Exhibit 10.15
ADDENDUM TO MANUFACTURING AGREEMENT
This ADDENDUM made effective as of the 26 October, 2001, is between SYNCO
BIO PARTNERS B.V. (hereinafter "SYNCO") having an office at Xxxxxxxxxxxxx
00, 0000 XX Xxxxxxxxx Zuidoost, the Netherlands and NPS ALLELIX CORP., a
corporation incorporated under the laws of Ontario and having as office at 0000
Xxxxxxx Xxxxx, Xxxxxxxxxxx, Xxxxxxx Xxxxxx X0X 0X0 (hereinafter "NPS ALLELIX").
WHEREAS, SYNCO and NPS ALLELIX entered into a Manufacturing
Agreement, effective as of 17 May, 2001 (hereafter the "Agreement"); and
WHEREAS, both NPS ALLELIX and SYNCO wish to continue the Agreement but in
addition NPS ALLELIX now desires SYNCO to prepare a PTH Standard for NPS ALLELIX
and SYNCO wishes to produce such PTH Standard for NPS ALLELIX.
THEREFORE, the parties agree to the following addendum to the Agreement;
1. SYNCO shall produce a minimum of 4,500 vials of PTH Standard ("Vials of
PTH Standard") in accordance with Appendix D. Each vial shall contain
0.3ml of a 2.1mg PTH/ml solution. The Vials of PTH Standard shal1 be
prepared according to European GMP Guidelines. Batch Production Records
shal1 be prepared by SYNCO and approved by NPS ALLELIX.
2. NPS ALLELIX shall pay SYNCO 31,500 Euros for the Vials of PTH Standard. On
release of the Vials of PTH Standard by SYNCO to NPS ALLELIX, SYNCO shall
invoice NPS ALLELIX in the amount of 31,500 Euros and NPS ALLELIX shall
pay within thirty (30) days of such invoice.
3. The Vials of PTH Standard shall be filled by week 47 and tested as set
out in Appendix X. XXXXX shall release the Batch Documents together with
the Vials of PTH Standard to NPS within ten (10) weeks of filling the
Vials of PTH Standard.
4. Unless explicitly altered by the Addendum, a1l terms of the Agreement as
applicable shall apply to the production and release of the Vials of PTH
Standard. Furthermore, this Addendum is not intended to alter any of the
rights or obligations set out in the Agreement in the production of PTH
under the Agreement.
IN WITNESS WHEREOF, the parties hereto have caused this Addendum to be
executed by their duly authorized representatives
SYNCO BIO PARTNERS B.V. NPS ALLELIX CORP.
/s/ Mic X. Xxxxxx /s/ Xxxxxx X. Marriott
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Mic X. Xxxxxx, Ph.D. Xxxxxx X. Marriott, Ph.D.
Managing Director Vice President, Development Research
