EXHIBIT 10.14
LONZA
AMENDMENT NO. 1
TO
THE DEVELOPMENT AND MANUFACTURING SERVICES AGREEMENT
dated 08 January 2004
between
LONZA BIOLOGICS PLC
and
TRUBION PHARMACEUTICALS, INC.
Re:
Schedule 2 -- Services
New Stage
Add Stage 15 Development Pilot Batch (non-cGMP) at *** Scale
Schedule 3 -- Price and Payment
Price and Payment for Stage 15
CONFIDENTIAL TREATMENT
LONZA
THIS AMENDMENT is made the 4th day of June 2004
BETWEEN
1. LONZA BIOLOGICS PLC, the registered office of which is at 000 Xxxx Xxxx,
Xxxxxx, Xxxxxxxxx XX0 0XX, Xxxxxxx ("LB") and
2. TRUBION PHARMACEUTICALS, INC., of 0000 0xx Xxxxxx, Xxxxx 0000, Xxxxxxx, XX
00000, XXX (herein after referred to as the "Customer").
WHEREAS
A. Customer and LB entered into a development and manufacturing services
agreement dated 08 January 2004 ("the Agreement'), under which LB is
required to perform Services relating to the Cell Line and the Product, as
further described in the Agreement, and
B. Customer would like LB to perform additional services under the Agreement,
and
C. LB is prepared to perform the additional services, and the parties wish to
amend the Agreement accordingly.
NOW THEREFORE it is agreed hereby as follows:
1. Schedule 2 of the Agreement shall be amended to include the following
additional stage, Stage 15 (Development Pilot Batch (non-cGMP) at ***
Scale):
SCHEDULE 2
15 STAGE 15 -- Development Pilot Batch (non-cGMP) at *** Scale
15.1 OBJECTIVES
***
15.2 ACTIVITIES
- ***.
15.3 TIMESCALE
This Stage will commence any time after:
- the *** is available for use, and/or;
- sufficient information is available from Stages 1 and 3 of the
Services to proceed.
CONFIDENTIAL TREATMENT
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LONZA
This Stage shall be complete upon issue of the summary report to the
Customer. It is estimated that this report shall be issued *** from
commencement of this Stage.
2. Schedule 3 of the Agreement shall be amended by the addition of the
following provisions in respect of the additional Stages contained in this
Amendment No. 1:
SCHEDULE 3
Price and Terms of Payment
1. Price
In consideration for LB carrying out the Services described in Stage 15 as
detailed in Schedule 2 the Customer shall pay LB as follows:
STAGE ***
Stage 15 Development Pilot Batch (non-cGMP) at *** Scale ***
2. Payment
Payment by the Customer of the Price for Stage 15 shall be made against
LB's invoices as follows:
2.1 For Stage 15
*** upon commencement of Stage 15.
*** upon completion of Stage 15.
3. Any capitalized term used but not defined in this Amendment No. 1 shall
have the meaning given in the Agreement.
4. Save as herein provided all other terms and conditions of the Agreement
shall remain in full force and effect.
CONFIDENTIAL TREATMENT
-3-
LONZA
IN WITNESS WHEREOF the parties have caused this Amendment No. 1 to be
executed by their duly authorised representatives thereunto as of the day and
year first above written.
Signed for and on behalf of
LONZA BIOLOGICS PLC /s/ Xxxx Imwinkleried
----------------------------------------
Director
TITLE
Signed for and on behalf of
TRUBION PHARMACEUTICALS, INC. /s/ Xxxxxxx Xxxxxx
----------------------------------------
SVP, R&D
TITLE
CONFIDENTIAL TREATMENT
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