[LETTERHEAD OF SCHERING CORPORATION]
June 23, 1999
Xx. Xxxxxxx X. Xxxxx
President and Chief Executive Officer
Corvas International, Inc.
0000 Xxxxxxx Xxxx Xxxx
Xxx Xxxxx, Xxxxxxxxxx 00000
RE: Factor Xa Research Programs
Dear Xx. Xxxxx:
This "Letter of Agreement" is in reference to the Agreement by and
between Corvas International, Inc. ("Corvas") and Schering Corporation and
Schering-Plough Ltd. (collectively "Schering"), effective as of December 14,
1994, as amended (the "Agreement").
The current term of the Research Program will expire on September 14,
1999, unless extended by the parties pursuant to the Letter of Agreement dated
December 15, 1998. This is to confirm the parties' agreement to extend until
August 15, 1999 the deadline for notification of extension of the term of the
Factor Xa Research Program.
Please confirm Corvas' agreement to the provisions set forth in this
Letter of Agreement by signing below on behalf of Xxxxxx and returning one
signed original to Schering.
Very truly yours,
LEGAL REVIEW LEGAL REVIEW
SCHERING CORPORATION SCHERING -PLOUGH LTD.
/s/ XXXXX XXXXXXX, PH.D. /s/ XXXXX XXXXXXX, PH.D.
--------------------------- ---------------------------
Xxxxx Xxxxxxx, Ph.D. Xxxxx Xxxxxxx, Ph.D.
Vice President Prokurist
Acknowledged and Agreed to CORVAS INTERNATIONAL, INC.
By: /s/ XXXXXXX X. XXXXX
----------------------
Date: June 24, 1999
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cc: Corporate Secretary, Corvas International
Xxxxxx Godward LLP
Xxxxx X. Xxxxxxx, Ph.D.
Xxxxx Xxxxxxx, Ph.D.
Xxxxxxx Xxxxxxx, Ph.D.
