August 29, 2016 Via email: John Slebir General Counsel VIVUS, Inc.

Exhibit 10.1

August 29, 2016

Via email:

Xxxx Xxxxxx

General Counsel

VIVUS, Inc.

000 X. Xxxxxx Xxx.

Mountain View, CA 94041

Re: Termination Notice

Dear Xx. Xxxxxx:

This is to confirm our agreement that the date of termination of the License and Commercialization Agreement between VIVUS, Inc. and Auxilium Pharmaceuticals, LLC (formerly Auxilium Pharmaceuticals, Inc.), an Endo international company, dated October 10, 2013 (the “License Agreement”), is hereby extended to September  30, 2016.

Sincerely,

AUXILIUM PHARMACEUTICALS, LLC ENDO VENTURES LIMITED

/s/ Xxxxxx Xxxx /s/ Xxxxxx Xxxxxxx

Xxxxxx Xxxx Xxxxxx Xxxxxxx

Assistant Secretary Director

Accepted and agreed:

VIVUS, INC.

/s/ Xxxx X. Xxxxxx

Xxxx X. Xxxxxx

SVP, General Counsel