SECOND AMENDMENT TO THE SUPPLY AGREEMENT

Exhibit 10.1

SECOND AMENDMENT TO THE SUPPLY AGREEMENT

This Second Amendment dated May 6, 2010 (“Second Amendment”), to the Supply Agreement by and between Dendreon Corporation, a corporation organized under the laws of the State of Delaware, and having a place of business at 0000 Xxxxx Xxxxxx, Xxxxxxx, Xxxxxxxxxx 00000 (“DENDREON”), and Diosynth RTP Inc, a corporation organized under the laws of the State of Delaware and having a place of business at 000 X. Xxxxxx Xxxxxxx Xxxx, Xxxxxxxxxxx, XX  00000 (“DIOSYNTH”) dated December 22, 2005, as amended by the Settlement Agreement and Amendment to the Supply Agreement (the “Supply Agreement”).

WITNESSETH:

WHEREAS, the Parties entered into the Supply Agreement to undertake the manufacture and supply of the Ancillary Component (as defined in the Supply Agreement);

WHEREAS, the Parties wish to amend the terms of the Supply Agreement to extend the Supply Agreement by five years.

NOW, THEREFORE, in consideration of the mutual covenants and promises set forth herein, the parties agree as follows:

1.	Unless otherwise defined herein, each of the capitalized terms used in this Second Amendment shall have the meaning ascribed in the Supply Agreement.
2.	Section 3.1 of the Supply Agreement shall be amended in its entirely as follows:
	“The term of this Agreement shall commence on the Effective Date and shall continue until 31 December 2018 with automatic renewal for 5 year terms unless either Party gives written notice at least 24 months prior to the expiration of such initial or renewal term, or unless terminated sooner pursuant to Sections 3.2, 3.3, or 3.4 below (“Term”).”
3.	Except to the extent specifically modified by this Second Amendment, the terms and conditions of the Supply Agreement shall remain in full force and effect.
4.	From and after the execution of this Second Amendment, all references in the Agreement to “this Agreement”, “hereof”, “herein”, and similar words or phrases shall mean and refer to the Supply Agreement as amended, including this Second Amendment.  This Second Amendment shall not be modified, supplemented, amended or terminated in any manner whatsoever, except by a written instrument signed by a party against which such modification, supplement, amendment or termination is sought to be enforced.

IN WITNESS WHEREOF, the Parties have caused this Second Amendment to be executed by their respective duly authorized representatives as of the day and year first written above.

	DENDREON CORPORATION		DIOSYNTH RTP INC.
	By: /s/ Xxxxx Xxxxx		By: /s/ Xxxxxx Xxxxxxx
	Title: Sr. VP Operations		Title: Finance Director
	Date: 5-12-2010		Date: 5/7/2010
			By: /s/ Xxxxxxx Xxxxxxxx
			Title: Plant Manager
			Date: 05-07-10