JOINT FILING AGREEMENT
Page 38 of 40 Pages
EXHIBIT 4
JOINT FILING AGREEMENT
Each of the undersigned hereby acknowledges and agrees, in compliance
with the provisions of Rule 13d-1(k)(1) promulgated under the Securities
Exchange Act of 1934, as amended, that the Schedule 13D to which this Agreement
is attached as an Exhibit (the "Schedule 13D"), and any amendments thereto, will
be filed with the Securities and Exchange Commission jointly on behalf of the
undersigned.
This Agreement may be executed in one or more counterparts.
Dated: July 17, 2000
PERSEUS-XXXXX BIOPHARMACEUTICAL FUND,
LP
By: Perseus-Xxxxx Partners, LLC,
General Partner
By: SFM Participation, LP,
Member
By: SFM AH, Inc.,
General Partner
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Vice President
PERSEUS-XXXXX PARTNERS, LLC
By: SFM Participation, LP,
Member
By: SFM AH, Inc.,
General Partner
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Page 39 of 40 Pages
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Vice President
PERSEUS BIOTECH FUND PARTNERS, LLC
By: Rappahannock Investment Company,
Managing Member
By: /s/ Xxxxx X. Xxxxx
----------------------------
Name: Xxxxx X. Xxxxx
Title: Sole Shareholder
RAPPAHANNOCK INVESTMENT COMPANY
By: /s/ Xxxxx X. Xxxxx
----------------------------
Name: Xxxxx X. Xxxxx
Title: Sole Shareholder
XX. XXXXX X. XXXXX
By: /s/ Xxxxx X. Xxxxx
----------------------------
Name: Xxxxx X. Xxxxx
SFM PARTICIPATION, LP
By: SFM AH, Inc.,
General Partner
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Vice President
SFM AH, INC.
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Vice President
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Page 40 of 40 Pages
MR. XXXXXX XXXXX
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Attorney-in-fact
XXXXX FUND MANAGEMENT LLC
By: /s/ Xxxxxxx X. Xxxx
----------------------------
Name: Xxxxxxx X. Xxxx
Title: Deputy General Counsel
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