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EXHIBIT 10.15
AMENDMENT TO COLLABORATION AGREEMENT
THIS AMENDMENT TO COLLABORATION AGREEMENT (this "Amendment"), effective
as of July 3, 2000 (the "Effective Date"), is entered into between CELL MATRIX,
INC., f/k/a Bio-Management, Inc., a Nevada corporation ("CMI"), having a place
of business at Four Xxxx Xxxx, Xxxxxx Xxxx, XX 00000, and APPLIED MOLECULAR
EVOLUTION, INC., f/k/a Ixsys, Inc., a Delaware corporation ("AME"), having a
place of business at 0000 Xxxxxxx Xxxxxx, Xxx Xxxxx, XX 00000.
RECITALS
A. The parties have entered into the Collaboration Agreement effective
as of November 29, 1999 (the "Agreement"). All terms used, but not defined, in
this Amendment shall have the respective meanings set forth in the Agreement.
B. The parties now desire to amend the Agreement in certain respects on
the terms and conditions set forth below.
NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants set forth below, the parties hereby amend the Agreement and
otherwise agree as follows:
1. AMENDMENTS.
CMI shall have the right (in its sole discretion), exercisable by
giving AME express written notice of such exercise prior to August 15, 2000, to
extend the Program Term with respect to the following Candidate Molecules: mAb
XL313 and mAb FM155, for the period commencing on the date within ninety (90)
days following the date AME timely receives such notice of exercise from CMI and
continuing for the subsequent seven (7) months.
2. MISCELLANEOUS.
2.1 Continuing Effect. This Amendment shall be effective for all
purposes as of the Effective Date. Except as otherwise expressly modified by
this Amendment, the Agreement shall remain in full force and effect in
accordance with its terms.
2.2 Governing Law. This Amendment shall be governed by and construed in
accordance with the laws of the State of California.
2.3 Counterparts. This Amendment may be executed in counterparts,
each of which shall be deemed to be an original and together shall be deemed to
be one and the same document.
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IN WITNESS WHEREOF, the undersigned have duly executed and delivered
this Amendment effective as of the Effective Date.
APPLIED MOLECULAR EVOLUTION, INC. CELL MATRIX, INC.
By: /s/ Xxxxxxxx X. Xxxxx, M.D. By: /s/ Xxxxxxx X. Xxxxx, Xx.
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Name: Xxxxxxxx X. Xxxxx, M.D. Name: Xxxxxxx X. Xxxxx, Xx.
Title: Chief Financial Officer and Title: Chief Executive Officer
Vice President of Business Development
