	*****	*****		*****	*****	*****	*****

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT, AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”.