Contract

00 Xxxxxxxx Xxxxxx, Xxxxxxxx 00 | Xxxxxxxxxxx, XX 00000 | Phone: 000-000-0000 | Fax: 000-000-0000

xxx.xxxxxx.xxx

December 18, 2018

VIA E-MAIL

Xxxxx Xxxxx

VP of Finance and Chief Financial Officer

Ajinomoto Xxxxxx, Inc.

00000 Xxxxxxx Xxxxxx

Xxx Xxxxx, XX 00000

RE: Extension of Commercial Fill/Finish Services Agreement

Dear Xx. Xxxxx,

As you know, Ajinomoto Xxxxxx, Inc. (“Xxxxxx”) and Insmed Incorporated (“Insmed”) are parties to the Commercial Fill/Finish Supply Agreement, dated January 1, 2015 (the “Agreement”). Per Section 7.1 of the Agreement, the Initial Term (as defined in the Agreement) of the Agreement was extended to, and now expires on, December 31, 2019 and the parties may mutually agree to extend the Agreement for an additional two (2) year period at least one (1) year prior to the expiration. Insmed kindly requests that Xxxxxx acknowledge and agree to a two (2) year extension of the Agreement until December 31, 2021 by signing below.

We appreciate all of the efforts made to date by Xxxxxx and look forward to continuing our relationship. Please contact me at 000-000-0000 with any questions.

Sincerely,

/s/ Xxx Xxxxxxx

Xxx Xxxxxxx

Vice President, Technical Operations

AGREED AND ACKNOWLEDGED:

Ajinomoto Xxxxxx, Inc.

By: /s/ Xxxxx X. Xxxxx

Name: Xxxxx X. Xxxxx

Title: VP of Finance and Chief Financial Officer